LOCUS       NM_026656               2518 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus mucolipin 2 (Mcoln2), transcript variant 1, mRNA.
ACCESSION   NM_026656
VERSION     NM_026656.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Plesch,E., Chen,C.C., Butz,E., Scotto Rosato,A., Krogsaeter,E.K.,
            Yinan,H., Bartel,K., Keller,M., Robaa,D., Teupser,D., Holdt,L.M.,
            Vollmar,A.M., Sippl,W., Puertollano,R., Medina,D., Biel,M.,
            Wahl-Schott,C., Bracher,F. and Grimm,C.
  TITLE     Selective agonist of TRPML2 reveals direct role in chemokine
            release from innate immune cells
  JOURNAL   Elife 7, e39720 (2018)
   PUBMED   30479274
  REMARK    GeneRIF: These data provide a direct link between TRPML2
            activation, CCL2 release and stimulation of macrophage migration in
            the innate immune response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Sun,L., Hua,Y., Vergarajauregui,S., Diab,H.I. and Puertollano,R.
  TITLE     Novel Role of TRPML2 in the Regulation of the Innate Immune
            Response
  JOURNAL   J Immunol 195 (10), 4922-4932 (2015)
   PUBMED   26432893
  REMARK    GeneRIF: study reveals interesting differences in the regulation
            and distribution of the members of the TRPML family and identifies
            a novel role for TRPML2 in the innate immune response.
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Remis,N.N., Wiwatpanit,T., Castiglioni,A.J., Flores,E.N.,
            Cantu,J.A. and Garcia-Anoveros,J.
  TITLE     Mucolipin co-deficiency causes accelerated endolysosomal
            vacuolation of enterocytes and failure-to-thrive from birth to
            weaning
  JOURNAL   PLoS Genet 10 (12), e1004833 (2014)
   PUBMED   25521295
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Asai,Y., Holt,J.R. and Geleoc,G.S.
  TITLE     A quantitative analysis of the spatiotemporal pattern of transient
            receptor potential gene expression in the developing mouse cochlea
  JOURNAL   J Assoc Res Otolaryngol 11 (1), 27-37 (2010)
   PUBMED   19834762
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Samie,M.A., Grimm,C., Evans,J.A., Curcio-Morelli,C., Heller,S.,
            Slaugenhaupt,S.A. and Cuajungco,M.P.
  TITLE     The tissue-specific expression of TRPML2 (MCOLN-2) gene is
            influenced by the presence of TRPML1
  JOURNAL   Pflugers Arch 459 (1), 79-91 (2009)
   PUBMED   19763610
  REMARK    GeneRIF: TRPML1 appears to play a novel role in the tissue-specific
            transcriptional regulation of TRPML2.
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Dong,X.P., Cheng,X., Mills,E., Delling,M., Wang,F., Kurz,T. and
            Xu,H.
  TITLE     The type IV mucolipidosis-associated protein TRPML1 is an
            endolysosomal iron release channel
  JOURNAL   Nature 455 (7215), 992-996 (2008)
   PUBMED   18794901
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Venkatachalam,K., Hofmann,T. and Montell,C.
  TITLE     Lysosomal localization of TRPML3 depends on TRPML2 and the
            mucolipidosis-associated protein TRPML1
  JOURNAL   J Biol Chem 281 (25), 17517-17527 (2006)
   PUBMED   16606612
  REMARK    GeneRIF: there is a hierarchy controlling the subcellular
            distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the
            localization of TRPML3 and not vice versa
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Ramsey,I.S., Delling,M. and Clapham,D.E.
  TITLE     An introduction to TRP channels
  JOURNAL   Annu Rev Physiol 68, 619-647 (2006)
   PUBMED   16460286
  REMARK    Review article
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Lindvall,J.M., Blomberg,K.E., Wennborg,A. and Smith,C.I.
  TITLE     Differential expression and molecular characterisation of Lmo7,
            Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells
  JOURNAL   Cell Immunol 235 (1), 46-55 (2005)
   PUBMED   16137664
  REMARK    GeneRIF: Expressed in both B-cell lines and primary B-lymphocytes.
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Di Palma,F., Belyantseva,I.A., Kim,H.J., Vogt,T.F., Kachar,B. and
            Noben-Trauth,K.
  TITLE     Mutations in Mcoln3 associated with deafness and pigmentation
            defects in varitint-waddler (Va) mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14994-14999 (2002)
   PUBMED   12403827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161212.9, AC171269.2 and AC122513.5.
            
            On Aug 17, 2018 this sequence version replaced NM_026656.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159172.1, AK152943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC161212.9         134217-134390
            175-177             AC161212.9         147919-147921
            178-334             AC171269.2         13752-13908
            335-508             AC171269.2         20146-20319
            509-662             AC171269.2         22167-22320
            663-747             AC171269.2         25671-25755
            748-844             AC171269.2         25871-25967
            845-944             AC171269.2         26725-26824
            945-1057            AC171269.2         30373-30485
            1058-1207           AC171269.2         31920-32069
            1208-1309           AC171269.2         33681-33782
            1310-1432           AC171269.2         33888-34010
            1433-1639           AC122513.5         24901-25107
            1640-1761           AC122513.5         26869-26990
            1762-2518           AC122513.5         29396-30152
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..2518
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /note="mucolipin 2"
                     /db_xref="GeneID:68279"
                     /db_xref="MGI:MGI:1915529"
     exon            1..174
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1798
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mucolipidin 2; transient receptor potential channel
                     mucolipin 2"
                     /codon_start=1
                     /product="mucolipin-2 isoform 1"
                     /protein_id="NP_080932.2"
                     /db_xref="CCDS:CCDS38663.1"
                     /db_xref="GeneID:68279"
                     /db_xref="MGI:MGI:1915529"
                     /translation="MPGDEETLDLPAWNRVPDLTWGPHHRSAMASLDSEVREECLRED
                     LKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFK
                     HLFLKGFSGVDEDDYSCSIYTQENTYESIFFAIKQYRHLKNISLATLGYGESEDNRTG
                     LKVCKQHYKTGAMFSSNETLNIDSDIETDCIHLDLQVLTTEPEDWAQTSFFRLDFYRL
                     VQVDISFALKGIDLQAVHSREIPDCYLFQNTITFDNTAHSGKIKIYLNSEANIEECKN
                     MNISGSTQRSTHYLLVFDVFVIMICLASLILCTRSIVLALRLRKRFLNFFLEKYKQRV
                     CGADQWEFVNGWYVLVTISDLMTIIGSILKMEIKAKKLTNYDVCSILLGTSTLFVWVG
                     VIRYLGYFQTYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHEKFENLN
                     IVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMVLSLFIALITD
                     SYHTIKKYQQHGFPETDLQKFLKESGSKDGYQKQPSALLSCLCCLRRRRSNDHLILID
                     "
     exon            175..334
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..508
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..662
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..747
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..844
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..944
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1057
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1207
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1309
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1432
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1639
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1761
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2518
                     /gene="Mcoln2"
                     /gene_synonym="3300002C04Rik; TRPML2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttataagg gcgtccactc cacctgcatc tcgcagacac ccgtaggcgg agccgggtgt
       61 ggggaccgtg gggactgagg gaatttgggg tcacgtcatg cccggagacg aggagacgct
      121 ggacctgcct gcgtggaacc gcgtcccgga cctgacttgg ggtccccacc acagatctgc
      181 gatggcgtct ctcgattctg aggtgaggga agagtgtctg agggaagacc tgaagttcta
      241 cttcatgagt ccctgtgaga agtaccgagc cagacgtcag atcccgtgga aactgggctt
      301 gcagatattg aagatagtca tggtaaccac acagcttgtt cggtttggct taagtaacca
      361 gttggtggtg gctttcaaag aagataacac tgttgctttt aagcacttgt ttttgaaagg
      421 attttctgga gttgatgaag atgactacag ctgtagcata tacactcagg agaacaccta
      481 tgagagcatc ttttttgcta taaagcagta tcgtcatctg aagaatattt ccctggcaac
      541 ccttggttat ggagaaagtg aagacaatag aactggcttg aaggtctgta agcagcacta
      601 caagacaggg gccatgtttt cttctaacga gaccctgaac attgacagtg acattgagac
      661 agactgcatt cacctggacc ttcaggtgct caccacggaa cccgaggact gggcacagac
      721 atctttcttc aggctggatt tttatcggct cgtgcaagtt gatatctcct ttgccctcaa
      781 aggaattgac ctacaggcag ttcattcccg agagataccg gactgttacc tctttcagaa
      841 tacgattacc ttcgacaaca cagcccacag tgggaaaatc aaaatctatc tcaacagcga
      901 ggccaacatc gaagagtgta aaaacatgaa catatctggg tctactcaga gaagcactca
      961 ctacctcctg gtgtttgatg tgttcgtcat tatgatctgc ctggcatccc ttatcctgtg
     1021 cacgagatcc attgttcttg ctctgaggct gaggaagaga tttctaaact tcttcctgga
     1081 gaagtacaaa cagcgcgtgt gtggcgctga ccagtgggaa ttcgtcaacg gatggtacgt
     1141 cctggtcact atcagcgacc tcatgacaat aattggatcc atattgaaga tggaaatcaa
     1201 agccaagaag ctcacaaact atgacgtgtg cagcatcttg ctcgggacgt cgacgctctt
     1261 tgtctgggtt ggagtcatca gatatctggg ttactttcag acgtacaacg tgctcatttt
     1321 aaccatgcaa gcctcactgc ccaaagttct ccggttctgt gcttgcgctg gcatgatcta
     1381 cctggggtac accttctgcg gctggattgt cttaggaccg taccacgaga agtttgaaaa
     1441 cctgaacata gtcgctgaat gcctgttttc tctggtcaac ggcgatgaca tgtttgccac
     1501 gttcgctcag atccagcaga agagcattct ggtgtggctg ttcagccgcc tctacctgta
     1561 ttcctttatc agcctattca tttacatggt cctcagcctc ttcatcgcgc tcatcaccga
     1621 ctcttaccac accattaaga agtaccagca gcatgggttt cctgaaacag atctgcagaa
     1681 attcctgaag gagagcggaa gcaaagatgg gtaccagaag cagccatcgg ccttgctgtc
     1741 ctgcctctgc tgtctgagga ggagaagaag caatgaccac ttgattctca ttgactaaaa
     1801 cctttggctg atgtcagtca agtccagatc cctttatgct gaggtcattc agagagaccc
     1861 cagaggtagc agcagtcggc tcaaagattg tcctgctgaa ttgtggaacc agaaggaggg
     1921 gtgtccatga gctgctgatc agacctgaca ttccaaagtt acttttcata gacatggagt
     1981 gtgaagagta agcctcttgt gaggccagcg tggcaatgaa attcaccagg agtctggtcg
     2041 tttgtgacat cataatgttg agatgtaaaa agaaatattc ccacttcaga gtgtgtaagc
     2101 aatatttaaa cccagataaa gatgcatgct tattgaaaaa acaaagattt gtttcaaaac
     2161 gtgacacttg gatttgaaga catttgttaa tttatggtct gcacagaaat aaatttgctt
     2221 ccaaaccaaa ttaagacttg aagctagaga gtggtaagcc actcagttcg tgactggttg
     2281 gactgtgagc ttgcttcttc agcaagcaca acaccagtgt ctgttagcac agtcagcggg
     2341 atgaaagagc acctggctgt cccctcaggt gagctctccc tggactggac acatgatgag
     2401 tgagtcaccc taagcttgga gtggccatct gtttcacaag tcagctccat tgtggtgggg
     2461 atttgccctt gtcatggaag gaagtgtaga tttttcatta aataaattta ttttcacg
//
