LOCUS       NM_027830               4663 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus minichromosome maintenance 9 homologous recombination
            repair factor (Mcm9), mRNA.
ACCESSION   NM_027830 NM_199147 XM_017314097 XM_125626 XM_137086
VERSION     NM_027830.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4663)
  AUTHORS   Lutzmann,M., Bernex,F., da Costa de Jesus,C., Hodroj,D., Marty,C.,
            Plo,I., Vainchenker,W., Tosolini,M., Forichon,L., Bret,C.,
            Queille,S., Marchive,C., Hoffmann,J.S. and Mechali,M.
  TITLE     MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic
            DNA Damage Driving p53-Dependent Myeloid Tumors
  JOURNAL   Cell Rep 28 (11), 2851-2865 (2019)
   PUBMED   31509747
  REMARK    GeneRIF: MCM8- and MCM9 Deficiencies Cause Lifelong Increased
            Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
REFERENCE   2  (bases 1 to 4663)
  AUTHORS   O'Driscoll,M.
  TITLE     The pathological consequences of impaired genome integrity in
            humans; disorders of the DNA replication machinery
  JOURNAL   J Pathol 241 (2), 192-207 (2017)
   PUBMED   27757957
  REMARK    Review article
REFERENCE   3  (bases 1 to 4663)
  AUTHORS   Luo,Y. and Schimenti,J.C.
  TITLE     MCM9 deficiency delays primordial germ cell proliferation
            independent of the ATM pathway
  JOURNAL   Genesis 53 (11), 678-684 (2015)
   PUBMED   26388201
  REMARK    GeneRIF: genetic studies of DNA damage response pathways that
            underlie germ cell depletion in mice mutant for minichromosome
            maintenance 9
REFERENCE   4  (bases 1 to 4663)
  AUTHORS   Traver,S., Coulombe,P., Peiffer,I., Hutchins,J.R., Kitzmann,M.,
            Latreille,D. and Mechali,M.
  TITLE     MCM9 Is Required for Mammalian DNA Mismatch Repair
  JOURNAL   Mol Cell 59 (5), 831-839 (2015)
   PUBMED   26300262
REFERENCE   5  (bases 1 to 4663)
  AUTHORS   Park,J., Long,D.T., Lee,K.Y., Abbas,T., Shibata,E., Negishi,M.,
            Luo,Y., Schimenti,J.C., Gambus,A., Walter,J.C. and Dutta,A.
  TITLE     The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage
            sites to facilitate homologous recombination
  JOURNAL   Mol Cell Biol 33 (8), 1632-1644 (2013)
   PUBMED   23401855
REFERENCE   6  (bases 1 to 4663)
  AUTHORS   Lutzmann,M., Grey,C., Traver,S., Ganier,O., Maya-Mendoza,A.,
            Ranisavljevic,N., Bernex,F., Nishiyama,A., Montel,N., Gavois,E.,
            Forichon,L., de Massy,B. and Mechali,M.
  TITLE     MCM8- and MCM9-deficient mice reveal gametogenesis defects and
            genome instability due to impaired homologous recombination
  JOURNAL   Mol Cell 47 (4), 523-534 (2012)
   PUBMED   22771120
  REMARK    GeneRIF: MCM8 and MCM9 form a complex and that they coregulate
            their stability.
REFERENCE   7  (bases 1 to 4663)
  AUTHORS   Hartford,S.A., Luo,Y., Southard,T.L., Min,I.M., Lis,J.T. and
            Schimenti,J.C.
  TITLE     Minichromosome maintenance helicase paralog MCM9 is dispensible for
            DNA replication but functions in germ-line stem cells and tumor
            suppression
  JOURNAL   Proc Natl Acad Sci U S A 108 (43), 17702-17707 (2011)
   PUBMED   21987787
  REMARK    GeneRIF: Minichromosome maintenance helicase paralog MCM9 is
            dispensible for DNA replication but functions in germ-line stem
            cells and tumor suppression.
REFERENCE   8  (bases 1 to 4663)
  AUTHORS   Lamberti,A., Sanges,C., Chambery,A., Migliaccio,N., Rosso,F., Di
            Maro,A., Papale,F., Marra,M., Parente,A., Caraglia,M.,
            Abbruzzese,A. and Arcari,P.
  TITLE     Analysis of interaction partners for eukaryotic translation
            elongation factor 1A M-domain by functional proteomics
  JOURNAL   Biochimie 93 (10), 1738-1746 (2011)
   PUBMED   21689717
REFERENCE   9  (bases 1 to 4663)
  AUTHORS   Lutzmann,M., Maiorano,D. and Mechali,M.
  TITLE     Identification of full genes and proteins of MCM9, a novel,
            vertebrate-specific member of the MCM2-8 protein family
  JOURNAL   Gene 362, 51-56 (2005)
   PUBMED   16226853
REFERENCE   10 (bases 1 to 4663)
  AUTHORS   Yoshida,K.
  TITLE     Identification of a novel cell-cycle-induced MCM family protein
            MCM9
  JOURNAL   Biochem Biophys Res Commun 331 (2), 669-674 (2005)
   PUBMED   15850810
  REMARK    GeneRIF: Identified a novel MCM family gene, MCM9, by using
            bioinformatics; mouse MCM9 mRNA was upregulated by transcription
            factor E2E1 and serum stimulation in NIH3T3 cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153949.3 and AC155941.3.
            
            On or before Jun 28, 2018 this sequence version replaced
            NM_199147.1, XM_017314097.1, NM_027830.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1028510.1,
                                           SRR13422600.1901929.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC153949.3         97829-98062         c
            235-553             AC153949.3         93821-94139         c
            554-870             AC153949.3         90861-91177         c
            871-952             AC153949.3         88239-88320         c
            953-1153            AC153949.3         83957-84157         c
            1154-1279           AC153949.3         80932-81057         c
            1280-1399           AC153949.3         79457-79576         c
            1400-1574           AC155941.3         135773-135947       c
            1575-1777           AC155941.3         120987-121189       c
            1778-1981           AC155941.3         119893-120096       c
            1982-2064           AC155941.3         114027-114109       c
            2065-2210           AC155941.3         113428-113573       c
            2211-4663           AC155941.3         108805-111257       c
FEATURES             Location/Qualifiers
     source          1..4663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 27.21 cM"
     gene            1..4663
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /note="minichromosome maintenance 9 homologous
                     recombination repair factor"
                     /db_xref="GeneID:71567"
                     /db_xref="MGI:MGI:1918817"
     exon            1..234
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..553
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3654
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /EC_number="3.6.4.12"
                     /note="DNA replication licensing factor MCM9;
                     mini-chromosome maintenance deficient 9; mini-chromosome
                     maintenance deficient domain-containing protein 1;
                     minichromosome maintenance complex component 9"
                     /codon_start=1
                     /product="DNA helicase MCM9"
                     /protein_id="NP_082106.3"
                     /db_xref="CCDS:CCDS23846.2"
                     /db_xref="GeneID:71567"
                     /db_xref="MGI:MGI:1918817"
                     /translation="MNSEQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNA
                     MSLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAILQSLPETEGLSMKQNLHARISG
                     LPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADF
                     EQYYTFSRPSSCPSLASCDSSKFSCLSDLSSSPARCRDYQEIKIQEQVQRLSVGSIPR
                     SMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDVRCEVEIVLKANYVQVNNEQSS
                     GMVMDEDTRKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAVAMVLAGGIQR
                     TDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD
                     SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTR
                     TTILAATNPKGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILEN
                     KGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQVLLRYYQMQRQSDSRNAARTTI
                     RLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQGGALLGGVNALHTSFPENP
                     RAQYQRQCELILEKLELQGLLQEELRRLERLQNESVHQCQSHSLEEEVAPGSCRNDPR
                     DKPRLRTSTQQEQSCSWSSTERSGADSPPGPGLNRPTSCNNSAENRDGRGDGLDWLDP
                     TSSPEIAPESTIVSPNVKTTEKNVNLKISNNKSQGKEKHGPQQRSKLLEAGHLPSSGA
                     MNAPLRSHGVKRTKASQAVVVSEAGRGDEEDSVPRRLPKLLKEGSQNVCRSTTRVRPL
                     PPTVPLSLSIPSPGSGKRSGTPKRKRRKSAQVEEPEPEGMETPTVKLAKFTFKQKTKL
                     THSPEGQGPIPPSASEIAVDSSKIPQQRTRREAAVPVVAPGKSTSTSGDRCSDQLHGK
                     TKELSRQPPDSNPPREEREQGPKRRVIQPKPELGNQAGHSHLACEKDRKEGVSCGNKS
                     SKVHAGTIARLASFSFTSPSESKSESLPPERKDSRDSRDSRDSRDRCHSPPATTAPVL
                     GQQRQTFQLQQPTERANLSTLSLFTLSELDDEALDFDWEEEMRKKP"
     exon            554..870
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..952
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1153
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1279
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1399
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1574
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1777
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1981
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2064
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2210
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..4663
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4618..4623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /note="hexamer: AATAAA"
     polyA_site      4663
                     /gene="Mcm9"
                     /gene_synonym="9030408O17Rik; Gm235; Mcmdc1"
                     /note="major polyA site"
ORIGIN      
        1 agaagcccca gcggccggaa agttgaggca gtgcgcggct cggggtccgc gggaagctca
       61 agtccttcag aggccgagcg agagcagcgc gaagaagcct gcgcgccccc gcgcaaggcg
      121 gccccctcga gcggccgcgc gcacgccccg ccccctccaa cgccgcgcgg gtcgggctgg
      181 ggcgaccacg gccgcagcgc ggtcccggcg accaagacag tgcgtgttga gccctaccca
      241 cccttcaaga tgaatagtga gcaggtcacc ctggtgggtc aggtgtttga gtcctatgtt
      301 tcagagtacc ataagaacga tattcttctg atcctgaaag aaagagatga agatgctcac
      361 tacccggttg tggttaatgc tatgagcctt ttcgagacca acatggaaat tggggactat
      421 ttcaccgtgt tccccaatga agtactaaca gtttttgaca gtgcacttcg aaggtcagcc
      481 ttggcaattc tgcagtccct tcctgagacg gaggggttat ccatgaagca gaatcttcat
      541 gccaggatat caggtttgcc tgtttgtcca gaactggtca gggaacacat tcccaaaacc
      601 aaggatgtgg gacacttctt atctgtcact gggacagtga tccgaacgag tctggtgaag
      661 gtcttggagt tcgagcggga ttacatgtgt aacaaatgca agcatgtgtt catggtggag
      721 gcagacttcg agcagtatta caccttcagt cggccatcgt catgtccaag tttagccagc
      781 tgtgactcct caaaattctc ttgcctctca gacttgtctt catctccagc cagatgtcgg
      841 gattaccagg aaatcaaaat tcaggagcag gtgcaaaggc tgtctgttgg aagtatccca
      901 cggtctatga aagttattct ggaagatgac ctagttgaca gttgcaaatc tggagatgac
      961 ctcaccatct atggggttgt aatgcaacgg tggaaaccct ttcagcgaga tgtacgctgt
     1021 gaagttgaga ttgtcttgaa agccaactat gtccaagtga ataatgagca atcctcgggg
     1081 atggtcatgg atgaggacac tcgaaaagaa tttgaagact tctgggaaca ctataagagt
     1141 gacccctttg cagggaggaa tgaaatattg gccagcttgt gtcctcaagt ttttgggatg
     1201 tatctagtga agcttgctgt ggccatggta ctggctggtg gaattcaaag aactgatgct
     1261 gcaggaacca gggttagagg ggaatctcac cttttattgg ttggggatcc tggcacaggg
     1321 aaatcacaat tccttaaata tgcagcaaag attaccccaa ggtccgtttt gaccacagga
     1381 attggatcta ctagtgcagg tctgaccgtg acagctgtca aagactcagg agaatggaat
     1441 ctagaggctg gggctttggt gcttgcagat gctggtctct gctgtattga cgaatttaac
     1501 agcctcaaag aacatgacag gacaagcatc catgaagcaa tggagcaaca aaccataagt
     1561 gttgctaagg ctggccttgt ttgtaagctg aacacaagga ccaccatcct ggcagcaact
     1621 aaccccaaag gccagtatga ccccaaggag tctgtgtctg tgaacattgc cctcgggagc
     1681 ccactcttaa gtcgatttga ccttgtcctg gttttgctcg acactaggaa tgaagactgg
     1741 gatcgtatca tttcttcctt tatcttagaa aataaaggtt atccaagcaa atcagagaat
     1801 ctgtggagca tggagaagat gaaaacctac ttctgcctca ttcggaatct ccaccccaca
     1861 ctgtctgaag tgagcaatca agtcctcctt cgatactacc aaatgcaaag gcagagtgat
     1921 tcccggaatg cagcccggac aaccatccgc ctgttagaaa gcttgatccg attagcagaa
     1981 gctcacgctc gcctgatgtt ccgcagtgcc gtgactctgg aagatgccgt tacagctgta
     2041 tctgtgatgg agtcttcaat gcagggaggt gctctgctag gaggtgtgaa tgctctccac
     2101 acttccttcc ctgaaaaccc ccgtgcacag taccagaggc agtgtgaact cattctggaa
     2161 aagctggaac tccagggcct cttgcaggaa gaacttcgaa gactggaaag gttacagaat
     2221 gagagtgtac accaatgcca gtcacattca ctagaggagg aggtggctcc aggttcctgc
     2281 agaaatgatc ccagggacaa gccaaggctc aggacttcaa cacagcagga acagagctgt
     2341 agctggagtt ccacagagag atctggtgca gactccccgc ctggtccagg gcttaataga
     2401 ccaacaagtt gtaacaactc agctgagaac agagatggca gaggtgacgg tttagactgg
     2461 ttggacccca catcaagtcc tgagattgca ccagaaagca ctattgtgtc tcccaatgtg
     2521 aaaacaactg agaaaaatgt gaatttgaaa atctccaaca ataaatctca gggcaaggag
     2581 aagcatgggc cacagcaaag aagcaaatta ttagaagctg gacatcttcc atcatcagga
     2641 gccatgaatg cccccttacg gtctcacggt gttaagcgta caaaggcaag tcaggcagtg
     2701 gttgtatctg aagcaggacg gggtgatgaa gaagactctg tgccccgaag actccccaag
     2761 ctgctgaagg aggggtcaca gaatgtgtgc agaagcacaa ccagagtgcg accactgcca
     2821 cccactgtcc ctctgtccct gtctatccct tcacctgggt caggaaaaag atcaggaaca
     2881 cccaaaagaa agagacggaa atctgctcag gtggaagagc ctgaacctga aggtatggag
     2941 actccaacag taaagctggc caaattcaca tttaaacaga agacaaaact gacccactcc
     3001 cccgaaggcc aaggccccat acctcccagt gctagtgaaa tagcagttga cagttctaaa
     3061 attccccaac aaagaacaag aagagaagca gctgtgcctg tggtagcgcc aggaaagtcg
     3121 acatccacct caggagacag atgctctgac cagctgcacg gaaagacaaa ggagctctca
     3181 aggcagccac cagacagtaa tccaccaaga gaggagaggg aacagggccc caaaagaagg
     3241 gttattcagc ccaaaccgga gcttgggaac caggctgggc attcgcatct agcctgtgag
     3301 aaagacagaa aggaaggggt ttcctgcggt aataaaagca gcaaggttca tgctggcacc
     3361 atagccagac tggcaagctt ctccttcact tccccatcag aatccaaatc ggaatccctc
     3421 cctcctgaaa ggaaggacag cagggacagc agggacagca gggacagcag ggacaggtgc
     3481 cacagccctc ctgcgaccac agctccagtg ctcggccagc aaaggcagac tttccagctg
     3541 cagcagccca cagagagagc gaatctttcc accctctccc tcttcactct gtcggaacta
     3601 gatgacgaag cattagattt tgactgggag gaagagatga ggaaaaagcc atgattagga
     3661 aaagctttct ggtcacagtt gtcttcccca gtccaaccaa gtgccttcaa agtatacaag
     3721 tggctacagg tgtgcacaca gtgtgtagta cgtgcgtggc cctgccgaag cccaactccc
     3781 ttgtcaggtt catcttcatc acctaaatgc tgaataatta attgcggttg gtgtgatatc
     3841 aatactttgg atgaatgaat taatgctcat ttcacaaaag atgacttaac atccaggacg
     3901 ttctagtttt tcacttggtt tttgtttttg tgtttttggt ttttggtttt tggttgattg
     3961 gttggttcat ttttgttgta ttggttttgt ttgggggttt ggtttggttt ttactagagg
     4021 agttctattc tgagcttctt ctctcacata tccagaccaa atggcaggat ggtggcactc
     4081 agaaatctaa caaggcagct aagtgctttc tgtttgcttt gcatttcctg cccaatatgt
     4141 actgaatgcg gtgtttatta acatttggaa tgacttgccg aaatcatgtg gtttttctca
     4201 tgcctctatg ttaattctca cgcatcagat taaaaggggc tggtggtttt ctgtcttcaa
     4261 gatgcatgct ttcattggac agcgtccccg gggaagccac accgtagctt acagaaacac
     4321 tggcccttgg atttgttccc cttgtgccag cacgcacgcc ttgcctttca ttcctttttg
     4381 ctctcagagc ttaccttcag tacaacttaa atcatgtggt tagaagagaa gcgagctccg
     4441 gaaggccagc tgtagccctg tcacatctgc aatggcatca gtatggaaac gtgatccctg
     4501 atagcttctc atctgtttgt ctttttataa aaccaagaac gttgggttgg gatatggctc
     4561 agaagaagaa tgtatatgta gcgtgtatga cattacttat tacataagta ataataaaat
     4621 aaaacggaga agtttccctg tctggtgggc agagatgact aaa
//
