LOCUS       NM_016977               2783 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus melanocortin 4 receptor (Mc4r), mRNA.
ACCESSION   NM_016977
VERSION     NM_016977.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Moya-Garzon,M.D., Wang,M., Li,V.L., Lyu,X., Wei,W., Tung,A.S.,
            Raun,S.H., Zhao,M., Coassolo,L., Islam,H., Oliveira,B., Dai,Y.,
            Spaas,J., Delgado-Gonzalez,A., Donoso,K., Alvarez-Buylla,A.,
            Franco-Montalban,F., Letian,A., Ward,C.P., Liu,L., Svensson,K.J.,
            Goldberg,E.L., Gardner,C.D., Little,J.P., Banik,S.M., Xu,Y. and
            Long,J.Z.
  TITLE     A beta-hydroxybutyrate shunt pathway generates anti-obesity ketone
            metabolites
  JOURNAL   Cell 188 (1), 175-186 (2025)
   PUBMED   39536746
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Rajput,M., Malik,I.A., Methi,A., Cortes Silva,J.A., Fey,D.,
            Wirths,O., Fischer,A., Wilting,J. and von Arnim,C.A.F.
  TITLE     Cognitive decline and neuroinflammation in a mouse model of
            obesity: An accelerating role of ageing
  JOURNAL   Brain Behav Immun 125, 226-239 (2024)
   PUBMED   39730092
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Koyama,K., Sakamaki,A., Morita,S., Nagayama,I., Kudo,M., Tanaka,Y.,
            Kimura,N., Arao,Y., Abe,H., Kamimura,K. and Terai,S.
  TITLE     Maid gene dysfunction promotes hyperobesity via the reduction of
            adipose tissue inflammation in Mc4r gene-deficient mice
  JOURNAL   Sci Rep 14 (1), 21126 (2024)
   PUBMED   39256539
  REMARK    GeneRIF: Maid gene dysfunction promotes hyperobesity via the
            reduction of adipose tissue inflammation in Mc4r gene-deficient
            mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Wei,W., Lyu,X., Markhard,A.L., Fu,S., Mardjuki,R.E., Cavanagh,P.E.,
            Zeng,X., Rajniak,J., Lu,N., Xiao,S., Zhao,M., Moya-Garzon,M.D.,
            Truong,S.D., Chou,J.C., Wat,L.W., Chidambaranathan-Reghupaty,S.,
            Coassolo,L., Xu,D., Shen,F., Huang,W., Ramirez,C.B., Jang,C.,
            Li,L., Svensson,K.J., Fischbach,M.A. and Long,J.Z.
  TITLE     PTER is a N-acetyltaurine hydrolase that regulates feeding and
            obesity
  JOURNAL   Nature 633 (8028), 182-188 (2024)
   PUBMED   39112712
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Petersen,J., Ludwig,M.Q., Juozaityte,V., Ranea-Robles,P.,
            Svendsen,C., Hwang,E., Kristensen,A.W., Fadahunsi,N., Lund,J.,
            Breum,A.W., Mathiesen,C.V., Sachs,L., Moreno-Justicia,R.,
            Rohlfs,R., Ford,J.C., Douros,J.D., Finan,B., Portillo,B., Grose,K.,
            Petersen,J.E., Trauelsen,M., Feuchtinger,A., DiMarchi,R.D.,
            Schwartz,T.W., Deshmukh,A.S., Thomsen,M.B., Kohlmeier,K.A.,
            Williams,K.W., Pers,T.H., Frolund,B., Stromgaard,K., Klein,A.B. and
            Clemmensen,C.
  TITLE     GLP-1-directed NMDA receptor antagonism for obesity treatment
  JOURNAL   Nature 629 (8014), 1133-1141 (2024)
   PUBMED   38750368
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Lu,D., Willard,D., Patel,I.R., Kadwell,S., Overton,L., Kost,T.,
            Luther,M., Chen,W., Woychik,R.P., Wilkison,W.O. et al.
  TITLE     Agouti protein is an antagonist of the
            melanocyte-stimulating-hormone receptor
  JOURNAL   Nature 371 (6500), 799-802 (1994)
   PUBMED   7935841
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Mountjoy,K.G., Mortrud,M.T., Low,M.J., Simerly,R.B. and Cone,R.D.
  TITLE     Localization of the melanocortin-4 receptor (MC4-R) in
            neuroendocrine and autonomic control circuits in the brain
  JOURNAL   Mol Endocrinol 8 (10), 1298-1308 (1994)
   PUBMED   7854347
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Magenis,R.E., Smith,L., Nadeau,J.H., Johnson,K.R., Mountjoy,K.G.
            and Cone,R.D.
  TITLE     Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin
            receptors in the mouse and human
  JOURNAL   Mamm Genome 5 (8), 503-508 (1994)
   PUBMED   7949735
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Gantz,I., Shimoto,Y., Konda,Y., Miwa,H., Dickinson,C.J. and
            Yamada,T.
  TITLE     Molecular cloning, expression, and characterization of a fifth
            melanocortin receptor
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1214-1220 (1994)
   PUBMED   8185570
REFERENCE   10 (bases 1 to 2783)
  AUTHORS   Gantz,I., Miwa,H., Konda,Y., Shimoto,Y., Tashiro,T., Watson,S.J.,
            DelValle,J. and Yamada,T.
  TITLE     Molecular cloning, expression, and gene localization of a fourth
            melanocortin receptor
  JOURNAL   J Biol Chem 268 (20), 15174-15179 (1993)
   PUBMED   8392067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB633776.1, AK136793.1 and
            BY646801.1.
            
            On Dec 21, 2012 this sequence version replaced NM_016977.3.
            
            Summary: This gene encodes a member of the melanocortin receptor
            family. Melanocortin receptors are transmembrane G-protein coupled
            receptors, which respond to small peptide hormones and exhibit
            diverse functions and tissue type localization. As part of the
            central nervous melanocortin system, the encoded protein is
            competitively bound by either melanocyte stimulating hormone or
            agouti-related protein to regulate energy homeostasis. Disruption
            of this gene promotes hyperphagia and obesity, and is associated
            with increased cholesterol levels and insulin resistance. [provided
            by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK136793.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BB633776.1         1-15
            16-2780             AK136793.1         2-2766
            2781-2783           BY646801.1         401-403
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.72 cM"
     gene            1..2783
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
                     /note="melanocortin 4 receptor"
                     /db_xref="GeneID:17202"
                     /db_xref="MGI:MGI:99457"
     exon            1..2783
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1446
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
                     /codon_start=1
                     /product="melanocortin receptor 4"
                     /protein_id="NP_058673.2"
                     /db_xref="CCDS:CCDS29316.1"
                     /db_xref="GeneID:17202"
                     /db_xref="MGI:MGI:99457"
                     /translation="MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQL
                     FVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETI
                     VITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI
                     MTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLM
                     ARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPY
                     CVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
                     /note="hexamer: ATTAAA"
     polyA_site      1739
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
                     /note="major polyA site"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
                     /note="hexamer: AATAAA"
     polyA_site      1969
                     /gene="Mc4r"
                     /gene_synonym="Mc4-r; Pkcp"
ORIGIN      
        1 ccgcactagg ctgctctggc tcacaaagat gctcaggaag ctgaacttct gagaggctgc
       61 ggtgtgagtg tgggcgcgca gatgcagacg cggctcccag cagtacagcg agtctcaggg
      121 aaaaggactc tgaaaagacc ccgagtgaat actaaagtga aagccgcact gagagagaga
      181 gaaaaaaaag caaacagcag actggtcaac cgagaatgag cattcagaag caccagcttc
      241 taaagagacg atgatctgag ccgaacccag aagagaccaa caactccttt gcgagttccg
      301 ctgcttctga ccctgctcct agcaggcgcc aagcgcagcc tcccaacttc tacaggcata
      361 cagactggga gagaatcact cggagcttcc ctgacccagg aggttggatc agttcaagga
      421 ggactcaaat ccagctgctg caggaagatg aactccaccc accaccatgg catgtatact
      481 tccctccacc tctggaaccg cagcagctac gggctgcacg gcaatgccag cgagtcgctg
      541 gggaagggcc acccggacgg aggatgctat gagcaacttt ttgtttcccc cgaggtgttt
      601 gtgactctgg gtgtcataag cctgttggag aacattctag tgatcgtggc gatagccaag
      661 aacaagaacc tgcactcacc catgtacttt ttcatctgta gcctggctgt ggcagatatg
      721 ctggtgagcg tttcgaatgg gtcggaaacc atcgtcatta ccctgttaaa cagtacggat
      781 acggatgccc agagcttcac cgtgaacatt gataatgtca ttgactctgt gatctgtagc
      841 tccttgctcg catccatttg cagcctgctt tccattgcgg tggacaggta tttcactatc
      901 ttttacgcgc tccagtacca taacatcatg acggttaggc gggtcgggat catcataagt
      961 tgtatctggg cagcttgcac tgtgtcaggc gtcctcttca tcatttactc ggacagcagc
     1021 gctgtcatca tctgcctcat ttccatgttc ttcactatgc tagttctcat ggcctctctc
     1081 tatgtccaca tgttcctgat ggcgaggctt cacattaaga ggattgctgt cctcccaggc
     1141 acagggacca tccgccaggg taccaacatg aagggggcga ttaccttgac catcctgatt
     1201 ggagtctttg ttgtctgctg ggccccgttc tttctccatt tactgttcta catctcttgc
     1261 cctcagaatc catactgcgt gtgcttcatg tctcatttta atttgtatct catactgatc
     1321 atgtgtaacg ccgtcatcga ccctctcatt tatgccctcc ggagtcaaga actgaggaaa
     1381 actttcaaag agatcatctg tttctatcct ctgggaggca tctgtgagtt gtctagcagg
     1441 tattaagtgg gggacagagt gcaaactagg tagatacctg cagactttgt cactctggcc
     1501 cgatctgagc agtgtacttc ccaacagctg cctcttctgt gtaatgcttt ggttgaaaat
     1561 atctactgta taaatgtaag tttgtgactt ttgacatgga aaaaaaagtc tcaacgtgtt
     1621 atgtttattg acacgctatt ttttttgttt gtaaaatgct tatttatgtt ctatatagtg
     1681 tgggcgttat gaattgacat gaaagaaaaa cagacaccct tattaaaact ttgacagtgt
     1741 ttctttcctg ttatttatca aggttccaca cttgttcttt ctgtagtggc cgaaatcaga
     1801 accttattaa acgtgttctc agctgttctc atgtattagc cccacagtac tgcagaggca
     1861 ctgaccccac tgtttatggg gaaatattta aacactacat gcttgatcat taaaatgagt
     1921 cagctctctt agtgaaattt cgagcaatcg aataaaagct tgcctattat ccttgctgtc
     1981 caaatacact gatgcttctt tttaagtaaa ggaaagagaa agggggaaga agcagctact
     2041 gaggagaaag tgagatttct gtcacatgca tttctccaag aaggaatggt tcattgcccg
     2101 agactcagag ttcacacagg caagtcagct gtggtagggg aaatgcccac ttaatagatt
     2161 aaagatatta taatagataa taatagataa aatagattaa tagataaaat agataccaat
     2221 cttaatagat taaagtgtcc tgttaaatat aaactgtcca caccatgctg aaatttccta
     2281 tgccaaatga taccccacca taacagaatg atttctttct ggcttcttac cagggatctg
     2341 gttcctacag aaaggtctag aacagctccc tctgcactta gaggtccagc gttcatttca
     2401 tcttagagtt aatagtgagt tgtgctatct ttcatgtggc gggggacttg ttgttcactt
     2461 tctgattact ttttgagctg gaatataagt gctgaagatc aagtgattta attcccaagc
     2521 caaatccaca tcacaaaaca ttttgggaca gggtttgtaa atatctaaag tgtggagccc
     2581 tgtggtgctt gcacataacg agatggaaag agaacacaaa tggggtcctg gaaggtacag
     2641 taaaacaccc tgctgttctt agtcatgtct tgggatgggg aatgcttgtt ttctccaaac
     2701 taataccaaa ggtgtggcca ctgagcaacc aaatctatgc tttctagtct gtgtatactt
     2761 tgaaataaaa gggataaaaa tct
//
