LOCUS       NM_008562               3498 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus myeloid cell leukemia sequence 1 (Mcl1), mRNA.
ACCESSION   NM_008562 XM_976767 XM_976805
VERSION     NM_008562.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Vier,J., Hacker,G. and Kirschnek,S.
  TITLE     Contribution of A1 to macrophage survival in cooperation with MCL-1
            and BCL-XL in a murine cell model of myeloid differentiation
  JOURNAL   Cell Death Dis 15 (9), 677 (2024)
   PUBMED   39285161
  REMARK    GeneRIF: Contribution of A1 to macrophage survival in cooperation
            with MCL-1 and BCL-XL in a murine cell model of myeloid
            differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Gaertner,F., Ishikawa-Ankerhold,H., Stutte,S., Fu,W., Weitz,J.,
            Dueck,A., Nelakuditi,B., Fumagalli,V., van den Heuvel,D., Belz,L.,
            Sobirova,G., Zhang,Z., Titova,A., Navarro,A.M., Pekayvaz,K.,
            Lorenz,M., von Baumgarten,L., Kranich,J., Straub,T., Popper,B.,
            Zheden,V., Kaufmann,W.A., Guo,C., Piontek,G., von Stillfried,S.,
            Boor,P., Colonna,M., Clauss,S., Schulz,C., Brocker,T., Walzog,B.,
            Scheiermann,C., Aird,W.C., Nerlov,C., Stark,K., Petzold,T.,
            Engelhardt,S., Sixt,M., Hauschild,R., Rudelius,M.,
            Oostendorp,R.A.J., Iannacone,M., Heinig,M. and Massberg,S.
  TITLE     Plasmacytoid dendritic cells control homeostasis of
            megakaryopoiesis
  JOURNAL   Nature 631 (8021), 645-653 (2024)
   PUBMED   38987596
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Wright,T., Turnis,M.E., Grace,C.R., Li,X., Brakefield,L.A.,
            Wang,Y.D., Xu,H., Kaminska,E., Climer,L.K., Mukiza,T.O.,
            Chang,C.L., Moldoveanu,T. and Opferman,J.T.
  TITLE     Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation
            through interaction with ACSL1
  JOURNAL   Mol Cell 84 (7), 1338-1353 (2024)
   PUBMED   38503284
  REMARK    GeneRIF: Anti-apoptotic MCL-1 promotes long-chain fatty acid
            oxidation through interaction with ACSL1.
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Revesz,C., Kaucsar,T., Godo,M., Bocskai,K., Krenacs,T., Mocsai,A.,
            Szenasi,G. and Hamar,P.
  TITLE     Neutrophils and NADPH Oxidases Are Major Contributors to Mild but
            Not Severe Ischemic Acute Kidney Injury in Mice
  JOURNAL   Int J Mol Sci 25 (5), 2948 (2024)
   PUBMED   38474193
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3498)
  AUTHORS   Okita,H., Umezawa,A., Suzuki,A. and Hata,J.
  TITLE     Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene,
            in the early stage of differentiation of murine embryonal carcinoma
            cells and embryonic stem cells
  JOURNAL   Biochim Biophys Acta 1398 (3), 335-341 (1998)
   PUBMED   9655929
REFERENCE   7  (bases 1 to 3498)
  AUTHORS   Li,L., Krajewski,S., Reed,J.C. and Choi,Y.S.
  TITLE     The apoptosis and proliferation of SAC-activated B cells by IL-10
            are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression
  JOURNAL   Cell Immunol 178 (1), 33-41 (1997)
   PUBMED   9184696
REFERENCE   8  (bases 1 to 3498)
  AUTHORS   Kingsmore,S.F., Spicer,A.P., Gendler,S.J. and Seldin,M.F.
  TITLE     Genetic mapping of the tumor-associated mucin 1 gene on mouse
            chromosome 3
  JOURNAL   Mamm Genome 6 (5), 378-379 (1995)
   PUBMED   7626896
REFERENCE   9  (bases 1 to 3498)
  AUTHORS   Yang,T., Kozopas,K.M. and Craig,R.W.
  TITLE     The intracellular distribution and pattern of expression of Mcl-1
            overlap with, but are not identical to, those of Bcl-2
  JOURNAL   J Cell Biol 128 (6), 1173-1184 (1995)
   PUBMED   7896880
REFERENCE   10 (bases 1 to 3498)
  AUTHORS   Craig,R.W., Jabs,E.W., Zhou,P., Kozopas,K.M., Hawkins,A.L.,
            Rochelle,J.M., Seldin,M.F. and Griffin,C.A.
  TITLE     Human and mouse chromosomal mapping of the myeloid cell leukemia-1
            gene: MCL1 maps to human chromosome 1q21, a region that is
            frequently altered in preneoplastic and neoplastic disease
  JOURNAL   Genomics 23 (2), 457-463 (1994)
   PUBMED   7835896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ183408.1, AK159504.1, AC092479.16 and AA174356.1.
            
            On Mar 21, 2007 this sequence version replaced NM_008562.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021638.1, AK159504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                CJ183408.1         1-88
            89-2073             AK159504.1         1-1985
            2074-3294           AC092479.16        69235-70455         c
            3295-3498           AA174356.1         9-212
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..3498
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="myeloid cell leukemia sequence 1"
                     /db_xref="GeneID:17210"
                     /db_xref="MGI:MGI:101769"
     exon            1..767
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1132
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="bcl-2-related protein EAT/mcl1"
                     /codon_start=1
                     /product="induced myeloid leukemia cell differentiation
                     protein Mcl-1 homolog"
                     /protein_id="NP_032588.1"
                     /db_xref="CCDS:CCDS57236.1"
                     /db_xref="GeneID:17210"
                     /db_xref="MGI:MGI:101769"
                     /translation="MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREG
                     GGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVS
                     PEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSL
                     EIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDI
                     KNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETIT
                     DVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR"
     exon            768..1015
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..3488
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2219..2224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="hexamer: AATAAA"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="hexamer: AACAAA"
     polyA_site      2246
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="major polyA site"
     polyA_site      2250
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="major polyA site"
     regulatory      3467..3472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="hexamer: AATAAA"
     polyA_site      3488
                     /gene="Mcl1"
                     /gene_synonym="Gm52627; Mcl-1"
                     /note="major polyA site"
ORIGIN      
        1 gggaagtcct cgcctgcgtc agcacggccc taaggcggcg gcagggaacg gccttcctca
       61 ctcctgactt ccgcctgcct ccggtctgga gtcgcggcct tccccgctcc ttcccctcag
      121 cctgcggcgt ccgaccatgt ttggcctgcg gagaaacgcg gtcatcggct tgaacctgta
      181 ctgcggcggc gccagcctcg gcgcgggcgg cggttctccg gcaggggcgc gcctggtggc
      241 cgaggaggcc aaggcgcggc gcgagggggg aggggaggcc gccctgctgc ccggcgcgcg
      301 ggtggtcgcc cggccgccgc ccgtgggcgc cgaggacccc gacgtcaccg cgtcggccga
      361 aaggcggctg cataagtcgc ccggcctcct cgccgtgccg cccgaggaga tggccgcgtc
      421 ggccgccgcc gccatcgtgt ctccggagga ggaactggac ggctgcgagc cggaggccat
      481 cggcaagcgc ccggccgtgc tgcccctcct ggagcgcgtg agcgaggcgg ccaagagctc
      541 cggggccgac ggctctctgc cctccacgcc gccgccgccc gaggaggaag aggacgacct
      601 ataccgccag tcgctggaga tcatctcgcg ctacttgcgg gagcaggcga ccggctccaa
      661 ggactcgaag cctctgggcg aggcgggcgc ggcgggccgg agagcgctgg agaccctgcg
      721 gcgcgtgggc gacggcgtgc agcgcaacca cgagacggcc ttccagggca tgctccggaa
      781 actggacatt aaaaacgaag gcgatgttaa atctttttct cgagtaatgg tccatgtttt
      841 caaagatggc gtaacaaact ggggcaggat tgtgactctt atttctttcg gtgcctttgt
      901 ggccaaacac ttaaagagcg taaaccaaga aagcttcatc gaaccattag cagaaactat
      961 cacagatgtt cttgtaagga cgaaacggga ctggcttgtc aaacaaagag gctgggatgg
     1021 gtttgtggag ttcttccacg tacaggacct agaaggcggc atcagaaatg tgctgctggc
     1081 ttttgcgggt gttgctggag taggggctgg tctggcatat ctaataagat agccttgtga
     1141 gtgcaatagg ggactcttaa agctccagcc accaaactac atgcatctgt gaaaacatgt
     1201 gtatttatga aggtggactt gaagctgccc aggattttaa cagtccagtt ctactgtagc
     1261 aacatagcaa aaagaaagtg gctacaggat tgtggctaac aagaataaat acatgggaaa
     1321 agtgctcccc ctggaagagt cactgtctga atgaagcaaa gttccctctc agcaaacact
     1381 gagaggccat ggagaaggac ttctagaatg aatgaaaggg gtggatggaa aggtttgatt
     1441 tcctatctag agatggaaga ggggccagtc atcaggctag tcacaaagct caataaatat
     1501 ccattactct gctcagagtg ttgagagaga agccctaatt aacaacgttg gtgacttgtg
     1561 taaaatggat ttgtaaccta caagtcacca aacgatgact agaagctgca gtgctgtaca
     1621 ggaatgtgaa gggaggcctc tgagcagtcc agggtgtgct tgacaaagtc ccaagtgctc
     1681 aggactttta gccctgtcta ctttggcttg gtttggatga ttcttaagtt tattagccta
     1741 gtgatggcca aaaagtactt gacttaaggt tcactaatta gttacaaaac tgaacagcct
     1801 cgatttttaa gaaaatttat gaaatgtatt tgtctgtaaa aattgtatat atttttacag
     1861 aaagtctatt tctttgaaca taagagggaa gtcttggatt tagttttttt ccataccctt
     1921 ttgaaatttg cagcttctct agttagaaat gtatttctta cagcttttta agactttgtc
     1981 atccgttcta gtgtatatgc agagcctgtt gtgtgtgtgg actggttata gatttataac
     2041 tatgcagggt taattatcca atcttttttt tttgtattta aagatcacag gtagatagat
     2101 gtaagacatt tgatcccctg ttgacttaca aaattgtaaa tggtaaagca ggctagagtc
     2161 ttaaccatgg tgctattcac tgggtttact tgtttaacac aagtttatac ctggtgtcaa
     2221 taaaacaaat atgtatttct tgtctactaa ggattgccaa gctttgtttt gaatttctgt
     2281 attggtctct aggtgtagcc tttacttcct ttactgttgg cgtgttatgc tcccagttcc
     2341 cctatagagt cgtctacact tcctccctgt gctcttcact ggccatttta gttatctgca
     2401 ttagaactct caccccaacc cccccaaaac tttgaaccta aataacccct cccccatcct
     2461 aatcagagtc agcacagctt tcctgtcaga ggataggaac acttgctctt tgagccccgt
     2521 gaccgacagt gaccagggat tggcattctt ggattggcat gctttccatt gttactttgt
     2581 ctattttggt aagaaaaaca tcaaaggtcc ccttgggaat ttcaaaggtt ggaaattata
     2641 cgtttatact tttattagtt tgctccaagt atgactgtgt tcacttaagt ttagagaaac
     2701 actgggtttt gctaaactcg gttaacaaaa gccactggta actgaaggta tttaagctag
     2761 ggtcatttga aagcttcagc ctcagaatgt gacctttagt cagggctgca gataaaaata
     2821 ggcaggaatc aaatgactaa gaatgtaata gggaagaagt gccctgcctg ccagcttggg
     2881 agtgatttgt acctgtgtat ttatccttga tcatagtttg cttatttatg tttaactctt
     2941 cggacttcag agcactttat gtagttgaat aaaccctaga ggttgaggtg actaaaaggt
     3001 tagcctctca taacccagcc atggaagttt tgtttactag gagcctgact tcccagctca
     3061 caaagggtga aatgaaagct gaagtacaga caggatctta gtaggtattt taggtccagg
     3121 gccatgaaga cttggagagc gcagtggctg ggcaaggggc tgctttggag ggaagaagca
     3181 tgtggtctga gtgctgacta gatgaatagt tgaggcacat ccttcagaga agagggaggg
     3241 gctgcttgga aagatggctc tcagcaaaat ctgtttgtct tacacgtctc tcagggaaaa
     3301 aacatgcagt cttcaagcat cttccatgta cattctatct gggtgaacac cttcattctg
     3361 gtagagcacc taacacttta acagctgttc ccgaaagggt taggaccaac tgcaagttaa
     3421 tgtgggttgt aaatgttccc ctaacttctg tttcttctga agagaaaata aacctttttc
     3481 cccccaaaaa aaaaaaaa
//
