LOCUS       NM_013596               3989 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus melanocortin 5 receptor (Mc5r), mRNA.
ACCESSION   NM_013596
VERSION     NM_013596.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Chen,N., Quan,Y., Chen,M., Lu,Y., Yang,L., Wang,S., Chen,F., Xu,Y.,
            Shen,M., Zeng,H., Chen,S., Wang,F., Wang,J. and Hu,M.
  TITLE     Melanocortin/MC5R axis regulates the proliferation of hematopoietic
            stem cells in mice after ionizing radiation injury
  JOURNAL   Blood Adv 7 (13), 3199-3212 (2023)
   PUBMED   36920787
  REMARK    GeneRIF: Melanocortin/MC5R axis regulates the proliferation of
            hematopoietic stem cells in mice after ionizing radiation injury.
REFERENCE   3  (bases 1 to 3989)
  AUTHORS   Ng,T.F., Manhapra,A., Cluckey,D., Choe,Y., Vajram,S. and
            Taylor,A.W.
  TITLE     Melanocortin 5 Receptor Expression and Recovery of Ocular Immune
            Privilege after Uveitis
  JOURNAL   Ocul Immunol Inflamm 30 (4), 876-886 (2022)
   PUBMED   33617397
  REMARK    GeneRIF: Melanocortin 5 Receptor Expression and Recovery of Ocular
            Immune Privilege after Uveitis.
REFERENCE   4  (bases 1 to 3989)
  AUTHORS   Muhammad,F., Trivett,A., Wang,D. and Lee,D.J.
  TITLE     Tissue-specific production of MicroRNA-155 inhibits melanocortin 5
            receptor-dependent suppressor macrophages to promote experimental
            autoimmune uveitis
  JOURNAL   Eur J Immunol 49 (11), 2074-2082 (2019)
   PUBMED   31177529
  REMARK    GeneRIF: Tissue-specific production of MiR-155 inhibits
            Mc5R-dependent suppressor macrophages to promote experimental
            autoimmune uveitis.
REFERENCE   5  (bases 1 to 3989)
  AUTHORS   Muhammad,F.Y., Peters,K., Wang,D. and Lee,D.J.
  TITLE     Exacerbation of autoimmune uveitis by obesity occurs through the
            melanocortin 5 receptor
  JOURNAL   J Leukoc Biol 106 (4), 879-887 (2019)
   PUBMED   31287586
  REMARK    GeneRIF: This report demonstrates that obesity exacerbates
            autoimmune uveitis and inhibits the promotion of post-experimental
            autoimmune uveitis regulatory immunity through the melanocortin 5
            receptor.
REFERENCE   6  (bases 1 to 3989)
  AUTHORS   Chen,W., Kelly,M.A., Opitz-Araya,X., Thomas,R.E., Low,M.J. and
            Cone,R.D.
  TITLE     Exocrine gland dysfunction in MC5-R-deficient mice: evidence for
            coordinated regulation of exocrine gland function by melanocortin
            peptides
  JOURNAL   Cell 91 (6), 789-798 (1997)
   PUBMED   9413988
REFERENCE   7  (bases 1 to 3989)
  AUTHORS   Schioth,H.B., Muceniece,R., Szardenings,M., Prusis,P. and
            Wikberg,J.E.
  TITLE     Evidence indicating that the TM4, EL2, and TM5 of the melanocortin
            3 receptor Do not participate in ligand binding
  JOURNAL   Biochem Biophys Res Commun 229 (3), 687-692 (1996)
   PUBMED   8954958
REFERENCE   8  (bases 1 to 3989)
  AUTHORS   Fathi,Z., Iben,L.G. and Parker,E.M.
  TITLE     Cloning, expression, and tissue distribution of a fifth
            melanocortin receptor subtype
  JOURNAL   Neurochem Res 20 (1), 107-113 (1995)
   PUBMED   7739752
REFERENCE   9  (bases 1 to 3989)
  AUTHORS   Gantz,I., Shimoto,Y., Konda,Y., Miwa,H., Dickinson,C.J. and
            Yamada,T.
  TITLE     Molecular cloning, expression, and characterization of a fifth
            melanocortin receptor
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1214-1220 (1994)
   PUBMED   8185570
REFERENCE   10 (bases 1 to 3989)
  AUTHORS   Labbe,O., Desarnaud,F., Eggerickx,D., Vassart,G. and Parmentier,M.
  TITLE     Molecular cloning of a mouse melanocortin 5 receptor gene widely
            expressed in peripheral tissues
  JOURNAL   Biochemistry 33 (15), 4543-4549 (1994)
   PUBMED   8161509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111069.9.
            
            On May 31, 2019 this sequence version replaced NM_013596.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100720.1, U08354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC111069.9         115065-115279
            216-3989            AC111069.9         116227-120000
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 41.46 cM"
     gene            1..3989
                     /gene="Mc5r"
                     /note="melanocortin 5 receptor"
                     /db_xref="GeneID:17203"
                     /db_xref="MGI:MGI:99420"
     exon            1..215
                     /gene="Mc5r"
                     /inference="alignment:Splign:2.1.0"
     exon            216..3989
                     /gene="Mc5r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc5r"
                     /note="hexamer: ATTAAA"
     polyA_site      1249
                     /gene="Mc5r"
     regulatory      3965..3970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc5r"
                     /note="hexamer: AATAAA"
     polyA_site      3989
                     /gene="Mc5r"
                     /note="major polyA site"
ORIGIN      
        1 aggtcgggag gagactgcgc cctggcaatg gccctactct ctcgccgagg tccgcctagg
       61 tggacatcag gtgcccaggc agagcgaagc gtccagtgag ggctcctggc tcggatgcaa
      121 gaccagagcc cggtaaacag aagattcaac tcccagaaac cgcctggaac ccgtgaagaa
      181 tcatgcttac ctttgcgcgg agcagagcag aatggtaaat ccgatgccaa gaagtggggg
      241 cattctcttc cagcaatgaa ctcctcctcc accctgactg tattgaatct taccctgaac
      301 gcctcagagg atggcatttt aggatcaaat gtcaagaaca agtctttggc ctgtgaagaa
      361 atgggcattg ccgtggaggt gttcctgacc ctgggtctcg tcagcctctt agagaacatc
      421 ctggtcattg gggccatagt aaagaacaaa aacctgcact cacccatgta cttctttgtg
      481 ggcagcttag ccgtggccga catgctggtg agcatgtcca atgcctggga gactgtcacc
      541 atatacttgc taaataataa acacctggtg atagccgaca cctttgtgcg acacatcgac
      601 aacgtgttcg actccatgat ctgcatctct gtggtggcct cgatgtgcag tttgctggcc
      661 attgcggtgg acaggtacat caccatcttc tatgccttgc gctaccacca catcatgacc
      721 gcgaggcgct cgggggtgat catcgcctgc atctggacct tctgcataag ctgcggcatt
      781 gttttcatca tctactatga gtccaagtat gtgatcattt gcctcatctc catgttcttc
      841 accatgctgt tcttcatggt gtctctgtat atacacatgt tcctcctggc ccggaaccat
      901 gtcaagcgga tagcagcttc ccccagatac aactccgtga ggcaaaggac cagcatgaag
      961 ggggctatta ccctcaccat gctactgggg attttcattg tctgctggtc tcccttcttt
     1021 cttcacctta tcttaatgat ctcctgccct cagaacgtct actgctcttg ctttatgtct
     1081 tacttcaaca tgtaccttat actcatcatg tgcaactccg tgatcgatcc tctcatctac
     1141 gccctccgca gccaagagat gcggaggacc tttaaggaga tcgtctgttg tcacggattc
     1201 cggcgacctt gtaggctcct tggcgggtat taaacgcctt cctctctcag tggctctcgt
     1261 ctctcagtca attaggttca gccaaggcat gagcaaggct gctaaggctc tcagatgtat
     1321 tgttcctcgc cccctttgca gctccgtttg gttattgtgt gtccgaggta tgcacatgtg
     1381 aattgtctcc gtggtggaaa tggtctgtga caatttgtgt gtttttttaa attattatta
     1441 ttattttctt attccttgct cactctctgc tccccattcc atttttagga ggtttcacca
     1501 tgctctgcct gacttggtaa gtgacctgag gagatgcata atctcctggg tgagctgtca
     1561 ttgtacaaac cactgtggaa gcttatatca ccatgagtgg cttttgtgtt tggtttagct
     1621 ttctccatgc tgctgtccat gtttgcagga tgcacctttt acattctttt caggaatgga
     1681 gagacatccg gctccttctt atttgagaat tccattattt tttatttttt tactacagtt
     1741 cccctatcct agacttctgg ccctatggct tgcattcaga attgtctggg ggggaccaac
     1801 tttaactact taaactcctg tccttcatag ttttggactt actcagacat agaacttcta
     1861 tgctaaacac cttgcttcgt gttttgtgaa aacctccatg cctctcgctg tctttttttt
     1921 tttttttttt tttttttgac tcaattcagt gtttccaaga aatttggggg cggtcacatg
     1981 gcgactctag gtacaaactc gccctcactc catttagcat gtgccaccca gagtcaaact
     2041 agaatggctt tctcacacat aatcatttat cagttcttgg tgtctgaaaa gtccacattg
     2101 gatgctttga agcatcttaa cctgccccta gcaacctgcc cctagcaacc tgcccctagc
     2161 aaccatcaaa ggcccggtcc acagcaaaga caagccattt tctccagtct ggagtagagg
     2221 aaagggacga aagctcaagc accaaccctg acactggctg tgtgcctttc cctcctcccc
     2281 aggctccacc tctgtgctga cctctcagaa tggccaaaaa aaaaaaaaaa aaaaaaaaac
     2341 tacctgaaaa aaaaaaaagg agaacttctt gtaaaatttg aaaaacatac aggatgggtt
     2401 ttgtttgttt gtttgtttgt ttttgttatt taaaagaact atttcacatg ggtgggatca
     2461 cacatgaagg aagggtacag gtgtcagtgg ccagagcagt gttttggatg ccaagagact
     2521 tgctgtgctc aacagagcca cgtggccctc tggatcccag cgaagatcat agggttagaa
     2581 taagacattg atcttggtgg tcacactgct tgtccagaca cccagctatc tatcacgagt
     2641 cttaattctc tgctctgggt gctaaaatga cttgctacaa atcctgacct ttattttaag
     2701 gtatttaaga acacgcttga cggcatttta atctctatgt aaacaaaatc gcccttgtgt
     2761 tccagtgctg ttatttttgg gatcttcatc tgaagcaaag ggtacgagtc cctccagctc
     2821 acaggttcgg tttcgcagta atatgctgga attagtgttt tctctgtggt tggatacttg
     2881 acatctaggc tgcttccaaa tgaaagagaa atgtaaataa ggcagcggac atacaggtca
     2941 tcccacagtg aactgtgggt gtaagagggg tcctgtctac agaagattgg aagagcagaa
     3001 ggactttcta tagtatggtg tcataattag cttatgagaa tgatctcttt agaagctcag
     3061 caaagaaaaa caaaaacaaa aaccatagtg ctggtgttaa cagtaaggtg aatgagatgt
     3121 ccaaatcttt acaaagtgga aaacaagcag attgtttgca actgatttgc aaagagcctc
     3181 taacctttca aaatgtttcc tgttcatagc tgctgaatat tcacacgcag gaagtaaaag
     3241 ttctcattgt agccattata ggaagccgag ttcacattgt agccattata ggaatccgag
     3301 tccactgtca cagtggatgt gactgggata tggggtgtct gaggcttcct ctcctctgta
     3361 cagagcaagc gcttgcggtg tttgtaattt ccaagttgaa ttttctgcct agagtccttg
     3421 agtaatctta agcaaagtga ctctagtcct gatcacaggg gaagaataag acattgatgt
     3481 tggtggtcac actgcttgtc tggacaccca actgtcacta gtctgattct cttctctggg
     3541 tgcttaaatg acttactaca attaaggtat ttaagaacag gctcaactgc attttaatct
     3601 ctatgtaaac aatatagccc aactgttgtg ttcaactgtt gttgtgtttg ggaaaatata
     3661 tgcctgtagt aacttgttac atttatgaaa ataagccaac ctcaaaatga agtcccctta
     3721 acaagaacaa aaaagaatac acatgcttgc caaacatgtg gcattgtatg ttagttttct
     3781 gttggaaatg catttgcatg aaggtccctt agcaaaagaa tagacatgca tgtgaaacat
     3841 gtgacattgt atgttaactt tatgtctctg tgggaaacgt atttgctgta aaatatgtgt
     3901 ccaaagaaat tgttagtaaa gtagaaggat gattcaattt gtactaataa acatgtatat
     3961 aattaataaa atggatggac taaactata
//
