LOCUS       NM_001291054            3481 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus minichromosome maintenance 8 homologous recombination
            repair factor (Mcm8), transcript variant 1, mRNA.
ACCESSION   NM_001291054 XM_006500020
VERSION     NM_001291054.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Lutzmann,M., Bernex,F., da Costa de Jesus,C., Hodroj,D., Marty,C.,
            Plo,I., Vainchenker,W., Tosolini,M., Forichon,L., Bret,C.,
            Queille,S., Marchive,C., Hoffmann,J.S. and Mechali,M.
  TITLE     MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic
            DNA Damage Driving p53-Dependent Myeloid Tumors
  JOURNAL   Cell Rep 28 (11), 2851-2865 (2019)
   PUBMED   31509747
  REMARK    GeneRIF: MCM8- and MCM9 Deficiencies Cause Lifelong Increased
            Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   O'Driscoll,M.
  TITLE     The pathological consequences of impaired genome integrity in
            humans; disorders of the DNA replication machinery
  JOURNAL   J Pathol 241 (2), 192-207 (2017)
   PUBMED   27757957
  REMARK    Review article
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Lutzmann,M., Grey,C., Traver,S., Ganier,O., Maya-Mendoza,A.,
            Ranisavljevic,N., Bernex,F., Nishiyama,A., Montel,N., Gavois,E.,
            Forichon,L., de Massy,B. and Mechali,M.
  TITLE     MCM8- and MCM9-deficient mice reveal gametogenesis defects and
            genome instability due to impaired homologous recombination
  JOURNAL   Mol Cell 47 (4), 523-534 (2012)
   PUBMED   22771120
  REMARK    GeneRIF: MCM8 and MCM9 form a complex and that they coregulate
            their stability.
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY766288.1, BC046780.1 and BC052070.1.
            
            [WARNING] On Jul 17, 2024 this sequence was replaced by
            NM_001291054.2.
            
            On Mar 22, 2014 this sequence version replaced XM_006500020.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133858.1, BC046780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY766288.1         1-53
            54-1996             BC046780.1         1-1943
            1997-3481           BC052070.1         1719-3203
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.75 cM"
     gene            1..3481
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /note="minichromosome maintenance 8 homologous
                     recombination repair factor"
                     /db_xref="GeneID:66634"
                     /db_xref="MGI:MGI:1913884"
     exon            1..325
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            326..497
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..2851
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /EC_number="3.6.4.12"
                     /note="isoform a is encoded by transcript variant 1; DNA
                     replication licensing factor MCM8; DNA helicase MCM8;
                     minichromosome maintenance deficient 8"
                     /codon_start=1
                     /product="DNA helicase MCM8 isoform a"
                     /protein_id="NP_001277983.1"
                     /db_xref="CCDS:CCDS71152.1"
                     /db_xref="GeneID:66634"
                     /db_xref="MGI:MGI:1913884"
                     /translation="MSGAYRGRGFGRGRFQSWKRGRGGGNFSGRWRERENRVDLNEAS
                     GKHASAQASQPLLQQSTLDQFIPYKGWKLYFSEVYSNNSPFIEKIQAFEKFFTRHIDL
                     YDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACMGLAIHQVLTKD
                     LERHAAELQAQEGLSNGGETMVNVPHIYARVYNYEPLTHLKNIRATCYGKYISIRGTV
                     VRVSNIKPLCTNMAFQCAACGEIQSFPLPDGKYTLPTKCPVPACRGRSFAPLRSSPLT
                     VTLDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKVSNSE
                     EGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAE
                     ENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPG
                     LGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGIC
                     GIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTV
                     SENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQ
                     DSNTSVLEVVSEKPLSERLKVAPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQAL
                     QDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHS
                     MLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQYHQLRQIAK
                     ELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQTM"
     exon            498..581
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            582..664
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..814
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..918
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1117
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1203
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1355
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1551
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1582
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1723
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1865
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2061
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2281
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2491
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2568
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2758
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..3481
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2994
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3182
                     /gene="Mcm8"
                     /gene_synonym="5730432L01Rik"
                     /note="major polyA site"
ORIGIN      
        1 tagtcgcgtg gcttccttaa gcagaagcgc gtcatagacg cgccaaaaaa gaacttcaag
       61 cgaggtccga gtttgccttc tgggcttgtg ctcggccttc cccgccctgc gtctggcgtt
      121 ctggcgcgca gtgacgcggg caccgggcgg ctccggagac ggagtgtccg cggagccctg
      181 cgtgagagtg tatacggctt acggctctgt cgcaggctcc ggggctcctg aaagcaggac
      241 gcgaggaaga cggggagtca gggattgcgt acgacttttc tcaggctgct tccctatgta
      301 gatgttggaa tcgccaccgt tctcagagtg ctcttgactt gtggaagaca tgagtggtgc
      361 ttatagaggc agaggttttg gacgaggaag attccaaagc tggaaaagag gaagaggtgg
      421 tgggaacttc tcaggaaggt ggagagaaag agaaaacaga gttgacctga atgaagcttc
      481 aggaaagcac gcttctgcac aagcctcaca accgttactt caacagtcaa cattggatca
      541 gtttatcccg tataagggct ggaagcttta cttctctgaa gtttacagta ataactctcc
      601 ctttattgag aagattcaag catttgagaa atttttcaca aggcatatcg acttatacga
      661 taaggatgaa atagaaagaa aaggaagcat tttggtggat tttaaagaac tgacaaaagc
      721 tgatgaaata actaacttga tacccgatat agaaaacgca ctaagagatg cccctgagaa
      781 aacactggcg tgtatggggc tggcaataca tcaggtatta actaaggacc ttgaaaggca
      841 tgccgccgaa ttacaagctc aagagggatt gtctaacggt ggagagacaa tggtaaatgt
      901 accacatatt tatgcaagag tgtacaacta tgagcccttg acacacctca agaatatccg
      961 agcaacttgc tatgggaaat acatctctat acgagggact gtggtccggg tcagcaacat
     1021 aaagcctctt tgcaccaaca tggcttttca gtgcgctgca tgtggagaga ttcagagctt
     1081 tcctctgcca gatggaaaat acacccttcc tacaaagtgt cctgtgcctg cgtgccgagg
     1141 gaggtcattt gctccactgc gcagctctcc tctcacagtt acactggact ggcagttgat
     1201 caaaatccag gagctgatgt ctgatgcaca gagagaagct ggtcggatcc ctcggacgat
     1261 agaatgtgaa cttgttcacg atcttgtaga tagttgtgtc ccaggagata cagtgactgt
     1321 tactggaatt gtcaaagtct ccaattctga agaaggttct cgaaataaga atgataagtg
     1381 catgttcctt ttgtacattg aggcaaattc tgttagcaac agcaaggggc cgaaagcaca
     1441 gactgcagaa gatggttgca agcatgggac actgatggag ttctccctta aagacctcta
     1501 tgccatccga gagatccagg ctgaagagaa cctgctcaag ctcgttgtca actcactctg
     1561 tcctgtcatt tttggtcatg aactcgtcaa agcaggtctg acgttagcac tctttggcgg
     1621 tagccagaag tacgcagatg acaaaaacag aattcccatt cgaggagacc cacatgtcct
     1681 gattgttgga gatccaggct tggggaagag tcagatgcta caggcagcat gcaacgtggc
     1741 gccacgtggt gtgtatgttt gtggaaatac caccaccagc tctggtctca ctgtgactct
     1801 ttcaaaggac agttcctctg gagattttgc tttggaagct ggtgcccttg tacttggtga
     1861 ccaaggcatc tgtggaatag atgaatttga taaaatgggg aaccaacatc aagccctgtt
     1921 agaagccatg gaacagcaga gtattagcct tgcgaaggct ggggtagttt gcagcctccc
     1981 tgcaagaact tccattattg ctgctgcaaa tccagtcgga ggacactaca ataaagccag
     2041 aacggtttct gagaatttaa agatggggag tgccctactg tccagattcg atttggtctt
     2101 tatcttgtta gatacgccaa atgaacagca tgaccactta ctttctgaac atgtgatcgc
     2161 gataagagct gggaagcaga aagcggttag cagtgccaca gtcactcgtg tgctcagtca
     2221 agactcaaat acttctgtac ttgaagtggt ttctgagaaa ccattatcag aaagactaaa
     2281 ggtggctcct ggagaacaga cagatccgat tccacatcag ctgttgagga agtacattgg
     2341 ctatgcacgg cagtatgtcc acccaaggtt atctacggac gctgctcagg cccttcagga
     2401 tttctacctg gagctccgca agcagagcca gcgcgtgggc agctcaccca tcaccactcg
     2461 gcagctggag tctttgatcc gtctgacaga ggcacgggca aggttagaat tgagagagga
     2521 agcaactaga gaagatgctg aagatataat tgaaattatg aagcatagca tgctaggaac
     2581 ttactcagat gaattcggaa acctggactt tgagcgatcc cagcatggct ctgggatgag
     2641 caacaggtca acagcaaaaa gatttatttc tgctctcaac agcattgctg aaagaactta
     2701 taacaacata tttcaatatc atcaacttcg tcagattgct aaagaactaa acattcaggt
     2761 tgccgatttt gaaaacttca ttggatcact gaatgaccaa ggttatctct tgaagaaagg
     2821 cccaaagatt taccaacttc aaactatgtg aaagacttta ccacatcagg gcttcctgtg
     2881 gttcaaaata gttcagaatc atcgtaatta caaaactgaa aataaaagtt ctgaaaaatg
     2941 acacaactcc tataacagaa taaaggccta tccataattt atccagaaga gtaagaagag
     3001 taaattgttt ccattatttt atctaaatag cataagcata tgcttttaac tcatcatatt
     3061 tttagtagtg ctttttagtt ttgtatatca gatgtctagc aggcattcag ctaatgcaaa
     3121 aacagattag tatgtgttca ggtgaacttt tacttaaaac attaaacttt ggctctccta
     3181 aattgttcag gtcacaaaaa ctcttcattc atttttaact ttatgattat gggcagtggg
     3241 tctgacttgg cttctcattt gaaagtagtg gaaatttatt gacttaatta gaagtctttt
     3301 ctggggctag agagatgact cagtggttaa gagcactgac tgctcttcca taggtcctga
     3361 gttcaagtcc cagcaaccac atggtgactc acaaccatct gtaatgggat ccaatgccct
     3421 cttctcgtgt ctctgaagag agtaacagtg cactcacata aataaatctt aaaaaaaaaa
     3481 a
//
