LOCUS       XM_017312790            8892 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus microcephaly, primary autosomal recessive 1
            (Mcph1), transcript variant X12, mRNA.
ACCESSION   XM_017312790
VERSION     XM_017312790.2
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000074.7) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Aug 8, 2019 this sequence version replaced XM_017312790.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="8"
     gene            1..8892
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /note="microcephaly, primary autosomal recessive 1;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 7 ESTs, 240 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:244329"
                     /db_xref="MGI:MGI:2443308"
     CDS             156..2264
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /codon_start=1
                     /product="microcephalin isoform X12"
                     /protein_id="XP_017168279.1"
                     /db_xref="GeneID:244329"
                     /db_xref="MGI:MGI:2443308"
                     /translation="MKRRLQDMKEKRENLSPTCKWLQCRMKRMSAGELQKKASQMLEQ
                     SQQNPCVSLFETSLNISHQPLSSDESFASGSHSSFGDSCGDQERKLGRSANEMTTVTC
                     PSSPVLRASSFYGSASPNHLRQPRPQKAPDSPSKESINCQKDATGAVADSERKQAAGV
                     SQGVPDEKLCLSPTMSIIEEHQVRLGPKNSSAKRKRAADLGSSPKGKLKKRYKRKSAL
                     AIQLFKSDQSPPSTIRLIPGTPDVEASSYEDYFSPDNLKERNSERLPPEAQQLASPSL
                     FHCRGLSKWERRNMLEMCDFTCIGEKHRSISSISDLISKSASSLEKPVKEEVNTASTC
                     LLLVETSANDSPGLCSQPGPQLRDDTGPEGSSHPDTLSSSAHHITPLKGNSTETRDPG
                     DGKGSPKEGSTPPASASPEDEVHICNLSLGEDCNVEKSVEEKENIATGYSESVKNGPG
                     RPDPSDSSCTGLVRPQQKPKKSEKEEKAGGFASVRSGVSPQGSVLQYITGVDSQFKSC
                     SFLQPTRTLVMTSMPSEKQTLIIQVVSTLKGFSFAPEVCETTTHVLVGKSARTLNVLM
                     GIARGCWILSYEWVLLSLELGHWISEEPFELSETFPAAPICRLERHLSTQQYQGTLFA
                     NQPKMFIAPASSPPRAKLCELVLLCGGQVSPAPQLASLIIGPYKGKKKARIQYLSEKW
                     VLDSITQHKICDFNNYQLLQ"
ORIGIN      
        1 tgcaggatgg ctggagcact tgttgatgag tctttgttcc ctgcagtgaa taccgatgaa
       61 catctaccaa acttaagtag aaaaaaaatg atgacgttcc tgtcctcctg tttgagtccc
      121 ctcgctcact ggtgtacagc tccccagtga atgtgatgaa gaggagactg caggatatga
      181 aggagaagag ggagaacctt tcccctacct gtaagtggct gcagtgtaga atgaaaagga
      241 tgtctgctgg cgaactacag aagaaagcct cccagatgtt ggagcagtct cagcagaatc
      301 catgtgtcag tctgtttgaa acatccttga acatttctca ccaacctttg agttcagatg
      361 aatcctttgc cagtggctcc cactcatctt tcggtgattc ctgtggagat caagaaagga
      421 aactgggaag atctgctaat gagatgacca cggtgacatg cccttcctca cctgtgttga
      481 gggcaagcag tttttatggc tcagcatcac ccaaccatct caggcagcca cgtcctcaga
      541 aagctccaga cagtccttca aaggagagca tcaactgtca gaaggatgct acaggtgcgg
      601 tagctgattc cgagagaaag caagctgcag gtgtatctca gggggtgcct gatgagaagc
      661 tctgtctgtc tcctacgatg tccatcatag aagaacacca agtacggttg ggacccaaga
      721 attcttctgc aaagagaaaa agggcagcgg acttgggttc atctccaaaa ggaaaactga
      781 agaagaggta caagagaaag tctgctctgg caatacagtt attcaagtcc gaccagagcc
      841 cgccgtccac aatcagactc attccgggaa ctcctgacgt tgaggcttct tcctatgagg
      901 actatttttc ccctgataat ctcaaggaga ggaattcgga gagacttcct cctgaggctc
      961 agcaactagc aagcccttct ctgttccact gcagaggtct ctcaaagtgg gagcgaagaa
     1021 acatgctgga aatgtgtgat tttacctgca ttggtgaaaa gcacagatcc atcagcagca
     1081 ttagtgactt aatttcaaaa agtgcctcta gtcttgagaa acctgtcaag gaggaagtga
     1141 atacagcttc tacctgcttg cttttggtgg agacctctgc taacgacagc ccagggcttt
     1201 gcagtcagcc tggccctcag ctgagggatg acacaggccc agagggaagc agccaccctg
     1261 acaccctgtc tagttctgcc caccacatca cacccttgaa aggaaatagt acagaaacca
     1321 gagacccagg tgatggaaaa ggctccccca aagaaggtag cacgcctcct gcatcagcct
     1381 ctcctgaaga tgaagtacac atctgtaatc tcagtttggg agaggattgt aatgtagaaa
     1441 agtctgtaga agaaaaggag aacatagcca caggatatag tgaaagtgtt aaaaatggac
     1501 cagggcggcc agatccttca gacagctctt gcacaggcct tgtcagacct cagcagaaac
     1561 caaagaaaag tgagaaagaa gaaaaggcag gtgggtttgc atcagtaaga agtggagtct
     1621 ctcctcaagg tagcgtgctg cagtacatca ctggagttga ctcccaattt aagtcctgct
     1681 ctttcctcca gccaacgaga acattggtca tgacaagcat gccatctgag aagcagaccc
     1741 tcatcatcca ggtggtgagc acactgaaag gcttttcatt cgcacccgag gtctgcgaga
     1801 ccaccaccca cgtgctggta gggaagtctg cccgtaccct gaacgtgctg atgggaattg
     1861 cccgcggctg ctggattctt tcttacgaat gggtactgtt gtctttagag ttgggccact
     1921 ggatttctga ggagcctttt gaactctctg aaaccttccc tgcagctccg atctgccgac
     1981 ttgaacgcca tttatctacc cagcaatacc aaggaaccct ctttgctaat cagccgaaga
     2041 tgttcatagc gccagccagc agccctccca gagccaaact gtgtgaactg gtactcctgt
     2101 gtggtggcca agtcagccca gcccctcagc tggccagcct catcattggt ccctacaagg
     2161 gcaagaagaa agcaaggatc cagtacctgt cagagaaatg ggtcttagat tccatcaccc
     2221 aacacaagat ctgtgacttt aacaactacc aactgctaca gtgagacatc tacaatgagg
     2281 ctgctatcct caacactcaa gaagaacaac tctggagaaa aggaaccagc agacacctta
     2341 gggcttgaag tcacatgtca ctttgtgtgc tatggttttt atcttcagag ggtatgtggt
     2401 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtctaggtgt
     2461 ctagagatta aatccaaggc ttgctaagta agcactgtac tgtggaacta catctccagc
     2521 ttttatcctt aaaactcttt atgtaactta ttcatgactc attgtatttc agagaagtct
     2581 tgaccagcac cagttgggta ctttatacaa tactaataat gatcatgatg gaaaggtcac
     2641 agaacctttg tccttgagat acttgttccc aattatagaa tggaagttga tttaaattgc
     2701 tgtagtccta aacaatcaaa tagctcccta actcttctga cttagacgct gagatcttta
     2761 ttagcatgtt gtgtctagat aggaaggaca atcatgcatt attaagattg caattatgtc
     2821 ccttgagatg cccctcagaa caactaagga agacaggtat gaacgtttta ttcaccgacc
     2881 ttgcgaatgt ctaccactct gcctctactg actcccctga ggttccctaa ggaaagtcag
     2941 cttctggggt agagttctgt caaaggtgtc caacccatga cccatgtatc aaacttgttt
     3001 aagggtacct agaatgtagc tcatataaaa ttataaacat atttaaaagt attaagagat
     3061 ttgtgtgtac atatatttcc cccaacccca gcggggttgt aactcaattg cacaattctt
     3121 ccgggtgaac tctagatgac cacgttgtat tacactgtga aaaggctgga cgtgccatca
     3181 tcaggtcaat cactcttcag tgtgtcgaca cgggagactg gcctggggct tgcagacctc
     3241 ctcttgttgg tgtccccagt gttgggctgt agtctagtgc caccacatgt catgctgctc
     3301 cgtcacctaa cagacactga gtcccagtga gcttaaaagc agtgctcagc tcactgtagt
     3361 tttctgtgtt acgactcatg tcagctgctg tttccatctc aggaagcctc aacaccactt
     3421 ccaaaacctt gtcatctccg agataagcaa ttaaagcgta cagtttgtga ctctggcatt
     3481 ggccttgttc cctgtacaat taatgctctg atggttcatt catgtcatgt gtgtcagcac
     3541 gtaatttctt tttgttgcca aacactatcc tatggcatgg atgctctaca gacttgctcc
     3601 tcgccccatg agcagagtgc aggtgtaaag cccagtggga aagcagttga tgatgtcacg
     3661 ttgcgttggg tgatagttga tgatgtcatg ttgttctggg tgatggttga tgatgtcatg
     3721 tgttgctgga tgatagttga tgatgtcacg ttgtgctggg tgatgatagt tgatgatgtc
     3781 aggttgtgct tggtgatcag tagtccaggc tccgtggaag aagaggatca gatgagggtg
     3841 tgagagaccc cactcatcac cctcctcatc ttctgtaatc tgagtaattc tgtttcccct
     3901 cacaaatcca tagcttgaag ccatcacttg aagccagaat aatggtgttt aaaaagtggg
     3961 gtttgggaga aataaaagag atgcccagca aagagaagca ataattttaa ttattagaaa
     4021 tcagtctggt gaaatgtcaa gctgcactta taattatgga aaacactaca atggaaaaaa
     4081 tacttacaat atgatttaaa actaccaact tattatacaa ttctatagtc agccatgcca
     4141 agtgtatatg cacagtacag tgacgtaagt gatttaagta aaccacagtt gatttttatg
     4201 gttcttgtta atgctacaat gcttgtctgg taatttcaaa atgcaaaatt caggcacctg
     4261 cagtcaagac caaagctcct gggctccagg ggggtgaaaa ggaactgaaa taagatgtca
     4321 gcagagctga ttcccctgag aaccctaggg agaagccatt cacctgcatg ttttctgcat
     4381 gagagtctcc cacccctccc ctctggcgtt tctttcacct tagtcacgtt gaagtagtgt
     4441 cttgcctatt cactccacta tgattctttt tcccagtgta cccattatct tcaattgagg
     4501 gataatcaca tggactagcc atataatcta ggatttgtct ttattctaca gtcagttgag
     4561 taccccactt tcccatatac ctctgcaaag cacagttgtg ggggctccag gtcaggacat
     4621 ggatgtcttg acaaggcttt gattctgtgt cctgcactgc tcctcgtctc cccacactga
     4681 aatcagaggt ttgccaaaca gctattttct gataggtcat cccctgtcct ttcaaccgat
     4741 gaaatcatca ttgcacctgc cctgatgtct gacatcccag ggtacaagtt taggagacat
     4801 accctcatgg aaaagggagc cagggctctg aggtctgtat tatgctgagt tatctccacc
     4861 caaaacaact cgtgagtatt cctagcacag atgagaaaaa tgtctactac acagcccaga
     4921 gtccagacaa tggagacagt agataattat tttcagttat tatgtgctca gcaataattg
     4981 gatttaatta atatcaggct gcaaagtcta tcttagagta tctgcggctg cagagtgttg
     5041 tggtctctgc tctcaatgtc actttcttct cctaatttaa agctgtgaaa gttttatgtg
     5101 tgccaagaag acagtatcga cttttctccc tcccatatct aaactgttag ctgaaagaca
     5161 gtaattaaaa tgattgacct gaaactaaac caagagcaca cacatattcc atgggctaaa
     5221 ctaatatttt atttggtaca agttcccagc ttaggcgttc ctgttttccc aaagccttaa
     5281 gaccttccag gggtgaagct ccacctagaa ttctaagatg ctggcagctg ctgcttcatt
     5341 aatctggttt caatttttta agtatttgga ttcacggctt atctatggga acaaatgatt
     5401 gttctatctt gaagagtcca gagggaagat ttacggagaa agttaacttc atatcccctt
     5461 ctgtgggcca gccaatgtga tcccagccaa agctaaggag agaggactgg cagggaaaaa
     5521 ctccctcgag ggctgggcca gcacccacag gggagaggag agggctctat cagtcagcag
     5581 actgggccag gaagagctaa agaagaagag gctgccagac ctcagggctc aacaccaaga
     5641 gcaccctatc agctagaggg ggcgttcagc cagtgatgtg aaacccaatc attaaatgat
     5701 tgggagccag ttaggggagg aaggaggagg actgtctgtc ctgagagtgt gaagctgtgg
     5761 gtggcaggag ccatgcaagg gttctgactc aggagaccac aagcctcctt ccaaaagtag
     5821 aacgaggatg ctatgtggga cagggccagt agcacagaag gagctataag gcccaagata
     5881 gatctccttt ctcagggtga tgaaaagctg tcaccttggc ttgtggccaa agacttagaa
     5941 gggactctac aacagccttc caccataatc agatcttaac agaagaattt gaattctatc
     6001 aattttcatg agaaatccta ccacagccct agttagggat tattggatac agggcccacc
     6061 ttatatcctt tgagcccaaa ttagacctta actcttagca tagtcgtgaa caggtgttct
     6121 tgccttctta tggatatcta aggttggttc acaccaaaca aatagggaca tttacattta
     6181 ttctgtatca ctcacatgca ccaagcccca aaggtcagca gtacctagga ccacactgct
     6241 gtcagagggc tgatggcctc ttactatggc actgcccgta gggtgatggc cttgaagggg
     6301 ctgaatacat ctgagatggt gtgtagcaag ttgagtgaag accaggagaa ggtgcaagct
     6361 agttctatag cggaaggggt gggtttagaa aatgcttcca gtaaagatgg ggatctgctt
     6421 gtttttaaaa gcataggact gcagagggac cagggagaag ctgggcaccg ggagtgactg
     6481 gtgaatacag agggctttag catggctgga gagtcaagga gcctatggag aggaatcagg
     6541 aagacaccag acttccgtag agtttgtaga aaagggggaa agcagtaggt ttgctttagc
     6601 ttggctggta tgtcaaggat ggaatgtcct ccaataggtg aaaatagagg aagcttttag
     6661 agccttgtgg tgtaccactg agggagccag atgctacata tgaatgcttt taaaagaaaa
     6721 aaaaaatcat aaacaaaacc aggcatgctg cctcctacct gccatgtcag tactggagag
     6781 gctgaagcaa ggagtgccat cagattgagg tgagcctggc atacatagtg agaaactatc
     6841 tccaaaagcc caaattgatt attcacacaa agaaagaaat tgcaaagatt taaagcagta
     6901 acaattgaag gtaggcaaag gagatgcaac tctgggggac tgagggtaac aaagaaaaaa
     6961 atactaaaaa ctataactcc agaatatttt actgaattac caaagatttg agactctaca
     7021 tttaaaaaat atgtcttgta cctgagaaga tcaactcaaa acaatgagat tcctaagatt
     7081 taaaaataaa taaataaata tccttgggcc attgagctag ccggggctgc agtagcaagg
     7141 catctgcctg gtggattaaa tgacaatagc cctttccttt cctgcagttg ttgagctgga
     7201 ggtgtaaaac ccaggtgttg gcttggtttc tagagagcct ctgtcctagg gtggtctcct
     7261 ccctgtatat gaaagcttgg tgtccacctc ctcttctcag gacagcagtc ataatggact
     7321 agggctccac cctccagacc tcctatgtct ctagtcacct gttacatctc ttctagtagt
     7381 gactcgcttg gcaggcctaa aaacctagaa gcagttttga ggcagagtct caaggaaact
     7441 cagcctctta gaactttgac attctcatag ctagaatgtc tcagatttgt ccctgtaata
     7501 ttgtggagtg tcttacatgt tttcttatag tattttactg gataagagtt agaaatctcg
     7561 ccgggcatgg tgatgcacac ctttaatccc agcactcagg aagcagaggc aggcggattt
     7621 ctgaggacag cctggtctac agagtgaatt ccaggacagc cagggctata cagagaaacc
     7681 ctgtctcgaa aaaacaaaaa accaaaaaaa caaaacaaaa caaaaaaaaa acaaacaaca
     7741 acaaaaaaaa cagagaaatc tcagggcaag cttagcaaag tatatttaga atctttatta
     7801 cagccagtta tagcagacaa cattgtatat tagaagcaag ttggtgaatt ctcttgacaa
     7861 atggagattc cccacagata cttaaaagaa cagccaagtt actctcatat gcaagaattt
     7921 accaaggcct aggaaatagg ggggttgtgg tattgcatta ttcatgagaa ggtctgctag
     7981 agcagaaccc cctggtgcta gctttcacaa gactcaaagg agtaacacaa attgtgacta
     8041 gggtgtgaaa tccttacctg tcattaggtg accctaggca gggctgtttt atctttactg
     8101 taaatgttac ctggttcctg taagttcctt ttgaagtcat tcctttgttt tgtgtcaggt
     8161 aacttcaatg tactttgcct gctgtgacat cctacccctt tgttttctgt atcatataag
     8221 actagtgttc actttgtgac attactttgt cattcgccca cctgcaacca gagacccatt
     8281 cctagcagat agcagatcca aaaaaggaga tagtctgcaa cagtcaccac cttaaagacc
     8341 ctgtctccag aatcagtcaa gttcaacgtc tggactttga cattgactta gtgtgtatat
     8401 ataagtttat ataacattat aaacacatgc atgtatatat atacagttaa tagacatgca
     8461 ttatgcatac atagtaagaa gcaaatggca tataagaact aaattttttc ataacaatgt
     8521 ataagaaagt gaataatgtt atttaagatc ttcaaaagaa cacatgactt aaaattttat
     8581 atttaaaagc taactcttaa gcaaatatga catggcaaac tcataactga atgccaggac
     8641 ccaggactgt tattgccatg gtcttggagg aagagtccac tgggaggcaa agtctaaaca
     8701 agcaagatga ggagtcagtg aggctgtggt ggttaggtat ggaaatagag gtatacaaat
     8761 agagataagc aaataggcag agagataaaa ccaatgccta ggactgaaag gagtggtaga
     8821 gtgggtgggg gctagaagct ctgatagagg aagacttaga tatgtacaca gcaataaaac
     8881 attttcagtg tt
//
