LOCUS       NM_001025251            2186 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus myelin basic protein (Mbp), transcript variant 1,
            mRNA.
ACCESSION   NM_001025251
VERSION     NM_001025251.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2186)
  AUTHORS   Sztachera,M., Wendlandt-Stanek,W., Serwa,R.A., Stanaszek,L.,
            Smuszkiewicz,M., Wronka,D. and Piwecka,M.
  TITLE     Interrogation of RNA-bound proteome with XRNAX illuminates
            molecular alterations in the mouse brain affected with
            dysmyelination
  JOURNAL   Cell Rep 44 (1), 115095 (2025)
   PUBMED   39709601
REFERENCE   2  (bases 1 to 2186)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   3  (bases 1 to 2186)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2186)
  AUTHORS   Bagheri,H., Friedman,H., Hadwen,A., Jarweh,C., Cooper,E., Oprea,L.,
            Guerrier,C., Khadra,A., Collin,A., Cohen-Adad,J., Young,A.,
            Victoriano,G.M., Swire,M., Jarjour,A., Bechler,M.E., Pryce,R.S.,
            Chaurand,P., Cougnaud,L., Vuckovic,D., Wilion,E., Greene,O.,
            Nishiyama,A., Benmamar-Badel,A., Owens,T., Grouza,V., Tuznik,M.,
            Liu,H., Rudko,D.A., Zhang,J., Siminovitch,K.A. and Peterson,A.C.
  TITLE     Myelin basic protein mRNA levels affect myelin sheath dimensions,
            architecture, plasticity, and density of resident glial cells
  JOURNAL   Glia 72 (10), 1893-1914 (2024)
   PUBMED   39023138
  REMARK    GeneRIF: Myelin basic protein mRNA levels affect myelin sheath
            dimensions, architecture, plasticity, and density of resident glial
            cells.
REFERENCE   5  (bases 1 to 2186)
  AUTHORS   MacArthur,I.C., Ma,L., Huang,C.Y., Bhavsar,H., Suzuki,M. and
            Dawlaty,M.M.
  TITLE     Developmental DNA demethylation is a determinant of neural stem
            cell identity and gliogenic competence
  JOURNAL   Sci Adv 10 (35), eado5424 (2024)
   PUBMED   39196941
REFERENCE   6  (bases 1 to 2186)
  AUTHORS   Grima,B., Zelenika,D. and Pessac,B.
  TITLE     A novel transcript overlapping the myelin basic protein gene
  JOURNAL   J Neurochem 59 (6), 2318-2323 (1992)
   PUBMED   1279125
REFERENCE   7  (bases 1 to 2186)
  AUTHORS   Privat,A., Jacque,C., Bourre,J.M., Dupouey,P. and Baumann,N.
  TITLE     Absence of the major dense line in myelin of the mutant mouse
            'shiverer'
  JOURNAL   Neurosci Lett 12 (1), 107-112 (1979)
   PUBMED   460693
REFERENCE   8  (bases 1 to 2186)
  AUTHORS   Dupouey,P., Jacque,C., Bourre,J.M., Cesselin,F., Privat,A. and
            Baumann,N.
  TITLE     Immunochemical studies of myelin basic protein in shiverer mouse
            devoid of major dense line of myelin
  JOURNAL   Neurosci Lett 12 (1), 113-118 (1979)
   PUBMED   88695
REFERENCE   9  (bases 1 to 2186)
  AUTHORS   Bird,T.D., Farrell,D.F. and Sumi,S.M.
  TITLE     Brain lipid composition of the shiverer mouse: (genetic defect in
            myelin development)
  JOURNAL   J Neurochem 31 (1), 387-391 (1978)
   PUBMED   671037
REFERENCE   10 (bases 1 to 2186)
  AUTHORS   Doolittle,D.P. and Schweikart,K.M.
  TITLE     Myelin deficient, a new neurological mutant in the mouse
  JOURNAL   J Hered 68 (5), 331-332 (1977)
   PUBMED   599283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY245551.1, CO425201.1,
            BF457157.1 and AC119259.15.
            
            On May 11, 2006 this sequence version replaced NM_001025251.1.
            
            Summary: The protein encoded by the classic Mbp gene is a major
            constituent of the myelin sheath of oligodendrocytes and Schwann
            cells in the nervous system. However, Mbp-related transcripts are
            also present in the bone marrow and the immune system. These mRNAs
            arise from the long Mbp gene (otherwise called 'Golli-Mbp') that
            contains 3 additional exons located upstream of the classic Mbp
            exons. Alternative splicing from the Golli and the Mbp
            transcription start sites gives rise to 2 sets of Mbp-related
            transcripts and gene products. The Golli mRNAs contain 3 exons
            unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They
            encode hybrid proteins that have N-terminal Golli aa sequence
            linked to Mbp aa sequence. The second family of transcripts contain
            only Mbp exons and produce the well characterized myelin basic
            proteins. This complex gene structure is conserved among species
            suggesting that the Mbp transcription unit is an integral part of
            the Golli transcription unit and that this arrangement is important
            for the function and/or regulation of these genes. Mutation of the
            Mbp gene is associated with the 'shiverer' and 'myelin deficient'
            phenotypes in mouse. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest of the
            classic Mbp isoforms (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2680377.279184.1,
                                           SRR1660825.50440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BY245551.1         1-78
            79-537              CO425201.1         1-459
            538-660             BF457157.1         51-173
            661-2186            AC119259.15        26369-27894         c
FEATURES             Location/Qualifiers
     source          1..2186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 55.84 cM"
     gene            1..2186
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="myelin basic protein"
                     /db_xref="GeneID:17196"
                     /db_xref="MGI:MGI:96925"
     exon            1..288
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..705
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="isoform 1 is encoded by transcript variant 1;
                     shiverer; myelin A1 protein; myelin deficient"
                     /codon_start=1
                     /product="myelin basic protein isoform 1"
                     /protein_id="NP_001020422.1"
                     /db_xref="CCDS:CCDS29376.1"
                     /db_xref="GeneID:17196"
                     /db_xref="MGI:MGI:96925"
                     /translation="MASQKRPSQRSKYLATASTMDHARHGFLPRHRDTGILDSIGRFF
                     SGDRGAPKRGSGKVPWLKQSRSPLPSHARSRPGLCHMYKDSHTRTTHYGSLPQKSQHG
                     RTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRASDYKS
                     AHKGFKGAYDAQGTLSKIFKLGGRDSRSGSPMARR"
     exon            289..366
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            367..468
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            469..504
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            505..537
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            538..660
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     exon            661..2186
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="Mbp"
                     /gene_synonym="golli-mbp; Hmbpr; jve; mld; shi"
                     /note="major polyA site"
ORIGIN      
        1 ttttcccgag atgccccggg aagggaggac aacaccttca aagacaggcc ctcagagtcc
       61 gacgagcttc agaccatcca agaagacccc acagcagctt ccggaggcct ggatgtgatg
      121 gcatcacaga agagaccctc acagcgatcc aagtacctgg ccacagcaag taccatggac
      181 catgccaggc atggcttcct cccaaggcac agagacacgg gcatccttga ctccatcggg
      241 cgcttcttta gcggtgacag gggtgcgccc aagcggggct ctggcaaggt accctggcta
      301 aagcagagcc ggagccctct gccctctcat gcccgcagcc gtcctgggct gtgccacatg
      361 tacaaggact cacacacgag aactacccat tatggctccc tgccccagaa gtcgcagcac
      421 ggccggaccc aagatgaaaa cccagtagtc catttcttca agaacattgt gacacctcga
      481 acaccacctc catcccaagg gaaggggaga ggcctgtccc tcagcagatt tagctggggg
      541 gccgaggggc agaagccagg atttggctac ggaggcagag cttccgacta taaatcggct
      601 cacaagggat tcaagggggc ctacgacgcc cagggcacgc tttccaaaat ctttaagctg
      661 ggaggaagag acagccgctc tggatctccc atggcgagac gctgagagcc ctccccgctc
      721 agccttcccg aatcctgccc tcggcttctt aatataactg ccttaaactt ttaattctac
      781 ttgcaccgat tagctagtta gagcagaccc tctcttaatc ccgtggagcc gtgatcgcgg
      841 tggggccagg cccacggcac cccgactggt taaaactatt cgtccctttt cgtttgaaga
      901 ttgagttttc tcggggtctt ctcagccctg acttgttccc cgtgcacctt gttcgactcc
      961 ggaggttcag gtgcacggac acccttccaa gttcacccct actccatcct cagacttttc
     1021 acggtgaggc acacccctcc agcttccgtg ggcactgcgg atagacaggc acaccgccaa
     1081 ggagccagag agcatggcgc aggggactgt gtggtccagg cttcctttgt tttcttcccc
     1141 ctaaagagct ttgtttttcc taacaggatc agacagtctt ggagtggctt atacaacggg
     1201 ggcttgtggt atgtgagcac aggctgggca gctgtgagag tccagagtgg ggtggccctg
     1261 gggacacttc caggccagct atcccctgca ccccaccagc tgatttcgag cgtggcagag
     1321 ggaaggaaag gggcgagtgg gctgggcaat ggccccaaca ggaaacgggg acttaggaga
     1381 acacgctgga gatatgtgtg gccgccaaat gtcaccatct ctcctcagtg gctccccaga
     1441 gctggtgctt ttaagaaccc tgtttcctct cagagcccag ggagagtcca aggacatggc
     1501 gcatctggaa gtgggactgc aggagttctc tggtggcctc gtgctgtccc tctggccact
     1561 tctcatggtg gggtggtcag cggcagctcg ccatggcagt gcccattggt acacactaac
     1621 ctcggtggaa aaataaccat tccctgcctc ctagaaagga ctcattctta gctttagggg
     1681 ggttcctgtc actgaatcga gtcgctgccc tggatgcagg gctggcctgg gcgacgctcc
     1741 agggatgagg agctgagaac cccagtctaa taatgtccat cgacacctcc ttatccctct
     1801 aacgtactat gtcttttgat ttagcatgcc ttctgtagac cttccaaaga gccccacact
     1861 ggcaccgtca cccctaggaa ggcaggtgat ggttgatgta gcccaatact gcatcttgtt
     1921 aatctgttct aactctgagt agagtgtggg tttaagataa caccgattaa tgtatcgcca
     1981 caataacgtg agggtaagag aaaaagcagg gaagaaattt ccagaaaaaa accctccaga
     2041 ttgtcccacg ggagtgtttg ccctccagtg tgactgaacg accttgccca tggcttcgtc
     2101 cagacagcgc agctgcagta tggctggaca gaagcaccta ctattcttga atattgaaat
     2161 aaaataataa acttgcaatg atcttt
//
