LOCUS       NM_030026               2146 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
            (Mccc2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_030026 XM_127493 XM_619146
VERSION     NM_030026.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Baumer,D., Lee,S., Nicholson,G., Davies,J.L., Parkinson,N.J.,
            Murray,L.M., Gillingwater,T.H., Ansorge,O., Davies,K.E. and
            Talbot,K.
  TITLE     Alternative splicing events are a late feature of pathology in a
            mouse model of spinal muscular atrophy
  JOURNAL   PLoS Genet 5 (12), e1000773 (2009)
   PUBMED   20019802
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Gallardo,M.E., Desviat,L.R., Rodriguez,J.M., Esparza-Gordillo,J.,
            Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P., Criado,O., Sanz,R.,
            Morton,D.H., Gibson,K.M., Le,T.P., Ribes,A., de Cordoba,S.R.,
            Ugarte,M. and Penalva,M.A.
  TITLE     The molecular basis of 3-methylcrotonylglycinuria, a disorder of
            leucine catabolism
  JOURNAL   Am J Hum Genet 68 (2), 334-346 (2001)
   PUBMED   11170888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237319.1, AK145564.1 and BC058987.1.
            
            On Oct 26, 2006 this sequence version replaced NM_030026.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143233.1, AK132265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY237319.1         1-49
            50-2015             AK145564.1         2-1967
            2016-2146           BC058987.1         1030-1160
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 52.9 cM"
     gene            1..2146
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /note="methylcrotonoyl-Coenzyme A carboxylase 2 (beta)"
                     /db_xref="GeneID:78038"
                     /db_xref="MGI:MGI:1925288"
     exon            1..254
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1817
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /EC_number="6.4.1.4"
                     /note="MCCase subunit beta; 3-methylcrotonyl-CoA
                     carboxylase 2; 3-methylcrotonyl-CoA:carbon dioxide ligase
                     subunit beta; 3-methylcrotonyl-CoA carboxylase
                     non-biotin-containing subunit"
                     /codon_start=1
                     /product="methylcrotonoyl-CoA carboxylase beta chain,
                     mitochondrial"
                     /protein_id="NP_084302.1"
                     /db_xref="CCDS:CCDS36764.1"
                     /db_xref="GeneID:78038"
                     /db_xref="MGI:MGI:1925288"
                     /translation="MWGALRSALRPCCRAAVPPQRAYHGDSVARLGTQPDSASSTYQE
                     NYEQMKALVSQLHERAQYVRLGGSEKARARHTSRGKLLPRDRIDNLIDPGSPFLEFSQ
                     FAGYQLYGDEEVPAGGIITGIGRVSGVECMIVANDATVKGGTYYPVTVKKHVRAQEIA
                     LQNRLPCIYLVDSGGANLPRQADTFPDRDHFGRIFYNQAIMSSKNITQIAVVMGSCTA
                     GGAYVPAMADENIIVQKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVTDHY
                     ALDDHHALHLTRKVVRSLNYQKKMDVTIEPSEEPLFPADELYGIVGANLKRSFDVREV
                     IARIVDGSRFNEFKALYGDTLVTGFARIFGYPVGIIGNNGVLFSESAKKGAHFVQLCC
                     QRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVAAVACAKVPKITVIIGGSYGAGNY
                     GMCGRAYSPRFLYMWPNARISVMGGEQAATVLATVARDQKAREGKQFSSAEEAALKEP
                     IIKRFEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIQRTDFGIFRM"
     exon            255..321
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            322..406
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            407..508
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            509..636
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            637..749
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            750..863
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            864..928
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1028
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1124
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1197
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1274
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1341
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1498
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1613
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1699
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..2124
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /note="hexamer: AATAAA"
     polyA_site      2124
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /note="major polyA site"
ORIGIN      
        1 ggggctggcc tgggagctga tggaccaggg ctggtgctgc aaggactctg gaggagcagc
       61 ccccaggagc tgcagaaccg agctgcaggg ccgctctctt tctcttttgg gtgtttgcca
      121 tcgccatgtg gggcgcgctg aggtcagctc tgcgaccgtg ctgtcgggct gctgtacccc
      181 cgcagcgtgc ctatcacggg gactcagtgg cccgactggg cacccagcct gactcggcct
      241 cctccaccta ccaggagaac tatgagcaga tgaaagcttt agtgagtcaa cttcatgagc
      301 gagcccagta tgtgagacta ggagggagtg agaaggcccg ggcgcggcac acatccagag
      361 gaaaactgct ccccagagac agaatcgaca atctcataga cccagggtct ccctttctgg
      421 aattctccca gtttgcaggt taccagttat atggcgacga ggaagtcccc gccggtggca
      481 tcatcacggg cattgggcga gtgtcggggg tagaatgcat gattgtggct aacgatgcca
      541 ccgtcaaagg aggcacctac tacccagtga ctgtgaaaaa gcacgtgcgg gcacaagaga
      601 ttgcgctgca gaaccgactc ccatgcatct atctggttga ctcaggaggg gccaacttac
      661 ctcggcaagc agacaccttt ccagaccggg accactttgg ccgcatattc tataatcagg
      721 caattatgtc ttctaaaaac atcacacaga tagctgtggt catgggctcc tgtacggcag
      781 gaggtgcgta tgtgcctgca atggctgatg aaaacatcat tgtacagaag cagggtacca
      841 tcttcttggc tggaccaccc ttggtgaagg cagctacagg tgaagaggtg tccgctgagg
      901 atctcggagg tgccgacctg cattgcagaa agtctggggt cactgaccac tatgctttgg
      961 acgaccacca cgccctccac ttaacaagga aggttgtgag gagtctcaat tatcagaaga
     1021 aaatggatgt taccattgag ccttctgagg agcccttgtt ccctgcagat gagctctatg
     1081 gaatagttgg tgcaaacctg aagaggagct ttgatgtccg agaggtcatt gctagaatcg
     1141 tggatggaag cagattcaat gagttcaagg ccttatatgg agacacccta gttacaggat
     1201 ttgctcgaat atttgggtac cccgttggca tcattggaaa caatggagtt ttgttttctg
     1261 aatctgctaa gaagggtgct cacttcgtcc agctgtgctg ccagagaaat atccctctgc
     1321 tgtttcttca gaatatcacc ggattcatgg ttggcagaga ctatgaagct gaagggattg
     1381 ccaaggatgg tgccaaaatg gtagctgcag tagcctgtgc caaagtgcct aagataactg
     1441 tcataattgg gggatcgtac ggggctggaa actacggaat gtgtggcaga gcatacagtc
     1501 caaggtttct ctacatgtgg ccaaatgccc gcatctctgt gatgggagga gagcaggcag
     1561 ccacggtgtt agccacagtg gctagagacc agaaagcacg cgaggggaag cagttctcca
     1621 gtgcagagga ggcagctttg aaagaaccca tcattaagag gttcgaagag gaagggaacc
     1681 cttactactc tagtgcaagg ctgtgggacg atgggattat tgacccggtg gacaccaggc
     1741 tggtcctggg gctcagcctc agtgcagccc tcaatgcgcc catccagagg actgactttg
     1801 gcatcttcag gatgtaaccc agatatggaa catgctgcca cacccgtaac aagaattagc
     1861 gcgtgtaact agccttgaaa cttgagattt actggacatg tagctgtcac aggaattctt
     1921 ttcttaacag tatgatttgt taaaactgtg aaaatcagtg actagtctgc ctgatgagct
     1981 ttgacttttt ttttaaaaaa aaattttttt cttacagaca tttttcacgg ctcattttta
     2041 ccacccataa aatgaagaga gcgattttgc aattatcctt tgagtaccac aaacagtatg
     2101 aaaaataaat ctctttaatc tgtaaaaaaa aaaaaaaaaa aaaaaa
//
