LOCUS       NM_010779                990 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mast cell protease 4 (Mcpt4), mRNA.
ACCESSION   NM_010779
VERSION     NM_010779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 990)
  AUTHORS   Bao,C., Chen,O., Sheng,H., Zhang,J., Luo,Y., Hayes,B.W., Liang,H.,
            Liedtke,W., Ji,R.R. and Abraham,S.N.
  TITLE     A mast cell-thermoregulatory neuron circuit axis regulates
            hypothermia in anaphylaxis
  JOURNAL   Sci Immunol 8 (81), eadc9417 (2023)
   PUBMED   36930731
REFERENCE   2  (bases 1 to 990)
  AUTHORS   Cespedes,N., Donnelly,E.L., Lowder,C., Hansten,G., Wagers,D.,
            Briggs,A.M., Schauer,J., Haapanen,L., Abrink,M., Van de Water,J.
            and Luckhart,S.
  TITLE     Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to
            Plasmodium yoelii, Limits Malaria-Associated Disruption of
            Intestinal Barrier Integrity and Reduces Parasite Transmission to
            Anopheles stephensi
  JOURNAL   Front Immunol 13, 801120 (2022)
   PUBMED   35154114
  REMARK    GeneRIF: Mast Cell Chymase/Mcpt4 Suppresses the Host Immune
            Response to Plasmodium yoelii, Limits Malaria-Associated Disruption
            of Intestinal Barrier Integrity and Reduces Parasite Transmission
            to Anopheles stephensi.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 990)
  AUTHORS   Vincent,L., Lapointe,C., Lo,M., Gagnon,H., Pejler,G., Takai,S.,
            Day,R. and D'Orleans-Juste,P.
  TITLE     Mast Cell Degranulation Increases Mouse Mast Cell Protease
            4-Dependent Vasopressor Responses to Big Endothelin-1 But Not
            Angiotensin I
  JOURNAL   J Pharmacol Exp Ther 376 (2), 213-221 (2021)
   PUBMED   33154104
  REMARK    GeneRIF: Mast Cell Degranulation Increases Mouse Mast Cell Protease
            4-Dependent Vasopressor Responses to Big Endothelin-1 But Not
            Angiotensin I.
REFERENCE   4  (bases 1 to 990)
  AUTHORS   Madjene,L.C., Danelli,L., Dahdah,A., Vibhushan,S., Bex-Coudrat,J.,
            Pacreau,E., Vaugier,C., Claver,J., Rolas,L., Pons,M.,
            Madera-Salcedo,I.K., Beghdadi,W., El Ghoneimi,A., Benhamou,M.,
            Launay,P., Abrink,M., Pejler,G., Moura,I.C., Charles,N., Daugas,E.,
            Perianin,A. and Blank,U.
  TITLE     Mast cell chymase protects against acute ischemic kidney injury by
            limiting neutrophil hyperactivation and recruitment
  JOURNAL   Kidney Int 97 (3), 516-527 (2020)
   PUBMED   31866111
  REMARK    GeneRIF: Mast cell chymase protects against acute ischemic kidney
            injury by limiting neutrophil hyperactivation and recruitment.
REFERENCE   5  (bases 1 to 990)
  AUTHORS   Desbiens,L., Lapointe,C., Gendron,L., Gharagozloo,M., Vincent,L.,
            Pejler,G., Gris,D. and D'Orleans-Juste,P.
  TITLE     Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast
            Cell Protease 4-Dependent Pressor Responses to Centrally or
            Systemically Administered Big Endothelin-1
  JOURNAL   J Pharmacol Exp Ther 370 (3), 437-446 (2019)
   PUBMED   31248979
  REMARK    GeneRIF: mMCP-4 activity is enhanced both centrally and
            systemically in a mouse model of EAE
REFERENCE   6  (bases 1 to 990)
  AUTHORS   Gurish,M.F., Ghildyal,N., McNeil,H.P., Austen,K.F., Gillis,S. and
            Stevens,R.L.
  TITLE     Differential expression of secretory granule proteases in mouse
            mast cells exposed to interleukin 3 and c-kit ligand
  JOURNAL   J Exp Med 175 (4), 1003-1012 (1992)
   PUBMED   1372640
REFERENCE   7  (bases 1 to 990)
  AUTHORS   Huang,R.Y., Blom,T. and Hellman,L.
  TITLE     Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three
            mouse mast cell-specific serine proteases
  JOURNAL   Eur J Immunol 21 (7), 1611-1621 (1991)
   PUBMED   2060576
REFERENCE   8  (bases 1 to 990)
  AUTHORS   Reynolds,D.S., Gurley,D.S., Austen,K.F. and Serafin,W.E.
  TITLE     Cloning of the cDNA and gene of mouse mast cell protease-6.
            Transcription by progenitor mast cells and mast cells of the
            connective tissue subclass
  JOURNAL   J Biol Chem 266 (6), 3847-3853 (1991)
   PUBMED   1995638
REFERENCE   9  (bases 1 to 990)
  AUTHORS   Serafin,W.E., Sullivan,T.P., Conder,G.A., Ebrahimi,A., Marcham,P.,
            Johnson,S.S., Austen,K.F. and Reynolds,D.S.
  TITLE     Cloning of the cDNA and gene for mouse mast cell protease 4.
            Demonstration of its late transcription in mast cell subclasses and
            analysis of its homology to subclass-specific neutral proteases of
            the mouse and rat
  JOURNAL   J Biol Chem 266 (3), 1934-1941 (1991)
   PUBMED   1988455
REFERENCE   10 (bases 1 to 990)
  AUTHORS   Serafin,W.E., Reynolds,D.S., Rogelj,S., Lane,W.S., Conder,G.A.,
            Johnson,S.S., Austen,K.F. and Stevens,R.L.
  TITLE     Identification and molecular cloning of a novel mouse mucosal mast
            cell serine protease
  JOURNAL   J Biol Chem 265 (1), 423-429 (1990)
   PUBMED   1688433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144385.1, CJ046459.1 and AV018388.1.
            
            On Sep 8, 2006 this sequence version replaced NM_010779.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144385.1, AY007569.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK144385.1         2-12
            12-450              CJ046459.1         15-453
            451-987             AK144385.1         452-988
            988-990             AV018388.1         214-216
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..990
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /note="mast cell protease 4"
                     /db_xref="GeneID:17227"
                     /db_xref="MGI:MGI:96940"
     exon            1..91
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..777
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /note="myonase; MSMCP; serosal mast cell protease"
                     /codon_start=1
                     /product="mast cell protease 4 precursor"
                     /protein_id="NP_034909.2"
                     /db_xref="CCDS:CCDS27140.1"
                     /db_xref="GeneID:17227"
                     /db_xref="MGI:MGI:96940"
                     /translation="MQALLFLMALLLPSGAGAEEIIGGVESRPHSRPYMAHLEITTER
                     GFTATCGGFLITRQFVLTAAHCSGREITVTLGAHDVSKTESTQQKIKVEKQIVHPKYN
                     FYSNLHDIMLLKLQKKAKETPSVNVIPLPRPSDFIKPGKMCRAAGWGRTGVTEPTSDI
                     LREVKLRIMDKEACKNYWHYDYNLQVCVGSPRKKRSAYKGDSGGPLLCAGVAHGIVSY
                     GRGDAKPPAVFTRISSYVPWINRVIKGK"
     exon            92..242
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /inference="alignment:Splign:2.1.0"
     exon            243..378
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /inference="alignment:Splign:2.1.0"
     exon            379..633
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /inference="alignment:Splign:2.1.0"
     exon            634..990
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /note="hexamer: AGTAAA"
     polyA_site      988
                     /gene="Mcpt4"
                     /gene_synonym="Mcp-4; Mcp4; MMCP-4; MMCP-4A; MMCP-4B"
                     /note="major polyA site"
ORIGIN      
        1 agaatctctc tccaagctgt gaccgacact ggcaagatgc aggccctact attccttatg
       61 gcacttctct tgccttctgg ggctggagct gaggagatta ttggtggtgt tgagtctaga
      121 ccacattctc gcccttacat ggcccatctg gagatcacca ctgagagagg gttcacagct
      181 acctgtggtg ggtttctcat aacccgccaa tttgtgttga ctgctgcaca ctgtagtgga
      241 agagaaatca ctgtcaccct tggagctcat gatgtgagca agacagaatc cacacagcag
      301 aagataaaag tagaaaaaca aatcgttcac ccaaagtaca acttctattc caatctccat
      361 gacatcatgt tgctgaagct tcaaaagaaa gccaaagaga ctccctctgt gaatgtaatt
      421 cctctgcctc gtccttctga ctttatcaag ccggggaaga tgtgccgggc agctggctgg
      481 gggcgaactg gagtgacaga acctacctca gatatactga gggaggtgaa actgagaatc
      541 atggataaag aggcctgtaa aaactattgg cattacgact ataacctcca ggtctgcgtg
      601 ggcagtccca gaaagaaaag atcagcatac aagggagact ctggaggacc tctactgtgt
      661 gctggggtgg cccatggtat tgtatcttat ggacgcggag atgcaaagcc ccctgcagtc
      721 ttcacccgaa tctcctcata tgtgccctgg attaacagag ttataaaggg caagtagtga
      781 aaagcctgac ctgcgtgcat cagagtcttc aagccagagc tcttctgata acccttgggt
      841 tcaacaaagc atgtgtccat cctgtcacct gcctgccccc ggcctgtcct cagcctgccc
      901 ccagcctgcc cccaagatga tctgaaagat gaattctgtg atgatggact gttccctgta
      961 atgcacctca gtaaagccct aacctccagc
//
