LOCUS       NM_008570               1028 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mast cell protease 1 (Mcpt1), mRNA.
ACCESSION   NM_008570
VERSION     NM_008570.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Tauber,M., Basso,L., Martin,J., Bostan,L., Pinto,M.M.,
            Thierry,G.R., Houmadi,R., Serhan,N., Loste,A., Bleriot,C.,
            Kamphuis,J.B.J., Grujic,M., Kjellen,L., Pejler,G., Paul,C.,
            Dong,X., Galli,S.J., Reber,L.L., Ginhoux,F., Bajenoff,M., Gentek,R.
            and Gaudenzio,N.
  TITLE     Landscape of mast cell populations across organs in mice and humans
  JOURNAL   J Exp Med 220 (10) (2023)
   PUBMED   37462672
  REMARK    Erratum:[J Exp Med. 2024 Feb 5;221(2):e2023057001172024c. doi:
            10.1084/jem.2023057001172024c.. PMID: 38265438]
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Galvez,I., Hinchado,M.D., Martin-Cordero,L., Moran-Plata,F.J.,
            Graham,G., Francisco-Morcillo,J. and Ortega,E.
  TITLE     The anti-inflammatory and bioregulatory effects of habitual
            exercise in high-fat diet-induced obesity involve crown-like
            structures and MCP-1 in white adipose tissue
  JOURNAL   Exerc Immunol Rev 29, 111-120 (2023)
   PUBMED   37358368
  REMARK    GeneRIF: The anti-inflammatory and bioregulatory effects of
            habitual exercise in high-fat diet-induced obesity involve
            crown-like structures and MCP-1 in white adipose tissue.
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Zhang,Y., Liu,J.Y., Shao,J.W., Luo,Q.Q., Zhang,Y.Q., Song,G.,
            Wang,C.Y., Zhao,S.Y., Wan,C., Du,X.H. and Xu,L.Z.
  TITLE     Effective Model of Food Allergy in Mice Sensitized with Ovalbumin
            and Freud's Adjuvant
  JOURNAL   Bull Exp Biol Med 171 (3), 352-356 (2021)
   PUBMED   34297293
  REMARK    GeneRIF: Effective Model of Food Allergy in Mice Sensitized with
            Ovalbumin and Freud's Adjuvant.
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Kasakura,K., Nagata,K., Miura,R., Iida,M., Nakaya,H., Okada,H.,
            Arai,T., Arai,T., Kawakami,Y., Kawakami,T., Yashiro,T. and
            Nishiyama,C.
  TITLE     Cooperative Regulation of the Mucosal Mast Cell-Specific Protease
            Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors
  JOURNAL   J Immunol 204 (6), 1641-1649 (2020)
   PUBMED   32005755
  REMARK    GeneRIF: Cooperative Regulation of the Mucosal Mast Cell-Specific
            Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription
            Factors.
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   Zhang,J., Xiao,Z., Qu,C., Cui,W., Wang,X. and Du,J.
  TITLE     CD8 T cells are involved in skeletal muscle regeneration through
            facilitating MCP-1 secretion and Gr1(high) macrophage infiltration
  JOURNAL   J Immunol 193 (10), 5149-5160 (2014)
   PUBMED   25339660
  REMARK    GeneRIF: CD8 T cells are involved in skeletal muscle regeneration
            through facilitating MCP-1 secretion and Gr1(high) macrophage
            infiltration.
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   Huang,R. and Hellman,L.
  TITLE     Genes for mast-cell serine protease and their molecular evolution
  JOURNAL   Immunogenetics 40 (6), 397-414 (1994)
   PUBMED   7959952
REFERENCE   7  (bases 1 to 1028)
  AUTHORS   Ghildyal,N., McNeil,H.P., Stechschulte,S., Austen,K.F.,
            Silberstein,D., Gurish,M.F., Somerville,L.L. and Stevens,R.L.
  TITLE     IL-10 induces transcription of the gene for mouse mast cell
            protease-1, a serine protease preferentially expressed in mucosal
            mast cells of Trichinella spiralis-infected mice
  JOURNAL   J Immunol 149 (6), 2123-2129 (1992)
   PUBMED   1517575
REFERENCE   8  (bases 1 to 1028)
  AUTHORS   Huang,R.Y., Blom,T. and Hellman,L.
  TITLE     Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three
            mouse mast cell-specific serine proteases
  JOURNAL   Eur J Immunol 21 (7), 1611-1621 (1991)
   PUBMED   2060576
REFERENCE   9  (bases 1 to 1028)
  AUTHORS   Reynolds,D.S., Stevens,R.L., Lane,W.S., Carr,M.H., Austen,K.F. and
            Serafin,W.E.
  TITLE     Different mouse mast cell populations express various combinations
            of at least six distinct mast cell serine proteases
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3230-3234 (1990)
   PUBMED   2326280
REFERENCE   10 (bases 1 to 1028)
  AUTHORS   Trong,H.L., Newlands,G.F., Miller,H.R., Charbonneau,H., Neurath,H.
            and Woodbury,R.G.
  TITLE     Amino acid sequence of a mouse mucosal mast cell protease
  JOURNAL   Biochemistry 28 (1), 391-395 (1989)
   PUBMED   2706264
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X68803.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100700.1, SRR5189685.11884.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1028
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /note="mast cell protease 1"
                     /db_xref="GeneID:17224"
                     /db_xref="MGI:MGI:96937"
     exon            1..90
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..776
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /EC_number="3.4.21.39"
                     /note="MMCP-1"
                     /codon_start=1
                     /product="mast cell protease 1 precursor"
                     /protein_id="NP_032596.1"
                     /db_xref="CCDS:CCDS27137.1"
                     /db_xref="GeneID:17224"
                     /db_xref="MGI:MGI:96937"
                     /translation="MQALLFLMALLLPSGAGAEEIIGGVEARPHSRPYMAHLKIITDR
                     GSEDRCGGFLIAPQFVLTAAHCKGREITVTLGAHDVSKSESTQQRIKVEKQIIHKNYN
                     VSFNLYDIMLLKLEEKAELTPTVDVIPLPGPSDFIDPGKMCWTAGWGKTGEKEPTSET
                     LREVELRIMDKEACKMYKHYDYNFQVCVGSSTKLKTAYMGDSGGPLLCAGVAHGIVSY
                     GDSHGKPPAVFTRISAYVPWIKTVINGK"
     exon            91..241
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..377
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..632
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1028
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1004..1009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /note="hexamer: AATAAA"
     polyA_site      1022
                     /gene="Mcpt1"
                     /gene_synonym="Mcp-1"
                     /note="major polyA site"
ORIGIN      
        1 ccctagaagc tcaccaaggc tgcaccactg gcaaaatgca ggccctacta ttcctgatgg
       61 cacttctctt gccttctgga gctggagctg aggagattat tggtggtgtt gaggctagac
      121 cacactcccg tccttacatg gcccatctga agatcatcac ggacagaggt tctgaggaca
      181 gatgtggtgg gtttctcata gccccccaat ttgtgttgac tgctgcacac tgtaaaggaa
      241 gagaaatcac tgtcaccctt ggagctcatg atgtgagcaa gagtgaatcc acacaacaga
      301 ggataaaagt cgaaaaacaa atcattcaca aaaattacaa cgtctctttc aatctctatg
      361 acatcatgtt actgaagctt gaagagaaag ctgagttgac tcctactgtg gatgtaattc
      421 ccttgcctgg tccctctgac tttatcgacc ctgggaagat gtgctggaca gctggctggg
      481 ggaaaactgg agagaaagaa cctacctcag aaaccctgag agaggttgaa ctgagaatca
      541 tggataaaga ggcctgtaaa atgtataagc attatgacta taacttccag gtctgtgtgg
      601 gaagttccac aaagttaaaa acagcataca tgggagactc tgggggacct cttctgtgtg
      661 ctggtgtggc ccatggtatt gtatcttatg gggattcaca tggaaagccc cctgcagtct
      721 tcaccagaat ctctgcatat gtgccctgga ttaaaacagt cataaatggc aagtagctga
      781 gaagtctgac cagcctgaga cagattctcc aagccagagc tctctggtac tctttgtgtt
      841 caacaaagct tgtccccaga ctatccccag tctgccccca gcctcacccc agcctatgtg
      901 cagcctgcct ttagcttgcc cccattctgt ccccagctgt ccctttgagg atctcaaaga
      961 tacaggagtc tgtgatgatg gtttgttccc tgtaatgcac ctcaataaag acctaacctc
     1021 cagcagct
//
