LOCUS       NP_084302                563 aa            linear   ROD 28-APR-2025
DEFINITION  methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [Mus
            musculus].
ACCESSION   NP_084302 XP_127493 XP_619146
VERSION     NP_084302.1
DBSOURCE    REFSEQ: accession NM_030026.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 563)
  AUTHORS   Baumer,D., Lee,S., Nicholson,G., Davies,J.L., Parkinson,N.J.,
            Murray,L.M., Gillingwater,T.H., Ansorge,O., Davies,K.E. and
            Talbot,K.
  TITLE     Alternative splicing events are a late feature of pathology in a
            mouse model of spinal muscular atrophy
  JOURNAL   PLoS Genet 5 (12), e1000773 (2009)
   PUBMED   20019802
REFERENCE   3  (residues 1 to 563)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (residues 1 to 563)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (residues 1 to 563)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   6  (residues 1 to 563)
  AUTHORS   Gallardo,M.E., Desviat,L.R., Rodriguez,J.M., Esparza-Gordillo,J.,
            Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P., Criado,O., Sanz,R.,
            Morton,D.H., Gibson,K.M., Le,T.P., Ribes,A., de Cordoba,S.R.,
            Ugarte,M. and Penalva,M.A.
  TITLE     The molecular basis of 3-methylcrotonylglycinuria, a disorder of
            leucine catabolism
  JOURNAL   Am J Hum Genet 68 (2), 334-346 (2001)
   PUBMED   11170888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237319.1, AK145564.1 and BC058987.1.
            
            On or before Aug 20, 2005 this sequence version replaced
            XP_127493.5, XP_619146.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143233.1, AK132265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 52.9 cM"
     Protein         1..563
                     /product="methylcrotonoyl-CoA carboxylase beta chain,
                     mitochondrial"
                     /EC_number="6.4.1.4"
                     /note="MCCase subunit beta; 3-methylcrotonyl-CoA
                     carboxylase 2; 3-methylcrotonyl-CoA:carbon dioxide ligase
                     subunit beta; 3-methylcrotonyl-CoA carboxylase
                     non-biotin-containing subunit"
                     /calculated_mol_wt=58986
     transit_peptide 1..22
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q3ULD5.1)"
                     /calculated_mol_wt=2411
     Region          8..563
                     /region_name="Carboxyl_trans"
                     /note="Carboxyl transferase domain; cl47203"
                     /db_xref="CDD:481543"
     mat_peptide     23..563
                     /product="Methylcrotonoyl-CoA carboxylase beta chain,
                     mitochondrial. /id=PRO_0000284068"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ULD5.1)"
                     /calculated_mol_wt=58986
     Region          49..555
                     /region_name="Carboxyltransferase.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01138"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ULD5.1)"
     Site            70
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q3ULD5.1)"
     Region          343..372
                     /region_name="Acyl-CoA binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ULD5.1)"
     Site            495
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q3ULD5.1)"
     Site            511
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q3ULD5.1)"
     CDS             1..563
                     /gene="Mccc2"
                     /gene_synonym="4930552N12Rik; MCCB"
                     /coded_by="NM_030026.2:126..1817"
                     /db_xref="CCDS:CCDS36764.1"
                     /db_xref="GeneID:78038"
                     /db_xref="MGI:MGI:1925288"
ORIGIN      
        1 mwgalrsalr pccraavppq rayhgdsvar lgtqpdsass tyqenyeqmk alvsqlhera
       61 qyvrlggsek ararhtsrgk llprdridnl idpgspflef sqfagyqlyg deevpaggii
      121 tgigrvsgve cmivandatv kggtyypvtv kkhvraqeia lqnrlpciyl vdsgganlpr
      181 qadtfpdrdh fgrifynqai mssknitqia vvmgsctagg ayvpamaden iivqkqgtif
      241 lagpplvkaa tgeevsaedl ggadlhcrks gvtdhyaldd hhalhltrkv vrslnyqkkm
      301 dvtiepseep lfpadelygi vganlkrsfd vreviarivd gsrfnefkal ygdtlvtgfa
      361 rifgypvgii gnngvlfses akkgahfvql ccqrnipllf lqnitgfmvg rdyeaegiak
      421 dgakmvaava cakvpkitvi iggsygagny gmcgrayspr flymwpnari svmggeqaat
      481 vlatvardqk aregkqfssa eeaalkepii krfeeegnpy yssarlwddg iidpvdtrlv
      541 lglslsaaln apiqrtdfgi frm
//
