LOCUS       NM_023644               2992 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
            (Mccc1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_023644 XM_913175
VERSION     NM_023644.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2992)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   2  (bases 1 to 2992)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 2992)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   4  (bases 1 to 2992)
  AUTHORS   Obata,K., Fukuda,T., Morishita,R., Abe,S., Asakawa,S.,
            Yamaguchi,S., Yoshino,M., Ihara,K., Murayama,K., Shigemoto,K.,
            Shimizu,N. and Kondo,I.
  TITLE     Human biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase
            gene (MCCA): cDNA sequence, genomic organization, localization to
            chromosomal band 3q27, and expression
  JOURNAL   Genomics 72 (2), 145-152 (2001)
   PUBMED   11401427
REFERENCE   5  (bases 1 to 2992)
  AUTHORS   Baumgartner,M.R., Almashanu,S., Suormala,T., Obie,C., Cole,R.N.,
            Packman,S., Baumgartner,E.R. and Valle,D.
  TITLE     The molecular basis of human 3-methylcrotonyl-CoA carboxylase
            deficiency
  JOURNAL   J Clin Invest 107 (4), 495-504 (2001)
   PUBMED   11181649
REFERENCE   6  (bases 1 to 2992)
  AUTHORS   Gallardo,M.E., Desviat,L.R., Rodriguez,J.M., Esparza-Gordillo,J.,
            Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P., Criado,O., Sanz,R.,
            Morton,D.H., Gibson,K.M., Le,T.P., Ribes,A., de Cordoba,S.R.,
            Ugarte,M. and Penalva,M.A.
  TITLE     The molecular basis of 3-methylcrotonylglycinuria, a disorder of
            leucine catabolism
  JOURNAL   Am J Hum Genet 68 (2), 334-346 (2001)
   PUBMED   11170888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY139695.1, AK031072.1, AK032203.1 and AA198778.1.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_023644.5.
            
            On Apr 25, 2008 this sequence version replaced NM_023644.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF310338.1, AK031072.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY139695.1         2-41
            41-2449             AK031072.1         2-2410
            2450-2976           AK032203.1         2409-2935
            2977-2992           AA198778.1         489-504
FEATURES             Location/Qualifiers
     source          1..2992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.41 cM"
     gene            1..2992
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /note="methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)"
                     /db_xref="GeneID:72039"
                     /db_xref="MGI:MGI:1919289"
     exon            1..198
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2275
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /EC_number="6.4.1.4"
                     /note="3-methylcrotonyl-CoA carboxylase biotin-containing
                     subunit; MCCase subunit alpha; 3-methylcrotonyl-CoA
                     carboxylase 1; 3-methylcrotonyl-CoA:carbon dioxide ligase
                     subunit alpha"
                     /codon_start=1
                     /product="methylcrotonoyl-CoA carboxylase subunit alpha,
                     mitochondrial"
                     /protein_id="NP_076133.3"
                     /db_xref="CCDS:CCDS17307.1"
                     /db_xref="GeneID:72039"
                     /db_xref="MGI:MGI:1919289"
                     /translation="MAAAALLAAVDRNQLRRVPILLLQPREWAWKLRTMKYGTTPGGS
                     ITKVLIANRGEIACRVIRTAKKMGVQSVAVYSEADRNSMHVDMADEAYSIGPAPSQQS
                     YLAMEKIIQVAKSSAAQAIHPGYGFLSENMEFAELCKQEGIIFIGPPSSAIRDMGIKS
                     TSKSIMAAAGVPVVEGYHGKDQSDQCLREHAGKIGYPVMIKAVRGGGGKGMRIVRSER
                     EFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQR
                     RHQKIIEEAPAPGINPEVRRKLGEAAVRAAKAVKYVGAGTVEFIMDSRHNFYFMEMNT
                     RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIPLQGHAFEARIYAEDPDNNFM
                     PGAGPLVHLSTPSADMSTRIETGVRQGDEVSVHYDPMIAKLVVWASDRQSALSKLRYC
                     LHQYNIVGLRSNVDFLLRLSGHPEFEAGNVHTDFIPQHHKDLLPSHSTIAKESVCQAA
                     LGLILKEKEMTSAFKLHTQDQFSPFSFSSGRRLNISYTRNMTLRSGKSDIVIAVTYNR
                     DGSYDMQIDNKSFRVLGDLSSEDGCTYLKSSINGVARKSKFILLDNTVHLFSMEGSIE
                     VGIPVPKYLSPVSAEGAQGGTIAPMTGTIEKVFVKAGDRVKAGDSLMVMIAMKMEHTI
                     KAPKDGRIKKVFFSEGAQANRHAPLVEFEEEESDK"
     exon            199..245
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            246..382
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            383..478
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            479..600
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            601..748
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            749..870
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            871..982
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1064
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1192
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1376
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1486
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1703
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1790
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1840
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1978
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2086
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2158
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2992
                     /gene="Mccc1"
                     /gene_synonym="1810045E08Rik; 2310058B18Rik; Mcca;
                     MCCalpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacgcct acttgctctt cggagctacg gtggcggatc ggggacaaga agcttgcgca
       61 gggagggacg ctttcaagaa taagccaagc agcttttgga atccagcaga acagcgcgga
      121 gatggcggcg gcggcgttgt tggctgcggt ggacaggaac cagttgcgac gggtcccgat
      181 cctgctgctg cagccgaggg aatgggcttg gaagttgaga accatgaagt atggaacaac
      241 cccaggagga agtattacca aggtcctcat tgcaaacaga ggagaaattg cctgcagggt
      301 gatacgaaca gccaaaaaga tgggtgtgca gtcggtggct gtgtacagtg aggccgaccg
      361 gaattccatg catgtagata tggcagacga ggcatattcc attggccctg ctccatctca
      421 gcagagctac ctcgcaatgg agaaaatcat tcaagtggcc aagagctctg cagcacaggc
      481 catccatcca ggctacggtt ttctttcgga aaacatggag tttgctgaac tttgtaagca
      541 agagggaatc atttttatag gtcctccttc gtctgcaatt agagacatgg gtataaagag
      601 cacgtccaag tccatcatgg ctgctgctgg agttcctgtt gtggaaggtt accatggcaa
      661 ggaccagtct gatcagtgcc tgagagagca tgctgggaaa atcgggtatc ctgttatgat
      721 caaagcagtc cgtggtggag gaggaaaagg catgaggatc gttagatcag agagagaatt
      781 ccaagagcag ttagagtcag cccggaggga ggcgaagaag tctttcaatg atgatgcaat
      841 gttgatcgag aagttcgtgg acactccaag gcatgtagaa gtccaggtgt ttggtgatca
      901 ccatggcaac gcagtgtact tgtttgaaag agactgtagt gtgcagaggc gacatcagaa
      961 gatcattgag gaggccccag cgcctggtat taatcctgaa gtaagaagaa agctgggaga
     1021 ggctgcagtc agagctgcga aggctgtcaa gtacgtggga gcaggaactg tggaattcat
     1081 tatggactca aggcacaatt tttatttcat ggagatgaac accaggctac aagtggaaca
     1141 tcctgtcact gaaatgatca cagggactga cttggtggag tggcaactca ggattgcagc
     1201 aggagagaag attcctttga gccaggaaga aatccctctg cagggccatg cctttgaggc
     1261 tagaatctat gcagaagacc ctgacaataa cttcatgcca ggggctggac cgttggttca
     1321 tctctctacc ccttcggcag acatgtctac gaggattgaa actggagtcc ggcaaggaga
     1381 tgaagtctcg gtgcattacg atcccatgat cgcaaagctc gttgtgtggg cctcagaccg
     1441 ccagtcagcc ctgtcgaagc tgaggtactg ccttcatcag tacaacattg tcggcttgcg
     1501 cagcaacgtg gacttcctgc tccggctctc cggccaccca gagtttgagg ctgggaacgt
     1561 gcacacggac ttcatccctc agcaccacaa ggacctgctg ccgagtcaca gcactatagc
     1621 caaagagtct gtgtgccagg cagctctggg gctcatcctc aaagagaaag aaatgaccag
     1681 cgcttttaaa ctccacactc aagatcaatt ctctccgttt tcattcagca gtgggagaag
     1741 actgaatatc tcttacacca ggaacatgac tctgagaagt ggtaaaagtg atatagtcat
     1801 agctgtgacg tataaccgcg atgggtcata tgatatgcag attgacaaca agtccttccg
     1861 agtcctgggc gatctttcca gtgaagatgg ctgtacctac ctgaagtctt ctattaatgg
     1921 ggtagcccgt aaatccaagt tcatcctcct ggacaacact gtccacctgt tttctatgga
     1981 aggcagtatt gaagttggca ttccagtgcc caagtacttg tctccagtga gtgcagaagg
     2041 agctcagggg ggcaccatcg cgcccatgac tggaaccatt gaaaaggtgt ttgtgaaagc
     2101 tggagacaga gtaaaagctg gagactctct gatggttatg attgccatga agatggagca
     2161 taccataaag gctccaaagg atggcaggat aaagaaggta ttcttcagtg aaggagccca
     2221 agccaacaga catgcacctt tagtggaatt tgaggaggag gagtctgaca aatgagaatc
     2281 gcagtgaact gtgtccagaa agaaatagac gaccgcatag cgccttatct gtctgcgaac
     2341 agcaagtgcc tcttcagtct ctagatctcg gagagaggag ctttattaaa tcaatgatgg
     2401 tgtgattata tttaaaccct tttataaatt atcttaaaag atttcataga aataagactg
     2461 agctgtagtt tttttttttt ttaatttgga aactaatatt ttctttaaat catatatgtt
     2521 gtactcttag taataaggca gggagtagct tgatcaaaac agaagaggaa tagtcctgta
     2581 ggtgagtggc tttgtagtta cccctgatgg caatacagtg acatgcttca gaggcacgtg
     2641 tcacagagct aaactcagcc aacagtaacg tcatcaagca ggacacgagt gttacttgtc
     2701 tcttgtcctt gtgtttggaa agcttctctc taggtccctc tgcctttgtt gtgcttgtgg
     2761 gggtctcagg gagccctgag tggtgttgac tcagtgtgtg ctgttgacat ggccacagcc
     2821 atatccagga cctcacttca ccttagatcc ctgccccaat ggcaaaggct ctttctctcc
     2881 tcttcccctt gccaagatct ccttggggag gtgggaggct cagagaaact ttgggaaagc
     2941 cttcctctgt ttcatgtcca gatactggta ttgtgtgaaa aaaaaaaaaa aa
//
