LOCUS       NM_177722               2553 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus minichromosome maintenance domain containing 2
            (Mcmdc2), mRNA.
ACCESSION   NM_177722 XM_975177 XM_976917
VERSION     NM_177722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   McNairn,A.J., Rinaldi,V.D. and Schimenti,J.C.
  TITLE     Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis
            Requires a Minichromosome Maintenance (MCM) Paralog
  JOURNAL   Genetics 205 (2), 529-537 (2017)
   PUBMED   27986806
  REMARK    GeneRIF: In MCMDC2-deficient mice meiosis is arrested in prophase
            I, and is characterized by persistent meiotic double-stranded DNA
            breaksfailure of homologous chromosome synapsis and XY body
            formation, and an absence of crossing over.
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Finsterbusch,F., Ravindranathan,R., Dereli,I., Stanzione,M.,
            Trankner,D. and Toth,A.
  TITLE     Alignment of Homologous Chromosomes and Effective Repair of
            Programmed DNA Double-Strand Breaks during Mouse Meiosis Require
            the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
  JOURNAL   PLoS Genet 12 (10), e1006393 (2016)
   PUBMED   27760146
  REMARK    GeneRIF: our work suggests that MCMDC2 plays an important role in
            either the formation, or the stabilization, of DNA strand invasion
            events that promote homologue alignment and provide the basis for
            inter-homologue crossover formation during meiotic recombination.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK031395.1,
            CA978963.1 and AC102570.8.
            
            On or before Apr 17, 2008 this sequence version replaced
            XM_976917.1, XM_975177.1, NM_177722.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AK031395.1         1-322
            323-932             CA978963.1         78-687
            933-1170            AC102570.8         175096-175333       c
            1171-1376           AC102570.8         171506-171711       c
            1377-1543           AC102570.8         164821-164987       c
            1544-1723           AC102570.8         163587-163766       c
            1724-1866           AC102570.8         161703-161845       c
            1867-1976           AC102570.8         158663-158772       c
            1977-2553           AC102570.8         154814-155390       c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.19 cM"
     gene            1..2553
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /note="minichromosome maintenance domain containing 2"
                     /db_xref="GeneID:240697"
                     /db_xref="MGI:MGI:3045334"
     exon            1..53
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            54..191
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2143
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /note="MCM domain-containing protein C8orf45 homolog; MCM
                     domain-containing protein 2"
                     /codon_start=1
                     /product="minichromosome maintenance domain-containing
                     protein 2"
                     /protein_id="NP_808390.2"
                     /db_xref="CCDS:CCDS48215.1"
                     /db_xref="GeneID:240697"
                     /db_xref="MGI:MGI:3045334"
                     /translation="METLQMKEAALVYLDRSGGLQKFIDDCKSYNDSKQSYAVYRFSI
                     LIDPCDVVELDADLGNHILHHPLKAARVFQSVCFVAVKTLSLIGQLQTETQINIVLKL
                     THLPALPSYTLDLCEFPLNYASQRFYMMQGIVIAMTTITKYTQGARFLCSDGVCPLSK
                     GFQYVRVHVPGATESATVRNDFLCSLCSSSLQEDRKFRVLGDKQIVEIITTKMFHAFQ
                     GDSKNQPFRFQSLGIFLRDELVNKMKIGNEYKIIGIPVCVKTSQTALCVEANNITPHT
                     AKVPLGISDNFRRLLSLTSSSCWKFTAMLANVFASQIVAPGTYNLLKLCLLMSLVQTR
                     DCNREREDCLDILVITSDTLLVDRLLNFSMNLVSRGIRHPVCTEVFPTVSRNKYGTGA
                     VSIQAGSALLAKGGICFIGDLTSHKKDKLEQLQSALESRSVTVFIPGKKFGDDFDQQM
                     TFPIQCSFWSFVDMDSSSRRNVQKTSTLIGQMDCSLIPANLAEAFGLLINCSEASPCH
                     PLLPTVQHTLKKAVEPEGLLYLASKQFTTEDFEKLLAFAKSLNMEFSLEAERMIHGYY
                     LASRRIRTDSIHGSKLSASALKYLVSLSEAHARLSLRTTVLREDALIAALLLEISLTL
                     RYGATPFCVAPNALFPFELYNEEYLEQRDLYLTQCQQQLQQFIATCGPGTTVFSSDE"
     exon            192..322
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            323..382
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            383..578
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..701
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            702..806
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            807..932
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1170
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1376
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1543
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1723
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1866
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1976
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2553
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2550
                     /gene="Mcmdc2"
                     /gene_synonym="6030422M02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcgt gcgcaggagg ccctctgtag cccacgcggg tcctgcagtg cagctgtggt
       61 taatgttcta ataatagaga ttaccaacaa ggagaaaatg gagactcttc agatgaaaga
      121 ggcagccctt gtctatcttg acagaagtgg aggcctccaa aagtttatag acgactgcaa
      181 gtcctacaat gattcaaagc agagttatgc tgtctatcgg ttcagtattc taatagaccc
      241 ctgtgacgtt gttgaattag atgctgacct tggaaatcac attttacacc atcccttaaa
      301 agctgctcga gtttttcaat cagtctgctt tgttgctgtt aagactctct cattaattgg
      361 acagttacag actgaaactc aaatcaatat tgtgctgaag ttaacacatt taccagccct
      421 gccaagctat actcttgatc tttgtgagtt tccacttaat tatgcatctc agagatttta
      481 tatgatgcaa ggaattgtga ttgcaatgac aactataacc aagtacactc aaggtgcaag
      541 gttcttgtgt tcagatggag tgtgtcctct ttcaaaagga tttcagtatg tgagagtcca
      601 tgtgcctgga gctacagaat ctgcaacagt aagaaatgac tttttatgca gtctctgttc
      661 atcttcactt caagaagaca gaaaatttag agtacttggt gataaacaga tagttgaaat
      721 aatcaccaca aaaatgtttc atgcttttca aggagactct aaaaaccagc catttaggtt
      781 tcaatcactt ggtattttcc taagagatga actagtgaat aagatgaaaa taggaaatga
      841 atataaaatt attggaattc cagtctgtgt caaaacttca caaactgctc tctgtgtaga
      901 agcaaataat atcactcccc acacagcaaa agttccttta ggaattagtg acaactttag
      961 gcgtctcctc tccttgactt cgagctcgtg ctggaaattc acagcaatgc tggccaatgt
     1021 ctttgcatca cagattgttg ctcctgggac ttacaatttg ctcaaacttt gtttgttgat
     1081 gagtctagta cagacaagag actgcaacag ggaacgagaa gactgcttgg atattttagt
     1141 tataaccagt gacactctgc ttgtagacag acttttgaat tttagcatga atcttgtctc
     1201 ccgtggtata cgtcatcctg tctgtacaga agtttttcct acagtgtcca gaaataaata
     1261 tggaacagga gcagtgagca ttcaggccgg cagtgctttg cttgctaagg gtggtatctg
     1321 ctttatagga gacctgacat cccataaaaa agataaactt gaacagcttc aatcagcttt
     1381 ggagagcaga agcgttacag tattcatccc aggaaagaag tttggggatg atttcgatca
     1441 gcaaatgact tttcccattc agtgcagttt ttggtctttt gttgatatgg attcatcttc
     1501 aaggagaaat gtgcagaaaa ccagtactct gattggtcag atggattgca gtttgattcc
     1561 agccaacctt gcagaggcat ttggattact gattaactgc agtgaggcat ctccttgcca
     1621 cccacttctt cctactgtgc agcacacttt aaagaaagca gtggagcctg aggggctgct
     1681 gtacttagcg tctaagcagt tcacaactga agactttgaa aagctactgg cttttgcaaa
     1741 gagtttgaat atggaattca gcttggaagc agaaagaatg attcatggct attatctagc
     1801 aagtcgcaga ataagaacag attctataca tggatcaaag ctgtcagcat ctgcattaaa
     1861 atatttagtg tctttatctg aagcccacgc ccggctgagc ctaaggacca cagtgctcag
     1921 agaagacgca ctcatcgcag ccttgttgtt ggaaatctct ctcacactga gatacggggc
     1981 cactccattt tgtgttgctc ccaatgcatt atttccattt gagctgtata atgaagaata
     2041 tttagagcaa agagatctct acctgactca gtgccaacag cagctccaac agtttattgc
     2101 cacatgtgga cctgggacaa ctgtcttttc tagtgatgaa taagcaattt aagaattacc
     2161 tttcgggcct agcaaacaca gaagtggatg ttcacagtca gctataggat ggaacacagg
     2221 gcccccaatg gaggagctag agaaagtacc caaggagctg aaggggtctg caaccctata
     2281 ggtggaacaa caatatgaac taaccagtac ccccaggagc tcgtgtctct ggctgcatat
     2341 gtagcagaag atggcctagt tggccatcag tggaaagaga ggcccattgg tcttgtaaac
     2401 tttatatgcc tcagtacagg ggaacgccag ggccaagaag tgggaggggg gaagggggag
     2461 agggcatggg ggacttttgg gatagctttg gaaatgtaaa tgaagaaagt acctaataaa
     2521 aaaaaaggaa aaattacctt tcatgcccca taa
//
