LOCUS       NM_134012               5284 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus mbt domain containing 1 (Mbtd1), transcript variant 1,
            mRNA.
ACCESSION   NM_134012
VERSION     NM_134012.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5284)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5284)
  AUTHORS   Takubo,K., Htun,P.W., Ueda,T., Sera,Y., Iwasaki,M., Koizumi,M.,
            Shiroshita,K., Kobayashi,H., Haraguchi,M., Watanuki,S., Honda,Z.I.,
            Yamasaki,N., Nakamura-Ishizu,A., Arai,F., Motoyama,N., Hatta,T.,
            Natsume,T., Suda,T. and Honda,H.
  TITLE     MBTD1 preserves adult hematopoietic stem cell pool size and
            function
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2206860120 (2023)
   PUBMED   37523546
  REMARK    GeneRIF: MBTD1 preserves adult hematopoietic stem cell pool size
            and function.
REFERENCE   4  (bases 1 to 5284)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5284)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5284)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 5284)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   8  (bases 1 to 5284)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5284)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 5284)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124943.1, BC062907.1, AK162128.1, AK161472.1, BB028323.1 and
            BB527030.1.
            
            On May 17, 2018 this sequence version replaced NM_134012.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062907.1, SRR7652917.995632.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY124943.1         1-48
            49-3616             BC062907.1         1-3568
            3617-4909           AK162128.1         904-2196
            4910-5270           AK161472.1         2564-2924
            5271-5279           BB028323.1         235-243
            5280-5284           BB527030.1         301-305
FEATURES             Location/Qualifiers
     source          1..5284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.86 cM"
     gene            1..5284
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /note="mbt domain containing 1"
                     /db_xref="GeneID:103537"
                     /db_xref="MGI:MGI:2143977"
     exon            1..246
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            247..446
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2188
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /note="isoform 1 is encoded by transcript variant 1; MBT
                     domain-containing protein 1"
                     /codon_start=1
                     /product="MBT domain-containing protein 1 isoform 1"
                     /protein_id="NP_598773.2"
                     /db_xref="CCDS:CCDS48883.1"
                     /db_xref="GeneID:103537"
                     /db_xref="MGI:MGI:2143977"
                     /translation="MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTY
                     PDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTK
                     KAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAGNSAISVEGFSWGNYINSNSFIAAPV
                     ACFKHAPMGTCWGDISENVRIEVPNTDCSLPTKVFWIAGIIKLAGYNALLRYEGFEND
                     SSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTGAKTLPPDF
                     SQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWC
                     HMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMK
                     LEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCE
                     INMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLME
                     PRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQ
                     SSRESQSASSKQKKKAKSQQYKGHKKMTTSQLKEELLDGEDYSFLHGASDQESNGSAT
                     VYIKQEP"
     exon            447..580
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            581..704
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            705..787
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            788..905
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1040
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1129
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1364
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1420
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1525
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1673
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1756
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1991
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2069
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..5284
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5230..5235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /note="hexamer: ACTAAA"
     regulatory      5256..5261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /note="hexamer: AATAAA"
     polyA_site      5271
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
     polyA_site      5274
                     /gene="Mbtd1"
                     /gene_synonym="hemp"
                     /note="major polyA site"
ORIGIN      
        1 gctggggagg gagggctatg ctaatgttgt tgatatcctg gggccacccg agttaaaagg
       61 ggggaaatcc gggggctgcc actgctgtcg ctggccctgg cccagccggg ggtcccccct
      121 gtagtcgccg cagtcccggg gagaggcacc ggccccctgc tcgcgggggg ggagggggcg
      181 ccgcgggctc ggggagcacg gacggcccct acccatgagg ccctgatgga aaacacaaag
      241 gatctgacag aacattcttc acaatccaaa agaaaaagca gactggttcg ggatgtttga
      301 cggctatgat agctgcagtg aggacacaag tagcagctcc agctctgagg agagtgaaga
      361 agaagttgct cctttacctt ccaatctccc aatcatcaag aataatggac aagtctacac
      421 atacccagat ggtaaatctg gcatggctac ctgtgagatg tgtgggatgg tcggtgtgcg
      481 agatgctttt tactctaaaa cgaaacgttt ctgcagtgtt tcctgttcaa gaagttactc
      541 gtcaaactct aagaaggcaa gcattctggc cagacttcag ggtaagcctc caacaaagaa
      601 agcaaaagtc cttcaaaaac aacctttagt tgctaaatta gctgcctatg cccagtatca
      661 agctaccttg caaaatcaag caaagacaaa agcaggcaat tctgcaatct ctgtggaagg
      721 cttcagctgg ggtaactaca tcaacagcaa cagcttcata gcagctccag tggcctgttt
      781 taagcatgca cctatgggga cctgctgggg tgatatctcg gaaaatgtaa ggatagaagt
      841 tcccaataca gactgcagtc tacctaccaa agtcttctgg attgctggaa ttataaaatt
      901 agcaggttat aatgcccttt tgagatatga aggatttgaa aatgattctt ctctggactt
      961 ctggtgcaat atatgtgggt ctgatattca tccagttggt tggtgtgcag ctagtggaaa
     1021 acctctcgtt cctcctagaa ctgttcaaca taaatataca aactggaaag cttttctagt
     1081 aaaaagactt actggtgcca aaacacttcc tcctgatttc tcacaaaagg tttctgagag
     1141 tatgcaatat cctttcaaac cttgcatgag agtagaagta gttgacaaga ggcatttatg
     1201 tcgaacaaga gtagcagtgg tggaaagtgt aattggagga cgactacggc tggtgtatga
     1261 agagagtgaa gatagaacag acgacttctg gtgccacatg cacagcccct taatccacca
     1321 tattggatgg tcaagaagca taggccatcg attcaagaga tcagatatta cgaagaaaca
     1381 ggacggacat ttcgatacac ctccacactt atttgctaag gtaaaagaag tagaccagag
     1441 tggagaatgg ttcaaagaag gaatgaaatt ggaagctata gacccattaa atctttctac
     1501 aatatgtgtt gccaccatta gaaaggtgct ggctgatgga ttcctgatga ttgggattga
     1561 tggctcagaa gcagcagatg gatctgactg gttctgttat catgcaacct ctccttccat
     1621 tttccctgtg ggtttctgtg aaattaacat gatagaactg actccaccca gaggttacac
     1681 aaaacttcct tttaaatggt ttgactacct cagggaaacc ggctccattg cagcaccagt
     1741 aaaactattt aataaggatg ttccaaacca cggattccgt gtaggaatga aattagaagc
     1801 tgtagatctc atggagccac ggttaatatg tgtagccaca gttactcgaa ttattcaccg
     1861 tctcttgagg atacattttg atggttggga agaagagtat gaccagtggg tagactgtga
     1921 gtcccctgac ctctatcctg tagggtggtg tcagttaact ggatatcaac tacagcctcc
     1981 agcatcacag tcatcaagag aaagccaatc agcttcttca aaacagaaga aaaaggctaa
     2041 gtctcagcaa tacaaaggac ataagaaaat gaccacgtca cagctgaagg aggagctgct
     2101 ggacggggag gactatagct tcctccatgg agcatctgac caggaaagca atggctctgc
     2161 caccgtctac atcaaacaag agccatgagg cgactcggaa accatgggca ggcggggctg
     2221 tttacaggac tgatttggaa tcagccagct gtatagcggg ctattctact gggacatttt
     2281 gctaaacaca gaaaaaagtt cagttccaga tttttcaggt gggggggaaa ctattttggt
     2341 gggggggcaa tttttcaatt tataaagacg gacaattttt gtgttgtatt tgaagctttt
     2401 gaaagaattt tgtaatattt tccaagtttg gatttatgtg cattgttaac aagaactgaa
     2461 attataactt ttttggtaag ataaaagttt aggtagcagg attgaaggaa atgattaaga
     2521 aggatatagt tgtaaatgca aatgaactgt cattacaaat gaaccttctt ggtacctgtt
     2581 gggagatttt ttggatttta gagttaggcc agtcacatct ccagcttcct ttgctgcgaa
     2641 aatatgcaac tgaacccctc acagagggct catcaccatg tagatcacgg aaggggtcat
     2701 taattgtgct cgctgacgtt ttattgcagc ccatttaact gtttgtacag aaactttttc
     2761 attctgctaa aatttatttg gagttgtata tgaaactagg agaactctgg atacttttat
     2821 atgctctcct tcacgtaaag atgattaaaa ttgtctaaca ctaaagtgtt aaactggaat
     2881 ggttgacaaa gtacacaaga tctcagtcta cataaagggt tgggggaaat tagtattttc
     2941 ctaagtttat tctgttttcc ttgctagaaa aatcccataa aagggatatt cttgtcagac
     3001 ctctgccatt tcttccatct gtgagagagc aacgtgatgt aaccacacct gagagcaggt
     3061 actgtcctgt gttacaaaag aatcacatgg aaaattgtta accaaaataa gtgtagattt
     3121 cagaatcatt ccagctctac tcttaactgt cctgaatttg ttagaaactg atttgaaaga
     3181 aatgtttctt aaaattccat acacacacac acacatatta tgaattgtct ttaattgtag
     3241 tcagaattta ttataacaat atttgatttg gaccatttta aacattccct attttaaaat
     3301 tcatacggct tccttaagaa gtagaatgaa agggtaaatt ggtgacatgt ttgctctctg
     3361 cattttctaa ccttctaccg aattgtgact gactcagaga gctctagcat ttaccagtga
     3421 ggttcagaaa ctaaactctc aggaattcat tgcatctgtt gtagaagtgc ttctgggtct
     3481 gagcctggcc tcctcagagt ggtaatactg cccacttcct ctggaaaata ggcagggcta
     3541 atgagaaact aatcaaatga ttaacctctg cggcccttca gcctttggaa tgctttaaaa
     3601 aaaaaaaaaa aaaaaagaaa gtaaaaagaa tgctaatgga aaaccccagg agacatttta
     3661 ggtaagattt tttgtttgac ttttaaatgc atagaacatt aaaaaccagc aatttatttt
     3721 ctaaaatatt gctctacttt tgggaataat agcattggta atatgcacag gtttacctca
     3781 ttctatgcaa gaggggttaa taacataagg ttttgtagta gctactggaa gtaaaatgtg
     3841 ttacttttta gtgtaaaaat gtatggaatc gcatgtcacc atttttttaa tactgactct
     3901 gggggctaaa tgcagatcac atcaatgcaa gttgattctt gtgtcaaata tatgtgaatt
     3961 cagctgtaaa attactggat atttatctta acagtgctga gagggaccta ctgtaaatgt
     4021 gacatcctca cacttcccaa atctttgact tggaaggatc ttcccagaag cttaaagcct
     4081 agaagaggtc caaagcaaag gtcatagcag tctttattct caggctcagc atgaaaccca
     4141 gaactgtgct tccatggtac cagggcaaga agcctgttgg atggggtgct ctcctgcctt
     4201 gggtggagga gctctccagg gaactaactt taagccagga aggatgtgat ttcaaggcag
     4261 ccagtcctgg taatcagttc tgtgaaataa tcatttgtag ccaggtttta caagcttcca
     4321 attctacacc aaaaccaggc ttggcgttag aattccccgc ctacattcac aaagtgttta
     4381 tgttctctaa tagtgaaggg ttggtaagga cttgctagag tccaaacaga acccgaagcc
     4441 ctcttctttg ttaagaccct cgctcctgct gctaacacag accgttaacc agaggaggct
     4501 tccatcgtag ccataatgcc tgtcgtcgta cagctcagta gcccgttctc tttcacagtt
     4561 caacgtgtac tgccgacctt ggacttgttt gtgttttcct gttagaagcc tgggaacttt
     4621 tagtagttta atctttttaa ccattttcct tgcagtgtat gaggaaagct aaagctgtta
     4681 tcaacttctt attctgcgga tactaacacg ggttttcagt gtttgtttgt ttttattatt
     4741 aattaatttt gtgtgatgtg aataccctcg cccatcaata tttgtattat ggtgctatat
     4801 atttggtaat gatcctttaa tattggggag ggattttaaa aatactgtga ttaaactggg
     4861 tatcttcctt tgattttcat attttaaata aagccacagt catttataca aaaaaaaaaa
     4921 aaaaaaaagc atctgtccct gggcaaacct ttcaaggaca gaggccaaag taaagtacgt
     4981 aaggttttta cattgtttct gtgtgcgttt gatatataaa caatatctgg acaaatttaa
     5041 tcttttattt tctggtaact tgtgattatt gaggaagtgt ttgaagcttt ctcatggaat
     5101 gtatataatg gcgtgaaaaa ttccttcaga gaaatttatg ttcctttcat ttttaccaaa
     5161 atgcaaattt tcagcatgga tgtgaaaagc attaaaatta taactttgtg tacaagatga
     5221 aaataattca ctaaatttgc ccttttttta cacaaaataa aatgttaaag ttaagcttta
     5281 tttt
//
