LOCUS       NM_008571                970 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus mast cell protease 2 (Mcpt2), mRNA.
ACCESSION   NM_008571
VERSION     NM_008571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Kasakura,K., Nagata,K., Miura,R., Iida,M., Nakaya,H., Okada,H.,
            Arai,T., Arai,T., Kawakami,Y., Kawakami,T., Yashiro,T. and
            Nishiyama,C.
  TITLE     Cooperative Regulation of the Mucosal Mast Cell-Specific Protease
            Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors
  JOURNAL   J Immunol 204 (6), 1641-1649 (2020)
   PUBMED   32005755
  REMARK    GeneRIF: Cooperative Regulation of the Mucosal Mast Cell-Specific
            Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription
            Factors.
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Mirghomizadeh,F., Bullwinkel,J., Orinska,Z., Janssen,O.,
            Petersen,A., Singh,P.B. and Bulfone-Paus,S.
  TITLE     Transcriptional regulation of mouse mast cell protease-2 by
            interleukin-15
  JOURNAL   J Biol Chem 284 (47), 32635-32641 (2009)
   PUBMED   19801677
  REMARK    GeneRIF: interleukin-15 transcriptionally regulates mouse mast cell
            protease-2
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Gallwitz,M. and Hellman,L.
  TITLE     Rapid lineage-specific diversification of the mast cell chymase
            locus during mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 641-654 (2006)
   PUBMED   16807746
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Gallwitz,M., Reimer,J.M. and Hellman,L.
  TITLE     Expansion of the mast cell chymase locus over the past 200 million
            years of mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 655-669 (2006)
   PUBMED   16807745
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Pemberton,A.D., Wright,S.H., Knight,P.A. and Miller,H.R.
  TITLE     Anaphylactic release of mucosal mast cell granule proteases: role
            of serpins in the differential clearance of mouse mast cell
            proteases-1 and -2
  JOURNAL   J Immunol 176 (2), 899-904 (2006)
   PUBMED   16393974
  REMARK    GeneRIF: both the accumulation and the longevity of MCP-1 in blood
            is due to complex formation, protecting it from a pathway that
            rapidly clears MCP-2, which is unable to form complexes with
            serpins
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Huang,R. and Hellman,L.
  TITLE     Genes for mast-cell serine protease and their molecular evolution
  JOURNAL   Immunogenetics 40 (6), 397-414 (1994)
   PUBMED   7959952
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Ghildyal,N., McNeil,H.P., Gurish,M.F., Austen,K.F. and Stevens,R.L.
  TITLE     Transcriptional regulation of the mucosal mast cell-specific
            protease gene, MMCP-2, by interleukin 10 and interleukin 3
  JOURNAL   J Biol Chem 267 (12), 8473-8477 (1992)
   PUBMED   1569097
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Gurish,M.F., Ghildyal,N., McNeil,H.P., Austen,K.F., Gillis,S. and
            Stevens,R.L.
  TITLE     Differential expression of secretory granule proteases in mouse
            mast cells exposed to interleukin 3 and c-kit ligand
  JOURNAL   J Exp Med 175 (4), 1003-1012 (1992)
   PUBMED   1372640
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Reynolds,D.S., Gurley,D.S., Austen,K.F. and Serafin,W.E.
  TITLE     Cloning of the cDNA and gene of mouse mast cell protease-6.
            Transcription by progenitor mast cells and mast cells of the
            connective tissue subclass
  JOURNAL   J Biol Chem 266 (6), 3847-3853 (1991)
   PUBMED   1995638
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Serafin,W.E., Reynolds,D.S., Rogelj,S., Lane,W.S., Conder,G.A.,
            Johnson,S.S., Austen,K.F. and Stevens,R.L.
  TITLE     Identification and molecular cloning of a novel mouse mucosal mast
            cell serine protease
  JOURNAL   J Biol Chem 265 (1), 423-429 (1990)
   PUBMED   1688433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163646.2.
            
            On Sep 13, 2022 this sequence version replaced NM_008571.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133521.1, AY007570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC163646.2         22710-22795         c
            87-237              AC163646.2         22067-22217         c
            238-373             AC163646.2         21420-21555         c
            374-628             AC163646.2         20981-21235         c
            629-970             AC163646.2         20285-20626         c
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..970
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /note="mast cell protease 2"
                     /db_xref="GeneID:17225"
                     /db_xref="MGI:MGI:96938"
     exon            1..86
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..766
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /EC_number="3.4.21.39"
                     /codon_start=1
                     /product="mast cell protease 2 precursor"
                     /protein_id="NP_032597.1"
                     /db_xref="CCDS:CCDS27139.1"
                     /db_xref="GeneID:17225"
                     /db_xref="MGI:MGI:96938"
                     /translation="MQALLFLMALLLPSGAGAEEIIGGVEAKPHSRPYMAYLKFTTKN
                     GSKERCGGFLIAPQFVMTAAHCNGSEISVILGAHNINKNEPTQQIIKTEKTFVHPKFQ
                     YLSGFYDIMLLKLQKKAELNSDVDVISLPSSSDFIKPGKMCWTAGWGKTGKNNPLSVT
                     LREVELRIMDQEACKDHSDYDYQLQVCAGSPTTSKSIGQGDSGGPLVCDSVAHGIASS
                     YEAKAPAVFTRISYYLPWIYKVLKSK"
     exon            87..237
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..373
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..628
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..970
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      951..956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="Mcpt2"
                     /gene_synonym="Mcp-2; MMCP-2"
                     /note="major polyA site"
ORIGIN      
        1 agaagctcac caaggcctca acactggcaa aatgcaggcc ctactattcc tgatggcact
       61 tcttttgcct tctggagctg gagctgagga gattattggt ggtgttgagg ctaaaccaca
      121 ctcccgtcct tacatggcct atctgaagtt caccactaag aacggttcga aggagaggtg
      181 tggtgggttt ctcatagccc cacaatttgt gatgactgct gcacactgta atggaagtga
      241 aatcagtgtc atccttggag ctcataatat aaacaagaac gaacccacac agcagataat
      301 aaaaactgaa aaaacatttg ttcacccaaa gtttcagtac ctttcgggtt tctatgacat
      361 catgttactg aagctacaaa agaaagcaga gttgaattct gatgtggatg taatttcatt
      421 gcctagttcc tctgacttca tcaagcctgg gaagatgtgc tggacagctg gatgggggaa
      481 aacaggaaag aataaccctc tatcagttac cctgagagag gttgaactga gaatcatgga
      541 tcaagaggcc tgtaaagacc acagtgatta cgattatcaa ctccaggttt gcgcaggcag
      601 tcccacaaca tcaaaatcaa taggacaagg agattctggg ggacctctag tgtgtgatag
      661 tgtggcccat ggtattgcat cttcttatga agcaaaggcc cctgcagtct tcacccgaat
      721 ctcctattac ctgccctgga tatataaagt cttaaagagc aagtagctga aaagcctaac
      781 cagcctgagt cagactcttc aagatcaagc tcatctggta cctctgagtt catcccagcc
      841 tgttctcatc ctgcatcaag tctgccccta gcctgtcccc agtctgtccc caagatcata
      901 tcaaagatgc acatgtctgt gatgatggat tgttctctgt gatgcatctc aataaagacc
      961 taacctcttg
//
