LOCUS       NM_008568               2423 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus minichromosome maintenance complex component 7 (Mcm7),
            transcript variant 1, mRNA.
ACCESSION   NM_008568
VERSION     NM_008568.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2423)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   2  (bases 1 to 2423)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2423)
  AUTHORS   Carper,M.B., Troutman,S., Wagner,B.L., Byrd,K.M., Selitsky,S.R.,
            Parag-Sharma,K., Henry,E.C., Li,W., Parker,J.S., Montgomery,S.A.,
            Cleveland,J.L., Williams,S.E., Kissil,J.L., Hayes,D.N. and
            Amelio,A.L.
  TITLE     An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous
            Cell Carcinoma
  JOURNAL   Cell Rep 29 (6), 1660-1674 (2019)
   PUBMED   31693903
REFERENCE   4  (bases 1 to 2423)
  AUTHORS   McNairn,A.J., Chuang,C.H., Bloom,J.C., Wallace,M.D. and
            Schimenti,J.C.
  TITLE     Female-biased embryonic death from inflammation induced by genomic
            instability
  JOURNAL   Nature 567 (7746), 105-108 (2019)
   PUBMED   30787433
REFERENCE   5  (bases 1 to 2423)
  AUTHORS   Leturcq,M., Mortuaire,M., Hardiville,S., Schulz,C., Lefebvre,T. and
            Vercoutter-Edouart,A.S.
  TITLE     O-GlcNAc transferase associates with the MCM2-7 complex and its
            silencing destabilizes MCM-MCM interactions
  JOURNAL   Cell Mol Life Sci 75 (23), 4321-4339 (2018)
   PUBMED   30069701
REFERENCE   6  (bases 1 to 2423)
  AUTHORS   You,Z., Ishimi,Y., Masai,H. and Hanaoka,F.
  TITLE     Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the
            mouse Mcm4/6/7 complex
  JOURNAL   J Biol Chem 277 (45), 42471-42479 (2002)
   PUBMED   12207017
  REMARK    GeneRIF: role of subunits in DNA helicases activity
REFERENCE   7  (bases 1 to 2423)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   8  (bases 1 to 2423)
  AUTHORS   You,Z., Komamura,Y. and Ishimi,Y.
  TITLE     Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase
            activity
  JOURNAL   Mol Cell Biol 19 (12), 8003-8015 (1999)
   PUBMED   10567526
REFERENCE   9  (bases 1 to 2423)
  AUTHORS   Furumura,M., Sakai,C., Potterf,S.B., Vieira,W.D., Barsh,G.S. and
            Hearing,V.J.
  TITLE     Characterization of genes modulated during pheomelanogenesis using
            differential display
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7374-7378 (1998)
   PUBMED   9636156
REFERENCE   10 (bases 1 to 2423)
  AUTHORS   Takizawa,N., Kimura,H. and Sugimoto,K.
  TITLE     Sequence of mouse CDC47, a member of the minichromosome maintenance
            (Mcm) family involved in the DNA replication licensing system
  JOURNAL   Gene 167 (1-2), 343-344 (1995)
   PUBMED   8566808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151719.3 and AK133091.1.
            
            On Oct 11, 2017 this sequence version replaced NM_008568.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065164.1, AK133091.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC151719.3         202031-202055       c
            26-2404             AK133091.1         1-2379
            2405-2423           AC151719.3         194755-194773       c
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.97 cM"
     gene            1..2423
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /note="minichromosome maintenance complex component 7"
                     /db_xref="GeneID:17220"
                     /db_xref="MGI:MGI:1298398"
     exon            1..158
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2287
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /EC_number="3.6.4.12"
                     /note="isoform a is encoded by transcript variant 1; DNA
                     replication licensing factor MCM7; CDC47 homolog; mini
                     chromosome maintenance deficient 7; minichromosome
                     maintenance deficient 7"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM7 isoform a"
                     /protein_id="NP_032594.1"
                     /db_xref="CCDS:CCDS19793.1"
                     /db_xref="GeneID:17220"
                     /db_xref="MGI:MGI:1298398"
                     /translation="MALKDYAIEKEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHRE
                     QVALYVDLDDIAEDDPELVDSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVY
                     IEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREVRADSVGKL
                     LTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGG
                     RLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGI
                     FLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSEELKQIAEEDFYE
                     KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLS
                     YIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKM
                     AEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLP
                     AALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMC
                     HERQPTVPESLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDI
                     VEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATIRELVSRGRSVHFSEAEQ
                     RCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV"
     exon            159..238
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            239..403
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            404..528
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            529..709
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            710..847
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            848..997
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1112
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1244
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1328
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1722
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1806
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1975
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2085
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2423
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /note="hexamer: AATAAA"
     polyA_site      2406
                     /gene="Mcm7"
                     /gene_synonym="mCDC47; Mcmd7"
                     /note="major polyA site"
ORIGIN      
        1 cacatgggtg acgacgtttc gcgccaattt cggttggccg gctacgtccc gccgcgcgtt
       61 cgttttctgc ttccccagag agagattttt gagcccttca agtcctgcca caccgtcccc
      121 ggcagcgatg gcgcttaagg actacgcgat cgaaaaagaa aaagttaaga agttcctcca
      181 agagttttat tacgagaatg agcttggaaa gaagcagttc aagtatggga cccagttggt
      241 tcatctggct catcgggaac aagtggcact gtatgtggac ctggatgaca tagctgaaga
      301 tgaccctgag ttggtcgact caatttgcga gaatgccaag cgctactcaa gactgtttgg
      361 tgatgttgtg caagagcttt tgcctgagta caaggagaag gaggtggtga ataaggatgt
      421 cttagatgtt tacattgaac accggctgat gatggagcag cgaagcagag accctggggc
      481 agtccggaac ccccaaaacc agtatccttc tgaactcatg cgaagatttg agttgtattt
      541 ccgaggccca agtagcagca agcctcgagt gatccgggaa gtacgagctg actctgtggg
      601 gaaattgtta actgtgcgtg gcattgtcac tcgtgtgtct gaagtcaagc ccaggatggt
      661 ggtggccaca tacacttgtg atcagtgtgg ggcagagacc taccagccaa tccagtctcc
      721 cactttcatg cctctgatca tgtgccccag ccaggagtgc cagaccaatc gctcaggggg
      781 gcggctgtac ctacagactc gtggctccaa atttgttaaa ttccaggaaa tgaagattca
      841 agagcatagt gaccaagttc ctgtgggaaa catccctcgt agcatcacag tggttctaga
      901 aggtgagaac acaagaattg cccagcctgg tgaccatgtc agcgtcactg gcatcttctt
      961 gccagtcctg cgcacagggt tccaacagat ggcacagggc ttactctcag aaacttacct
     1021 ggaagcccac tggattgtga agatgacaaa gagtgacgat gatgtctctg gggccggaga
     1081 gctgagctca gaggagctga agcagattgc agaggaggat ttctatgaga agctggccgc
     1141 ttctattgct ccggagatct atggacatga agatgtgaag aaggcgctgc tgctgcttct
     1201 ggtgggtggt gtggaccagt ctcctcaagg catgaagatc agaggaaaca tccacatctg
     1261 ccttatggga gaccctggtg tggccaaatc tcagctccta tcttacatcg accgtctggc
     1321 accgcgaagt cagtacacaa caggccgtgg ctcctctggt gtagggctca cagcagctgt
     1381 gttgagagac tctgtgagtg gagaactgac tttagagggc ggtgccctgg tgctggctga
     1441 ccagggcgtg tgctgcattg atgagtttga caagatggcc gaggctgacc gcacagccat
     1501 ccatgaggtt atggagcagc agaccatctc catcgccaag gcggggattc tcaccacgct
     1561 caatgcccga tgctccatcc tggctgcggc caatcctgcc tacggccgat ataatccccg
     1621 ccgcagtctg gagcagaacg tccagcttcc ggctgctctg ctttctcgat tcgacctcct
     1681 ctggctgatt caagaccggc ccgacagaga caatgacctc cggttggccc agcacatcac
     1741 ctatgtccac cagcacagcc ggcagccccc tgcccaattt gaacctttgg acatgaaact
     1801 tatgagacgg tacatagcca tgtgccacga gagacagccc acagtgcctg aatctctggc
     1861 tgactacatc accgcagcat atgtggagat gaggcgagag gcccgggcca gtaaggatgc
     1921 cacctatact tctgcccgga ccctgctggc cattctccga ctttccactg ctctggctcg
     1981 acttcggatg gtagacattg tggagaagga agatgtaaat gaagccataa ggttgatgga
     2041 gatgtcgaag gactcccttc taggtgaaaa gggacagaca gctaggaccc agaggccagc
     2101 agatgtgata tttgccacca tccgtgaatt ggtgtcacgg gggcggagtg tccacttttc
     2161 tgaggctgaa cagcgctgca tatctcgtgg cttcacacca gcccagttcc aggcagctct
     2221 ggatgaatat gaggagctaa atgtctggca ggttaatact tctcggacac ggatcacctt
     2281 tgtctgatag ccagttttta caccctcctg cctacaccag agggcatgct gaatgccccc
     2341 tcaagaaaaa atctcattct cccatgctgc acttttttat tctgccaata aagtgttttg
     2401 attgcctctt gcttgttaat aac
//
