LOCUS       NM_139295               2050 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus multiple coagulation factor deficiency 2 (Mcfd2),
            transcript variant 2, mRNA.
ACCESSION   NM_139295
VERSION     NM_139295.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2050)
  AUTHORS   Everett,L.A., Lin,Z., Friedman,A., Tang,V.T., Myers,G.,
            Balbin-Cuesta,G., King,R., Zhu,G., McGee,B. and Khoriaty,R.
  TITLE     LMAN1 serves as a cargo receptor for thrombopoietin
  JOURNAL   JCI Insight 9 (24), e175704 (2024)
   PUBMED   39499573
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2050)
  AUTHORS   Everett,L.A., Khoriaty,R.N., Zhang,B. and Ginsburg,D.
  TITLE     Altered phenotype in LMAN1-deficient mice with low levels of
            residual LMAN1 expression
  JOURNAL   Blood Adv 4 (22), 5635-5643 (2020)
   PUBMED   33196840
REFERENCE   3  (bases 1 to 2050)
  AUTHORS   Zhu,M., Zheng,C., Wei,W., Everett,L., Ginsburg,D. and Zhang,B.
  TITLE     Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct
            functions in vivo
  JOURNAL   Blood Adv 2 (9), 1014-1021 (2018)
   PUBMED   29735583
  REMARK    GeneRIF: MCFD2-deficient mice generated by gene targeting also
            demonstrate reduced plasma FV and FVIII, with levels lower than
            those in LMAN1-deficient mice, similar to previous observations in
            LMAN1- and MCDF2-deficient humans.
REFERENCE   4  (bases 1 to 2050)
  AUTHORS   Zhang,B., Zheng,C., Zhu,M., Tao,J., Vasievich,M.P., Baines,A.,
            Kim,J., Schekman,R., Kaufman,R.J. and Ginsburg,D.
  TITLE     Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver
            accumulation of alpha1-antitrypsin
  JOURNAL   Blood 118 (12), 3384-3391 (2011)
   PUBMED   21795745
REFERENCE   5  (bases 1 to 2050)
  AUTHORS   Renna,M., Faraonio,R., Bonatti,S., De Stefano,D., Carnuccio,R.,
            Tajana,G. and Remondelli,P.
  TITLE     Nitric oxide-induced endoplasmic reticulum stress activates the
            expression of cargo receptor proteins and alters the glycoprotein
            transport to the Golgi complex
  JOURNAL   Int J Biochem Cell Biol 38 (12), 2040-2048 (2006)
   PUBMED   16899390
  REMARK    GeneRIF: These results indicate that increased levels of cargo
            receptor proteins might have a function either in the quality
            control of protein folding in the endoplasmic reticulum or in the
            homeostasis of the intermediate compartment and Golgi complex.
REFERENCE   6  (bases 1 to 2050)
  AUTHORS   Toda,H., Tsuji,M., Nakano,I., Kobuke,K., Hayashi,T., Kasahara,H.,
            Takahashi,J., Mizoguchi,A., Houtani,T., Sugimoto,T., Hashimoto,N.,
            Palmer,T.D., Honjo,T. and Tashiro,K.
  TITLE     Stem cell-derived neural stem/progenitor cell supporting factor is
            an autocrine/paracrine survival factor for adult neural
            stem/progenitor cells
  JOURNAL   J Biol Chem 278 (37), 35491-35500 (2003)
   PUBMED   12832409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084383.1, AK151803.1 and AK033139.1.
            
            On Jan 26, 2010 this sequence version replaced NM_139295.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033139.1, AF475283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC084383.1         14358-14369         c
            13-1833             AK151803.1         2-1822
            1834-2050           AK033139.1         1768-1984
FEATURES             Location/Qualifiers
     source          1..2050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.06 cM"
     gene            1..2050
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /note="multiple coagulation factor deficiency 2"
                     /db_xref="GeneID:193813"
                     /db_xref="MGI:MGI:2183439"
     exon            1..113
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     exon            114..275
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..567
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /note="neural stem cell derived neuronal survival protein;
                     multiple coagulation factor deficiency protein 2 homolog"
                     /codon_start=1
                     /product="multiple coagulation factor deficiency protein 2
                     homolog precursor"
                     /protein_id="NP_647456.1"
                     /db_xref="CCDS:CCDS29015.1"
                     /db_xref="GeneID:193813"
                     /db_xref="MGI:MGI:2183439"
                     /translation="MATLQLLRAPLLCVLLWVFCAPGARAHDHGADVHHGSVGLDKST
                     VHDQEHIMEHLEGVIDQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSIAITHVHKE
                     EGSEQAPVMSEDELVSIIDGVLRDDDKNNDGYIDYAEFAKSLQ"
     exon            276..435
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     exon            436..2050
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /note="hexamer: AATAAA"
     polyA_site      1835
                     /gene="Mcfd2"
                     /gene_synonym="1810021C21Rik; F5f8d; Lman1ip; Sdnsf"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgcgcgg ctgggcgagg ggcgggaccg gcgtgcggag aaaagcgtcc cagggacggc
       61 agctggcaag gttcacgttg gagtgcttcg cgactgcgtc ggggattatc ggggtaccca
      121 cccggaagca tggcaaccct acagctgctc agagctccct tgctgtgtgt cctgctttgg
      181 gtcttttgtg ctccaggtgc cagagcccat gaccacgggg ctgatgtcca tcatggcagc
      241 gtgggcctgg ataagagcac agtgcacgac caagagcaca tcatggaaca tctggaaggt
      301 gtcatcgacc agccagaggc ggagatgtcc ccacaggaac tgcagctcca ttacttcaaa
      361 atgcatgatt acgacggcaa cagtttgctt gacggcctag agctctccat agccatcact
      421 cacgtgcaca aggaggaggg gagtgagcag gcgccagtca tgagcgagga tgagctcgtc
      481 agcatcatag atggtgtcct gagggacgat gacaagaaca acgacggcta catcgactac
      541 gctgagtttg caaagtcact gcagtagacc gttggctctt tcctttgtgc acatgtgacc
      601 cttgctaatg tgatggatgt gtctggtaat gcgaaacaac ttatttccgt ctactgctca
      661 gcactttggt aagagcctgt ggcagtctgt aagagtgggg tgaggaagaa gccacatgac
      721 tgtggagaga agtgggacag gcctcagtcc ctagaggtgt gtttaagctt gttgggcaag
      781 agctggatgc ggatcttcgg aagggcggtg ggtatcccga gttctcagga atccgactgt
      841 agaatgccac tctgacttct tgatgttaat ccatgctacc taaagtaaag acaggctgct
      901 tggccaagtg gacacacttg agaaacagtg gagggagagt gtgaaagcca cacgcttgcc
      961 ctggttggtc ctgtctttag gcagatgtgg tcagtattct gttccccagg catacagcat
     1021 catatattaa agccacagca gaagaggaat gtcgcccact gaggccaccc agatgcagag
     1081 tctaggattc cttgcccact ggccttttgg aaatgaagca ccactggcct gaataattag
     1141 ccttttccag atcttcagta tcttccacaa ctactgccat accctgtgtt gtatcatttg
     1201 accaggaggg aaaccttgaa ttggggtgtg ttctctaatc actttccact gtctgagctt
     1261 tcctgacccc tgtattgtat ccttgctccc agggctccct tcatggcttg tgaactgtta
     1321 acttggtatc tcaggttaaa ctgtcagctg gtctagcctg agcgaggcct gagaccatca
     1381 gtcactaaga gcagtggcta acctcatcga agttggaagg aatgttttta aaattacctc
     1441 ttcgagcctg aatacaaaga ataaaagaat aaaagaattc ttttaatttc agggaagatc
     1501 agaaaagaaa gcctaaagcc ctttagcgtt gtgaacctca gtagtagctg aaagagaagc
     1561 tgccacaggt tgtacttgct ctgtgagatg ttgtagacat tccgtaagag aatccagaat
     1621 gatagcagga tcaggaaaga aatggagcca aatctgctct aaggtgaata gagacttatt
     1681 tttctttatt aaagtattct tgtaagacag ttttctgtgt caagtatttg tgaaatcaga
     1741 gctgacatgt aagctattct tgtaatatct cattattttg aaagatttat ataatgaact
     1801 ctggctatct gacaataaaa tggatgaaaa agcaagcagc tgttgacgtt gactctgtcc
     1861 cccatgaagc ctcctgccgc atggaggctg gatcagtgcc agcattcaca cctgccttcc
     1921 tcccagaagc tgtgaggtag ctcaccaggc cctgggccgt tctgtcttgc acaggggatt
     1981 ctgtgttcag cttctctttc ctttttagcg tggtttgtat ccttccgaat gaactcgctt
     2041 ttgaatcttc
//
