LOCUS       NM_134160               1712 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus mucolipin 3 (Mcoln3), mRNA.
ACCESSION   NM_134160
VERSION     NM_134160.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Spix,B., Castiglioni,A.J., Remis,N.N., Flores,E.N., Wartenberg,P.,
            Wyatt,A., Boehm,U., Gudermann,T., Biel,M., Garcia-Anoveros,J. and
            Grimm,C.
  TITLE     Whole-body analysis of TRPML3 (MCOLN3) expression using a
            GFP-reporter mouse model reveals widespread expression in secretory
            cells and endocrine glands
  JOURNAL   PLoS One 17 (12), e0278848 (2022)
   PUBMED   36520788
  REMARK    GeneRIF: Whole-body analysis of TRPML3 (MCOLN3) expression using a
            GFP-reporter mouse model reveals widespread expression in secretory
            cells and endocrine glands.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Spix,B., Butz,E.S., Chen,C.C., Rosato,A.S., Tang,R., Jeridi,A.,
            Kudrina,V., Plesch,E., Wartenberg,P., Arlt,E., Briukhovetska,D.,
            Ansari,M., Gunsel,G.G., Conlon,T.M., Wyatt,A., Wetzel,S.,
            Teupser,D., Holdt,L.M., Ectors,F., Boekhoff,I., Boehm,U.,
            Garcia-Anoveros,J., Saftig,P., Giera,M., Kobold,S., Schiller,H.B.,
            Zierler,S., Gudermann,T., Wahl-Schott,C., Bracher,F.,
            Yildirim,A.O., Biel,M. and Grimm,C.
  TITLE     Lung emphysema and impaired macrophage elastase clearance in
            mucolipin 3 deficient mice
  JOURNAL   Nat Commun 13 (1), 318 (2022)
   PUBMED   35031603
  REMARK    GeneRIF: Lung emphysema and impaired macrophage elastase clearance
            in mucolipin 3 deficient mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Plesch,E., Chen,C.C., Butz,E., Scotto Rosato,A., Krogsaeter,E.K.,
            Yinan,H., Bartel,K., Keller,M., Robaa,D., Teupser,D., Holdt,L.M.,
            Vollmar,A.M., Sippl,W., Puertollano,R., Medina,D., Biel,M.,
            Wahl-Schott,C., Bracher,F. and Grimm,C.
  TITLE     Selective agonist of TRPML2 reveals direct role in chemokine
            release from innate immune cells
  JOURNAL   Elife 7, e39720 (2018)
   PUBMED   30479274
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Wiwatpanit,T., Remis,N.N., Ahmad,A., Zhou,Y., Clancy,J.C.,
            Cheatham,M.A. and Garcia-Anoveros,J.
  TITLE     Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells
            Diminishes Outer Hair Cell Longevity and Accelerates Age-Related
            Hearing Loss
  JOURNAL   J Neurosci 38 (13), 3177-3189 (2018)
   PUBMED   29453205
  REMARK    GeneRIF: Mice lacking both mucolipins 3 and 1, but not either one
            alone, experienced hearing loss as early as at 1 month of age.
REFERENCE   5  (bases 1 to 1712)
  AUTHORS   Miao,Y., Li,G., Zhang,X., Xu,H. and Abraham,S.N.
  TITLE     A TRP Channel Senses Lysosome Neutralization by Pathogens to
            Trigger Their Expulsion
  JOURNAL   Cell 161 (6), 1306-1319 (2015)
   PUBMED   26027738
  REMARK    GeneRIF: Study shows that, when uropathogenic E. coli infect
            bladder epithelial cells, they are targeted by autophagy but avoid
            degradation because of their capacity to neutralize lysosomal pH.
            This change is detected by TRPML3, TRPML3 activation then
            spontaneously initiates lysosome exocytosis, resulting in expulsion
            of exosome-encased bacteria.
REFERENCE   6  (bases 1 to 1712)
  AUTHORS   Lane,P.W., Bronson,R.T. and Spencer,C.A.
  TITLE     Rostral cerebellar malformation, (rcm): a new recessive mutation on
            chromosome 3 of the mouse
  JOURNAL   J Hered 83 (4), 315-318 (1992)
   PUBMED   1401878
REFERENCE   7  (bases 1 to 1712)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   8  (bases 1 to 1712)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
REFERENCE   9  (bases 1 to 1712)
  AUTHORS   Taylor,B.A.
  TITLE     Linkage of the cadmium resistance locus to loci on mouse chromosome
            12
  JOURNAL   J Hered 67 (6), 389-390 (1976)
   PUBMED   1021597
REFERENCE   10 (bases 1 to 1712)
  AUTHORS   Marks,S.C. Jr. and Lane,P.W.
  TITLE     Osteopetrosis, a new recessive skeletal mutation on chromosome 12
            of the mouse
  JOURNAL   J Hered 67 (1), 11-18 (1976)
   PUBMED   1262696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF475086.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106856.2, AF475086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..1712
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /note="mucolipin 3"
                     /db_xref="GeneID:171166"
                     /db_xref="MGI:MGI:1890500"
     exon            1..230
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1664
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /note="varitint-waddler; transient receptor potential
                     channel mucolipin 3"
                     /codon_start=1
                     /product="mucolipin-3"
                     /protein_id="NP_598921.1"
                     /db_xref="CCDS:CCDS17900.1"
                     /db_xref="GeneID:171166"
                     /db_xref="MGI:MGI:1890500"
                     /translation="MANPEVLVSSCRARQDESPCTFHPSSSPSEQLLLEDQMRRKLKF
                     FFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLF
                     LKGYMDRMDDTYAVYTQSEVYDQIIFAVTQYLQLQNISVGNHAYENKGTKQSAMAICQ
                     HFYRQGTICPGNDTFDIDPEVETECFLVEPDEASHLGTPGENKLNLSLDFHRLLTVEL
                     QFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIKECKDWHVSG
                     SIQKNTHYMMIFDAFVILTCLASLVLCARSVIRGLQLQQEFVNFFLLHYKKEVSASDQ
                     MEFINGWYIMIIISDILTIVGSVLKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYL
                     GFFAKYNLLILTLQAALPNVMRFCCCAAMIYLGYCFCGWIVLGPYHEKFRSLNRVSEC
                     LFSLINGDDMFSTFAKMQQKSYLVWLFSRVYLYSFISLFIYMILSLFIALITDTYETI
                     KHYQQDGFPETELRKFIAECKDLPNSGKYRLEDDPPGSLLCCCKK"
     exon            231..398
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            399..552
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            553..637
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            638..734
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            735..834
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            835..947
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1097
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1199
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1322
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1529
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1712
                     /gene="Mcoln3"
                     /gene_synonym="6720490O21Rik; TRPML3; Va"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatggcaaa tcccgaggtg ctggttagca gctgcagagc tcgccaagat gaaagcccct
       61 gcactttcca cccgagctcg tccccgtcag agcagcttct cttagaagac cagatgaggc
      121 ggaaactcaa gttctttttt atgaatcctt gtgagaagtt ctgggctcgg ggtaggaagc
      181 catggaaact tgccatacag attctgaaaa tcgcgatggt gactatccag ctggttctgt
      241 ttggactaag taaccagatg gtagtagctt tcaaagagga gaacactata gccttcaaac
      301 acctcttcct aaagggctac atggatcgaa tggacgacac ctatgcagtg tacactcaga
      361 gtgaagtgta tgaccagatc atctttgcag tgacccagta cttgcagctt cagaacatct
      421 ccgtgggcaa tcacgcttat gagaacaagg ggactaagca gtcggcgatg gcaatctgtc
      481 agcacttcta caggcaagga accatctgcc ccgggaacga cacctttgac atcgatccag
      541 aagttgaaac agaatgtttc cttgtagagc cagatgaagc ttcccacctt ggaacgcctg
      601 gagaaaataa actcaacctg agcctggact tccacagact tctgacggtg gagctccagt
      661 ttaagctcaa agccatcaat ctgcagacag ttcgacacca ggagcttcct gactgttacg
      721 actttacgct gactataaca ttcgacaaca aggctcacag tggaagaatc aaaataagct
      781 tagacaacga catttctatc aaagaatgca aagactggca tgtgtctgga tcaattcaga
      841 agaacacaca ctacatgatg atctttgatg cctttgtcat tctgacctgc ttggcctcac
      901 tggtgctgtg tgccaggtct gtgattaggg gtcttcagct tcagcaggag tttgtcaact
      961 tcttccttct tcactacaag aaggaagttt cggcctctga tcagatggag ttcatcaacg
     1021 ggtggtacat tatgatcatc attagtgaca tattgacaat cgttggatca gttctgaaaa
     1081 tggaaatcca agccaagagt ctcacaagct atgatgtctg cagcatactt ctcgggacgt
     1141 caactatgct cgtgtggctt ggagttatcc gatacctggg tttctttgcg aagtacaatc
     1201 tccttattct gaccctccag gcagcgctgc ccaacgtcat gaggttctgt tgctgcgctg
     1261 ctatgatcta tctaggctat tgcttttgcg gatggattgt gctgggccct taccatgaga
     1321 agttccgttc cctgaacagg gtctccgagt gcctgttctc gctgataaac ggagacgata
     1381 tgttttccac atttgcgaaa atgcagcaga agagttacct ggtgtggctg ttcagccgag
     1441 tctacctgta ctcgttcatc agcctcttca tttacatgat tctgagcctt ttcatcgcgc
     1501 tcatcacaga cacatacgaa acaattaagc actaccagca agatggcttc ccagagacgg
     1561 aacttcgaaa gtttatagcg gaatgcaaag acctccccaa ctccggaaaa tacagattag
     1621 aagatgaccc tccgggttct ttactctgct gctgcaaaaa gtaactgttg ggcttctctg
     1681 tgcttgggag gaaaatacag tgtgtggctg ag
//
