LOCUS       NM_010777               2531 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus myelin basic protein (Mbp), transcript variant 7,
            mRNA.
ACCESSION   NM_010777
VERSION     NM_010777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2531)
  AUTHORS   Sztachera,M., Wendlandt-Stanek,W., Serwa,R.A., Stanaszek,L.,
            Smuszkiewicz,M., Wronka,D. and Piwecka,M.
  TITLE     Interrogation of RNA-bound proteome with XRNAX illuminates
            molecular alterations in the mouse brain affected with
            dysmyelination
  JOURNAL   Cell Rep 44 (1), 115095 (2025)
   PUBMED   39709601
REFERENCE   2  (bases 1 to 2531)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   3  (bases 1 to 2531)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2531)
  AUTHORS   Bagheri,H., Friedman,H., Hadwen,A., Jarweh,C., Cooper,E., Oprea,L.,
            Guerrier,C., Khadra,A., Collin,A., Cohen-Adad,J., Young,A.,
            Victoriano,G.M., Swire,M., Jarjour,A., Bechler,M.E., Pryce,R.S.,
            Chaurand,P., Cougnaud,L., Vuckovic,D., Wilion,E., Greene,O.,
            Nishiyama,A., Benmamar-Badel,A., Owens,T., Grouza,V., Tuznik,M.,
            Liu,H., Rudko,D.A., Zhang,J., Siminovitch,K.A. and Peterson,A.C.
  TITLE     Myelin basic protein mRNA levels affect myelin sheath dimensions,
            architecture, plasticity, and density of resident glial cells
  JOURNAL   Glia 72 (10), 1893-1914 (2024)
   PUBMED   39023138
  REMARK    GeneRIF: Myelin basic protein mRNA levels affect myelin sheath
            dimensions, architecture, plasticity, and density of resident glial
            cells.
REFERENCE   5  (bases 1 to 2531)
  AUTHORS   MacArthur,I.C., Ma,L., Huang,C.Y., Bhavsar,H., Suzuki,M. and
            Dawlaty,M.M.
  TITLE     Developmental DNA demethylation is a determinant of neural stem
            cell identity and gliogenic competence
  JOURNAL   Sci Adv 10 (35), eado5424 (2024)
   PUBMED   39196941
REFERENCE   6  (bases 1 to 2531)
  AUTHORS   Grima,B., Zelenika,D. and Pessac,B.
  TITLE     A novel transcript overlapping the myelin basic protein gene
  JOURNAL   J Neurochem 59 (6), 2318-2323 (1992)
   PUBMED   1279125
REFERENCE   7  (bases 1 to 2531)
  AUTHORS   Privat,A., Jacque,C., Bourre,J.M., Dupouey,P. and Baumann,N.
  TITLE     Absence of the major dense line in myelin of the mutant mouse
            'shiverer'
  JOURNAL   Neurosci Lett 12 (1), 107-112 (1979)
   PUBMED   460693
REFERENCE   8  (bases 1 to 2531)
  AUTHORS   Dupouey,P., Jacque,C., Bourre,J.M., Cesselin,F., Privat,A. and
            Baumann,N.
  TITLE     Immunochemical studies of myelin basic protein in shiverer mouse
            devoid of major dense line of myelin
  JOURNAL   Neurosci Lett 12 (1), 113-118 (1979)
   PUBMED   88695
REFERENCE   9  (bases 1 to 2531)
  AUTHORS   Bird,T.D., Farrell,D.F. and Sumi,S.M.
  TITLE     Brain lipid composition of the shiverer mouse: (genetic defect in
            myelin development)
  JOURNAL   J Neurochem 31 (1), 387-391 (1978)
   PUBMED   671037
REFERENCE   10 (bases 1 to 2531)
  AUTHORS   Doolittle,D.P. and Schweikart,K.M.
  TITLE     Myelin deficient, a new neurological mutant in the mouse
  JOURNAL   J Hered 68 (5), 331-332 (1977)
   PUBMED   599283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117825.9, L07507.1 and
            AC119259.15.
            
            On May 11, 2006 this sequence version replaced NM_010777.2.
            
            Summary: The protein encoded by the classic Mbp gene is a major
            constituent of the myelin sheath of oligodendrocytes and Schwann
            cells in the nervous system. However, Mbp-related transcripts are
            also present in the bone marrow and the immune system. These mRNAs
            arise from the long Mbp gene (otherwise called 'Golli-Mbp') that
            contains 3 additional exons located upstream of the classic Mbp
            exons. Alternative splicing from the Golli and the Mbp
            transcription start sites gives rise to 2 sets of Mbp-related
            transcripts and gene products. The Golli mRNAs contain 3 exons
            unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They
            encode hybrid proteins that have N-terminal Golli aa sequence
            linked to Mbp aa sequence. The second family of transcripts contain
            only Mbp exons and produce the well characterized myelin basic
            proteins. This complex gene structure is conserved among species
            suggesting that the Mbp transcription unit is an integral part of
            the Golli transcription unit and that this arrangement is important
            for the function and/or regulation of these genes. Mutation of the
            Mbp gene is associated with the 'shiverer' and 'myelin deficient'
            phenotypes in mouse. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (7) contains 3 exons unique to
            Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes
            the longer of the Golli-Mbp isoforms (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L07507.1, SRR7345562.795283.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC117825.9         3082-3121           c
            41-1194             L07507.1           1-1154
            1195-2531           AC119259.15        26369-27705         c
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 55.84 cM"
     gene            1..2531
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="myelin basic protein"
                     /db_xref="GeneID:17196"
                     /db_xref="MGI:MGI:96925"
     exon            1..272
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            273..348
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1050
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="isoform 1 is encoded by transcript variant 7;
                     shiverer; myelin A1 protein; myelin deficient"
                     /codon_start=1
                     /product="Golli-Mbp isoform 1"
                     /protein_id="NP_034907.1"
                     /db_xref="CCDS:CCDS29373.1"
                     /db_xref="GeneID:17196"
                     /db_xref="MGI:MGI:96925"
                     /translation="MGNHSGKRELSAEKASKDGEIHRGEAGKKRSVGKLSQTASEDSD
                     VFGEADAIQNNGTSAEDTAVTDSKHTADPKNNWQGAHPADPGNRPHLIRLFSRDAPGR
                     EDNTFKDRPSESDELQTIQEDPTAASGGLDVMASQKRPSQRSKYLATASTMDHARHGF
                     LPRHRDTGILDSIGRFFSGDRGAPKRGSGKDSHTRTTHYGSLPQKSQHGRTQDENPVV
                     HFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR"
     exon            349..436
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            437..867
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            868..969
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1005
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..2531
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="hexamer: AATAAA"
     polyA_site      2523
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="major polyA site"
ORIGIN      
        1 gtcccccgcc ctcccagtgg cgcgcgttta cctgctttca agcactggga ggcggggcgg
       61 gagcggggtg cgcgcccgtc cccggagcag ccgctgtcag tcaccgccgc tgcgcgccag
      121 ggaggaccag cctctggctc aggcggcctg agcttcacga ccccggaaca tagtatccgc
      181 gccccagcga cccctagccc agcgttgggt cccatccgcc gggatcccgg gatcctgggc
      241 ccctcttggc ctccgagcag cagccagcac cactcttgaa caccccattg ggtcgccatg
      301 ggaaaccact ctggaaagag agaattatct gctgagaagg ccagtaagga tggagagatt
      361 caccgaggag aggctggaaa gaagagaagc gtgggcaagc tttctcagac ggcctcagag
      421 gacagtgatg tgtttgggga ggcagatgcg atccagaaca atgggacctc ggctgaggac
      481 acggcggtga cagactccaa gcacacagca gacccaaaga ataactggca aggcgcccac
      541 ccagctgacc cagggaaccg cccccacttg atccgcctct tttcccgaga tgccccggga
      601 agggaggaca acaccttcaa agacaggccc tcagagtccg acgagcttca gaccatccaa
      661 gaagacccca cagcagcttc cggaggcctg gatgtgatgg catcacagaa gagaccctca
      721 cagcgatcca agtacctggc cacagcaagt accatggacc atgccaggca tggcttcctc
      781 ccaaggcaca gagacacggg catccttgac tccatcgggc gcttctttag cggtgacagg
      841 ggtgcgccca agcggggctc tggcaaggac tcacacacga gaactaccca ttatggctcc
      901 ctgccccaga agtcgcagca cggccggacc caagatgaaa acccagtagt ccatttcttc
      961 aagaacattg tgacacctcg aacaccacct ccatcccaag ggaagggagg aagagacagc
     1021 cgctctggat ctcccatggc gagacgctga gagccctccc cgctcagcct tcccgaatcc
     1081 tgccctcggc ttcttaatat aactgcctta aacttttaat tctacttgca ccgattagct
     1141 agttagagca gaccctctct taatcccgtg gagccgtgat cgcggtgggg ccaggcccac
     1201 ggcaccccga ctggttaaaa ctattcgtcc cttttcgttt gaagattgag ttttctcggg
     1261 gtcttctcag ccctgacttg ttccccgtgc accttgttcg actccggagg ttcaggtgca
     1321 cggacaccct tccaagttca cccctactcc atcctcagac ttttcacggt gaggcacacc
     1381 cctccagctt ccgtgggcac tgcggataga caggcacacc gccaaggagc cagagagcat
     1441 ggcgcagggg actgtgtggt ccaggcttcc tttgttttct tccccctaaa gagctttgtt
     1501 tttcctaaca ggatcagaca gtcttggagt ggcttataca acgggggctt gtggtatgtg
     1561 agcacaggct gggcagctgt gagagtccag agtggggtgg ccctggggac acttccaggc
     1621 cagctatccc ctgcacccca ccagctgatt tcgagcgtgg cagagggaag gaaaggggcg
     1681 agtgggctgg gcaatggccc caacaggaaa cggggactta ggagaacacg ctggagatat
     1741 gtgtggccgc caaatgtcac catctctcct cagtggctcc ccagagctgg tgcttttaag
     1801 aaccctgttt cctctcagag cccagggaga gtccaaggac atggcgcatc tggaagtggg
     1861 actgcaggag ttctctggtg gcctcgtgct gtccctctgg ccacttctca tggtggggtg
     1921 gtcagcggca gctcgccatg gcagtgccca ttggtacaca ctaacctcgg tggaaaaata
     1981 accattccct gcctcctaga aaggactcat tcttagcttt aggggggttc ctgtcactga
     2041 atcgagtcgc tgccctggat gcagggctgg cctgggcgac gctccaggga tgaggagctg
     2101 agaaccccag tctaataatg tccatcgaca cctccttatc cctctaacgt actatgtctt
     2161 ttgatttagc atgccttctg tagaccttcc aaagagcccc acactggcac cgtcacccct
     2221 aggaaggcag gtgatggttg atgtagccca atactgcatc ttgttaatct gttctaactc
     2281 tgagtagagt gtgggtttaa gataacaccg attaatgtat cgccacaata acgtgagggt
     2341 aagagaaaaa gcagggaaga aatttccaga aaaaaaccct ccagattgtc ccacgggagt
     2401 gtttgccctc cagtgtgact gaacgacctt gcccatggct tcgtccagac agcgcagctg
     2461 cagtatggct ggacagaagc acctactatt cttgaatatt gaaataaaat aataaacttg
     2521 caatgatctt t
//
