LOCUS       NM_008572                845 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus mast cell protease 8 (Mcpt8), mRNA.
ACCESSION   NM_008572
VERSION     NM_008572.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 845)
  AUTHORS   Takahashi,K., Miyake,K., Ito,J., Shimamura,H., Suenaga,T.,
            Karasuyama,H. and Ohashi,K.
  TITLE     Topical Application of a PDE4 Inhibitor Ameliorates Atopic
            Dermatitis through Inhibition of Basophil IL-4 Production
  JOURNAL   J Invest Dermatol 144 (5), 1048-1057 (2024)
   PUBMED   37827277
REFERENCE   2  (bases 1 to 845)
  AUTHORS   Tchen,J., Simon,Q., Chapart,L., Thaminy,M.K., Vibhushan,S.,
            Saveanu,L., Lamri,Y., Saidoune,F., Pacreau,E., Pellefigues,C.,
            Bex-Coudrat,J., Karasuyama,H., Miyake,K., Hidalgo,J., Fallon,P.G.,
            Papo,T., Blank,U., Benhamou,M., Hanouna,G., Sacre,K., Daugas,E. and
            Charles,N.
  TITLE     PD-L1- and IL-4-expressing basophils promote pathogenic
            accumulation of T follicular helper cells in lupus
  JOURNAL   Nat Commun 15 (1), 3389 (2024)
   PUBMED   38649353
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 845)
  AUTHORS   Park,J., Cho,Y., Yang,D., Yang,H., Lee,D., Kubo,M. and Kang,S.J.
  TITLE     The transcription factor NFIL3/E4BP4 regulates the developmental
            stage-specific acquisition of basophil function
  JOURNAL   J Allergy Clin Immunol 153 (1), 132-145 (2024)
   PUBMED   37783432
REFERENCE   4  (bases 1 to 845)
  AUTHORS   Hashimoto,T., Yokozeki,H., Karasuyama,H. and Satoh,T.
  TITLE     IL-31-generating network in atopic dermatitis comprising
            macrophages, basophils, thymic stromal lymphopoietin, and periostin
  JOURNAL   J Allergy Clin Immunol 151 (3), 737-746 (2023)
   PUBMED   36410530
REFERENCE   5  (bases 1 to 845)
  AUTHORS   Tchen,J., Simon,Q., Chapart,L., Pellefigues,C., Karasuyama,H.,
            Miyake,K., Blank,U., Benhamou,M., Daugas,E. and Charles,N.
  TITLE     CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a
            Nonredundant Role in Lupus-Like Disease Development
  JOURNAL   Front Immunol 13, 900532 (2022)
   PUBMED   35844602
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 845)
  AUTHORS   Gallwitz,M., Enoksson,M. and Hellman,L.
  TITLE     Expression profile of novel members of the rat mast cell protease
            (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse
            mast cell protease (mMCP)-8
  JOURNAL   Immunogenetics 59 (5), 391-405 (2007)
   PUBMED   17342483
  REMARK    GeneRIF: The proteolytic activity of mMCP-8 as a first
            representative for the Mcpt8-subfamilywas studied.
REFERENCE   7  (bases 1 to 845)
  AUTHORS   Gallwitz,M. and Hellman,L.
  TITLE     Rapid lineage-specific diversification of the mast cell chymase
            locus during mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 641-654 (2006)
   PUBMED   16807746
REFERENCE   8  (bases 1 to 845)
  AUTHORS   Gallwitz,M., Reimer,J.M. and Hellman,L.
  TITLE     Expansion of the mast cell chymase locus over the past 200 million
            years of mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 655-669 (2006)
   PUBMED   16807745
REFERENCE   9  (bases 1 to 845)
  AUTHORS   Lunderius,C. and Hellman,L.
  TITLE     Characterization of the gene encoding mouse mast cell protease 8
            (mMCP-8), and a comparative analysis of hematopoietic serine
            protease genes
  JOURNAL   Immunogenetics 53 (3), 225-232 (2001)
   PUBMED   11398967
REFERENCE   10 (bases 1 to 845)
  AUTHORS   Lutzelschwab,C., Huang,M.R., Kullberg,M.C., Aveskogh,M. and
            Hellman,L.
  TITLE     Characterization of mouse mast cell protease-8, the first member of
            a novel subfamily of mouse mast cell serine proteases, distinct
            from both the classical chymases and tryptases
  JOURNAL   Eur J Immunol 28 (3), 1022-1033 (1998)
   PUBMED   9541598
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X78545.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78545.1, AK136485.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849388 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="Leaden x A1 F1"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..845
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /note="mast cell protease 8"
                     /db_xref="GeneID:17231"
                     /db_xref="MGI:MGI:1261780"
     exon            1..65
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..754
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /codon_start=1
                     /product="mast cell protease 8 precursor"
                     /protein_id="NP_032598.1"
                     /db_xref="CCDS:CCDS27141.1"
                     /db_xref="GeneID:17231"
                     /db_xref="MGI:MGI:1261780"
                     /translation="MFLLLVLLVAALPVNAEGGEIIWGTESKPHSRPYMAYIRFNDSK
                     SVYRCGGFLVARDIVMTAAHCNGKVINVTLGIHNLKKKKNTQLIPVSEAIPHESFDNE
                     TLVNDIMLLKLERKAQLNSAVDTIALPKSKDWVKPGQVCTVAGWGKLANCTLSDTLQE
                     VNLEVQKGQKCRSMSQTYNDSIQLCVGNPSENKATGKGDSGGPFVCNGVVQGIVSCRL
                     CTGTLPRVFTRISSFMPWIRKTMKLLQQP"
     exon            66..213
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            214..346
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            347..601
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            602..839
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      819..824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /note="hexamer: AAGAAA"
     polyA_site      839
                     /gene="Mcpt8"
                     /gene_synonym="MMCP-8"
                     /note="major polyA site"
ORIGIN      
        1 cctgaagagg atgttcctgc tcctggtcct cctggtggct gccctgccag tcaacgctga
       61 aggaggggaa atcatatggg gtacagagtc caaaccccac tcccggccct atatggcata
      121 cataaggttt aatgacagca aatcagtcta tcgctgtggt ggtttcctgg tggcaagaga
      181 catcgtaatg acagcagctc actgtaatgg aaaagttata aatgtaacct taggaattca
      241 caatctcaag aaaaagaaaa acacccagct cattcctgtc agtgaagcca tacctcacga
      301 gagctttgac aatgaaacac tggtcaatga catcatgctc ctgaagctgg aacgcaaagc
      361 tcaactcaac agtgctgtgg atactattgc ccttccaaag agcaaggatt gggtgaaacc
      421 tgggcaggtg tgcacagtgg caggttgggg aaagttggcc aattgcactt tgtctgacac
      481 acttcaagaa gtgaatctag aagttcaaaa gggccagaag tgtcgcagca tgtcccaaac
      541 ctacaacgac tccatccagc tctgtgtggg aaatcccagt gagaataagg ctactggtaa
      601 gggtgactct ggcggaccct ttgtgtgtaa tggggtggtc cagggcattg tcagttgtcg
      661 cttgtgtact gggacacttc ctcgggtatt caccagaatt tccagcttta tgccttggat
      721 tcggaaaaca atgaaactcc tgcaacaacc ctagaacaca aaacctgtgt ctgggccagt
      781 gtccagcatc ctggggtatg gttgtctgag ccttaataaa gaaatctgtc tgcaggaaaa
      841 aaaaa
//
