LOCUS       NM_008566               3441 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus minichromosome maintenance complex component 5 (Mcm5),
            transcript variant 1, mRNA.
ACCESSION   NM_008566
VERSION     NM_008566.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3441)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3441)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3441)
  AUTHORS   McNairn,A.J., Chuang,C.H., Bloom,J.C., Wallace,M.D. and
            Schimenti,J.C.
  TITLE     Female-biased embryonic death from inflammation induced by genomic
            instability
  JOURNAL   Nature 567 (7746), 105-108 (2019)
   PUBMED   30787433
REFERENCE   4  (bases 1 to 3441)
  AUTHORS   Leturcq,M., Mortuaire,M., Hardiville,S., Schulz,C., Lefebvre,T. and
            Vercoutter-Edouart,A.S.
  TITLE     O-GlcNAc transferase associates with the MCM2-7 complex and its
            silencing destabilizes MCM-MCM interactions
  JOURNAL   Cell Mol Life Sci 75 (23), 4321-4339 (2018)
   PUBMED   30069701
REFERENCE   5  (bases 1 to 3441)
  AUTHORS   Kuipers,M.A., Stasevich,T.J., Sasaki,T., Wilson,K.A.,
            Hazelwood,K.L., McNally,J.G., Davidson,M.W. and Gilbert,D.M.
  TITLE     Highly stable loading of Mcm proteins onto chromatin in living
            cells requires replication to unload
  JOURNAL   J Cell Biol 192 (1), 29-41 (2011)
   PUBMED   21220507
REFERENCE   6  (bases 1 to 3441)
  AUTHORS   Fletcher,R.J., Bishop,B.E., Leon,R.P., Sclafani,R.A., Ogata,C.M.
            and Chen,X.S.
  TITLE     The structure and function of MCM from archaeal M.
            Thermoautotrophicum
  JOURNAL   Nat Struct Biol 10 (3), 160-167 (2003)
   PUBMED   12548282
REFERENCE   7  (bases 1 to 3441)
  AUTHORS   Pfisterer,P., Ehlermann,J., Hegen,M. and Schorle,H.
  TITLE     A subtractive gene expression screen suggests a role of
            transcription factor AP-2 alpha in control of proliferation and
            differentiation
  JOURNAL   J Biol Chem 277 (8), 6637-6644 (2002)
   PUBMED   11741941
REFERENCE   8  (bases 1 to 3441)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   9  (bases 1 to 3441)
  AUTHORS   Hill,A.L., Phelan,S.A. and Loeken,M.R.
  TITLE     Reduced expression of pax-3 is associated with overexpression of
            cdc46 in the mouse embryo
  JOURNAL   Dev Genes Evol 208 (3), 128-134 (1998)
   PUBMED   9601985
REFERENCE   10 (bases 1 to 3441)
  AUTHORS   Kimura,H., Takizawa,N., Nozaki,N. and Sugimoto,K.
  TITLE     Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs
            and characterization of the products: physical interaction between
            P1(MCM3) and CDC46 proteins
  JOURNAL   Nucleic Acids Res 23 (12), 2097-2104 (1995)
   PUBMED   7610039
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084823.11, CJ075220.1 and
            AK033196.1.
            
            On Oct 28, 2014 this sequence version replaced NM_008566.2.
            
            Summary: The protein encoded by this gene is a member of the
            oligameric minichromosome maintenance protein complex. During DNA
            replication, the complex loads onto chromatin in early G1 and is
            converted into an active replicative helicase during S phase. It
            functions to limit DNA synthesis to once per cell cycle. During
            embryogenesis, the encoded protein is negatively regulated through
            expression of paired box protein Pax 3. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033196.1, BC094416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC084823.11        120387-120401
            16-60               CJ075220.1         6-50
            61-349              AK033196.1         1-289
            350-350             AC084823.11        121029-121029
            351-3107            AK033196.1         291-3047
            3108-3441           AC084823.11        138984-139317
FEATURES             Location/Qualifiers
     source          1..3441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.59 cM"
     gene            1..3441
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /note="minichromosome maintenance complex component 5"
                     /db_xref="GeneID:17218"
                     /db_xref="MGI:MGI:103197"
     exon            1..113
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            114..288
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            289..415
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            416..544
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            545..717
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            718..873
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1040
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1212
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1324
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1468
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1534
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1711
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1824
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1953
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2096
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2224
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..3441
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2646..2651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /note="major polyA site"
     regulatory      2710..2715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
                     /note="hexamer: AATACA"
     polyA_site      2716
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
     polyA_site      2756
                     /gene="Mcm5"
                     /gene_synonym="Cdc46; Mcmd5; P1-CDC46"
ORIGIN      
        1 aacgaaccaa taggagcgca gagaccgcgg tggacaaacg cggaggctgg tttttcccgc
       61 gaaagtcggc ttcctctagg agggctgagg ttcgtgtggc gcgccgctgt gaggtacagt
      121 catgtcgggc ttcgacgacc cgggcatttt ctacagcgac agcttcggtg gcgaccccgg
      181 tgcggaagag ggccaggccc gcaagtcgca actgcagagg cgattcaagg agttcctgag
      241 acagtaccga gtgggcaccg atcgcacggg cttcaccttc aagtacagag atgaactcaa
      301 gcggcattac aacctgggtg aatactggat cgaggtggag atggaggacc tggccagttt
      361 tgacgaggaa ctggctgacc acttgcataa acagccggcc gagcacttac agctgcttga
      421 ggaagctgcc aaggaggtgg cagatgaggt gacccggccc cggccagctg gagatgagct
      481 gctccaagac atccaggtca tgctcaagtc agatgccagc ccgtcgagca ttcggattct
      541 gaagtcagac atgatgtcac acctggtgaa gatccctggc atcatcattt cagcctctgc
      601 agtccgtgcc aaggctactc gtatctccat tcagtgccgc agctgccaca ataccctcac
      661 caatatcgcc atgcgcccag gcctagaggg ctatgccctt cccaggaagt gcaatatgga
      721 tcaggctggg cgcccaaagt gcccactgga tccatacttc atcatgcctg acaagtgcaa
      781 gtgtgtggac ttccagactc tgaaactgca ggagctgcct gatgcagtcc ctcatggtga
      841 gatgcccagg cacatgcagc tttattgtga caggtacctg tgtgacaagg ttgttcctgg
      901 gaacagggtc accatcatgg gcatttattc catcaagaag tttggcttga accccagcaa
      961 gggccgggac agggtaggtg tgggcatccg gagctcgtac atccgagtgc tgggcatcca
     1021 ggtggacaca gatggctctg gccgaagctt tgctgggtct gtcagcccac aggaagagga
     1081 ggaatttcgt cgcctggctg ccctccccaa catatatgag ctcatctcca agagcatttc
     1141 cccctccatc tttgggggca tggatatgaa gaaggccatt gcctgcctgc tttttggggg
     1201 ttcccggaag aggctcccag atggactcac tcgccgaggt gatatcaact tgctgatgtt
     1261 gggagaccct ggtacagcca agtctcagct tctgaagttt gtggagaagt gctctcccat
     1321 tggggtgtac acatctggga aaggtagcag tgctgctggc ttgactgcct cagtgatacg
     1381 ggacccctca tctcgaaact tcatcatgga aggtggagcc atggttctgg ccgatggtgg
     1441 ggttgtctgt attgatgagt ttgacaagat gcgggaagat gaccgtgttg caatccatga
     1501 ggctatggag cagcagacca tctccattgc taaagctggg atcactacca ccttgaactc
     1561 tcgctgctct gttctggctg cagccaactc agtgtttggc cgatgggatg agacaaaagg
     1621 ggaggacaat attgacttca tgcctaccat cttgtcccga tttgatatga tcttcatcgt
     1681 caaagatgag cacaatgagg agagggacat gatgctagcc aaacatgtga tgactctgca
     1741 tgtgagtgca ctgacacaga cacaggctgt ggagggtgag atcgacctgg ccaagatgaa
     1801 gaagttcatt gcctactgcc gagcgaggtg tggacctcgg ctatcagcag aggcagcaga
     1861 gaagctgaaa aaccgctaca tcatcatgcg gagtggggct cgtcagcatg agagggacag
     1921 tgaccggcgt tccagcatcc ccatcactgt gcggcagctg gaggctattg tgcgcattgc
     1981 tgaggccctc agtaagatga aactgcagcc ctttgccact gaggctgatg tagaggaggc
     2041 attgagactg ttccaggtgt ccacactgga tgctgctttg tctggcaatc tgtcgggggt
     2101 ggagggcttc actacccagg aggaccagga gatgctgagc cgcattgaga agcaactcaa
     2161 gcgccgtttt gccattggct ctcaggtgtc tgaacacagc attgtccagg acttcaccaa
     2221 acagaaatat ccagagcacg ctatccgaaa ggtgctgcag ctcatgctac gcaggggtga
     2281 gatccaacac cgtatgcagc gcaaggtgct ctatcgcctc aagtgagccc attgcccatc
     2341 aaccctcaag cctgaaatgc tgccaccacc ctatctccca gtcagtgctc caaacctcct
     2401 tttgccctgc ctctccacct cagactgcag tctgcagcac atctgcagcc cctggaaatg
     2461 tactttggtc tgttggcctc atactgtgtt tgagtgtctg aggactctct gctctgggtg
     2521 tctatcccct gtcatgcctt ctcaacaaga tgagtctgga gcaggaacag gccctggaat
     2581 gtagatgggt ctgtatattg gctcccgggc cactcactgc caagcttctt tgtatgtaca
     2641 gaggtaataa agcaattgag tccctggctg ctaaggtcag tggacccagt atgatagtag
     2701 tgctgtgtga atacaaggtt gactctttca gctttcttca gcagcaccta atgtgagaac
     2761 tggatcattc attgagttgt ctgcctcagt ttcctaatct gcaaacaaat ttgatgaagc
     2821 tgagctcagt gagtgagtgg ctgtcagtga aaacccaagt agactccaat gtagaatgtc
     2881 tccagggctt tatttatagc aagtgggcct cagtggtgtc tggggaagga accagacgtc
     2941 agggtttatc agttaaggag ctatgagtac ctgagcaagc ttcagcacag taggaggtat
     3001 tagtgacaac attgttaaaa gaagacaccc aacacctcgt attaccaaaa tgccgaaaat
     3061 tatgatttta gaaatctata atttataaaa ttaaggaaaa gtcagtgaaa tatttaagta
     3121 tttgttatgt aaagtacatt tataaatggg aagctagtgc tgaaaacact gcagtcacca
     3181 acagtaaagt tactgtagga ggaaggcttg agagaacagg aagtacatac acaggccttt
     3241 ctcgtagatg gcgtcctgtg ctgaaatggc tgttgcttga ggtgtttgct tttttttttt
     3301 ttttttttta gttttttgag acagggtttc tctgtgtagc cctggctgcc tggaactcac
     3361 tttgtagacc aggctggcct cgaactcaga aatccgcctg cctctgcctt ctgagtactg
     3421 ggattaaaag tgtgggccac c
//
