LOCUS       NM_008563               3031 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus minichromosome maintenance complex component 3 (Mcm3),
            mRNA.
ACCESSION   NM_008563 XM_001005862
VERSION     NM_008563.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Schaefer,S., Doktor,T.K., Frederiksen,S.B., Chea,K., Hlavacova,M.,
            Bruun,G.H., Rabjerg,M., Andresen,B.S., Dominguez,I. and Guerra,B.
  TITLE     Down-regulation of CK2alpha correlates with decreased expression
            levels of DNA replication minichromosome maintenance protein
            complex (MCM) genes
  JOURNAL   Sci Rep 9 (1), 14581 (2019)
   PUBMED   31601942
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   McNairn,A.J., Chuang,C.H., Bloom,J.C., Wallace,M.D. and
            Schimenti,J.C.
  TITLE     Female-biased embryonic death from inflammation induced by genomic
            instability
  JOURNAL   Nature 567 (7746), 105-108 (2019)
   PUBMED   30787433
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Leturcq,M., Mortuaire,M., Hardiville,S., Schulz,C., Lefebvre,T. and
            Vercoutter-Edouart,A.S.
  TITLE     O-GlcNAc transferase associates with the MCM2-7 complex and its
            silencing destabilizes MCM-MCM interactions
  JOURNAL   Cell Mol Life Sci 75 (23), 4321-4339 (2018)
   PUBMED   30069701
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Tamberg,N., Tahk,S., Koit,S., Kristjuhan,K., Kasvandik,S.,
            Kristjuhan,A. and Ilves,I.
  TITLE     Keap1-MCM3 interaction is a potential coordinator of molecular
            machineries of antioxidant response and genomic DNA replication in
            metazoa
  JOURNAL   Sci Rep 8 (1), 12136 (2018)
   PUBMED   30108253
  REMARK    GeneRIF: Study characterize the interaction of Keap1, a central
            antioxidant response regulator in Metazoa, with the replicative
            helicase subunit protein MCM3. Analysis suggests that structural
            determinants of the interaction of Keap1 with its critical
            downstream target - Nrf2 master transactivator of oxidative stress
            response genes - may have evolved in evolution to mimic the
            conserved helix-2-insert motif of MCM3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3031)
  AUTHORS   Kimura,H., Takizawa,N., Nozaki,N. and Sugimoto,K.
  TITLE     Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs
            and characterization of the products: physical interaction between
            P1(MCM3) and CDC46 proteins
  JOURNAL   Nucleic Acids Res 23 (12), 2097-2104 (1995)
   PUBMED   7610039
REFERENCE   7  (bases 1 to 3031)
  AUTHORS   Starborg,M., Brundell,E., Gell,K., Larsson,C., White,I.,
            Daneholt,B. and Hoog,C.
  TITLE     A murine replication protein accumulates temporarily in the
            heterochromatic regions of nuclei prior to initiation of DNA
            replication
  JOURNAL   J Cell Sci 108 (Pt 3), 927-934 (1995)
   PUBMED   7622621
REFERENCE   8  (bases 1 to 3031)
  AUTHORS   Kimura,H., Nozaki,N. and Sugimoto,K.
  TITLE     DNA polymerase alpha associated protein P1, a murine homolog of
            yeast MCM3, changes its intranuclear distribution during the DNA
            synthetic period
  JOURNAL   EMBO J 13 (18), 4311-4320 (1994)
   PUBMED   7925275
REFERENCE   9  (bases 1 to 3031)
  AUTHORS   Hu,B., Burkhart,R., Schulte,D., Musahl,C. and Knippers,R.
  TITLE     The P1 family: a new class of nuclear mammalian proteins related to
            the yeast Mcm replication proteins
  JOURNAL   Nucleic Acids Res 21 (23), 5289-5293 (1993)
   PUBMED   8265339
REFERENCE   10 (bases 1 to 3031)
  AUTHORS   Thommes,P., Fett,R., Schray,B., Burkhart,R., Barnes,M., Kennedy,C.,
            Brown,N.C. and Knippers,R.
  TITLE     Properties of the nuclear P1 protein, a mammalian homologue of the
            yeast Mcm3 replication protein
  JOURNAL   Nucleic Acids Res 20 (5), 1069-1074 (1992)
   PUBMED   1549468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156980.9 and AC159614.7.
            
            On Feb 14, 2018 this sequence version replaced NM_008563.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145563.1, BC020400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC156980.9         178550-178731
            183-295             AC156980.9         180957-181069
            296-504             AC156980.9         181411-181619
            505-635             AC156980.9         182083-182213
            636-874             AC159614.7         156523-156761       c
            875-983             AC159614.7         156233-156341       c
            984-1137            AC159614.7         154795-154948       c
            1138-1269           AC159614.7         154398-154529       c
            1270-1478           AC159614.7         153799-154007       c
            1479-1653           AC159614.7         151892-152066       c
            1654-1780           AC159614.7         151430-151556       c
            1781-1931           AC159614.7         150555-150705       c
            1932-2072           AC159614.7         148576-148716       c
            2073-2176           AC159614.7         147631-147734       c
            2177-2253           AC159614.7         147097-147173       c
            2254-2344           AC159614.7         146651-146741       c
            2345-3031           AC159614.7         144802-145488       c
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.5 cM"
     gene            1..3031
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /note="minichromosome maintenance complex component 3"
                     /db_xref="GeneID:17215"
                     /db_xref="MGI:MGI:101845"
     exon            1..182
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2543
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /EC_number="3.6.4.12"
                     /note="DNA polymerase alpha holoenzyme-associated protein
                     P1; mini chromosome maintenance deficient; minichromosome
                     maintenance deficient 3"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM3"
                     /protein_id="NP_032589.1"
                     /db_xref="CCDS:CCDS14843.1"
                     /db_xref="GeneID:17215"
                     /db_xref="MGI:MGI:101845"
                     /translation="MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQ
                     YRLIVSVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGL
                     EGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYS
                     DLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVD
                     VILDDDLVDKVKPGDRIQVVGTYRCLPGKKGCYTSGTFRTVLIACNVKQMSKDIQPAF
                     SADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSH
                     IRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERR
                     LEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLA
                     AANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYR
                     APGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKKKEKMVSAA
                     FMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRL
                     ATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKASEDESDLEDEEEKSQ
                     EDTEQKRKRRKTHAKDGESYDPYDFSEAETQMPQVHTPKTDDSQEKTDDSQETQDSQK
                     VELSEPRLKAFKAALLEVFQEAHEQSVGMLHLTESINRNREEPFSSEEIQACLSRMQD
                     DNQVMVSEGIVFLI"
     exon            183..295
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            296..504
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            505..635
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            636..874
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            875..983
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1137
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1269
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1478
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1653
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1780
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1931
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2072
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2176
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2253
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2344
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..3031
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /note="hexamer: AATATA"
     polyA_site      2993
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /note="major polyA site"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
                     /note="hexamer: AATACA"
     polyA_site      3031
                     /gene="Mcm3"
                     /gene_synonym="Mcmd; P1; P1-MCM3; p1.m"
ORIGIN      
        1 tccaccataa acttccgtgg cgggaaaact tgggaagttt tggcgccaag gcggtgtcac
       61 gcgtttccgg actgtttggt ggccggcgat ttcggagctg cgacatggcg ggcacagtag
      121 tgctggatga tgtggagctg cgggaagcgc agagagacta cttggacttc ctggatgacg
      181 aggaggacca aggcatttac cagaacaagg ttcgggaact gatcagtgac aatcagtatc
      241 ggctgattgt cagcgtgaat gacctgcgca ggaagaatga aaagagggct aaccgcctcc
      301 tgaacaatgc gtttgaggag ctggttgcct tccagcgggc cttgaaggat ttcgtggcct
      361 ccattgacgc cacctacgcc aagcagtatg aggagttcta cataggattg gaaggcagct
      421 ttggctcaaa gcacgtctct ccccggactc tcacttcctg cttcctcagc tgtgtggtct
      481 gtgtggaagg cattgttact aaatgctctc tggttcgccc caaagtcgtt cgcagtgttc
      541 actactgtcc tgctactaag aagaccatag agcgacgcta ctctgacctc accaccctag
      601 tggctttccc atccagttct gtttatccca caaaggatga ggagaacaac cccctggaga
      661 cagagtatgg cctgtctgtc tacaaggacc atcagaccat caccatccag gagatgccag
      721 agaaggcccc tgctggtcag ctccctcgct ctgtggatgt cattctagac gatgacctgg
      781 tggataaagt gaagcctggt gacagaatac aggtggtggg gacctaccgc tgccttccag
      841 ggaagaaggg ctgctacacc tcggggacct tcaggaccgt cctgattgcc tgtaatgtga
      901 agcagatgag taaggatatt cagcctgcat tctctgcgga cgatatagcc aagatcaaga
      961 agttcagcaa aactcgttcc aaggatgtct ttgagcagct ggcccggtcg ttagccccga
     1021 gcatccatgg gcatgactat gtcaagaagg caatcctctg cttgctcctg ggaggggtgg
     1081 agcgggaact tgaaaacggc agccacatcc gtggagacat caatattctt ctaataggtg
     1141 acccctccgt tgccaagtcc cagcttctgc ggtacgtgct ttgcacggcg cccagggcca
     1201 ttcccaccac gggacggggc tcctctggag tgggtctcac agctgctgtc actacagacc
     1261 aggaaacagg ggagcgccgc ctggaagctg gtgctatggt cctggctgac cgtggagtgg
     1321 tttgcattga tgagtttgac aagatgtctg acatggaccg cacagccatc cacgaggtga
     1381 tggagcaggg tcgagtgacc attgcaaagg ctggcatcca tgcccggctc aatgcccgct
     1441 gcagtgtttt ggcagctgcc aatccagtct atggcaggta tgatcagtat aagacgccca
     1501 tggagaacat tgggctgcag gactcactgc tgtctagatt tgacctgctc ttcatcatgc
     1561 tggatcagat ggatcctgaa caggatcggg agatctcaga ccacgtcctg aggatgcacc
     1621 aatacagggc cccgggggag caggacggtg atgctttgcc attgggtagt tcagtggata
     1681 tcctggccac agacgatcct gactttaccc aggatgacca gcaagatacc cgcatttatg
     1741 agaagcatga cagccttcta catgggacca agaagaaaaa ggagaagatg gtgagcgcag
     1801 cttttatgaa gaagtacatt cacgtggcca aaattatcaa gcccaccctg acacaggagt
     1861 cagcagccta cattgcagaa gaatactcac gcctgcgcag ccaggacagt atgagctcag
     1921 acactgcccg gacatctcca gttacagcac ggacactgga aactctgatt cgactggcca
     1981 cggcccatgc gaaggcccgg atgagcaaga ctgtggacct gcaggatgca gaggaagccg
     2041 tggagctggt tcagtatgct tatttcaaga aggttctgga gaaggagaag aaacgtaaga
     2101 aggcaagtga ggatgaatca gacctagaag atgaagagga aaagagccag gaagacactg
     2161 agcagaagcg gaaaaggagg aagactcatg ccaaggatgg agagtcctat gacccttacg
     2221 acttcagtga agcagagacg cagatgcctc aagtgcacac cccaaagact gacgattccc
     2281 aagagaagac cgatgattct caggagaccc aggactccca gaaagtggaa ctcagtgagc
     2341 ccaggctgaa ggcttttaag gcggccctct tagaagtgtt ccaggaagct catgagcagt
     2401 ctgtgggcat gctccacctc acagaatcca tcaaccggaa tagagaagag ccgttctcct
     2461 cagaggaaat ccaggcttgc ctgagccgga tgcaggatga taaccaggtc atggtgtctg
     2521 agggcatcgt cttccttatc tgaagttgtt gctaccaagt actgccctgt ccccagcctt
     2581 tgtctcccat cctccagtaa cttttttaag ggatggaagc tgatggtgag acgatcagga
     2641 cttggtggaa gctttgtgta tgacttctgc cttggggcaa gagctggagg gagggccagg
     2701 actcaggcag aaggcctgcc tcacaagccc cagtcctaaa catggggagt cttcatgatt
     2761 tgagctgtgt ttctgggcac agctgtgtcc tgcgtttgtt acttgtgttt ttacccccac
     2821 ccccaggcac tttagtccag gaagctttga ggtctgttgg gccaagagtg gctcaggcag
     2881 atgacaaggt tggattggag aaagctttct ttgcaattag actagtatgt attgttgacc
     2941 taaatatcca agacattcat actgagtaaa tataactatt ttgtacatgt ggacttcatg
     3001 ctttgtgctt taaaaaaaat acatttattt a
//
