LOCUS       NM_001411911            2052 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus microspherule protein 1 (Mcrs1), transcript variant 3,
            mRNA.
ACCESSION   NM_001411911 XM_030248640
VERSION     NM_001411911.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Ju,J.Q., Pan,Z.N., Zhang,K.H., Ji,Y.M., Liu,J.C. and Sun,S.C.
  TITLE     Mcrs1 regulates G2/M transition and spindle assembly during mouse
            oocyte meiosis
  JOURNAL   EMBO Rep 24 (5), e56273 (2023)
   PUBMED   36951681
  REMARK    GeneRIF: Mcrs1 regulates G2/M transition and spindle assembly
            during mouse oocyte meiosis.
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Garrido,A., Kim,E., Teijeiro,A., Sanchez Sanchez,P., Gallo,R.,
            Nair,A., Matamala Montoya,M., Perna,C., Vicent,G.P., Munoz,J.,
            Campos-Olivas,R., Melms,J.C., Izar,B., Schwabe,R.F. and Djouder,N.
  TITLE     Histone acetylation of bile acid transporter genes plays a critical
            role in cirrhosis
  JOURNAL   J Hepatol 76 (4), 850-861 (2022)
   PUBMED   34958836
  REMARK    GeneRIF: Histone acetylation of bile acid transporter genes plays a
            critical role in cirrhosis.
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Sheikh,B.N., Guhathakurta,S., Tsang,T.H., Schwabenland,M.,
            Renschler,G., Herquel,B., Bhardwaj,V., Holz,H., Stehle,T.,
            Bondareva,O., Aizarani,N., Mossad,O., Kretz,O., Reichardt,W.,
            Chatterjee,A., Braun,L.J., Thevenon,J., Sartelet,H., Blank,T.,
            Grun,D., von Elverfeldt,D., Huber,T.B., Vestweber,D., Avilov,S.,
            Prinz,M., Buescher,J.M. and Akhtar,A.
  TITLE     Neural metabolic imbalance induced by MOF dysfunction triggers
            pericyte activation and breakdown of vasculature
  JOURNAL   Nat Cell Biol 22 (7), 828-841 (2020)
   PUBMED   32541879
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Min,J.N., Tian,Y., Xiao,Y., Wu,L., Li,L. and Chang,S.
  TITLE     The mINO80 chromatin remodeling complex is required for efficient
            telomere replication and maintenance of genome stability
  JOURNAL   Cell Res 23 (12), 1396-1413 (2013)
   PUBMED   23979016
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Ren,Y., Busch,R.K., Perlaky,L. and Busch,H.
  TITLE     The 58-kDa microspherule protein (MSP58), a nucleolar protein,
            interacts with nucleolar protein p120
  JOURNAL   Eur J Biochem 253 (3), 734-742 (1998)
   PUBMED   9654073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161198.5.
            
            On Sep 9, 2022 this sequence version replaced XM_030248640.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.787644.1,
                                           SRR7345562.4187643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC161198.5         163869-164104       c
            237-356             AC161198.5         162610-162729       c
            357-495             AC161198.5         162023-162161       c
            496-634             AC161198.5         161515-161653       c
            635-793             AC161198.5         160849-161007       c
            794-903             AC161198.5         160598-160707       c
            904-1012            AC161198.5         159426-159534       c
            1013-1151           AC161198.5         159074-159212       c
            1152-1227           AC161198.5         156795-156870       c
            1228-1256           AC161198.5         156495-156523       c
            1257-1349           AC161198.5         156292-156384       c
            1350-1432           AC161198.5         156072-156154       c
            1433-1520           AC161198.5         155827-155914       c
            1521-1648           AC161198.5         155465-155592       c
            1649-2052           AC161198.5         154964-155367       c
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.09 cM"
     gene            1..2052
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /note="microspherule protein 1"
                     /db_xref="GeneID:51812"
                     /db_xref="MGI:MGI:1858420"
     exon            1..236
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            237..356
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1735
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /note="isoform 1 is encoded by transcript variant 3;
                     nucleolar protein; 58 kDa microspherule protein"
                     /codon_start=1
                     /product="microspherule protein 1 isoform 1"
                     /protein_id="NP_001398840.1"
                     /db_xref="GeneID:51812"
                     /db_xref="MGI:MGI:1858420"
                     /translation="MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPK
                     RRSSSRFIKRKKFDDELVESSLAKSSTRVKGAGGVESGRCSGSEPSSSEKKKVSKAPS
                     TPVPPSPAPTPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGV
                     KFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLS
                     KVGSSSQPTLETFQDLLHTHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGD
                     QVLNFSDAEDLIDDSKLKDMRDEVLEHELTVADRRQKREIRQLEQELHKWQVLVDSIT
                     GMGSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQG
                     VIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIA
                     LIRAEAAKITPQ"
     exon            357..495
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            496..634
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            635..793
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            794..903
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1012
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1151
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1227
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1256
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1349
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1432
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1520
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1648
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2052
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /note="hexamer: AATAAA"
     polyA_site      2049
                     /gene="Mcrs1"
                     /gene_synonym="ICP22BP; MSP58; P78"
                     /note="major polyA site"
ORIGIN      
        1 aacccggaag tagatgtgtc tcacggaagc cggctttggc cctgcggctc ctgccgtcgc
       61 cgcggagaaa ttgttggagc tggcagccta ggaatggtga gaccccgcga ctcgtctcct
      121 agtgttctga gtagacctgg agggtgaagt ggagtttccc aacgtgcctc ggggcacaac
      181 cccacaacaa gatttggggc cccgccccgg tatcgccccg aaaaatctgc gcatgcactc
      241 tcttctcagc atccaagctc gcttggtcag aacccttgga tgagcctgtg ggacccttcc
      301 tcctagccct gtggtttgga gccggaggct ttgggactgt gagaggatgg acaaagattc
      361 tcaggggctg ctagactcgt ccctgatggc gtcaggcaca gccagccgct ccgaggatga
      421 ggagtcactg gcagggcaga agcgagcatc ctcccaggcc ctgggcacta tccccaaacg
      481 cagaagctcc tccaggttca tcaaaaggaa gaaattcgat gatgaactgg tagagagcag
      541 cctggccaaa tcctccaccc gggtgaaggg ggccggcggg gtggagtcag gccgctgctc
      601 agggagcgag ccctcctcta gtgagaagaa gaaggtatcc aaggctccca gtactcctgt
      661 acctcccagc cctgccccaa cccctgggct gaccaagcgt gtgaagaaaa gcaaacagcc
      721 acttcaggtg accaaggatc tgggccgatg gaagcctgca gatgacctcc tcctcatcaa
      781 tgctgtgctg cagactaacg acctgacatc tgtccacctg ggtgtgaagt tcagctgccg
      841 cttcaccctt cgggaagttc aggagcgctg gtacgccctg ctctacgacc ctgtcatctc
      901 caagctggct tgccaggcca tgaggcagtt acacccagaa gccattgcag ccattcagag
      961 caaggccctg ttcagcaagg ctgaggagca gctgctgagc aaagtgggat caagcagcca
     1021 gcccaccttg gagaccttcc aggacttgct gcatacacac cctgatgcct tctacctggc
     1081 tcgtactgcc aaggctctgc aggcccactg gcagctcatg aaacagtatt acctactcga
     1141 ggatcagaca gtgcagccac tgcctaaggg ggaccaagtg ctcaacttct cagatgcaga
     1201 ggacctgatt gacgacagta agctcaagga catgcgagat gaagtcctgg aacatgagct
     1261 gacagtggct gaccggcgcc agaaacgaga gatccggcag ctggaacagg aactgcataa
     1321 gtggcaggtg ctagtggaca gcatcacagg catgggctct ccagacttcg acaaccagac
     1381 cctggccgtg ctgcggggcc gcatggtgcg gtacctaatg cgctctcgtg agataaccct
     1441 gggcagagca accaaggaca accagattga cgtggacctg tctctggagg gtccggcttg
     1501 gaagatctcc cgaaagcaag gtgtcatcaa gttgaaaaac aatggtgact tcttcattgc
     1561 caacgagggc cggcggccca tctatatcga tgggcgacca gtgctgtgcg gctccaagtg
     1621 gcgccttagc aacaactctg tggtagagat cgccagcctg cgattcgtct tcctcatcaa
     1681 ccaggacctc attgccctca tccgggctga ggctgccaag atcaccccac agtgaggcgg
     1741 tagcagaaac cagggcattc tccagcctca gtttccctgt cattccagct cccttgagct
     1801 gggaactcag gctcctggaa aacccttgta cccagagtgg ggagtggagg cccgactgct
     1861 ggcccattga ttgagccttt gaggcaaggt ggggtcacca tggggaagcc aggagaggct
     1921 gggacccctg tgcctcccca gagccagagc cccaccatcg ccaccattgt cactcctgtg
     1981 tctccagtga gtcagcttta gactcctttt tgtttttgtt tttgtaaata aaaagtactg
     2041 agttccaaag ta
//
