LOCUS       NM_173189               4678 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus microcephaly, primary autosomal recessive 1 (Mcph1),
            mRNA.
ACCESSION   NM_173189
VERSION     NM_173189.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4678)
  AUTHORS   Webber AM, Bradstreet TR, Wang X, Guo H, Nelson CA, Fremont DH,
            Edelson BT and Liu C.
  TITLE     Antigen-guided depletion of anti-HLA antibody-producing cells by
            HLA-Fc fusion proteins
  JOURNAL   Blood 140 (16), 1803-1815 (2022)
   PUBMED   36070233
REFERENCE   2  (bases 1 to 4678)
  AUTHORS   Wang Y, Zong W, Sun W, Chen C, Wang ZQ and Li T.
  TITLE     The Central Domain of MCPH1 Controls Development of the Cerebral
            Cortex and Gonads in Mice
  JOURNAL   Cells 11 (17), 2715 (2022)
   PUBMED   36078123
  REMARK    GeneRIF: The Central Domain of MCPH1 Controls Development of the
            Cerebral Cortex and Gonads in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4678)
  AUTHORS   Chakraborty P, Parikh RY, Choi S, Tran D, Gooz M, Hedley ZT, Kim
            DS, Pytel D, Kang I, Nadig SN, Beeson GC, Ball L, Mehrotra M, Wang
            H, Berto S, Palanisamy V, Li H, Chatterjee S, Rodriguez PC,
            Maldonado EN, Diehl JA, Gangaraju VK and Mehrotra S.
  TITLE     Carbon Monoxide Activates PERK-Regulated Autophagy to Induce
            Immunometabolic Reprogramming and Boost Antitumor T-cell Function
  JOURNAL   Cancer Res 82 (10), 1969-1990 (2022)
   PUBMED   35404405
REFERENCE   4  (bases 1 to 4678)
  AUTHORS   Ho UY, Feng CA, Yeap YY, Bain AL, Wei Z, Shohayeb B, Reichelt ME,
            Homer H, Khanna KK, Bowles J and Ng DCH.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4678)
  AUTHORS   Caduff N, McHugh D, Rieble L, Forconi CS, Ong'echa JM, Oluoch PO,
            Raykova A, Murer A, Boni M, Zuppiger L, Schulz TF, Blackbourn DJ,
            Chijioke O, Moormann AM and Munz C.
  TITLE     KSHV infection drives poorly cytotoxic CD56-negative natural killer
            cell differentiation in vivo upon KSHV/EBV dual infection
  JOURNAL   Cell Rep 35 (5), 109056 (2021)
   PUBMED   33951431
REFERENCE   6  (bases 1 to 4678)
  AUTHORS   Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL,
            Rossini AA and Appel MC.
  TITLE     Rejection of human islets and human HLA-A2.1 transgenic mouse
            islets by alloreactive human lymphocytes in immunodeficient
            NOD-scid and NOD-Rag1(null)Prf1(null) mice
  JOURNAL   Clin Immunol 112 (3), 273-283 (2004)
   PUBMED   15308121
REFERENCE   7  (bases 1 to 4678)
  AUTHORS   Marron MP, Graser RT, Chapman HD and Serreze DV.
  TITLE     Functional evidence for the mediation of diabetogenic T cell
            responses by HLA-A2.1 MHC class I molecules through transgenic
            expression in NOD mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13753-13758 (2002)
   PUBMED   12361980
REFERENCE   8  (bases 1 to 4678)
  AUTHORS   Jackson AP, Eastwood H, Bell SM, Adu J, Toomes C, Carr IM, Roberts
            E, Hampshire DJ, Crow YJ, Mighell AJ, Karbani G, Jafri H, Rashid Y,
            Mueller RF, Markham AF and Woods CG.
  TITLE     Identification of microcephalin, a protein implicated in
            determining the size of the human brain
  JOURNAL   Am J Hum Genet 71 (1), 136-142 (2002)
   PUBMED   12046007
REFERENCE   9  (bases 1 to 4678)
  AUTHORS   Newberg MH, Smith DH, Haertel SB, Vining DR, Lacy E and Engelhard
            VH.
  TITLE     Importance of MHC class 1 alpha2 and alpha3 domains in the
            recognition of self and non-self MHC molecules
  JOURNAL   J Immunol 156 (7), 2473-2480 (1996)
   PUBMED   8786307
REFERENCE   10 (bases 1 to 4678)
  AUTHORS   Le AX, Bernhard EJ, Holterman MJ, Strub S, Parham P, Lacy E and
            Engelhard VH.
  TITLE     Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition
            of HLA alloantigens and utilization of HLA-A2.1 as a restriction
            element
  JOURNAL   J Immunol 142 (4), 1366-1371 (1989)
   PUBMED   2464645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083572.1 and BC056924.1.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_173189.4.
            
            On Oct 26, 2017 this sequence version replaced NM_173189.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056924.1, AY070216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK083572.1         2-43
            43-4678             BC056924.1         1-4636
FEATURES             Location/Qualifiers
     source          1..4678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.24 cM"
     gene            1..4678
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /note="microcephaly, primary autosomal recessive 1"
                     /db_xref="GeneID:244329"
                     /db_xref="MGI:MGI:2443308"
     exon            1..505
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..2934
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /codon_start=1
                     /product="microcephalin"
                     /protein_id="NP_775281.2"
                     /db_xref="CCDS:CCDS22124.1"
                     /db_xref="GeneID:244329"
                     /db_xref="MGI:MGI:2443308"
                     /translation="MEASGGVGGAFLKDVVAYVEVWSSKGTENYSRTFAKQLEDMGAT
                     VSKTLNKQVTHVIFKDGYQSTWDKAQKTGAKLVSVLWVEKCRMAGALVDESLFPAVNT
                     DEHLPNLSRKKHKCMQPKDFILKTPENDKRLQKKFEKMAEELQRQKAALDDDVPVLLF
                     ESPRSLVYSSPVNVMKRRLQDMKEKRENLSPTSSQMLEQSQQNPCVSLFETSLNISHQ
                     PLSSDESFASGSHSSFGDSCGDQERKLGRSANEMTTVTCPSSPVLRASSFYGSASPNH
                     LRQPRPQKAPDSPSKESINCQKDATGAVADSERKQAAGVSQGVPDEKLCLSPTMSIIE
                     EHQVRLGPKNSSAKRKRAADLGSSPKGKLKKRYKRKSALAIQLFKSDQSPPSTIRLIP
                     GTPDVEASSYEDYFSPDNLKERNSERLPPEAQQLASPSLFHCRGLSKWERRNMLEMCD
                     FTCIGEKHRSISSISDLISKSASSLEKPVKEEVNTASTCLLLVETSANDSPGLCSQPG
                     PQLRDDTGPEGSSHPDTLSSSAHHITPLKGNSTETRDPGDGKGSPKEGSTPPASASPE
                     DEVHICNLSLGEDCNVEKSVEEKENIATGYSESVKNGPGRPDPSDSSCTGLVRPQQKP
                     KKSEKEEKPTRTLVMTSMPSEKQTLIIQVVSTLKGFSFAPEVCETTTHVLVGKSARTL
                     NVLMGIARGCWILSYEWVLLSLELGHWISEEPFELSETFPAAPICRLERHLSTQQYQG
                     TLFANQPKMFIAPASSPPRAKLCELVLLCGGQVSPAPQLASLIIGPYKGKKKARIQYL
                     SEKWVLDSITQHKICDFNNYQLLQ"
     exon            506..597
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            598..716
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            717..804
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            805..919
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1042
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1132
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..2260
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2361
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2399
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2562
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2640
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2878
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..4662
                     /gene="Mcph1"
                     /gene_synonym="5430437K10Rik; BRIT1; D030046N04Rik; MCT;
                     Tg(HLA-A2.1)1Enge"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgacccg ccccctcgca gactcgcggg cgggaggttt gaagacccag agggcccgcg
       61 gacgctgcag cagtcccgct cgcgctccag ggtgcagggc tgaggcaggg cccacgggtg
      121 ggtcccctcc ccggtcaccg agcgctgcgc aacgaggacg agcgaaccct gcggggacaa
      181 gcgaccgcgg cgctgacctg cgccctgaag ccgcggtgcg gcgggctgac tcctgccagg
      241 tcgccggaga gcttcagggc cgcccgtgag cgatcaggtc tcggctgtcg tgtgtcactg
      301 agccgggcgc tctcggcgag ggaagggaac ccggagccct tgcgcacaca cacacacacc
      361 cctaagcctg acgcggcgag cccagggggc acggcctgcg catgcgcacc cctctgcctt
      421 cctgccggcg cacgctcggt cccgcagctt caagctggtc gggtcatgga ggcctcggga
      481 ggcgttgggg gcgcctttct gaaagatgtt gtggcctatg ttgaagtatg gtcttccaaa
      541 gggacagaga attactcaag gacgtttgca aagcaacttg aggatatggg ggcaacggtt
      601 tcaaaaacct tgaacaagca agtgacccat gtgatcttca aagatggata tcagagcacc
      661 tgggacaaag cccagaagac cggggcgaag ctggtttccg tcctctgggt tgaaaaatgc
      721 aggatggctg gagcacttgt tgatgagtct ttgttccctg cagtgaatac cgatgaacat
      781 ctaccaaact taagtagaaa aaaacacaaa tgtatgcaac ccaaagattt tattcttaaa
      841 acaccagaaa atgacaaaag acttcaaaag aaatttgaga aaatggctga agagctacaa
      901 aggcaaaagg cagctctaga tgatgacgtt cctgtcctcc tgtttgagtc ccctcgctca
      961 ctggtgtaca gctccccagt gaatgtgatg aagaggagac tgcaggatat gaaggagaag
     1021 agggagaacc tttcccctac ctcctcccag atgttggagc agtctcagca gaatccatgt
     1081 gtcagtctgt ttgaaacatc cttgaacatt tctcaccaac ctttgagttc agatgaatcc
     1141 tttgccagtg gctcccactc atctttcggt gattcctgtg gagatcaaga aaggaaactg
     1201 ggaagatctg ctaatgagat gaccacggtg acatgccctt cctcacctgt gttgagggca
     1261 agcagttttt atggctcagc atcacccaac catctcaggc agccacgtcc tcagaaagct
     1321 ccagacagtc cttcaaagga gagcatcaac tgtcagaagg atgctacagg tgcggtagct
     1381 gattccgaga gaaagcaagc tgcaggtgta tctcaggggg tgcctgatga gaagctctgt
     1441 ctgtctccta cgatgtccat catagaagaa caccaagtac ggttgggacc caagaattct
     1501 tctgcaaaga gaaaaagggc agcggacttg ggttcatctc caaaaggaaa actgaagaag
     1561 aggtacaaga gaaagtctgc tctggcaata cagttattca agtccgacca gagcccgccg
     1621 tccacaatca gactcattcc gggaactcct gacgttgagg cttcttccta tgaggactat
     1681 ttttcccctg ataatctcaa ggagaggaat tcggagagac ttcctcctga ggctcagcaa
     1741 ctagcaagcc cttctctgtt ccactgcaga ggtctctcaa agtgggagcg aagaaacatg
     1801 ctggaaatgt gtgattttac ctgcattggt gaaaagcaca gatccatcag cagcattagt
     1861 gacttaattt caaaaagtgc ctctagtctt gagaaacctg tcaaggagga agtgaataca
     1921 gcttctacct gcttgctttt ggtggagacc tctgctaacg acagcccagg gctttgcagt
     1981 cagcctggcc ctcagctgag ggatgacaca ggcccagagg gaagcagcca ccctgacacc
     2041 ctgtctagtt ctgcccacca catcacaccc ttgaaaggaa atagtacaga aaccagagac
     2101 ccaggtgatg gaaaaggctc ccccaaagaa ggtagcacgc ctcctgcatc agcctctcct
     2161 gaagatgaag tacacatctg taatctcagt ttgggagagg attgtaatgt agaaaagtct
     2221 gtagaagaaa aggagaacat agccacagga tatagtgaaa gtgttaaaaa tggaccaggg
     2281 cggccagatc cttcagacag ctcttgcaca ggccttgtca gacctcagca gaaaccaaag
     2341 aaaagtgaga aagaagaaaa gccaacgaga acattggtca tgacaagcat gccatctgag
     2401 aagcagaccc tcatcatcca ggtggtgagc acactgaaag gcttttcatt cgcacccgag
     2461 gtctgcgaga ccaccaccca cgtgctggta gggaagtctg cccgtaccct gaacgtgctg
     2521 atgggaattg cccgcggctg ctggattctt tcttacgaat gggtactgtt gtctttagag
     2581 ttgggccact ggatttctga ggagcctttt gaactctctg aaaccttccc tgcagctccg
     2641 atctgccgac ttgaacgcca tttatctacc cagcaatacc aaggaaccct ctttgctaat
     2701 cagccgaaga tgttcatagc gccagccagc agccctccca gagccaaact gtgtgaactg
     2761 gtactcctgt gtggtggcca agtcagccca gcccctcagc tggccagcct catcattggt
     2821 ccctacaagg gcaagaagaa agcaaggatc cagtacctgt cagagaaatg ggtcttagat
     2881 tccatcaccc aacacaagat ctgtgacttt aacaactacc aactgctaca gtgagacatc
     2941 tacaatgagg ctgctatcct caacactcaa gaagaacaac tctggagaaa aggaaccagc
     3001 agacacctta gggcttgaag tcacatgtca ctttgtgtgc tatggttttt atcttcagag
     3061 ggtatgtggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3121 gtctaggtgt ctagagatta aatccaaggc ttgctaagta agcactgtac tgtggaacta
     3181 catctccagc ttttatcctt aaaactcttt atgtaactta ttcatgactc attgtatttc
     3241 agagaagtct tgaccagcac cagttgggta ctttatacaa tactaataat gatcatgatg
     3301 gaaaggtcac agaacctttg tccttgagat acttgttccc aattatagaa tggaagttga
     3361 tttaaattgc tgtagtccta aacaatcaaa tagctcccta actcttctga cttagacgct
     3421 gagatcttta ttagcatgtt gtgtctagat aggaaggaca atcatgcatt attaagattg
     3481 caattatgtc ccttgagatg cccctcagaa caactaagga agacaggtat gaacgtttta
     3541 ttcaccgacc ttgcgaatgt ctaccactct gcctctactg actcccctga ggttccctaa
     3601 ggaaagtcag cttctggggt agagttctgt caaaggtgtc caacccatga cccatgtatc
     3661 aaacttgttt aagggtacct agaatgtagc tcatataaaa ttataaacat atttaaaagt
     3721 attaagagat ttgtgtgtac atatatttcc cccaacccca gcggggttgt aactcaattg
     3781 cacaattctt ccgggtgaac tctagatgac cacgttgtat tacactgtga aaaggctgga
     3841 cgtgccatca tcaggtcaat cactcttcag tgtgtcgaca cgggagactg gcctggggct
     3901 tgcagacctc ctcttgttgg tgtccccagt gttgggctgt agtctagtgc caccacatgt
     3961 catgctgctc cgtcacctaa cagacactga gtcccagtga gcttaaaagc agtgctcagc
     4021 tcactgtagt tttctgtgtt acgactcatg tcagctgctg tttccatctc aggaagcctc
     4081 aacaccactt ccaaaacctt gtcatctccg agataagcaa ttaaagcgta cagtttgtga
     4141 ctctggcatt ggccttgttc cctgtacaat taatgctctg atggttcatt catgtcatgt
     4201 gtgtcagcac gtaatttctt tttgttgcca aacactatcc tatggcatgg atgctctaca
     4261 gacttgctcc tcgccccatg agcagagtgc aggtgtaaag cccagtggga aagcagttga
     4321 tgatgtcacg ttgcgttggg tgatagttga tgatgtcatg ttgttctggg tgatggttga
     4381 tgatgtcatg tgttgctgga tgatagttga tgatgtcacg ttgtgctggg tgatgatagt
     4441 tgatgatgtc aggttgtgct tggtgatcag tagtccaggc tccgtggaag aagaggatca
     4501 gatgagggtg tgagagaccc cactcatcac cctcctcatc ttctgtaatc tgagtaattc
     4561 tgtttcccct cacaaatcca tagcttgaag ccatcacttg aagccagaat aatggtgttt
     4621 aaaaagtggg gtttgggaga aataaaagag atgcccagca aaaaaaaaaa aaaaaaaa
//
