LOCUS       NM_145132               2205 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus melanin-concentrating hormone receptor 1 (Mchr1),
            mRNA.
ACCESSION   NM_145132
VERSION     NM_145132.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Fabregat,M., Nino-Rivero,S., Pose,S., Cardenas-Rodriguez,M.,
            Bresque,M., Hernandez,K., Prieto-Echague,V., Schlapp,G., Crispo,M.,
            Lagos,P., Lago,N., Escande,C., Irigoin,F. and Badano,J.L.
  TITLE     Generation and characterization of Ccdc28b mutant mice links the
            Bardet-Biedl associated gene with mild social behavioral phenotypes
  JOURNAL   PLoS Genet 18 (6), e1009896 (2022)
   PUBMED   35653384
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Wang,M., Zhai,Y., Lei,X., Xu,J., Jiang,B., Kuang,Z., Zhang,C.,
            Liu,S., Bian,S., Yang,X.M., Zan,T., Jin,L.N., Li,Q. and Zhang,C.
  TITLE     Determination of the Interaction and Pharmacological Modulation of
            MCHR1 Signaling by the C-Terminus of MRAP2 Protein
  JOURNAL   Front Endocrinol (Lausanne) 13, 848728 (2022)
   PUBMED   35311242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Alhassen,W., Kobayashi,Y., Su,J., Robbins,B., Nguyen,H., Myint,T.,
            Yu,M., Nauli,S.M., Saito,Y. and Alachkar,A.
  TITLE     Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence
            from Pharmacological, Genetic, Optogenetic, and Chemogenic
            Manipulations
  JOURNAL   Mol Neurobiol 59 (1), 245-265 (2022)
   PUBMED   34665407
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Jasso,K.R., Kamba,T.K., Zimmerman,A.D., Bansal,R., Engle,S.E.,
            Everett,T., Wu,C.H., Kulaga,H., Reed,R.R., Berbari,N.F. and
            McIntyre,J.C.
  TITLE     An N-terminal fusion allele to study melanin concentrating hormone
            receptor 1
  JOURNAL   Genesis 59 (7-8), e23438 (2021)
   PUBMED   34124835
  REMARK    GeneRIF: An N-terminal fusion allele to study melanin concentrating
            hormone receptor 1.
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Hsiao,Y.C., Munoz-Estrada,J., Tuz,K. and Ferland,R.J.
  TITLE     The Transition Zone Protein AHI1 Regulates Neuronal Ciliary
            Trafficking of MCHR1 and Its Downstream Signaling Pathway
  JOURNAL   J Neurosci 41 (17), 3932-3943 (2021)
   PUBMED   33741721
  REMARK    GeneRIF: The Transition Zone Protein AHI1 Regulates Neuronal
            Ciliary Trafficking of MCHR1 and Its Downstream Signaling Pathway.
REFERENCE   6  (bases 1 to 2205)
  AUTHORS   Lakaye,B., Adamantidis,A., Coumans,B. and Grisar,T.
  TITLE     Promoter characterization of the mouse melanin-concentrating
            hormone receptor 1
  JOURNAL   Biochim Biophys Acta 1678 (1), 1-6 (2004)
   PUBMED   15093132
  REMARK    GeneRIF: The gene encoding the mouse melanin-concentrating hormone
            receptor 1 was isolated and its structural organization and
            flanking regions were characterized.
REFERENCE   7  (bases 1 to 2205)
  AUTHORS   Chen,Y., Hu,C., Hsu,C.K., Zhang,Q., Bi,C., Asnicar,M., Hsiung,H.M.,
            Fox,N., Slieker,L.J., Yang,D.D., Heiman,M.L. and Shi,Y.
  TITLE     Targeted disruption of the melanin-concentrating hormone receptor-1
            results in hyperphagia and resistance to diet-induced obesity
  JOURNAL   Endocrinology 143 (7), 2469-2477 (2002)
   PUBMED   12072376
REFERENCE   8  (bases 1 to 2205)
  AUTHORS   Tan,C.P., Sano,H., Iwaasa,H., Pan,J., Sailer,A.W., Hreniuk,D.L.,
            Feighner,S.D., Palyha,O.C., Pong,S.S., Figueroa,D.J., Austin,C.P.,
            Jiang,M.M., Yu,H., Ito,J., Ito,M., Ito,M., Guan,X.M., MacNeil,D.J.,
            Kanatani,A., Van der Ploeg,L.H. and Howard,A.D.
  TITLE     Melanin-concentrating hormone receptor subtypes 1 and 2:
            species-specific gene expression
  JOURNAL   Genomics 79 (6), 785-792 (2002)
   PUBMED   12036292
REFERENCE   9  (bases 1 to 2205)
  AUTHORS   Marsh,D.J., Weingarth,D.T., Novi,D.E., Chen,H.Y., Trumbauer,M.E.,
            Chen,A.S., Guan,X.M., Jiang,M.M., Feng,Y., Camacho,R.E., Shen,Z.,
            Frazier,E.G., Yu,H., Metzger,J.M., Kuca,S.J., Shearman,L.P.,
            Gopal-Truter,S., MacNeil,D.J., Strack,A.M., MacIntyre,D.E., Van der
            Ploeg,L.H. and Qian,S.
  TITLE     Melanin-concentrating hormone 1 receptor-deficient mice are lean,
            hyperactive, and hyperphagic and have altered metabolism
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 3240-3245 (2002)
   PUBMED   11867747
REFERENCE   10 (bases 1 to 2205)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279235.1, AK134867.1 and AW049955.1.
            
            On Apr 16, 2010 this sequence version replaced NM_145132.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY276741.1, AK134867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               BY279235.1         1-118
            119-2179            AK134867.1         2-2062
            2180-2205           AW049955.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.02 cM"
     gene            1..2205
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch1r"
                     /note="melanin-concentrating hormone receptor 1"
                     /db_xref="GeneID:207911"
                     /db_xref="MGI:MGI:2180756"
     exon            1..357
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch1r"
                     /inference="alignment:Splign:2.1.0"
     exon            358..2189
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch1r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch1r"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch1r"
                     /note="major polyA site"
ORIGIN      
        1 gagtaggagc cgcagccggg accgaagagg ttaacatgca tctgcctccg aatgttaatg
       61 tgtctaggtg atgtcagtgg gagctgggaa ggagggagtg gggcgagcag ttgggctcag
      121 aggcagcaga ggctgccagg cggtagagga agaccctttt ctggactgcg gggctcaagc
      181 tccggacaag gcggtggagg gcgctggagg ctgccgcagc ctgcgtgggt ggacgggcgc
      241 tccactccag ggagcaggcg acctgcaccg gctgcatgga tctgcaagcc tcgttgctgt
      301 ccactggccc caatgccagc aacatctccg atggccagga taatttcaca ttggcggggc
      361 cacctcctcg cacaaggagt gtctcctaca tcaacatcat catgccttca gtgtttggta
      421 ccatctgtct cctgggcatt gtgggaaact ccacagtcat ttttgccgtg gtgaagaaat
      481 ccaagctgca ctggtgcagc aacgtccctg acatcttcat catcaacctc tctgtggtgg
      541 atctgctttt cctgctgggc atgcctttca tgatccacca gctcatgggt aatggtgtct
      601 ggcactttgg ggaaaccatg tgcaccctca tcacagccat ggacgccaac agtcagttca
      661 ccagcaccta catcctgact gctatggcca ttgaccgcta cttggccacc gtccatccca
      721 tctcctccac caagttccgg aagccctcca tggccaccct ggtgatctgc ctcctgtggg
      781 ctctctcgtt cattagcatc actcctgtgt ggctctatgc caggcttatc cccttcccag
      841 ggggtgctgt gggctgtggc atccgcctac caaacccaga tactgatctt tactggttca
      901 ctctgtatca gtttttcctg gccttcgccc ttccgtttgt ggtcatcact gctgcgtacg
      961 tgaaaatact acagcgcatg acgtcttcgg tggccccagc ctctcaacgc agcatccggc
     1021 ttcggacaaa gagggtgacc cgcacagcca ttgccatctg tctggtcttc tttgtgtgct
     1081 gggcgcccta ctacgtgctg cagctgaccc agttgtccat cagccgcccg accctcacat
     1141 tcgtctacct gtacaatgcg gctatcagct tgggctatgc caacagctgc ctcaatccct
     1201 ttgtgtacat agtactctgt gagacctttc gaaaacgctt ggtgctgtcg gtgaagcccg
     1261 cggcccaggg gcagcttcgc acggtcagca atgctcagac agctgacgag gagaggacag
     1321 aaagcaaagg cacctgacaa tcccccccgg tcacctccaa gtcaggtcac cgcatcaaac
     1381 cgtggggaga gatactgaga taaacccggg gctaccctgg gaggatgcag aagctggagg
     1441 ctgggggctt gtagcaaacc acattccacg gggcccacaa attgctaggg aggcttgcag
     1501 ccaggtttgg gggggaagcc tcagactgca gggatcccct tgacagaata gaagcggagc
     1561 aagaaggaaa gggtggtttg actggttctc ggggtctgta tctgttggct cgcatatatc
     1621 tttctctcaa gggaagaagg tggaggtgcc tagctgggtt cctttaaaac taggcagggc
     1681 taggatctga gcagctaggg ctctactgtg agactgggca agccgagcgt tccctcccat
     1741 ctctcattgg tgttgataga aggcagtctt tctcccaagc tggtggatct cctgaagcac
     1801 gctgcctggg ctccagcatc ctgtgcggat ttcacgttct ctttagggga tgcatgttga
     1861 cactggggtg tgggctctga gcccacagga gtttaaaaaa ccaaaagagc tcagagtgtc
     1921 gagagagatc caatcaccga gaatgacaag gcaacctggg gtggatgtgg atcttgaaac
     1981 taataaaaag gggttttcac agtgacagcg acattctctt catagggcac agctgtcagt
     2041 ctatggctga tccagagcga gcatccatga attctgcatg tgcaggggtc actctaatac
     2101 ctgatatgtt ggcatcatct ttgtgcttga gccttccact cccaaatggg aatgaaataa
     2161 aggcaaattc ccacccacgt cattctggaa aaaaaaaaaa aaaaa
//
