LOCUS       NM_001033231            1205 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus MAPK regulated corepressor interacting protein 1
            (Mcrip1), transcript variant 1, mRNA.
ACCESSION   NM_001033231 XM_203523 XM_912334
VERSION     NM_001033231.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1205)
  AUTHORS   Weng,J.S., Nakamura,T., Moriizumi,H., Takano,H., Yao,R. and
            Takekawa,M.
  TITLE     MCRIP1 promotes the expression of lung-surfactant proteins in mice
            by disrupting CtBP-mediated epigenetic gene silencing
  JOURNAL   Commun Biol 2, 227 (2019)
   PUBMED   31240265
  REMARK    GeneRIF: MCRIP1 interferes with interactions of CtBP with the
            lung-enriched transcriptional repressors, Foxp1 and Foxp2, thereby
            preventing the recruitment of the CtBP co-repressor complex to the
            SP-B and SP-C promoters and maintaining them in an active chromatin
            state. Homozygous deficiency of Mcrip1 in mice causes fatal
            respiratory distress due to abnormal transcriptional repression of
            surfactant proteins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1205)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI987638.1, AK147780.1 and AI845228.1.
            
            On May 17, 2018 this sequence version replaced NM_001033231.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI987638.1, AK147780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BI987638.1         1-23
            24-1203             AK147780.1         2-1181
            1204-1205           AI845228.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.25 cM"
     gene            1..1205
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /note="MAPK regulated corepressor interacting protein 1"
                     /db_xref="GeneID:192173"
                     /db_xref="MGI:MGI:2384752"
     exon            1..71
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /inference="alignment:Splign:2.1.0"
     exon            72..123
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..409
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /note="protein FAM195B; family with sequence similarity
                     195, member B"
                     /codon_start=1
                     /product="mapk-regulated corepressor-interacting protein
                     1"
                     /protein_id="NP_001028403.1"
                     /db_xref="CCDS:CCDS36391.1"
                     /db_xref="GeneID:192173"
                     /db_xref="MGI:MGI:2384752"
                     /translation="MTSSPVSRVVYNGKRNSSPRSPTNSSEIFTPAHEENVRFIYEAW
                     QGVERDLRSQLSSGERCLVEEYVEKVPNPSLKTFKPIDLSDLKRRNTQDAKKS"
     exon            124..242
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /inference="alignment:Splign:2.1.0"
     exon            243..344
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /inference="alignment:Splign:2.1.0"
     exon            345..1205
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1184..1189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /note="hexamer: AATAAA"
     polyA_site      1205
                     /gene="Mcrip1"
                     /gene_synonym="Fam195b"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgtcac ttccggccgg cccactggaa gcggcggcgg cggcggcagc ggcggcggcg
       61 aggagggcga ggccgcagga ccagcagcca agcactagga ctggacatcc cagcaatgac
      121 cagctctcct gtctccagag ttgtctacaa cggcaagagg aatagcagtc cccgctctcc
      181 caccaacagc agtgagattt tcacaccggc acacgaagag aatgtgcgct tcatttatga
      241 agcctggcag ggtgttgagc gagacctgcg cagccagctg tccagtggtg agcggtgcct
      301 agtggaggag tatgtggaga aagtccccaa ccccagcctg aagaccttca agcccatcga
      361 cctgagtgac ctgaagcgcc ggaacacgca ggatgccaag aagtcctaga gctcctggcg
      421 ccctcccctg gcctccagaa gctcaggtgc acttgatggt ggtttcctgt gttcctgtgg
      481 cgctgctcct ggggggaaga gtgtgctcta gcaggccgtg atcccagagc cagcaggatt
      541 gatgaccagg gcccttcctt tcctctccag ggtctcaagt tgcccctgtc actgggggaa
      601 caggggcctg gctgtaaccg cccctgtcct tttcccctgg ccagctgcat cttgggtagc
      661 acctggcccg acctatctag ccctctctgc tgttacctgc catgccttgc ccctctcctt
      721 cctggctact taaggtcagg aaggaaaaag gggacctctg tttcttcggc tgttggaacc
      781 ttgaaatgac cagaaagtag gacatgtgca gtcccacctg catccagtgt ggctctctcc
      841 atggagactt gctcttcttc tgccctggac atgtggggag ctcccgcttc cacccccact
      901 gtccatcctg acctttcctt gccccacttt cagagtcgaa tcagctctga gcctaggaca
      961 gtgctggctc tctgagggca accaggcctt gtgtcctggt acctgtgaca ctgttgtggt
     1021 cacagcagtg cccttggaca gggcattaag gctgaccctg aaggagtggt gctgccaggc
     1081 ctgtcctggc tttctggggt gtgctgggag gattaccaag gccccctttt tttgtgccct
     1141 cttgaatcca agtgtctgta gctttggaga ctgagggtct gtgaataaag gcggtggcac
     1201 tggaa
//
