LOCUS       NM_001037914            2354 bp    mRNA    linear   ROD 31-DEC-2022
DEFINITION  Mus musculus multiciliate differentiation and DNA synthesis
            associated cell cycle protein (Mcidas), mRNA.
ACCESSION   NM_001037914 XM_886847 XM_906712
VERSION     NM_001037914.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Li Q, Han Z, Singh N, Terre B, Fame RM, Arif U, Page TD, Zahran T,
            Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K,
            Wu L, Virga JQ, Zhao YT, Schuller U, Wechsler-Reya RJ, Lehtinen MK,
            Roy S, Liu Z, Stracker TH and Zhao H.
  TITLE     Disruption of GMNC-MCIDAS multiciliogenesis program is critical in
            choroid plexus carcinoma development
  JOURNAL   Cell Death Differ 29 (8), 1596-1610 (2022)
   PUBMED   35322202
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Herranz-Perez V, Nakatani J, Ishii M, Katada T, Garcia-Verdugo JM
            and Ohata S.
  TITLE     Ependymoma associated protein Zfta is expressed in immature
            ependymal cells but is not essential for ependymal development in
            mice
  JOURNAL   Sci Rep 12 (1), 1493 (2022)
   PUBMED   35087169
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Casoni F, Croci L, Vincenti F, Podini P, Riba M, Massimino L,
            Cremona O and Consalez GG.
  TITLE     ZFP423 regulates early patterning and multiciliogenesis in the
            hindbrain choroid plexus
  JOURNAL   Development 147 (22) (2020)
   PUBMED   33046507
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2354)
  AUTHORS   He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX,
            Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S and Jan LY.
  TITLE     Chloride channels regulate differentiation and barrier functions of
            the mammalian airway
  JOURNAL   Elife 9, e53085 (2020)
   PUBMED   32286221
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2354)
  AUTHORS   Wildung M, Esser TU, Grausam KB, Wiedwald C, Volceanov-Hahn L,
            Riedel D, Beuermann S, Li L, Zylla J, Guenther AK, Wienken M,
            Ercetin E, Han Z, Bremmer F, Shomroni O, Andreas S, Zhao H and Lize
            M.
  TITLE     Transcription factor TAp73 and microRNA-449 complement each other
            to support multiciliogenesis
  JOURNAL   Cell Death Differ 26 (12), 2740-2757 (2019)
   PUBMED   31068677
REFERENCE   6  (bases 1 to 2354)
  AUTHORS   Lu H, Anujan P, Zhou F, Zhang Y, Chong YL, Bingle CD and Roy S.
  TITLE     Mcidas mutant mice reveal a two-step process for the specification
            and differentiation of multiciliated cells in mammals
  JOURNAL   Development 146 (6) (2019)
   PUBMED   30877126
  REMARK    GeneRIF: GMNC protein induces Mci expression that drives the second
            step of basal body production for multiciliation
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2354)
  AUTHORS   Arbi M, Pefani DE, Kyrousi C, Lalioti ME, Kalogeropoulou A,
            Papanastasiou AD, Taraviras S and Lygerou Z.
  TITLE     GemC1 controls multiciliogenesis in the airway epithelium
  JOURNAL   EMBO Rep 17 (3), 400-413 (2016)
   PUBMED   26882546
REFERENCE   8  (bases 1 to 2354)
  AUTHORS   Kyrousi C, Arbi M, Pilz GA, Pefani DE, Lalioti ME, Ninkovic J, Gotz
            M, Lygerou Z and Taraviras S.
  TITLE     Mcidas and GemC1 are key regulators for the generation of
            multiciliated ependymal cells in the adult neurogenic niche
  JOURNAL   Development 142 (21), 3661-3674 (2015)
   PUBMED   26395491
  REMARK    GeneRIF: Results suggest that Mcidas and GemC1 are key players in
            the generation of multiciliated ependymal cells of the adult
            neurogenic niche.
REFERENCE   9  (bases 1 to 2354)
  AUTHORS   Stubbs JL, Vladar EK, Axelrod JD and Kintner C.
  TITLE     Multicilin promotes centriole assembly and ciliogenesis during
            multiciliate cell differentiation
  JOURNAL   Nat Cell Biol 14 (2), 140-147 (2012)
   PUBMED   22231168
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2354)
  AUTHORS   Pefani DE, Dimaki M, Spella M, Karantzelis N, Mitsiki E, Kyrousi C,
            Symeonidou IE, Perrakis A, Taraviras S and Lygerou Z.
  TITLE     Idas, a novel phylogenetically conserved geminin-related protein,
            binds to geminin and is required for cell cycle progression
  JOURNAL   J Biol Chem 286 (26), 23234-23246 (2011)
   PUBMED   21543332
  REMARK    GeneRIF: Idas as a novel Geminin binding partner, implicated in
            cell cycle progression, and a putative regulator of
            proliferation-differentiation decisions during development.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC165265.2.
            
            [WARNING] On Apr 14, 2023 this sequence was replaced by
            NM_001037914.4.
            
            On May 2, 2007 this sequence version replaced NM_001037914.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134107.1, BC150962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC165265.2         186475-186595
            122-218             AC165265.2         186695-186791
            219-310             AC165265.2         186964-187055
            311-383             AC165265.2         189450-189522
            384-598             AC165265.2         189970-190184
            599-709             AC165265.2         191087-191197
            710-2354            AC165265.2         191357-193001
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..2354
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /note="multiciliate differentiation and DNA synthesis
                     associated cell cycle protein"
                     /db_xref="GeneID:622408"
                     /db_xref="MGI:MGI:3648807"
     exon            1..121
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1144
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /note="protein Idas; multiciliate cell differentiation"
                     /codon_start=1
                     /product="multicilin"
                     /protein_id="NP_001033003.1"
                     /db_xref="CCDS:CCDS36783.1"
                     /db_xref="GeneID:622408"
                     /db_xref="MGI:MGI:3648807"
                     /translation="MQACEGSAAGRRAFDSICPNRMLDLSRRTLGKPGKPERKFVPSW
                     KSFSGCGGGSPVAVYEDPPDAEPAPLPALTTIDLQDLADCTSLLGTEASPSGDSSASQ
                     NPSLQTEEDFNLQNFRDAMDDLIADSSSLMSPPLTNSDFPFSPCDVSSFGSCLSPSLD
                     PPALGSPDLPPPPTEQYWKEVADQNQRALGTALIENNQLHVTLTQKQEEIASLRERNV
                     QLKELASRTRHLASVLDKLMITQSPAEPFQIKATTKRSLEELFCAAGQAGQGCAEVDA
                     ILRDISQRCEEALHNRDPKRPRLQPEPDSKDCSSRNLHGAFRGLRTDCSASSVNLSHS
                     ELEEGGSFSTPIRSHSTIRTLAFPQGKAFTIRTVTGGYKFRWVPS"
     exon            122..218
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
     exon            219..310
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
     exon            311..383
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
     exon            384..598
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
     exon            599..709
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
     exon            710..2354
                     /gene="Mcidas"
                     /gene_synonym="EG622408; Gm6320; Idas; Mci; Mcin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggatgcaa gcgtgcgagg gcagcgcagc cggacgccgg gccttcgaca gcatctgccc
       61 caacaggatg ctggacctgt cgcggcggac cctcggcaag cccgggaagc cggagaggaa
      121 gttcgttcct tcgtggaagt ccttttcggg atgcggtggc ggcagcccgg tggcggtgta
      181 cgaggaccct ccggacgcag agcccgcccc actgccagct ctcacaacca tagacctgca
      241 ggacctcgcc gactgcacct cgctgctcgg aaccgaagcg tctcctagtg gtgattcgtc
      301 cgcgtcgcag aacccctcct tgcaaactga agaagacttc aacctgcaga atttcagaga
      361 tgcaatggat gacctcattg cagattcatc ctctttgatg tcgcctcccc tgaccaacag
      421 tgactttccc ttttcccctt gtgatgtttc gtctttcggg tcctgcctct ccccatcgct
      481 ggacccacct gccttggggt ctccagacct gccgccacca ccaacggagc agtactggaa
      541 ggaggtggct gaccagaacc agagggcact ggggactgct ctcatagaga ataaccaact
      601 gcacgtgacg ctgacgcaga agcaggagga gatagcctcg ctccgggaga ggaacgtgca
      661 gctgaaagaa ctcgccagcc ggacccggca cctggcctca gtgctggata agctgatgat
      721 cacgcagtct cctgccgagc ccttccagat caaggcaaca acgaaaagga gcctggagga
      781 gctgttctgt gctgcggggc aagcagggca gggttgcgcg gaagtggacg ccatcctcag
      841 agacatctcc cagcgctgcg aggaagccct gcacaatcgt gaccctaagc ggcccaggct
      901 gcagccagag ccagacagca aggactgcag ctccaggaac ctccacggcg ccttccgagg
      961 actgcgcacc gactgcagcg ccagctcggt gaatctgagt cacagtgagc tggaggaagg
     1021 cggctccttc agcacgccca tccgcagcca cagtaccatc cgcaccctgg ctttccccca
     1081 gggcaaagcc ttcaccatcc ggacagtcac cggtggttac aaattccgct gggtccccag
     1141 ctgatctggg atgtggcttc ccctaaaata ctgccctgtg taacagcaga gagaagcgtc
     1201 tgcaagcaag tgggcatagc tagaaatgtt tcccacatct ggttcccaga attctctgca
     1261 agcaaacgct actcggaaac tttattatat attttttttt tttttcagaa acagaagtgt
     1321 cttggtacct gtgcaatgaa aagttctgct ccgaagcccc atatactgct tgcttttgca
     1381 cggtgaaatt gcgtgtatac acacgcacac ctgcggctaa gcacacgcca cagtcaaact
     1441 tagatgtatt tattttttag cgctttgttt gtttgaggca ggtccaggag gcacatagag
     1501 cagctggaca cagacttgct attatgattg cttctgtttc cttctgcttc catctcctga
     1561 gtgctgggtt agaggtgctc accgccatat ttgactgttt tagccttttt gtaagaagag
     1621 agaacagtgc aaaggaatga tggggggttc cactagagag gaattatcca atcacagcca
     1681 tttaaaggct tgggattcag aaccccggta tctgggtgtt ttggcacatc acccaattcc
     1741 cctctgtcct cagagtacac ctacctccta gctgtgttaa ctactggaaa atgctatttc
     1801 agttggaaaa aacaaaaaca aacaaaaaac caccaccacc aaaactccgg aaacaacttg
     1861 gcagttgtgg agcaagctca cacaaggatg cagtggtcat cccagcactt gggaggcaga
     1921 ggcaggcgga tctctgagtt ccaggccagc ctggtctaca gagtgagttc caggacagcc
     1981 aaagctatgc agagaaaccc tgtcttaaat agcaaagaaa caaaaccaag caaagctaca
     2041 caattaggca aatgctgatg caggataggt gctaaacaca gttgtttgaa ataatcatcc
     2101 tatgattttg taagagttgg tttgcgtgct tgctgctttt ggagagggct tggacttcag
     2161 aacccagcca gcatccatat caatggctca aatgggaaag aaactccagt cctggggtgg
     2221 gggtgtggtt atctgacatc atcctcttct ggtttctgtg ggcatctgta tactccggag
     2281 ctacacacac acacacacac acacacacac acacgcacag gcacagtcac ataagtaaaa
     2341 ttctttacaa aagg
//
