LOCUS       NM_008559               3645 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus melanocortin 1 receptor (Mc1r), mRNA.
ACCESSION   NM_008559
VERSION     NM_008559.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3645)
  AUTHORS   Thapa,K., Ghimire,B., Pokharel,K., Cai,M., Savontaus,E. and
            Rinne,P.
  TITLE     Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty
            acid metabolism and promotes adipocyte hypertrophy
  JOURNAL   Int J Obes (Lond) 48 (11), 1625-1637 (2024)
   PUBMED   39117851
  REMARK    GeneRIF: Hepatocyte-specific loss of melanocortin 1 receptor
            disturbs fatty acid metabolism and promotes adipocyte hypertrophy.
REFERENCE   2  (bases 1 to 3645)
  AUTHORS   Liu,Y., Liu,F., Li,Y., Li,Y., Feng,Y., Zhao,J., Zhou,C., Li,C.,
            Shen,J. and Zhang,Y.
  TITLE     LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote
            neuropathic pain by recruiting DHX30 in the trigeminal ganglion
  JOURNAL   J Headache Pain 25 (1), 28 (2024)
   PUBMED   38433184
  REMARK    GeneRIF: LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote
            neuropathic pain by recruiting DHX30 in the trigeminal ganglion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3645)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3645)
  AUTHORS   Srivastava,P., Nishiyama,S., Zhou,F., Lin,S.H., Srivastava,A.,
            Su,C., Xu,Y., Peng,W., Levy,M., Schwarzschild,M. and Chen,X.
  TITLE     Peripheral MC1R Activation Modulates Immune Responses and is
            Neuroprotective in a Mouse Model of Parkinson's Disease
  JOURNAL   J Neuroimmune Pharmacol 18 (4), 704-717 (2023)
   PUBMED   38110615
  REMARK    GeneRIF: Peripheral MC1R Activation Modulates Immune Responses and
            is Neuroprotective in a Mouse Model of Parkinson's Disease.
REFERENCE   5  (bases 1 to 3645)
  AUTHORS   Zakoh,K., Fujiwara,K., Takada,T., Osada,N. and Suzuki,H.
  TITLE     Genealogical characterization of regional populations and dorsal
            coat color variation in the house mouse Mus musculus from Asia
            based on haplotype structure analysis of a gene-rich region
            harboring Mc1r
  JOURNAL   Genes Genet Syst 98 (2), 73-87 (2023)
   PUBMED   37558462
  REMARK    GeneRIF: Genealogical characterization of regional populations and
            dorsal coat color variation in the house mouse Mus musculus from
            Asia based on haplotype structure analysis of a gene-rich region
            harboring Mc1r.
REFERENCE   6  (bases 1 to 3645)
  AUTHORS   Mountjoy,K.G., Robbins,L.S., Mortrud,M.T. and Cone,R.D.
  TITLE     The cloning of a family of genes that encode the melanocortin
            receptors
  JOURNAL   Science 257 (5074), 1248-1251 (1992)
   PUBMED   1325670
REFERENCE   7  (bases 1 to 3645)
  AUTHORS   Wolff,G.L., Galbraith,D.B., Domon,O.E. and Row,J.M.
  TITLE     Phaeomelanin synthesis and obesity in mice. Interaction of the
            viable yellow (Avy) and sombre (eso) mutations
  JOURNAL   J Hered 69 (5), 295-298 (1978)
   PUBMED   744871
REFERENCE   8  (bases 1 to 3645)
  AUTHORS   Lane,P.W., Beamer,T.C. and Myers,D.D.
  TITLE     Myodystrophy, a new myopathy on chromosome 8 of the mouse
  JOURNAL   J Hered 67 (3), 135-138 (1976)
   PUBMED   939913
REFERENCE   9  (bases 1 to 3645)
  AUTHORS   Poole,T.W. and Silvers,W.K.
  TITLE     An experimental analysis of the recessive yellow coat color mutant
            in the mouse
  JOURNAL   Dev Biol 48 (2), 377-381 (1976)
   PUBMED   767180
REFERENCE   10 (bases 1 to 3645)
  AUTHORS   Lamoreux,M.L. and Mayer,T.C.
  TITLE     Site of gene action in the development of hair pigment in recessive
            yellow (e/e) mice
  JOURNAL   Dev Biol 46 (1), 160-166 (1975)
   PUBMED   1098946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122266.2.
            
            On Feb 2, 2022 this sequence version replaced NM_008559.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK148437.1, BC119294.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3645              AC122266.2         126002-129646
FEATURES             Location/Qualifiers
     source          1..3645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.1 cM"
     gene            1..3645
                     /gene="Mc1r"
                     /gene_synonym="e; Mcr1; Mshra; Tob"
                     /note="melanocortin 1 receptor"
                     /db_xref="GeneID:17199"
                     /db_xref="MGI:MGI:99456"
     exon            1..3645
                     /gene="Mc1r"
                     /gene_synonym="e; Mcr1; Mshra; Tob"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..1358
                     /gene="Mc1r"
                     /gene_synonym="e; Mcr1; Mshra; Tob"
                     /note="MC1-R; MSH-R; melanocortin receptor 1; tobacco
                     darkening; extension recessive yellow"
                     /codon_start=1
                     /product="melanocyte-stimulating hormone receptor"
                     /protein_id="NP_032585.2"
                     /db_xref="CCDS:CCDS22756.1"
                     /db_xref="GeneID:17199"
                     /db_xref="MGI:MGI:99456"
                     /translation="MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFL
                     SLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAG
                     ILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRAR
                     RAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQG
                     IAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFK
                     NFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW"
     regulatory      3623..3628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mc1r"
                     /gene_synonym="e; Mcr1; Mshra; Tob"
                     /note="hexamer: ATTAAA"
     polyA_site      3645
                     /gene="Mc1r"
                     /gene_synonym="e; Mcr1; Mshra; Tob"
                     /note="major polyA site"
ORIGIN      
        1 ctccagagtc ccgtctaccc tggcttggcg agggaaagga accagacata tatcagaggc
       61 aagtaaccaa gaagtctgga ggtgttgagt ttaggcatgt ctctacctga gccacttggg
      121 aagagacagg gagaacagca gaaggctaag ctacttcaca ctggcagtga gagtccatga
      181 gcagagctca gggtcctcag caggaagtgt ctatgccatg ccgaggctgg cctgtccagc
      241 cagaaagaac acaagtgtaa aggaaaatcg gagcgtgcct gtatggaaag aggccggtct
      301 gagggatgtc agagaccccc gacaacaaca tgaagtgaat cagaagctgg gggctgatac
      361 cacctggagc tgcagcctcc acagaccgct tcctacttcc tgacaagact atgtccactc
      421 aggagcccca gaagagtctt ctgggttctc tcaactccaa tgccacctct caccttggac
      481 tggccaccaa ccagtcagag ccttggtgcc tgtatgtgtc catcccagat ggcctcttcc
      541 tcagcctagg gctggtgagt ctggtggaga atgtgctggt tgtgatagcc atcaccaaaa
      601 accgcaacct gcactcgccc atgtattact tcatctgctg cctggccctg tctgacctga
      661 tggtaagtgt cagcatcgtg ctggagacta ctatcatcct gctgctggag gcgggcatcc
      721 tggtggccag agtggctttg gtgcagcagc tggacaacct cattgacgtg ctcatctgtg
      781 gctccatggt gtccagtctc tgcttcctgg gcatcattgc tatagaccgc tacatctcca
      841 tcttctatgc gctgcgttat cacagcatcg tgacgctgcc cagagcacga cgggctgtcg
      901 tgggcatctg gatggtcagc atcgtctcca gcaccctctt tatcacctac tacaagcaca
      961 cagccgttct gctctgcctc gtcactttct ttctagccat gctggcactc atggcgattc
     1021 tgtatgccca catgttcacg agagcgtgcc agcacgctca gggcattgcc cagctccaca
     1081 aaaggcggcg gtccatccgc caaggcttct gcctcaaggg tgctgccacc cttactatcc
     1141 ttctggggat tttcttcctg tgctggggcc ccttcttcct gcatctcttg ctcatcgtcc
     1201 tctgccctca gcaccccacc tgcagctgca tcttcaagaa cttcaacctc ttcctcctcc
     1261 tcatcgtcct cagctccact gttgaccccc tcatctatgc tttccgcagc caggagctcc
     1321 gcatgacact caaggaggtg ctgctgtgct cctggtgatc agagggcgct gggcagaggg
     1381 tgacagtgat atccagtggc ctgcatcctg tgagaccaca ggtactcatc ccttcctgat
     1441 ctccatttgt ctaagggtcg acaggatgag ctttaaaata gaaacccaga gtgcctgggg
     1501 ccaggagaaa gggtaactgt gactgcaggg ctcacccagg gcagctacgg gaagtggagg
     1561 agacagggat gggaactcta gccctgagca agggtcagac cacaggctcc tgaagagctt
     1621 cacctctccc cacctacaag gcaactcctg ctcagccctt cagctcattc agcctgggct
     1681 ctcctgctgg gacagacatg aagtctctaa gttaaaagaa tgacagacaa gccgggcggt
     1741 ggtggcgcat gcctttaatt ccagcacttg ggaggcagag gcaggtggat ttctgagttc
     1801 gaggccagcc tggtcttcag agtgagttcc agtgacggcc agggctatac agagaaaccc
     1861 tgtctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaatgacaaa caagagctaa
     1921 gggggagcaa ctactcttgg tggaagcttc tgataagagg atttgtggcc atgaaaaccc
     1981 agccatagcc atgcagtagg cagcttaagg aagtgagacc cttcctcagc acatggagca
     2041 gaattgtaga atgtgcatct tgcaggaggg gcctacccat ttgcacaagc ggtgtgggac
     2101 tgacctaaaa atggctcctg ggaatcccaa gaggtgggca cccaactgct cacaccagca
     2161 ggctactctg tcaagtgcct cctccaccag ctgcagggga ggctgttggc ttatcactga
     2221 ccacagcctg tgtggctctg agccaggaag cagttgaaat gctaaggtca gagggaggga
     2281 gcctccttgc catcttccct agctctctcc agaagctgag tgaagtttgg gtgagaggac
     2341 agggagagtg gtcacattag ggagatggga gtctcagaag ccacagctag ctgcctgcct
     2401 gatttaggaa accacggtcc cgtcttggct tcctctatga ctacaaactt cagatcagag
     2461 caagcagcgg cagaaaaagt ttcctcgtgc ctctatggtg acaagaatcc ctttgttcag
     2521 gctccttctg gttcatccat acactgtagc aggaccgtag catctcagcc cctgatatga
     2581 cacatccgta accttggcca gagcctgtcc ctttcctgcc cccaccccac cccccatgtg
     2641 taggactttc aacctacttt gagctctcct gagaagccca ggggtggaga gtccctgagg
     2701 cacacgtagg gtggaccagg accaggggct gaggtctgtt tctatgggac actgcccttc
     2761 tgggaggagg tggggtggtc tcagtgctct gtcagatttg ggaattagac aagacctttc
     2821 aggcgtatct gagtcccagg agagtagcac ctggggtgaa ctaagaagct tgcacatccc
     2881 tgagcctttc tgctgctaca acctgggatt cctgcagcag agtctatctt gagtccccac
     2941 tggtactgaa cacttctttg tcctcctcct tggggtggcc tctcagtctg gagtgagatg
     3001 ccctcaacca tcaagtcagg aaatggcacc aggccaggac ctagccacac tatcagctcc
     3061 agccctgctg gactgagatt ggaagctggt tcccggcagg gccagccttt gctggaagac
     3121 aggaccatga gtcagccttt agcctgacac catagctccc tggggacaca gagagctctg
     3181 gcctgatgtc atctgtcaga gaagcatccc aggcctctgg atgcttctaa gcatcttctc
     3241 tgtccagaca aggagacaga gacagatgct cacccaatac ttcttgagcc aggccagctg
     3301 gaaccacaga aagccacatc atggacacat tgtgggggag gggcatctct tgagaacaaa
     3361 agacccattt ctaaactcgg ctaacttgga tgcttaccct cagagaaagt tgtatgcgca
     3421 gccgctctat ccagcgtgca cccgtgcgtg caaactggac gaaggcatct gcaggtgttt
     3481 ttaagctttt tagcggctct tgtgaaatga atgtttgtgg accattgaag tgtggtacta
     3541 ttgtctcaga ttcttcccga agaattttct gtcactgaaa tatcaaatag tcctcataag
     3601 gtgtcactgg tcctagatga atattaaatc agtgttgtct gtgaa
//
