LOCUS       NM_008564               3381 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus minichromosome maintenance complex component 2 (Mcm2),
            mRNA.
ACCESSION   NM_008564
VERSION     NM_008564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3381)
  AUTHORS   Zhao,T., Hong,Y., Yan,B., Huang,S., Ming,G.L. and Song,H.
  TITLE     Epigenetic maintenance of adult neural stem cell quiescence in the
            mouse hippocampus via Setd1a
  JOURNAL   Nat Commun 15 (1), 5674 (2024)
   PUBMED   38971831
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3381)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3381)
  AUTHORS   Waldhauser,V., Baroti,T., Frob,F. and Wegner,M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3381)
  AUTHORS   Han,Z., Andrs,M., Madhavan,B.K., Kaymak,S., Sulaj,A., Kender,Z.,
            Kopf,S., Kihm,L., Pepperkok,R., Janscak,P., Nawroth,P. and Kumar,V.
  TITLE     The importance of nuclear RAGE-Mcm2 axis in diabetes or
            cancer-associated replication stress
  JOURNAL   Nucleic Acids Res 51 (5), 2298-2318 (2023)
   PUBMED   36807739
  REMARK    GeneRIF: The importance of nuclear RAGE-Mcm2 axis in diabetes or
            cancer-associated replication stress.
REFERENCE   5  (bases 1 to 3381)
  AUTHORS   Loan,A., Leung,J.W., Cook,D.P., Ko,C., Vanderhyden,B.C., Wang,J.
            and Chan,H.M.
  TITLE     Prenatal low-dose methylmercury exposure causes premature neuronal
            differentiation and autism-like behaviors in a rodent model
  JOURNAL   iScience 26 (3), 106093 (2023)
   PUBMED   36843845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3381)
  AUTHORS   Lepke,M., Putter,V., Staib,C., Kneissl,M., Berger,C., Hoehn,K.,
            Nanda,I., Schmid,M. and Grummt,F.
  TITLE     Identification, characterization and chromosomal localization of
            the cognate human and murine DBF4 genes
  JOURNAL   Mol Gen Genet 262 (2), 220-229 (1999)
   PUBMED   10517317
REFERENCE   7  (bases 1 to 3381)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   8  (bases 1 to 3381)
  AUTHORS   Spanjaard,R.A., Lee,P.J., Sarkar,S., Goedegebuure,P.S. and
            Eberlein,T.J.
  TITLE     Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important
            growth regulator of melanoma
  JOURNAL   Cancer Res 57 (22), 5122-5128 (1997)
   PUBMED   9371513
REFERENCE   9  (bases 1 to 3381)
  AUTHORS   Kimura,H., Ohtomo,T., Yamaguchi,M., Ishii,A. and Sugimoto,K.
  TITLE     Mouse MCM proteins: complex formation and transportation to the
            nucleus
  JOURNAL   Genes Cells 1 (11), 977-993 (1996)
   PUBMED   9077461
REFERENCE   10 (bases 1 to 3381)
  AUTHORS   Takizawa,N., Kimura,H. and Sugimoto,K.
  TITLE     Sequence of mouse CDC47, a member of the minichromosome maintenance
            (Mcm) family involved in the DNA replication licensing system
  JOURNAL   Gene 167 (1-2), 343-344 (1995)
   PUBMED   8566808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY324067.1, AK129039.1 and CK378639.1.
            
            On Apr 5, 2008 this sequence version replaced NM_008564.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055318.1, AK037751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               BY324067.1         1-119
            120-3359            AK129039.1         1-3240
            3360-3381           CK378639.1         444-465
FEATURES             Location/Qualifiers
     source          1..3381
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.64 cM"
     gene            1..3381
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /note="minichromosome maintenance complex component 2"
                     /db_xref="GeneID:17216"
                     /db_xref="MGI:MGI:105380"
     exon            1..136
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2845
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /EC_number="3.6.4.12"
                     /note="nuclear protein BM28; minichromosome maintenance
                     protein 2 homolog; mini chromosome maintenance deficient
                     2; minichromosome maintenance deficient 2 mitotin"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM2"
                     /protein_id="NP_032590.2"
                     /db_xref="CCDS:CCDS39554.1"
                     /db_xref="GeneID:17216"
                     /db_xref="MGI:MGI:105380"
                     /translation="MAESSESLSASSPARQRRRISDPLTSSPGRSSRRADALTSSPGR
                     DLPPFEDESEGLLGTEGPMEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDV
                     EELTASQREAAERTMRQRDREAGRGLGRMRRGLLYDSSEEDEERPARKRRHVERATED
                     GEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKER
                     ISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDR
                     ITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNF
                     VLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPR
                     SKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNK
                     VAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPG
                     GKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVS
                     REWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARC
                     TVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGS
                     HVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQ
                     DKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVM
                     MESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQD
                     TIEIPEKDLMDKARQINIHNLSAFYDSDLFKFNKFSRDLKRKLILQQF"
     exon            137..366
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            367..542
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            543..803
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1023
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1231
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1366
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1558
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1652
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1903
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2030
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2143
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2395
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2578
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2734
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..3371
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /note="hexamer: AATAAA"
     polyA_site      3371
                     /gene="Mcm2"
                     /gene_synonym="BM28; CDCL1; Mcmd2; mKIAA0030"
                     /note="major polyA site"
ORIGIN      
        1 ttccgctcta gattgacgag gacgtagtga cgtctgagtc ctcccggcgc ttcccgggca
       61 tgggcgggtc acgtggtcta gttttcgcgc gaaaaccggt ggcagctggt gcggtggagc
      121 tagcgcagac atggcggagt cttctgagtc tctctcagca tctagccctg cccgtcagcg
      181 gcgccggatc agtgatcccc tcacctccag cccaggccgc agctccagac gtgctgacgc
      241 cctgacctcc agccctggca gagacctccc cccatttgaa gatgagtctg aggggctgct
      301 gggcacagag gggcccatgg aggaagaaga ggatggagag gaactcattg gtgatggcat
      361 ggagagagac taccgtccca ttccggagct cgatgtctac gaggccgagg gattggccct
      421 ggatgatgaa gatgtggagg agctgacagc cagtcagaga gaggcagctg agcggaccat
      481 gaggcagcgg gaccgtgagg ctggcagagg cctgggacgc atgcgccggg ggctgctcta
      541 tgacagcagc gaggaagatg aggagcggcc tgcccgtaag cgccgccacg tagaacgcgc
      601 cacagaggat ggcgaggagg atgaagagat gatcgagagt attgagaatc tggaggacct
      661 caagggccac tcggtgcgcg agtgggtgag catggcaggg cccaggctgg agatccacca
      721 ccgcttcaag aacttcctgc gcacccacgt ggacagccat ggccacaacg tcttcaagga
      781 gcgcatcagt gatatgtgca aagagaaccg tgagagtttg gtggtaaatt atgaagacct
      841 ggcagcccgg gagcacgtgt tggcatactt cctgccggaa gcaccggctg agttgctgca
      901 gatctttgac gaggctgccc tggaggtcgt gttggccatg taccctaaat atgaccgtat
      961 caccaaccac atccatgtgc gcatctccca cctgcctctg gtggaggagc tgcgttcact
     1021 gaggcagttg cacctgaacc agctgatccg taccagtggc gtggtgacca gctgcaccgg
     1081 agtcctgccc cagctcagca tggtcaagta caactgtagc aagtgcaact ttgtactggg
     1141 gcctttctgc cagtctcaga atcaggaggt gaagcctggc tcctgccctg agtgccagtc
     1201 tgctgggccc tttgagatca acatggagga gaccatctat cagaactacc aacgtatccg
     1261 catccaggag agtcccggca aggtggcggc tggccgactg ccccgttcca aggatgccat
     1321 tctcctcgct gatctggtgg acagctgcaa gccaggggac gagatagagc tgaccggcat
     1381 ttaccataat aactatgacg gctcgcttaa caccgccaac ggctttccag tctttgccac
     1441 tattatcttg gccaaccatg ttgccaagaa ggacaacaaa gtagctgtgg gggagctcac
     1501 cgatgaggac gtgaagatga tcaccggtct ctccaaggat cagcaaattg gagagaagat
     1561 ctttgccagc attgcaccct ccatctatgg gcatgaagac atcaagagag gcctggctct
     1621 ggccctgttt ggaggggagc ccaagaaccc aggtggaaag cacaaggttc gaggtgacat
     1681 taatgtgctc ttgtgtgggg accctggcac agcaaagtcc caattcctca aatacatcga
     1741 gaaagtgtct agccgtgcca tcttcaccac tggccagggt gcgtcagcag tgggtctcac
     1801 cgcgtacgtt cagcggcatc ccgtcagcag agagtggacc ttagaggcgg gagccctggt
     1861 tctggctgac cggggggtgt gtctcattga cgagtttgac aagatgaatg accaggacag
     1921 gaccagcatc cacgaggcca tggaacagca aagcatctcc atctccaagg ctggcatcgt
     1981 tacctcgctg caagcccgct gcactgtcat agctgctgcc aaccccatag gaggccgcta
     2041 cgacccttca ctgaccttct cagagaatgt agacctcaca gagcccatca tttcccgctt
     2101 tgatgtcctg tgtgtggtga gggacactgt tgatccagtt caggatgaga tgctggcccg
     2161 ctttgtggtt ggcagccacg tcagacacca ccccagtaac aagaaggatg aagggttgac
     2221 taatggtggc accttggagc cagccatgcc caacacatat ggcgtggagc ccctgcctca
     2281 ggaggtgctg aagaagtata tcatctatgc caaggagagg gtccgcccga agctcaacca
     2341 gatggaccag gataaagtgg ccaggatgta cagtgacctg aggaaggagt ccatggcaac
     2401 gggcagcatt cccatcacgg tgcgccacat cgagtccatg atccgcatgg ccgaggccca
     2461 tgcccgcatg cacctgcggg actacgtgat ggaagacgat gtcaacatgg ccatccgagt
     2521 gatgatggag agcttcattg acacccagaa gttcagcgtc atgcggagta tgcgcaagac
     2581 ttttgcccgg tatctctcct tccggcgaga taacaatgat ctgctgctct tcatactgaa
     2641 gcagttggtg gctgagcagg tgacatatca acgcaaccgc tttggggccc agcaggacac
     2701 cattgaaata cctgagaagg atctgatgga caaggccagg cagatcaata ttcacaacct
     2761 ctctgccttc tacgacagcg acctcttcaa attcaacaag ttcagccgtg acctgaaacg
     2821 caaactgatc ctacagcagt tctgagacca gcacaggggc ctctatgtct gaatgaggct
     2881 cggtcaccac gctgagccta cgtcacttcc cacttccact ggggcttggt gccctgtagg
     2941 ggtgggagga tggcttaatg cagaccttta cctgtgagcc cctaggccaa ggctgtagca
     3001 ttaaatgact atttattctt ctgcccccct ctagagcact cttcttggcc agaccctctg
     3061 tccaaggctc attagaaggc tggggttgtg ttcaggtgac agactttatc aaaactattg
     3121 ctgttttggc atgagttgtg tttctggact gttttgtttt cccctttaga caaagagcaa
     3181 cttagaagta tttgcaaact tttccagaac attctcaaag cctgtgatgg aggagcacaa
     3241 gaccctgtct gctgagggcc catgctcctc tcatgggttt cttcccacct agccagtgcc
     3301 ttcatttgct tgttgtacag tttcttgtag tttatttttt aatagatttg aataaaacct
     3361 aaatagcgct aaaaaaaaaa a
//
