LOCUS       NM_008560               1639 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus melanocortin 2 receptor (Mc2r), transcript variant 2,
            mRNA.
ACCESSION   NM_008560
VERSION     NM_008560.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Yadav,V.K., Berger,J.M., Singh,P., Nagarajan,P. and Karsenty,G.
  TITLE     Embryonic osteocalcin signaling determines lifelong adrenal
            steroidogenesis and homeostasis in the mouse
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34905510
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Novoselova,T.V., Hussain,M., King,P.J., Guasti,L., Metherell,L.A.,
            Charalambous,M., Clark,A.J.L. and Chan,L.F.
  TITLE     MRAP deficiency impairs adrenal progenitor cell differentiation and
            gland zonation
  JOURNAL   FASEB J 32 (11), fj201701274RR (2018)
   PUBMED   29879378
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Wang,C.M., Wang,R.X., Liu,R. and Yang,W.H.
  TITLE     Jun Dimerization Protein 2 Activates Mc2r Transcriptional Activity:
            Role of Phosphorylation and SUMOylation
  JOURNAL   Int J Mol Sci 18 (2), 304 (2017)
   PUBMED   28146118
  REMARK    GeneRIF: JDP2 acts as a novel transcriptional activator of the
            mouse Mc2r gene, suggesting that JDP2 may have physiological
            functions as a novel player in MC2R-mediated steroidogenesis as
            well as cell signaling in adrenal glands.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   Noon,L.A., Bakmanidis,A., Clark,A.J., O'Shaughnessy,P.J. and
            King,P.J.
  TITLE     Identification of a novel melanocortin 2 receptor splice variant in
            murine adipocytes: implications for post-transcriptional control of
            expression during adipogenesis
  JOURNAL   J Mol Endocrinol 37 (3), 415-420 (2006)
   PUBMED   17170082
  REMARK    GeneRIF: MC2-R gene is regulated both transcriptionally and
            post-transcriptionally during adipogenesis
REFERENCE   7  (bases 1 to 1639)
  AUTHORS   Allen,R.G., Carey,C., Parker,J.D., Mortrud,M.T., Mellon,S.H. and
            Low,M.J.
  TITLE     Targeted ablation of pituitary pre-proopiomelanocortin cells by
            herpes simplex virus-1 thymidine kinase differentially regulates
            mRNAs encoding the adrenocorticotropin receptor and aldosterone
            synthase in the mouse adrenal gland
  JOURNAL   Mol Endocrinol 9 (8), 1005-1016 (1995)
   PUBMED   7476975
REFERENCE   8  (bases 1 to 1639)
  AUTHORS   Cammas,F.M., Kapas,S., Barker,S. and Clark,A.J.
  TITLE     Cloning, characterization and expression of a functional mouse ACTH
            receptor
  JOURNAL   Biochem Biophys Res Commun 212 (3), 912-918 (1995)
   PUBMED   7626130
REFERENCE   9  (bases 1 to 1639)
  AUTHORS   Kubo,M., Ishizuka,T., Kijima,H., Kakinuma,M. and Koike,T.
  TITLE     Cloning of a mouse adrenocorticotropin receptor-encoding gene
  JOURNAL   Gene 153 (2), 279-280 (1995)
   PUBMED   7875603
REFERENCE   10 (bases 1 to 1639)
  AUTHORS   Schimmer,B.P., Kwan,W.K., Tsao,J. and Qiu,R.
  TITLE     ACTH-receptor deficient mutants of the Y1 mouse adrenocortical
            tumor cell line
  JOURNAL   Endocr Res 21 (1-2), 139-156 (1995)
   PUBMED   7588376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D85688.1, AK033100.1 and D85689.1.
            
            On Nov 9, 2012 this sequence version replaced NM_008560.2.
            
            Transcript Variant: This variant (2) lacks two internal exons in
            the 5' UTR, compared to variant 4. Variants 1, 2, 3 and 4 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033100.1, BB624152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                D85688.1           1-61
            62-1631             AK033100.1         1-1570
            1632-1639           D85689.1           427-434
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 41.89 cM"
     gene            1..1639
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /note="melanocortin 2 receptor"
                     /db_xref="GeneID:17200"
                     /db_xref="MGI:MGI:96928"
     exon            1..109
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            110..221
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            222..1639
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1208
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /note="ACTH receptor; melanocortin receptor 2;
                     adrenocorticotropin receptor"
                     /codon_start=1
                     /product="adrenocorticotropic hormone receptor"
                     /protein_id="NP_032586.1"
                     /db_xref="CCDS:CCDS29328.1"
                     /db_xref="GeneID:17200"
                     /db_xref="MGI:MGI:96928"
                     /translation="MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLI
                     VLLAVIKNKNLQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTA
                     DDIIDCMFILSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTG
                     SGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSHARKISTLPRTNMKGA
                     MTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIY
                     AFRSPELRDAFKRMLFCNRY"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /note="hexamer: AATAAA"
     polyA_site      1634
                     /gene="Mc2r"
                     /gene_synonym="ACTH-R; ACTHR; MC2-R"
                     /note="major polyA site"
ORIGIN      
        1 atgtatatgt tccggccttt cctgctccaa ggatcattta cttgctcttc ttaaaaactt
       61 attttttctc agtcatcttg ccgagaaaga tcctacttca gagctgaagc cagcaagcct
      121 gcctgtcaag cattagtgac aaagccaagg agaggagcat tattggaaaa gttctcagca
      181 ccacaaatga ttctgctgct tccaaggccc ttctaagcca gatccttcca cacaaagaaa
      241 acatactgca gaaacaatcg tgatttctgt aagtcaacgg caaacaccac ccccgtctta
      301 acggccagca ggaaaaaatg aagcatatta tcaattcgta tgaacacacc aatgacaccg
      361 caagaaataa ctccgattgt cctgatgtag ttttgccaga agagatattt ttcacaatct
      421 ctgtcattgg catattggag aacttgattg tcctcctggc tgtgatcaaa aataaaaatc
      481 tccagtcccc catgtatttt ttcatctgca gtttggccat ttctgacatg ttgggcagtc
      541 tgtataagat cttggaaaac atcctgatca tgttcagaaa catgggttat cttaagcctc
      601 gtggcagttt tgaaagcaca gcagatgaca tcattgactg catgttcatc ctctctttgc
      661 tgggctctat cttcagcctg tctgtcattg cagctgaccg ttacatcacc atcttccatg
      721 ccctgcaata ccatagcatt gtgaccatgc gccgcaccat catcacccta acaattatct
      781 ggatgttctg cacagggagc ggcatcacca tggtgatctt ctcccaccac atccccacag
      841 tgctcacctt cacatcgctg ttccctttga tgctggtttt tatcctgtgt ctctacatcc
      901 acatgttctt acttgcccgc tcccatgcta ggaagatctc tacccttcct agaaccaaca
      961 tgaagggtgc catgacacta accatccttc ttggagtctt catcttctgt tgggccccct
     1021 ttgtgctcca tgttctctta atgaccttct gcccaaataa cccttactgt gtttgctaca
     1081 tgtctctctt ccaggtcaat ggcatgttga tcatgtgcaa tgcagttatt gaccccttta
     1141 tatatgcctt tcggagccca gagctcagag atgcattcaa aaggatgctc ttctgcaacc
     1201 ggtattagta gaatttttga tccctgcttt gagtgttgta aagggaccaa ataacacatc
     1261 agtctgacat gtaccagtga ttcttctgac cagtagttca gtcccactga ctagtgttta
     1321 ccataactgc ctttcttatt cacagtctta ctgtacctgc atttttatat tgtatctaga
     1381 gagatgaaat gttgtgctaa acaggaaagt ttacaaagta cacatagcat acaaatgtga
     1441 ggactttggg ataaacaaat atttgttctt ctgtggatac ctgtgaaaac tgtcattggg
     1501 aggcctttcc aagcagaaag ccatggtaac caatactcta gaagttaaag tactttttgg
     1561 gcatctaact aactatatgt gttagtcata tttctatgta tgtagaaaat aaatgcaaac
     1621 aatcaacttt gaaagagga
//
