LOCUS       NM_010782               2000 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus mast cell protease 9 (Mcpt9), mRNA.
ACCESSION   NM_010782 XM_990890
VERSION     NM_010782.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2000)
  AUTHORS   Paul,J., Singh,A.K., Kathania,M., Elviche,T.L., Zeng,M., Basrur,V.,
            Theiss,A.L. and Venuprasad,K.
  TITLE     IL-17-driven intestinal fibrosis is inhibited by Itch-mediated
            ubiquitination of HIC-5
  JOURNAL   Mucosal Immunol 11 (2), 427-436 (2018)
   PUBMED   28612841
REFERENCE   2  (bases 1 to 2000)
  AUTHORS   Gallwitz,M. and Hellman,L.
  TITLE     Rapid lineage-specific diversification of the mast cell chymase
            locus during mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 641-654 (2006)
   PUBMED   16807746
REFERENCE   3  (bases 1 to 2000)
  AUTHORS   Gallwitz,M., Reimer,J.M. and Hellman,L.
  TITLE     Expansion of the mast cell chymase locus over the past 200 million
            years of mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 655-669 (2006)
   PUBMED   16807745
REFERENCE   4  (bases 1 to 2000)
  AUTHORS   Murakami,M., Ikeda,T., Ogawa,K. and Funaba,M.
  TITLE     Transcriptional activation of mouse mast cell protease-9 by
            microphthalmia-associated transcription factor
  JOURNAL   Biochem Biophys Res Commun 311 (1), 4-10 (2003)
   PUBMED   14575687
  REMARK    GeneRIF: The most significant segment for positive regulation by
            MITF was nt -183 to -177 of the mMCP-9 promoter, CATCATG, which
            bound MITF-M.
REFERENCE   5  (bases 1 to 2000)
  AUTHORS   Dansky,H.M., Shu,P., Donavan,M., Montagno,J., Nagle,D.L.,
            Smutko,J.S., Roy,N., Whiteing,S., Barrios,J., McBride,T.J.,
            Smith,J.D., Duyk,G., Breslow,J.L. and Moore,K.J.
  TITLE     A phenotype-sensitizing Apoe-deficient genetic background reveals
            novel atherosclerosis predisposition loci in the mouse
  JOURNAL   Genetics 160 (4), 1599-1608 (2002)
   PUBMED   11973313
REFERENCE   6  (bases 1 to 2000)
  AUTHORS   Ge,Y., Jippo,T., Lee,Y.M., Adachi,S. and Kitamura,Y.
  TITLE     Independent influence of strain difference and mi transcription
            factor on the expression of mouse mast cell chymases
  JOURNAL   Am J Pathol 158 (1), 281-292 (2001)
   PUBMED   11141502
REFERENCE   7  (bases 1 to 2000)
  AUTHORS   Detter,J.C., Zhang,Q., Mules,E.H., Novak,E.K., Mishra,V.S., Li,W.,
            McMurtrie,E.B., Tchernev,V.T., Wallace,M.R., Seabra,M.C.,
            Swank,R.T. and Kingsmore,S.F.
  TITLE     Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse
            reduces Rab prenylation and platelet synthesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4144-4149 (2000)
   PUBMED   10737774
REFERENCE   8  (bases 1 to 2000)
  AUTHORS   Hunt,J.E., Friend,D.S., Gurish,M.F., Feyfant,E., Sali,A., Huang,C.,
            Ghildyal,N., Stechschulte,S., Austen,K.F. and Stevens,R.L.
  TITLE     Mouse mast cell protease 9, a novel member of the chromosome 14
            family of serine proteases that is selectively expressed in uterine
            mast cells
  JOURNAL   J Biol Chem 272 (46), 29158-29166 (1997)
   PUBMED   9360993
REFERENCE   9  (bases 1 to 2000)
  AUTHORS   Serafin,W.E., Sullivan,T.P., Conder,G.A., Ebrahimi,A., Marcham,P.,
            Johnson,S.S., Austen,K.F. and Reynolds,D.S.
  TITLE     Cloning of the cDNA and gene for mouse mast cell protease 4.
            Demonstration of its late transcription in mast cell subclasses and
            analysis of its homology to subclass-specific neutral proteases of
            the mouse and rat
  JOURNAL   J Biol Chem 266 (3), 1934-1941 (1991)
   PUBMED   1988455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163646.2.
            
            On Sep 7, 2007 this sequence version replaced NM_010782.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY007568.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849380
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1282              AC163646.2         34423-35704
            1283-1433           AC163646.2         36204-36354
            1434-1569           AC163646.2         36884-37019
            1570-1824           AC163646.2         37218-37472
            1825-2000           AC163646.2         37879-38054
FEATURES             Location/Qualifiers
     source          1..2000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2000
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /note="mast cell protease 9"
                     /db_xref="GeneID:17232"
                     /db_xref="MGI:MGI:1194491"
     exon            1..1282
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             1228..1968
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /note="mast cell-specific serine protease"
                     /codon_start=1
                     /product="mast cell protease 9 precursor"
                     /protein_id="NP_034912.3"
                     /db_xref="CCDS:CCDS27138.1"
                     /db_xref="GeneID:17232"
                     /db_xref="MGI:MGI:1194491"
                     /translation="MQALLFLMALLLPSRAGAEEIIGGVESEPHSRPYMAYVNTFSKK
                     GYVAICGGFLIAPQFVMTAAHCSGRRMTVTLGAHNVRKRECTQQKIKVEKYILPPNYN
                     VSSKFNDIVLLKLKKQANLTSAVDVVPLPGPSDFAKPGTMCWAAGWGRTGVKKSISHT
                     LREVELKIVGEKACKIFRHYKDSLQICVGSSTKVASVYMGDSGGPLLCAGVAHGIVSS
                     GRGNAKPPAIFTRISPHVPWINRVIKGE"
     exon            1283..1433
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1569
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1824
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2000
                     /gene="Mcpt9"
                     /gene_synonym="MMCP-1; MMCP-9; MMCP9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattccaaa ttgttattat ttaagcagga ataatttttt aaaccaatgt tgcatttctg
       61 tgtaactgtg agccatgctt aatttccagt ggcacatgaa aagatgaaag ctccaagtct
      121 caatactgat ctgtacacat ttgatattgt tctcaggcaa ggagactctc cacatataac
      181 tagcaatcct gagatcctct gtggaacaca gagggggttc tttaaacatt ccattgtgtt
      241 ttctgttcat cccactggaa tgaaaagaat aagttataga aaccaactta aatgtatgat
      301 cttcctgttt tgtaatatcc tgaaagtcca ttgagttctc cctgaatgtg tattgcaaca
      361 tctatcaaag gggctgttaa tatgactaaa tcagaacatg catttacagc agctgttctc
      421 aacctgtggg tcatgacccc tctaggggtc aaatatcaga tattctgcat atcacatatt
      481 ttacatcata attcacaaca gtagcagaat tatagatatg aaatagcaat gaaataattt
      541 tatggctggg gtcaccacaa tgtgggaact gaattaaagg ctcacaccat taggaaagtt
      601 gaacaccact gatttaatta aggttggtta tgcctcatat gctgtgtatt caatatgctt
      661 caaatctttt ttctctcaca gccacattct atcatctctg atttatttga ataaaaatgt
      721 gatgccctca cactggttaa cacaaacaag aacctcaggc taaagcagcc caccaccagt
      781 ttttgtaaat aaaatgtcct tcctctcacc catatgttca caaaccacag acccctgtgt
      841 tacaggaaca gagatgagtc tttacacgta tgcagcatgg gtctataagc tgacaataat
      901 acctggatgc tttcaagaac agttccatga tccctgatca aggttcccct tcctttgtgt
      961 tgctctcctt cctcctggga actactttga agggtgcagt caccacctca tcatgggatc
     1021 caggagtctc atgatcaggc cacagattca acaccatcac aaagcagagt tgtgagaatt
     1081 tttgataaaa aacaaaacaa aaaaacttga ccaaggcaga cctgtggttc ccagccctgc
     1141 ctttctccca cgttggagct ataaaagcag gaaccaggac aagaacacac caaaatctct
     1201 ctccagactg cgaccgacac ttgcaagatg caggccctac tattcctgat ggcacttctc
     1261 ttgccttcta gggctggagc tgaggagatt attggtggtg ttgagtctga accacactcc
     1321 cgaccttaca tggcctatgt gaataccttc agtaagaaag gttatgtggc aatctgtggt
     1381 gggtttctca tagcccccca atttgtgatg actgctgcac actgtagtgg aagaagaatg
     1441 actgtcaccc ttggagctca taatgtgaga aagagagaat gcacacagca gaagataaaa
     1501 gttgaaaagt acatcttgcc tccaaattac aatgtgtctt ccaagttcaa tgacatcgta
     1561 ttactgaagc ttaaaaagca agctaacttg acttctgctg tggatgtagt tcccctgcct
     1621 ggcccctctg actttgccaa gcctgggacg atgtgttggg cagctggctg ggggcgaact
     1681 ggagtgaaaa aaagtatctc acataccctg agagaggtag aactgaaaat cgtgggggaa
     1741 aaggcctgta aaatatttag gcattacaag gatagcctcc agatctgtgt gggcagttcc
     1801 acaaaggtgg catcagtata catgggagac tctggaggac ctctactgtg tgctggggtg
     1861 gcccatggta ttgtatcttc tggacgcgga aatgcaaagc cccctgcaat cttcacccga
     1921 atctccccac atgtgccctg gattaacaga gtcataaagg gcgagtagtg aaaagcctga
     1981 cctgcgtgca tcagagtctt
//
