LOCUS       NM_008561               2623 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus melanocortin 3 receptor (Mc3r), mRNA.
ACCESSION   NM_008561
VERSION     NM_008561.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Gui,Y., Dahir,N.S., Wu,Y., Downing,G., Sweeney,P. and Cone,R.D.
  TITLE     Melanocortin-3 receptor expression in AgRP neurons is required for
            normal activation of the neurons in response to energy deficiency
  JOURNAL   Cell Rep 42 (10), 113188 (2023)
   PUBMED   37792535
  REMARK    GeneRIF: Melanocortin-3 receptor expression in AgRP neurons is
            required for normal activation of the neurons in response to energy
            deficiency.
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Cho,D., O'Berry,K., Possa-Paranhos,I.C., Butts,J., Palanikumar,N.
            and Sweeney,P.
  TITLE     Paraventricular Thalamic MC3R Circuits Link Energy Homeostasis with
            Anxiety-Related Behavior
  JOURNAL   J Neurosci 43 (36), 6280-6296 (2023)
   PUBMED   37591737
  REMARK    GeneRIF: Paraventricular Thalamic MC3R Circuits Link Energy
            Homeostasis with Anxiety-Related Behavior.
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Bedenbaugh,M.N., Brener,S.C., Maldonado,J., Lippert,R.N.,
            Sweeney,P., Cone,R.D. and Simerly,R.B.
  TITLE     Organization of neural systems expressing melanocortin-3 receptors
            in the mouse brain: Evidence for sexual dimorphism
  JOURNAL   J Comp Neurol 530 (16), 2835-2851 (2022)
   PUBMED   35770983
  REMARK    GeneRIF: Organization of neural systems expressing melanocortin-3
            receptors in the mouse brain: Evidence for sexual dimorphism.
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Vagena,E., Crneta,J., Engstrom,P., He,L., Yulyaningsih,E.,
            Korpel,N.L., Cheang,R.T., Bachor,T.P., Huang,A., Michel,G.,
            Attal,K., Berrios,D.I., Valdearcos,M., Koliwad,S.K., Olson,D.P.,
            Yi,C.X. and Xu,A.W.
  TITLE     ASB4 modulates central melanocortinergic neurons and calcitonin
            signaling to control satiety and glucose homeostasis
  JOURNAL   Sci Signal 15 (733), eabj8204 (2022)
   PUBMED   35536884
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Malas,S., Peters,J. and Abbott,C.
  TITLE     The genes for endothelin 3, vitamin D 24-hydroxylase, and
            melanocortin 3 receptor map to distal mouse chromosome 2, in the
            region of conserved synteny with human chromosome 20
  JOURNAL   Mamm Genome 5 (9), 577-579 (1994)
   PUBMED   8000144
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Magenis,R.E., Smith,L., Nadeau,J.H., Johnson,K.R., Mountjoy,K.G.
            and Cone,R.D.
  TITLE     Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin
            receptors in the mouse and human
  JOURNAL   Mamm Genome 5 (8), 503-508 (1994)
   PUBMED   7949735
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Gantz,I., Shimoto,Y., Konda,Y., Miwa,H., Dickinson,C.J. and
            Yamada,T.
  TITLE     Molecular cloning, expression, and characterization of a fifth
            melanocortin receptor
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1214-1220 (1994)
   PUBMED   8185570
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Desarnaud,F., Labbe,O., Eggerickx,D., Vassart,G. and Parmentier,M.
  TITLE     Molecular cloning, functional expression and pharmacological
            characterization of a mouse melanocortin receptor gene
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 367-373 (1994)
   PUBMED   8172596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK038677.1.
            
            On Apr 6, 2007 this sequence version replaced NM_008561.2.
            
            Summary: This gene encodes a member of the melanocortin receptor
            family. Melanocortin receptors are transmembrane G-protein coupled
            receptors, which respond to small peptide hormones and exhibit
            diverse functions and tissue type localization. As part of the
            central nervous melanocortin system, the encoded protein is
            competitively bound by either melanocyte stimulating hormone or
            agouti-related protein to regulate energy homeostasis and
            adaptation to food restriction. Disruption of this gene results in
            an increased ratio of weight gain to food intake, increased fat
            mass, and decreased lean mass, without having a large effect on
            insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK038677.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2623              AK038677.1         2-2624
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 94.8 cM"
     gene            1..2623
                     /gene="Mc3r"
                     /gene_synonym="MC3-R"
                     /note="melanocortin 3 receptor"
                     /db_xref="GeneID:17201"
                     /db_xref="MGI:MGI:96929"
     exon            1..2623
                     /gene="Mc3r"
                     /gene_synonym="MC3-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1340
                     /gene="Mc3r"
                     /gene_synonym="MC3-R"
                     /codon_start=1
                     /product="melanocortin receptor 3"
                     /protein_id="NP_032587.1"
                     /db_xref="CCDS:CCDS17127.1"
                     /db_xref="GeneID:17201"
                     /db_xref="MGI:MGI:96929"
                     /translation="MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEV
                     FLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVIN
                     SDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRK
                     ALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHV
                     QRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCIC
                     YTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc3r"
                     /gene_synonym="MC3-R"
                     /note="putative"
     polyA_site      2623
                     /gene="Mc3r"
                     /gene_synonym="MC3-R"
                     /note="putative"
ORIGIN      
        1 acatctagcg tcaagtccca caacccctgg ctcgctagaa gtagagctgt aactgtagca
       61 acgggtgtcg ggtggggatg agagaagact ggagagagag ggtcagagct agaggggatg
      121 aggcaggctg atcagactct gcactgattg ctggagaccg caaaggaaag ttctttctat
      181 gtctccaagc cccactccct ctctatctat ctatctatct atctatctat ctatctctcc
      241 ctctctggag aaactaaagt ctagactgga cagcatccac aagagaagca cctagaagga
      301 gaattttccc cagcagcttg ctcaggaccc tgcaggagcc gcagctggga ctggacctgc
      361 tgttaaccat gaactcttcc tgctgcctgt cttctgtttc tccgatgctg cctaacctct
      421 ctgagcaccc tgcagcccct cctgccagca accggagcgg cagtgggttc tgtgagcagg
      481 tcttcatcaa gccggaggtc ttcctggctc tgggcatcgt cagtctgatg gaaaacatcc
      541 tggtgatcct ggctgtggtc aggaatggca acctgcactc tcccatgtac ttcttcctgt
      601 gcagcctggc tgcagccgac atgctggtga gcctgtccaa ctccctggag accatcatga
      661 tcgccgtgat caacagcgac tccctgacct tggaggacca gtttatccag cacatggata
      721 atatcttcga ctctatgatt tgcatctccc tggtggcctc catctgcaac ctcctggcca
      781 ttgccatcga caggtacgtc accatcttct atgcccttcg gtaccacagc atcatgacag
      841 tgaggaaagc cctcaccttg atcggggtca tctgggtctg ctgcggcatc tgcggcgtga
      901 tgttcatcat ctactccgag agcaagatgg tcatcgtgtg tctcatcacc atgttcttcg
      961 ccatggtgct cctcatgggc accctatata tccacatgtt cctcttcgcc aggctccacg
     1021 tccagcgcat cgcagtgctg ccccctgctg gcgtggtggc cccacagcag cactcctgca
     1081 tgaagggggc tgtcaccatc actatcctgc tgggtgtttt catcttctgc tgggcgcctt
     1141 tcttcctcca cctggtcctc atcatcacct gccccaccaa tccctactgc atctgctaca
     1201 cggcccattt caacacctac ctggttctca tcatgtgcaa ctccgtcatc gaccccctca
     1261 tctacgcctt ccgcagcctg gagctgcgca acacgttcaa ggagattctc tgcggctgca
     1321 acagcatgaa cttgggctag gatgcccgtg gaggtgttcc acatccagcc aagagacaaa
     1381 aacaacgctc agacgggacg taaaagggtg ttaggagctg gaactgtgct tggcttcgtc
     1441 tgtaagctcg tggccctttg cagacgggac acggcgtagg atgggctgtc tgtgaggatc
     1501 tgtgtgtggg taagtcagtt tgatctagca catagcctgg aagaatcagg caaagcagcc
     1561 ctgagtgtca tctgtgttca ttgctaggca cccagggttt gtggcccctg cctgcttatt
     1621 ggctttgtac cagtaactgt gcttcaagcc aaccagaccg gagggctctc gtgagcagaa
     1681 agagtgctta gacttccggc aagcatcctg gctcacagcg gccacctcct gaccactacc
     1741 gggagagctt tgcacatatt ctgtgggaga ttgagtgaag ccctgaaaac aatgtgatat
     1801 ttgctgctcc cttccagaac ttacatctgt gccagcctcc ccgaacccct gcacagagac
     1861 atgaccccct tctccctgtg ccgttgtcat ggttgttatt attgttggag ttttgttcgt
     1921 taaaatctaa gcttcaaacc taatacatca aagcgctcta gtcagtgaga ggtcctagga
     1981 tcctggccac tgcaaggtag atgttactct ttaaagaaca aagcaagcaa gcaaacaaac
     2041 aaacaaaacg atggtcttct actgtttcgt ctctgccttt caaacgcgaa gaaagtgcag
     2101 gcaggaaggt gtgcgtttca ctagaaactg ccttgctgcc gttggtgatc atttgagcag
     2161 ctgggtctgc ctccttgttc tctccttact tactcccaag ctcctttccg gctcctggta
     2221 agtgcgttgt ctatcaaatg gttattttaa catcatttat aagagaggct gtcttggctg
     2281 ttgcttcttt tgctagatgc cgtgttaaag tcaaatgacc ctgtcggcaa cttctgtaac
     2341 cctgtcaagt aaagcagtca ctcccaccac tgcggggcaa gaagatgcac atacaggctt
     2401 gctgtataac accgctgtgt gctgctggca acagccagat cccttcttgc cctagacaac
     2461 ttcagctcgt gatatctccc tcggtctgtg ttctcctgct cttgaataca tgaggtggag
     2521 ggaccgtgct tgagtttctc ctgctagcat gatacagaca tcatttctct cttgctttaa
     2581 tcgtgatgct tgggagataa taaaggcttt ggtttcagtg acc
//
