LOCUS       NM_023061               2892 bp    mRNA    linear   ROD 12-FEB-2023
DEFINITION  Mus musculus melanoma cell adhesion molecule (Mcam), transcript
            variant 1, mRNA.
ACCESSION   NM_023061
VERSION     NM_023061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Wang W, Tang X, Duan C, Tian S, Han C, Qian W, Jiang X, Hou X and
            Lin R.
  TITLE     Intestinal epithelium-specific Fut2 deficiency promotes colorectal
            cancer through down-regulating fucosylation of MCAM
  JOURNAL   J Transl Med 21 (1), 82 (2023)
   PUBMED   36739428
  REMARK    GeneRIF: Intestinal epithelium-specific Fut2 deficiency promotes
            colorectal cancer through down-regulating fucosylation of MCAM.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   Vieira JR, Shah B, Dupraz S, Paredes I, Himmels P, Schermann G,
            Adler H, Motta A, Gartner L, Navarro-Aragall A, Ioannou E, Dyukova
            E, Bonnavion R, Fischer A, Bonanomi D, Bradke F, Ruhrberg C and
            Ruiz de Almodovar C.
  TITLE     Endothelial PlexinD1 signaling instructs spinal cord
            vascularization and motor neuron development
  JOURNAL   Neuron 110 (24), 4074-4089 (2022)
   PUBMED   36549270
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Bhalla P, Du Q, Kumar A, Xing C, Moses A, Dozmorov I, Wysocki CA,
            Cleaver OB, Pirolli TJ, Markert ML, de la Morena MT, Baldini A and
            van Oers NS.
  TITLE     Mesenchymal cell replacement corrects thymic hypoplasia in murine
            models of 22q11.2 deletion syndrome
  JOURNAL   J Clin Invest 132 (22), e160101 (2022)
   PUBMED   36136514
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Zhang ZY, Zhai C, Yang XY, Li HB, Wu LL and Li L.
  TITLE     Knockdown of CD146 promotes endothelial-to-mesenchymal transition
            via Wnt/beta-catenin pathway
  JOURNAL   PLoS One 17 (8), e0273542 (2022)
   PUBMED   36001597
  REMARK    GeneRIF: Knockdown of CD146 promotes endothelial-to-mesenchymal
            transition via Wnt/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Sa da Bandeira D, Kilpatrick AM, Marques M, Gomez-Salazar M,
            Ventura T, Gonzalez ZN, Stefancova D, Rossi F, Vermeren M, Vink CS,
            Beltran M, Henderson NC, Jung B, van der Linden R, van de Werken
            HJG, van Ijcken WFJ, Betsholtz C, Forbes SJ, Cuervo H and Crisan M.
  TITLE     PDGFRbeta+ cells play a dual role as hematopoietic precursors and
            niche cells during mouse ontogeny
  JOURNAL   Cell Rep 40 (3), 111114 (2022)
   PUBMED   35858557
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco
            G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T,
            Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T,
            Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ,
            Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A,
            Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso
            J, Hide W and Ko MS.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Tsukamoto Y, Sakaiuchi T, Hiroi S, Furuya M, Tsuchiya S, Sasaki F,
            Miki N and Taira E.
  TITLE     Expression of gicerin enhances the invasive and metastatic
            activities of a mouse mammary carcinoma cell line
  JOURNAL   Int J Oncol 23 (6), 1671-1677 (2003)
   PUBMED   14612940
  REMARK    GeneRIF: gicerin is an effector for the malignant progression of
            mammary carcinoma
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Kameya S, Hawes NL, Chang B, Heckenlively JR, Naggert JK and
            Nishina PM.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Alais S, Allioli N, Pujades C, Duband JL, Vainio O, Imhof BA and
            Dunon D.
  TITLE     HEMCAM/CD146 downregulates cell surface expression of beta1
            integrins
  JOURNAL   J Cell Sci 114 (Pt 10), 1847-1859 (2001)
   PUBMED   11329371
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Yang H, Wang S, Liu Z, Wu MH, McAlpine B, Ansel J, Armstrong C and
            Wu G.
  TITLE     Isolation and characterization of mouse MUC18 cDNA gene, and
            correlation of MUC18 expression in mouse melanoma cell lines with
            metastatic ability
  JOURNAL   Gene 265 (1-2), 133-145 (2001)
   PUBMED   11255016
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045252.1, CN699979.1, BQ178999.1, CJ133016.1, DT921196.1,
            BU516594.1, BF658183.1 and CJ237857.1.
            
            [WARNING] On May 16, 2023 this sequence was replaced by
            NM_023061.3.
            
            On Nov 15, 2007 this sequence version replaced NM_023061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026985.1, AB035508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               CJ045252.1         3-148
            147-678             CN699979.1         93-624
            679-1078            BQ178999.1         277-676
            1079-1367           CJ133016.1         158-446
            1368-1873           DT921196.1         21-526
            1874-2140           BU516594.1         468-734
            2141-2470           BF658183.1         126-455
            2471-2892           CJ237857.1         70-491
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..2892
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /note="melanoma cell adhesion molecule"
                     /db_xref="GeneID:84004"
                     /db_xref="MGI:MGI:1933966"
     exon            1..99
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1979
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; l-gicerin protein; cell surface glycoprotein
                     MUC18; melanoma adhesion molecule; melanoma-associated
                     antigen MUC18"
                     /codon_start=1
                     /product="cell surface glycoprotein MUC18 isoform 1
                     precursor"
                     /protein_id="NP_075548.2"
                     /db_xref="CCDS:CCDS23097.1"
                     /db_xref="GeneID:84004"
                     /db_xref="MGI:MGI:1933966"
                     /translation="MGLPKLVCVFLFAACCCCRRAAGVPGEEKQPVPTPDLVEAEVGS
                     TALLKCGPSRASGNFSQVDWFLIHKERQILIFRVHQGKGQREPGEYEHRLSLQDSVAT
                     LALSHVTPHDERMFLCKSKRPRLQDHYVELQVFKAPEEPTIQANVVGIHVDRQELREV
                     ATCVGRNGYPIPQVLWYKNSLPLQEEENRVHIQSSQIVESSGLYTLKSVLSARLVKED
                     KDAQFYCELSYRLPSGNHMKESKEVTVPVFYPAEKVWVEVEPVGLLKEGDHVTIRCLT
                     DGNPQPHFTINKKDPSTGEMEEESTDENGLLSLEPAEKHHSGLYQCQSLDLETTITLS
                     SDPLELLVNYVSDVQVNPTAPEVQEGESLTLTCEAESNQDLEFEWLRDKTGQLLGKGP
                     VLQLNNVRREAGGRYLCMASVPRVPGLNRTQLVSVGIFGSPWMALKERKVWVQENAVL
                     NLSCEASGHPQPTISWNVNGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLG
                     SNTTTIVLKLVTLTTLIPDSSQTTGLSTLTVSPHTRANSTSTEKKLPQPESKGVVIVA
                     VIVCTLVLAVLGAALYFFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMA
                     LLQGSNGDKRAPGDQGEKYIDLRH"
     exon            100..230
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            231..438
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            439..509
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            510..597
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            598..777
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            778..899
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1062
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1181
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1323
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1445
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1587
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1683
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1831
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1949
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2892
                     /gene="Mcam"
                     /gene_synonym="1-gicerin; CD146; CD149; Muc18; s-endo;
                     s-gicerin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcacttggc tcgcgccctc cgtcggggaa gcatggggct gcccaaactg gtgtgcgtct
       61 tcttgttcgc tgcctgctgc tgctgtcgcc gtgccgcggg tgtgccagga gaggaaaagc
      121 agccagtacc cacgcccgac ctggtggagg cagaagtggg cagcacagcc cttctcaagt
      181 gtggcccctc acgggcctca ggcaacttca gccaagtgga ctggtttttg attcacaagg
      241 agaggcagat actgattttc cgtgtgcacc aaggcaaggg ccagcgggaa cctggtgaat
      301 atgagcaccg ccttagcctc caagactcgg tggctactct ggccctgagt cacgtcactc
      361 cccatgatga gcgaatgttc ctgtgtaaga gcaagcgacc acggctccag gatcactacg
      421 ttgagcttca ggtcttcaaa gccccagagg aaccaactat tcaagccaat gtcgtgggca
      481 tccatgtgga caggcaagag ctcagggagg ttgctacctg tgtggggaga aacggctacc
      541 ccattcctca agtcctatgg tacaagaaca gtctgccctt gcaagaggag gagaaccgag
      601 ttcatatcca gtcatcacag attgtcgagt ccagtggctt gtacaccttg aagagtgttc
      661 tgagtgcacg cctagttaag gaagacaaag atgcccagtt ttactgtgaa ctcagctacc
      721 ggctacccag tgggaaccac atgaaggaat ctaaggaggt cactgtccct gttttctacc
      781 ctgcagaaaa agtgtgggtg gaggtagagc ctgtggggct gctgaaggaa ggggatcatg
      841 tgacaatcag gtgtctgaca gatggcaacc ctcaacccca cttcactatc aacaagaagg
      901 accccagcac tggggagatg gaagaggaga gcaccgatga aaatgggctc ctgtccttgg
      961 agcctgccga aaagcaccat agcgggctct accagtgtca gagtctggac ctggaaacta
     1021 ccatcacact gtcaagtgac cccctggagc tgctggtgaa ctatgtgtct gatgttcaag
     1081 tgaatccaac tgcccctgaa gtccaggaag gtgagagcct cacgctgacc tgcgaggcag
     1141 aaagtaacca ggaccttgag tttgagtggc tgagagacaa gacaggccag ctgctgggaa
     1201 agggtcccgt cctccagcta aacaacgtga gacgggaagc agggggacgg tatctctgca
     1261 tggcatctgt ccccagagtt cctggcttga atcgtaccca gctggtcagc gtgggcattt
     1321 ttgggtcccc atggatggca ttaaaggaga ggaaggtgtg ggtgcaagag aatgcagtgc
     1381 tgaatctgtc ttgtgaggct tcaggacatc ctcagcccac catctcctgg aatgtcaatg
     1441 gttcggcaac tgaatggaac ccagatccac agacagtagt gagcaccttg aatgtccttg
     1501 tgacgccaga gcttctggag acaggtgcag agtgtacagc ctccaactcc ctgggctcaa
     1561 acaccaccac cattgttctg aagctggtca ctttaaccac cctcatacct gactccagcc
     1621 aaaccactgg cctcagcacc ctcacagtca gtcctcacac cagagccaac agcacctcca
     1681 cagagaaaaa gctgccacag ccagagagca aaggtgtggt catcgtggct gtgatagtgt
     1741 gtaccttggt gcttgctgtg ctgggtgctg ctctctattt cttctacaag aagggcaagc
     1801 tgccatgtgg acgctcggga aaacaggaga tcacgctgcc cccgactcgt aagagtgaat
     1861 ttgtagttga agttaagtca gataagctcc cagaagagat ggctctcctt cagggcagca
     1921 acggtgacaa gagggctcca ggagaccagg gagagaaata catcgatctg aggcattaga
     1981 tggctcccat tgcactgctc gcagctccct gctcagactt caccccaagc tgaagcctcc
     2041 agagggacag cagggacgag ccacactcaa ccccccccct gcacatcagg tctgagagct
     2101 aggagctggg acaggagtcg tctgcaggag ctcagttggc tacagaggcc tggttttaga
     2161 gaccaagccc tcctctgtgt ccagtaaata atgcttatcc caaggggccc gtctcccagg
     2221 gcatttcccc ctcccgtgca cagccattgg tggcaaatcc ttctgccatc agctgtgtgg
     2281 gcttgcctct ttgagctcat ctcccctcac aggctgtctt catgatgcag gacctgggca
     2341 catggtcaca ttattccgtt cacattggtc cttgtgagaa cctcacagtc tggaggcggc
     2401 tgcttttgta ccttcctgcc tgctactaat tcagggtctc atttggaaca tttttccttt
     2461 gggtagtggt caggaactgg tgtaagtcct ccagacacat ccctgtgtaa ggaagccagg
     2521 cactgtttct ctgagttttg ttgttttgtt ttctttgaag gctactgagc ccaagcttcc
     2581 cgcattccct tagtaacaag agacaggaca gagagaaggt ctactgttca tggggattag
     2641 gcttatagga atgttagtac caaatttcta catgtgagct ttgggggcca ggtcctagag
     2701 agcccaagtg ggagaatggt atttaggaga tgaaaaacct ggcctagcaa gagcttttga
     2761 ggtgtgtgtg tgtgtgtgtg tatacatata tgtgtgtata tatatatata tatatatggt
     2821 tttgtctgta aatttgcaaa tttttccttt tatatgtgtg ttagaaaaat aaagtgttat
     2881 tgttccaaaa gc
//
