LOCUS       NM_001289731            4227 bp    mRNA    linear   ROD 09-MAR-2022
DEFINITION  Mus musculus mcf.2 transforming sequence (Mcf2), transcript variant
            1, mRNA.
ACCESSION   NM_001289731 XM_006527742
VERSION     NM_001289731.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4227)
  AUTHORS   Fort P and Blangy A.
  TITLE     The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting
            Eukaryotic Cells to Environmental Signals
  JOURNAL   Genome Biol Evol 9 (6), 1471-1486 (2017)
   PUBMED   28541439
REFERENCE   2  (bases 1 to 4227)
  AUTHORS   Gupta M, Qi X, Thakur V and Manor D.
  TITLE     Tyrosine phosphorylation of Dbl regulates GTPase signaling
  JOURNAL   J Biol Chem 289 (24), 17195-17202 (2014)
   PUBMED   24778185
REFERENCE   3  (bases 1 to 4227)
  AUTHORS   Ramasamy SK, Kusumbe AP, Wang L and Adams RH.
  TITLE     Endothelial Notch activity promotes angiogenesis and osteogenesis
            in bone
  JOURNAL   Nature 507 (7492), 376-380 (2014)
   PUBMED   24647000
REFERENCE   4  (bases 1 to 4227)
  AUTHORS   Ognibene M, Vanni C, Blengio F, Segalerba D, Mancini P, De Marco P,
            Torrisi MR, Bosco MC, Varesio L and Eva A.
  TITLE     Identification of a novel mouse Dbl proto-oncogene splice variant:
            evidence that SEC14 domain is involved in GEF activity regulation
  JOURNAL   Gene 537 (2), 220-229 (2014)
   PUBMED   24412292
  REMARK    GeneRIF: Msf2 variant molecule containing an altered SEC14 protein
            module displays enhanced translocation to the plasma membrane and
            cell transforming potential.Msf2 expression of this variant in
            mouse brain suggests that it can be implicated in brain
            development.
REFERENCE   5  (bases 1 to 4227)
  AUTHORS   Komai K, Mukae-Sakairi N, Kitagawa M and Shiozawa S.
  TITLE     Characterization of novel splicing variants of the mouse MCF-2
            (DBL) proto-oncogene
  JOURNAL   Biochem Biophys Res Commun 309 (4), 906-909 (2003)
   PUBMED   13679059
  REMARK    GeneRIF: provides fundamental data on the structure of Mcf-2, which
            regulates a variety of cellular signaling pathways
REFERENCE   6  (bases 1 to 4227)
  AUTHORS   Miki T, Smith CL, Long JE, Eva A and Fleming TP.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
REFERENCE   7  (bases 1 to 4227)
  AUTHORS   Faust CJ, Verkerk AJ, Wilson PJ, Morris CP, Hopwood JJ, Oostra BA
            and Herman GE.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   8  (bases 1 to 4227)
  AUTHORS   Djabali M, Mattei MG, Nguyen C, Roux D, Demengeot J, Denizot F,
            Moos M, Schachner M, Goridis C and Jordan BR.
  TITLE     The gene encoding L1, a neural adhesion molecule of the
            immunoglobulin family, is located on the X chromosome in mouse and
            man
  JOURNAL   Genomics 7 (4), 587-593 (1990)
   PUBMED   2387585
REFERENCE   9  (bases 1 to 4227)
  AUTHORS   Grant SG, Mattei MG, Galland F, Stephenson DA, Keitz BT, Birnbaum D
            and Chapman VM.
  TITLE     Localization of the mouse Mcf-2 (Dbl) protooncogene within a
            conserved linkage group on the mouse X chromosome
  JOURNAL   Cytogenet Cell Genet 54 (3-4), 175-181 (1990)
   PUBMED   2265564
REFERENCE   10 (bases 1 to 4227)
  AUTHORS   Eva,A. and Aaronson,S.A.
  TITLE     Isolation of a new human oncogene from a diffuse B-cell lymphoma
  JOURNAL   Nature 316 (6025), 273-275 (1985)
   PUBMED   3875039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670778.15, AK045424.1 and AL671984.12.
            
            [WARNING] On Jan 22, 2024 this sequence was replaced by
            NM_001289731.2.
            
            On Jan 27, 2014 this sequence version replaced XM_006527742.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045424.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AL670778.15        108457-108848       c
            393-3593            AK045424.1         395-3595
            3594-3594           AL671984.12        139187-139187       c
            3595-4218           AK045424.1         3596-4219
            4219-4227           AL671984.12        138554-138562       c
FEATURES             Location/Qualifiers
     source          1..4227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 33.5 cM"
     gene            1..4227
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /note="mcf.2 transforming sequence"
                     /db_xref="GeneID:109904"
                     /db_xref="MGI:MGI:96932"
     exon            1..508
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..3519
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="proto-oncogene DBL isoform 1"
                     /protein_id="NP_001276660.1"
                     /db_xref="CCDS:CCDS72384.1"
                     /db_xref="GeneID:109904"
                     /db_xref="MGI:MGI:96932"
                     /translation="MAEAGPPPARFPPARLPPAGSSRAGLPPTGSPPASTPALASQWL
                     AVKRLPRAAAKAPNLQLNQDHCSFVPFTQAVPVQVDMAMALHRVRIAEKYGKNYLCLL
                     QAVFLAETGLLLQLKDINHFLMQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAK
                     VLNYLTSIARQSGSDSRFTIILDRRLDTWASLKISLQKISASFPGSLHLVLVLRPTSF
                     LQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWII
                     FRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTA
                     VTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEK
                     HQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDK
                     SQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTF
                     KVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIES
                     LQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASEN
                     VMRSRMIFFSPKHVKKSWRQIHAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVL
                     NELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNN
                     IFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQR
                     KLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVND
                     SMHQTAINGYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKA
                     VMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQ
                     APNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVC
                     EETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYN
                     YFSSNNDHGEDRTQMRHMSEVTF"
     exon            509..577
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..692
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..783
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..903
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1020
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1170
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1304
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1419
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1539
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1731
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1923
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2095
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2139
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2219
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2286
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2402
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2472
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2565
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2658
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2784
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3006
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3099
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3178
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3242
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3385
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3492
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..4227
                     /gene="Mcf2"
                     /gene_synonym="B230117G22Rik; Dbl; Mcf-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctccctg tcctggggct tgttggtccc agctaggggg ctctagtctt ctaagccact
       61 gagctgcgta gactgcgacc cttctggccg cgtctgtgct tgcacagacg ggctgctagc
      121 gagccagagt ccggcagtgg ccagttgagg ttggggtcac caactagcga gtctggcttg
      181 aggatggcgg aagcagggcc ccctccagca aggttccctc cagcaaggct ccctccagca
      241 gggtcctctc gggctgggct ccctccaaca gggtcccctc ccgcttccac tccggccctg
      301 gcctcgcagt ggctggcggt caagcgtttg cctagggctg ccgccaaggc gcccaatctc
      361 cagctgaatc aggaccactg ttctttcgtg ccgttcacgc aggcggtccc ggtgcaggtg
      421 gacatggcca tggccctgca tcgcgttagg atcgcggaga agtacgggaa gaactacctc
      481 tgcttgctgc aggcagtctt cctagcagaa actgggctgc tcctccagtt aaaggacatc
      541 aatcatttcc taatgcaaga cattgctttc ctgtctggtg gccggggaaa ggacaatgct
      601 tggatcatta catttccaga aaactgtaac ttcagatgca taccagagga agtaattgca
      661 aaagtgctca attacttgac atctattgca aggcaaagtg gatctgactc ccgatttact
      721 attattctag atcgaagact ggatacatgg gcttccctca aaatttccct ccagaaaatc
      781 tcagcctcct tccctgggag cttacactta gtcctggttt tgcgtcctac cagttttctt
      841 caacggactt tcacggacat tggatttcga tttagccagg aggattttat gctgaaatta
      901 ccagttgtta tgctgagctc agttagtgat ttgctgacat acattgatga caagcagtta
      961 acccctgagt taggcggcac cttgcagtac tgccacagtg aatggatcat cttcagaaat
     1021 gccatagaga agtttgctgt cacagtgaaa gaaatggctc agatgttgca atcctttgga
     1081 acagaattgg ctgaaacaga gctaccacag gatatccttt caatagaaga gattctggca
     1141 ggtcgagccg aaaggtatca cctgttgaag aatgacttaa ctgctgtaac caaagaagga
     1201 aaagttctgc tcatgaacct gcaagtgcct gccactgaag aaactgtcag ttcaagcctt
     1261 gaatgtactc agcacataaa tggcgactgg caaactatta aaaagttgct ggctcaggtg
     1321 catgatatgg aaactgcttt tgatggattt tgggaaaaac atcagctgaa aatggagcag
     1381 tatctgcaac tgtggaagtt tgaacaagac tttcaagagg ctgtgactca agttgaattt
     1441 ttattaagtc aacaaagaga actgggtgat ataacaggga acttagctca agtaaaacaa
     1501 agacttaaaa aactagagat cttagatgat aaatctcagg aactgttaac caaggcccgg
     1561 attgtgatac tacgtggcca caagctggca tcgaatcacc actatgcact tgatttaatt
     1621 tgccagcgat gcaatgaact acgctacctt tctgatattt tagttaatga gatcagaaca
     1681 aagcgggtcc aactgagcag gactttcaaa gtgcatagac tcttacagca ggcacgtcag
     1741 tgctgtgatc aaggggaatg cctcctggct agccaaggaa tggataagtt tcagactaaa
     1801 gaagatgctc agaaagccct tcaggatgtg gacaatttcc ttcaaatggc catgcctttc
     1861 atcaattatg atatcgaaag cctgcaatat gaatttgatg tactcctatc tcctgaactc
     1921 aaggctcaaa tgcagaatat acaactaaag cttgaaaata ttcgaagtgc atttcagaac
     1981 caacaggctg gttgtaagag cctaaaagaa gtacccgagg gggcgttcca gaacttggtt
     2041 cctgcatctg aaaatgtgat gcggtccaga atgatattct tttcaccgaa acatgtgaaa
     2101 aagtcttgga gacagattca cgctcagagc aatgtgaaag ttgaagccgt tgaggatagc
     2161 caagagaaga attctgatca gtctcccaaa ttggacaata gcttggatat tttaaagaac
     2221 catgtcctaa atgagctgat acagacagag agagcatatg ttcgagagct gtttactgtt
     2281 ttgttgggct acagatctga gatggacaat ccacagatgt ttgatcttat gccacctctc
     2341 ctgagaaata aaaaggatgt tctctttgga aatatggcag aaatatacga attccataac
     2401 aacattttca tgagcagact ggaagattgc tctgatgctc cagaaagagt gggaccttgc
     2461 ttcctggaaa ggaaggatga ttttcagatg tatgccaaat attgtcagaa taaacccagg
     2521 tcagagttaa tttggaggaa gtattctgaa tgtgcctttt tccaggaatg tcaacgaaaa
     2581 ttgaaacatc gacttggtct ggattcctat ttgctcaaac ctgttcaacg aatcactaag
     2641 tatcagttgc ttttaaagga gcttttaaag tatagcaaag aaggtgaagg aactactaaa
     2701 ttaaaggagg cacttgactc aatgctggag ctgctgaagt cagtgaatga ctccatgcat
     2761 cagactgcca tcaatggcta tgttggaaat ataaatgagc tgggcaagat ggttcttcaa
     2821 ggttccttca atgtttggct aggacaccgg aaaggtgcta caaaaatgaa ggattttgca
     2881 cgtttcaaac ccatgcagag acatcttttc ttatatgaaa aagctgttat gttttgtaag
     2941 aggcgtttcg aatctggaga aggtgctgat agatacccat catacagttt taagcactgc
     3001 ctaaaaatgg aagatgttgg catcacagaa catgtgaaag gtgataaccg caaatttgaa
     3061 atacggtata gtgagaagga agaaatttac attgttcagg ctccaaatgt tgatgtgaag
     3121 atgttatggc taaaagaaat aagaaaaatt ttggtgcagc agaaggaact tatgactgct
     3181 aaaacccagc aggatcaggc actagaccag gaccaacttt tcccccagca gcagaatgcc
     3241 gagctatgca aaagctcacc tttttgtgtg tgtgaggaaa ctcttttcaa cgccacagaa
     3301 gcaggagcag aagtggagca agctggtgcc ctgataaagg tcagggaggc agctgtgcta
     3361 gctcaagcag aggcaagttc agcagcttgg aatgggatgt taccatctgc agaaggcgct
     3421 gctgcaattg ctgaacattc atacaattat ttctcctcta acaatgacca tggagaagat
     3481 aggacacaaa tgagacacat gtcggaggtg acattctagt tgtaaagaag ccacagtgtc
     3541 atctggcaag ttgctctgcc tgcctgcttc tcagcccatg tggaaaaaaa aaaacacccc
     3601 tcaaaggaat ttcagcccaa atgatgggat ttccgcgccc cccccccagg ttaatatatt
     3661 taaacatgca caaaaccaac ggcatatact tctttctttc actttttatt ccttaaattg
     3721 catacgtgtg taagtcattg tgccggataa aatcaatctc atctcagaat atttttgact
     3781 tgaaaattgt ttcttctctg tctactttgc aaccaaatgc aatcagtgtg ccttgaatta
     3841 tttagcttat tattaattaa gttaaactag ggctgtagaa tagttaaggc caagtgaagc
     3901 acaacgctat gatttaaagc gctttttaga cccagcgctc ctttaaccca tgcaagacaa
     3961 tggtggagtt cagaagtcct gggggtgggg gtccttagta aattctattc agggctattg
     4021 ccttttctat gtgccaagat gaacttttcc tgagagtagt ttacaaattg catttaaaat
     4081 gtaatatttt catgcttgtt tctttttctg gatttatgct tataattcat gtagcaaatt
     4141 agttgtgctc tattatcttc tgtacatttc atgctgtaat catttttttt ccaaataaaa
     4201 atgaaaactt caggttccac aaattga
//
