LOCUS       NM_008567               2966 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus minichromosome maintenance complex component 6 (Mcm6),
            transcript variant 1, mRNA.
ACCESSION   NM_008567
VERSION     NM_008567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2966)
  AUTHORS   Luo,Y., Yang,Y., Yang,C., Li,C., Hu,R., Geng,W., Kang,X. and Lin,H.
  TITLE     UBE3A and MCM6 synergistically regulate the proliferation and
            migration of lung adenocarcinoma cells
  JOURNAL   FEBS Open Bio 13 (9), 1756-1771 (2023)
   PUBMED   37454373
  REMARK    GeneRIF: UBE3A and MCM6 synergistically regulate the proliferation
            and migration of lung adenocarcinoma cells.
REFERENCE   2  (bases 1 to 2966)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2966)
  AUTHORS   McNairn,A.J., Chuang,C.H., Bloom,J.C., Wallace,M.D. and
            Schimenti,J.C.
  TITLE     Female-biased embryonic death from inflammation induced by genomic
            instability
  JOURNAL   Nature 567 (7746), 105-108 (2019)
   PUBMED   30787433
REFERENCE   4  (bases 1 to 2966)
  AUTHORS   Leturcq,M., Mortuaire,M., Hardiville,S., Schulz,C., Lefebvre,T. and
            Vercoutter-Edouart,A.S.
  TITLE     O-GlcNAc transferase associates with the MCM2-7 complex and its
            silencing destabilizes MCM-MCM interactions
  JOURNAL   Cell Mol Life Sci 75 (23), 4321-4339 (2018)
   PUBMED   30069701
REFERENCE   5  (bases 1 to 2966)
  AUTHORS   Poche,R.A., Zhang,M., Rueda,E.M., Tong,X., McElwee,M.L., Wong,L.,
            Hsu,C.W., Dejosez,M., Burns,A.R., Fox,D.A., Martin,J.F., Zwaka,T.P.
            and Dickinson,M.E.
  TITLE     RONIN Is an Essential Transcriptional Regulator of Genes Required
            for Mitochondrial Function in the Developing Retina
  JOURNAL   Cell Rep 14 (7), 1684-1697 (2016)
   PUBMED   26876175
REFERENCE   6  (bases 1 to 2966)
  AUTHORS   You,Z., Ishimi,Y., Masai,H. and Hanaoka,F.
  TITLE     Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the
            mouse Mcm4/6/7 complex
  JOURNAL   J Biol Chem 277 (45), 42471-42479 (2002)
   PUBMED   12207017
  REMARK    GeneRIF: role of subunits in dna helicase activity
REFERENCE   7  (bases 1 to 2966)
  AUTHORS   Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
REFERENCE   8  (bases 1 to 2966)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 2966)
  AUTHORS   You,Z., Komamura,Y. and Ishimi,Y.
  TITLE     Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase
            activity
  JOURNAL   Mol Cell Biol 19 (12), 8003-8015 (1999)
   PUBMED   10567526
REFERENCE   10 (bases 1 to 2966)
  AUTHORS   Kimura,H., Ohtomo,T., Yamaguchi,M., Ishii,A. and Sugimoto,K.
  TITLE     Mouse MCM proteins: complex formation and transportation to the
            nucleus
  JOURNAL   Genes Cells 1 (11), 977-993 (1996)
   PUBMED   9077461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY073760.1, AK146770.1 and BE447550.1.
            
            On Aug 27, 2015 this sequence version replaced NM_008567.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86726.1, BC057584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BY073760.1         1-57
            58-1040             AK146770.1         1-983
            1041-2950           AK146770.1         985-2894
            2951-2966           BE447550.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..2966
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /note="minichromosome maintenance complex component 6"
                     /db_xref="GeneID:17219"
                     /db_xref="MGI:MGI:1298227"
     exon            1..247
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2606
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     replication licensing factor MCM6; mini chromosome
                     maintenance deficient 6; minichromosome maintenance
                     deficient 6 (MIS5 homolog, S. pombe)"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM6 isoform 1"
                     /protein_id="NP_032593.1"
                     /db_xref="CCDS:CCDS15252.1"
                     /db_xref="GeneID:17219"
                     /db_xref="MGI:MGI:1298227"
                     /translation="MDLAAAAEPGAGSQHPEVRDEVAEKCQKLFLDFLEEFQGSDGEI
                     KYLQFAEELIRPERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK
                     EIPFAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLD
                     CQTVIKDVEQQFKYTQPNICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQAELPRG
                     SIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGY
                     ETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDEEQTAESIKNQMTVKEW
                     EKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINV
                     CIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALM
                     LADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG
                     HYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRV
                     YSLDDIRRYLLFARQFKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESM
                     IRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMETDEGQGG
                     VNGHADSPAPVNRFNGSSEDASQETVSKPSLRLGFAEYCRISNLIVLHLRKMEEEEDE
                     SALKRSELVNWYLKEIESEIDSEEELINKKTIIEKVVHRLTHYDHVLIELTQAGLKGS
                     SEGSESYEEDPYLVVNPNYLLED"
     exon            248..394
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            395..505
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            506..755
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            756..921
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1067
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1218
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1360
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1502
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1610
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1766
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1895
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2057
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2193
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2349
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2489
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2966
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2930..2935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /note="hexamer: AATAAA"
     polyA_site      2951
                     /gene="Mcm6"
                     /gene_synonym="ASP-l1; D1Wsu22e; Mcmd6"
                     /note="major polyA site"
ORIGIN      
        1 gagggcgggg ctagccggag gcgcgcgcga agtggcagcg cggaaggagc tacgcgtgga
       61 acctgcggcc gggctatctg cagctgcgga ctctcctccg cggtggtctt ccctcagcag
      121 cgcgtactct cggcgccgcc atggacctcg cagcggccgc ggagcccggc gccggaagcc
      181 agcacccgga ggtgcgcgac gaggtggccg agaaatgcca gaagctgttc ctagacttcc
      241 tggaagagtt ccagggtagt gatggagaaa ttaaatactt gcagtttgca gaggagctaa
      301 ttcgtcctga gagaaacacg ctggttgtga gttttgcaga cctggaacaa tttaaccaac
      361 aactttctac caccattcag gaagagttct atagagtcta cccttacctg tgtcgagcct
      421 tgaagacctt tgtcaaagac cgaaaggaga tcccttttgc taaggatttt tatgttgcat
      481 tccaagacct acctactaga cacaagattc gtgagctcac ttcatccagg attgggctgc
      541 tcacccgaat cagtggccag gtggtgcgca ctcacccagt tcaccctgag cttgtgagtg
      601 gaactttcct gtgccttgac tgtcaaacag tgattaagga cgtagagcag cagttcaaat
      661 acacacagcc gaatatctgc cgaaatccag tgtgtgccaa caggaagagg ttccttctag
      721 acactaataa atcaagattt gttgattttc aaaaggttcg cattcaagag actcaagcgg
      781 aacttccccg gggaagtatt ccccggagtt tagaggttat cctgagagct gaagctgtgg
      841 agtcagccca agctggtgac agatgtgatt tcacaggggc actgattgtt gtgcctgatg
      901 tctccaagct tagcacacca ggagcacgtg cagagactaa ctcccgagtc agtggagctg
      961 atgggtatga gacagaaggc attcgagggc tccgggccct tggtgtcaga gatctgtcat
     1021 acaggctggt cttccttgcc tgccatgttg caccaaccaa cccaaggttt ggagggaaag
     1081 aactcagaga tgaggaacag accgctgaga gcattaagaa ccaaatgacg gtgaaggaat
     1141 gggaaaaggt gtttgaaatg agtcaggaca aaaacctgta ccacaatctc tgcacgagcc
     1201 tcttccctac tatacatggc aatgatgaag taaaacgcgg tgtcttactg atgttgttcg
     1261 gtggtgttcc taagacaaca ggggaaggaa cctctcttcg tggggatata aatgtttgca
     1321 ttgttggtga tccaagtaca gctaagagcc aatttctcaa gcacgtggac gagttcagtc
     1381 ccagagctgt ctataccagt ggcaaagcct ccagcgctgc cggcttaaca gcagctgtgg
     1441 tgagagatga agaatctcac gaatttgtca ttgaggctgg agcgttgatg ctggctgata
     1501 atggtgtctg ttgtattgat gaatttgata agatggacat gcgggaccaa gttgctattc
     1561 acgaagctat ggagcagcag accatctcta tcacgaaagc aggagtgaag gcaactctga
     1621 atgccaggac atccatttta gctgcagcaa accctgtcag cggacactat gacagatcaa
     1681 aatctttgaa acagaacatc aatctgtcag cgcccatcat gtcccgcttt gatctcttct
     1741 tcattctggt ggatgaatgc aatgaggtga cagattatgc tattgccagg cgcatagtag
     1801 acttgcattc aagaattgaa gaatcgatcg atcgagttta ttcccttgat gatataagaa
     1861 ggtaccttct ctttgcccga cagtttaaac ccaagatttc caaagagtca gaagacttca
     1921 ttgtggagca gtacaaacgt ctccgccaga gggatggctc tggggtcacc aagtcctcgt
     1981 ggagaatcac cgtgcgacag cttgagagca tgatccgact ctcagaatca atggcccgca
     2041 tgcactgctg tgacgaggtt cagcctaaac atgtgaagga agcttttcga ttactgaata
     2101 aatcaatcat ccgtgtagag acgcctgatg tcaatctaga tcaagaggaa gagatccaga
     2161 tggagacgga tgagggacaa ggaggcgtca atggtcatgc cgacagccct gcccctgtga
     2221 ataggttcaa cggctccagt gaagatgcca gccaggagac tgtttccaag ccctccctga
     2281 ggctgggctt tgctgaatac tgccgaatct cgaacctcat cgtgctccac ctcaggaaaa
     2341 tggaagaaga ggaggacgag tcggcactaa agagaagcga gcttgtcaac tggtacctga
     2401 aggaaatcga atcagagata gactctgaag aagagctcat aaataaaaag acgatcattg
     2461 agaaggttgt tcatcgtctc acacactacg atcacgttct gattgagctc acccaggctg
     2521 ggctgaaagg ctccagtgaa ggaagcgaga gctatgagga agacccctac ctggtagtca
     2581 accctaacta cttgcttgaa gattgaggta ttgaaggtaa cttgatggcc agggacctgt
     2641 gctgtcctac ccttagcccg gaccctgcac ggcactgaga gacagtgtct ggagcaatgc
     2701 ttgaggagga tttcagaagt gatggctgag ttcatggctc tgtgaatttc atactgggac
     2761 aggcttgggc actctgtcaa taggcttctt gtactattga agttggaacc aaatcatgtt
     2821 gtttctataa gacatttctt catgtatagg aaaagcctgc tgcatttgtc atacatgtgt
     2881 ctgtggaaat tgctttcttc tgttcccagc cactgctttt acccatgaaa ataaaacaac
     2941 ttgttctgtg attgtctgtt ggattc
//
