LOCUS       NM_172307               4799 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus membrane-bound transcription factor peptidase, site 2
            (Mbtps2), mRNA.
ACCESSION   NM_172307 XM_980086
VERSION     NM_172307.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4799)
  AUTHORS   Danyukova,T., Alimy,A.R., Velho,R.V., Yorgan,T.A., Di Lorenzo,G.,
            von Kroge,S., Tidow,H., Wiegert,J.S., Hermans-Borgmeyer,I.,
            Schinke,T., Rolvien,T. and Pohl,S.
  TITLE     Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2
            variant display a compromised subchondral osteocyte
            lacunocanalicular network associated with abnormal articular
            cartilage
  JOURNAL   Bone 177, 116927 (2023)
   PUBMED   37797712
  REMARK    GeneRIF: Mice heterozygous for an osteogenesis imperfecta-linked
            MBTPS2 variant display a compromised subchondral osteocyte
            lacunocanalicular network associated with abnormal articular
            cartilage.
REFERENCE   2  (bases 1 to 4799)
  AUTHORS   Tibbo,A.J., Hartley,A., Vasan,R., Shaw,R., Galbraith,L., Mui,E.,
            Leung,H.Y. and Ahmad,I.
  TITLE     MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis
            through SREBP signalling in prostate cancer
  JOURNAL   Br J Cancer 128 (11), 1991-1999 (2023)
   PUBMED   36991255
  REMARK    GeneRIF: MBTPS2 acts as a regulator of lipogenesis and cholesterol
            synthesis through SREBP signalling in prostate cancer.
REFERENCE   3  (bases 1 to 4799)
  AUTHORS   Saito,A., Kamikawa,Y., Ito,T., Matsuhisa,K., Kaneko,M., Okamoto,T.,
            Yoshimaru,T., Matsushita,Y., Katagiri,T. and Imaizumi,K.
  TITLE     p53-independent tumor suppression by cell-cycle arrest via CREB/ATF
            transcription factor OASIS
  JOURNAL   Cell Rep 42 (5), 112479 (2023)
   PUBMED   37178686
REFERENCE   4  (bases 1 to 4799)
  AUTHORS   Liu,Y., Xu,D., Wang,L., Du,W., Zhang,L. and Xiang,X.
  TITLE     MBTPS2 exacerbates albuminuria in streptozotocin-induced type I
            diabetic nephropathy by promoting endoplasmic reticulum
            stress-mediated renal damage
  JOURNAL   Arch Physiol Biochem 128 (4), 1050-1057 (2022)
   PUBMED   32255378
  REMARK    GeneRIF: MBTPS2 exacerbates albuminuria in streptozotocin-induced
            type I diabetic nephropathy by promoting endoplasmic reticulum
            stress-mediated renal damage.
REFERENCE   5  (bases 1 to 4799)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 4799)
  AUTHORS   Drews,D., Klar,M., Dame,C. and Brauer,A.U.
  TITLE     Developmental expression profile of the YY2 gene in mice
  JOURNAL   BMC Dev Biol 9, 45 (2009)
   PUBMED   19638226
  REMARK    GeneRIF: Data detected yy1, yy2, and mbtps2 mRNA in primary mouse
            neurons, microglia cells, and astrocytes. In comparison to yy2 and
            mbtps2, yy1 revealed the highest expression level in all cell
            types.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4799)
  AUTHORS   Murakami,T., Kondo,S., Ogata,M., Kanemoto,S., Saito,A., Wanaka,A.
            and Imaizumi,K.
  TITLE     Cleavage of the membrane-bound transcription factor OASIS in
            response to endoplasmic reticulum stress
  JOURNAL   J Neurochem 96 (4), 1090-1100 (2006)
   PUBMED   16417584
REFERENCE   8  (bases 1 to 4799)
  AUTHORS   Cheverud,J.M., Ehrich,T.H., Hrbek,T., Kenney,J.P., Pletscher,L.S.
            and Semenkovich,C.F.
  TITLE     Quantitative trait loci for obesity- and diabetes-related traits
            and their dietary responses to high-fat feeding in LGXSM
            recombinant inbred mouse strains
  JOURNAL   Diabetes 53 (12), 3328-3336 (2004)
   PUBMED   15561968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY322697.1, AK164486.1 and BB556642.1.
            
            On Jun 20, 2007 this sequence version replaced NM_172307.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164486.1, BC038343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BY322697.1         3-67
            66-4794             AK164486.1         2-4730
            4795-4799           BB556642.1         306-310
FEATURES             Location/Qualifiers
     source          1..4799
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.55 cM"
     gene            1..4799
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /note="membrane-bound transcription factor peptidase, site
                     2"
                     /db_xref="GeneID:270669"
                     /db_xref="MGI:MGI:2444506"
     exon            1..220
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1693
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /EC_number="3.4.24.85"
                     /note="membrane-bound transcription factor protease, site
                     2; site-2 protease; S2P endopeptidase; endopeptidase S2P"
                     /codon_start=1
                     /product="membrane-bound transcription factor site-2
                     protease"
                     /protein_id="NP_758511.1"
                     /db_xref="CCDS:CCDS30498.1"
                     /db_xref="GeneID:270669"
                     /db_xref="MGI:MGI:2444506"
                     /translation="MIPVSLLVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLS
                     ISPFHIRWQTSIFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTL
                     AQMMADSPSPYSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFAAV
                     LISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFC
                     AGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVT
                     HLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNH
                     SLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSGASSSFCIVPSLETHTR
                     LIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGA
                     LAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLG
                     LWMVTAR"
     exon            221..369
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            370..571
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            572..675
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..803
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            804..922
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1103
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1198
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1394
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1470
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..4799
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4758..4763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4797
                     /gene="Mbtps2"
                     /gene_synonym="9630032G22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaaatgtt gccaccggag caaagaaccc ggtagcactt tagttcctgc gcggatgctg
       61 gagctggaag gctccgggcg ggcgcacggc tgactggggc tcgcagaagc aggccgccgg
      121 ggcccgccgt ccatccgtcg ctacgatgat tccggtgtcg ctgctggtgg tggtggtggg
      181 tggttggact gccgtctacc tggccgactt ggtgttgaag tcatctgtgt attttaaaca
      241 ttcttatgaa gactggctgg aaaacaatgg attgagcatc tctccttttc atataagatg
      301 gcaaacttca atttttaatc gtgcctttta cagttgggga cggcggaaag caaggatgct
      361 ttaccaatgg ttcaattttg gaatggtgtt tggcgtgatt gccatgttca gctctttttt
      421 tctccttgga aaaacactga tgcagacttt ggcacaaatg atggctgact ctccctctcc
      481 ttattcttcc tcttcctctt cctcctcttc ctcttcctcc tcttcctctt cctcctcctc
      541 tcttcacaat gaacaggtgt tgcaagttgt ggttcccggt ataaatttac ctgtcaatca
      601 gctgacttac ttcttcgctg cagtcctcat tagtggtgtt gtacatgaaa ttggacacgg
      661 tatagcagct attagggaac aagttcgatt taatggcttt ggaatttttc tcttcattat
      721 ttatcctggg gcatttgttg atctgttcac cacccatttg caacttatat caccagtcca
      781 gcagctaagg atattttgtg caggtatatg gcataatttt gtccttgctc tccttggtat
      841 tttagctctt gttctcctcc cagtaatcct cttgcctttt tactacactg gagttggggt
      901 acttatcact gaagtcgcag aggactcacc tgccattgga cccagaggcc tttttgtggg
      961 agaccttgtc actcatctac aggattgtcc cgttactaat gtgcaagatt ggaatgaatg
     1021 tttagacacc attgcatatg agccccaaat tgggtattgt ataagtgcat caacgttaca
     1081 acaattaagc ttcccagtta gagcatacaa acgactagat ggttctactg aatgctgtaa
     1141 caatcacagc ctcacagatg tgtgcttttc ctacagaaat aatttcaata aacgtttgca
     1201 tacgtgtcta cctgcccgga aagcagttga agctactcaa gtttgtagaa gcaataaaga
     1261 ttgcaaaagc ggcgcaagtt ctagcttctg tatagtaccg tccttggaaa ctcacacccg
     1321 actaatcaaa gtgaaacatc ccccgcaaat tgatatgctg tatgtagggc acccactgca
     1381 tcttcactac acagtgagca ttacaagttt catcccacgt ttcaactttc taagcataga
     1441 tctgccagtg attgtggaga catttgtcaa gtacctgatt tctctttctg gagctctggc
     1501 tattgttaat gcagtgccct gctttgcctt ggatggtcaa tggattttaa actctttcct
     1561 ggatgctacc cttacttcag taattggaga caatgatgtc aaagatctga ttggattttt
     1621 catcttgctt ggtggcagtg tacttttggc tgccaatgtg acactgggac tctggatggt
     1681 tacagcacgg taatgtttgc tctcatccaa cagaattaag aagtaaagct acatggcaat
     1741 atctgttgcc attgaaattc ttactagtta tgaaatgtaa agtgtttcct taaaacacct
     1801 tggccaacct ctttgagctc ctaatatcta gagaacccaa aaactctgta gtagagggag
     1861 tagaagaaat gaaaagcata attcctgact atatcctact ttaaagattg aatgtgcaaa
     1921 ctctgaatgt ttgttgaata atttgtaaac aagtgaaaat tcattcatgt aataccattt
     1981 tgtgtgacca tatagcattt tggaatagta aaaggaaaag cagaatcttg taggaaaacg
     2041 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgagag agagagagag agagagagag
     2101 agagaatgcg tgtgtatgtg gtatgtgtct gcgtgttcta ctagtgtttg aaagcagggc
     2161 cttacttatg ctacttaggc taagcttgcc tgtcccaggt aaaagttact gaaaagtgcc
     2221 attaaggtga tgtgctggtg cacacctata atcccagcac ctgcctctat gtgtttggag
     2281 ggctaggcat aaggatcgtg aattcaaggc catcatcttt agctacatag taggttccag
     2341 accagcactg gccacatagc aagacccttt cgtgcatgca tacatgcaca ggcgcgcaca
     2401 cacacccacc cacccaccca cacacacaca cacacacaca cacacacacg cacatacaca
     2461 aaatcattaa tgattggaag gaagctagac cttggttgaa tggaaagtag agcaagtgct
     2521 cttggtttta taactcttgt ctttatctta tttgaaaagt attttaaagt ttaatggtgt
     2581 attattctgt actctggtta caattctatg aaagtatctg ctaacatgaa agcaaaaact
     2641 ctgtacaagt gctatcaagt aaatgagcaa tgttgaaagc agataaggct tgtgatgtga
     2701 taagacagtt tgtcgcacaa gtattacatt tttcatagtg taagttacac tcaacatttt
     2761 taagccttgt tatatataga gtatgctgca ggaagggtct ctcacggcag catgtgagct
     2821 caggcagtta gaggtgaact tgagaactaa gctgagtcct ctaacagatc acaacagaac
     2881 ttcagcaaac ctacttaacc acttcctaga gctttgcagc ttagaactct tccagagtag
     2941 actttttcct ttgtgctgca agaacattca accttgagcc atactctgtc gtcaccagca
     3001 cctagtatgt ttctctctgt tggcgggatt aaacacctcc tctttgtttt ccatctcccc
     3061 ctaagctacc tctgtgagta cataaaagac ttggtagtct agtgagaatg gctgcacaaa
     3121 tgaaaatttc ccagaatcta gaaagagact tttgagctgt aaagaatcac aattggtctt
     3181 gtagggtagc agttcaagcc tgggaaattg agaaagtcag ctggctgatg tgacactgtt
     3241 agtcttaaga atatatatgc acatactgtt tctgtcatga aaaatacata tttcatgaaa
     3301 cacacacatt agaggtaaca aaaggcaatg atccatccat tcattcatta atagccagat
     3361 atatacctcc ctcctgaagt aaggtactcc ataaggtgac ctttttcaga acattagttc
     3421 tcttaagcgc ctaaaacttt taaatcaatt tttagaaatt ttttagactt tattacaaat
     3481 ttgccttcat tctttaatag gaaccataca ctgaatatca ttttgagatt ttattaatga
     3541 tgggccatta ttactaataa tactaaagtc atacaaatta ctaactttta ttgcagaaaa
     3601 tatggcattg ttgtcttcta agatcactca ggaccaaaat gtatctgcat attaaaaagg
     3661 cacagacctt ttcaggtaaa gcttagagaa tgccgtgaaa tactcacatt aacttcatcg
     3721 catgcatgaa gcagtttact aatgaaaatg tatgtgtgta aatcattgtt ttcaatactg
     3781 aggaaaacaa tttttggtat ggtacttagc ccaggacctc acacatgcga gcaagtattc
     3841 taccactaaa ctattatcca tagaccatga aactatttta ataagaggaa attctattca
     3901 ttaacttcat tttctgagtg aaggcaacaa tacaaaacct tatttcttat tagctgctga
     3961 acacctctgc cagctaatct ttagggtcgg gtttgggtgc ttctctcctg gagtccagat
     4021 ttgtatgcaa atggcctcat tactaaagaa aggagatgtt acttattgtc tcttccgctt
     4081 ccctgtgggc tcctggcttc cctgtgtagt gcatgcgcta tcagaattgc ttaatgtgct
     4141 tgaatgaatg atggtgatta gtgttattta tggctagaaa agcatgcttc tatttaagct
     4201 gtaaaaagga ttgtcgaata gttactgtaa atatatgttg acatagtaaa gcttggaatg
     4261 tcttatgtcc ctggtgtatt atcatcttta tggaaaaatt cattttggtt tctgtagagc
     4321 atttagaaaa atgagttata ttggaaaaat gaattatgtt ggtgatttga agaagtatct
     4381 ttttgtgttg tctctttgtt cagcagtgaa attttattct cagtgttcct attctgcatt
     4441 gtttacattc ttaaggtttt tattttaatc atccataagt gtgagacatg tacatattat
     4501 ttttagcatc tcagtttgaa gagacataca gttaaacttg actttgataa atacttctag
     4561 gtcattgtct gtgcgaacag cagattgtaa gcatacgctt cctagtgatg tagctttctg
     4621 tcattgtgtc cttggtattt attgaacatc cacatactgg tggcacacag atttgttcca
     4681 ataactcctt taattgagct gtaattcatt ttaaggcttt aatttgattt tataattgtc
     4741 agaatgtgat gtttagcaat aaaagaacaa atgtaataaa ccagcatttt acgtttatc
//
