LOCUS       NM_029934               2341 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus membrane bound O-acyltransferase domain containing 7
            (Mboat7), mRNA.
ACCESSION   NM_029934
VERSION     NM_029934.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Varadharajan,V., Ramachandiran,I., Massey,W.J., Jain,R.,
            Banerjee,R., Horak,A.J., McMullen,M.R., Huang,E., Bellar,A.,
            Lorkowski,S.W., Gulshan,K., Helsley,R.N., James,I., Pathak,V.,
            Dasarathy,J., Welch,N., Dasarathy,S., Streem,D., Reizes,O.,
            Allende,D.S., Smith,J.D., Simcox,J., Nagy,L.E. and Brown,J.M.
  TITLE     Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid
            homeostasis and function to control alcohol-associated liver injury
  JOURNAL   Elife 12, 92243 (2024)
   PUBMED   38648183
  REMARK    GeneRIF: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes
            lysosomal lipid homeostasis and function to control
            alcohol-associated liver injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Sato,T., Umebayashi,S., Senoo,N., Akahori,T., Ichida,H.,
            Miyoshi,N., Yoshida,T., Sugiura,Y., Goto-Inoue,N., Kawana,H.,
            Shindou,H., Baba,T., Maemoto,Y., Kamei,Y., Shimizu,T., Aoki,J. and
            Miura,S.
  TITLE     LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of
            phospholipids in murine skeletal muscles
  JOURNAL   J Biol Chem 299 (7), 104848 (2023)
   PUBMED   37217003
  REMARK    GeneRIF: LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1
            position of phospholipids in murine skeletal muscles.
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Wang,Z., Zhu,S., Jia,Y., Wang,Y., Kubota,N., Fujiwara,N.,
            Gordillo,R., Lewis,C., Zhu,M., Sharma,T., Li,L., Zeng,Q., Lin,Y.H.,
            Hsieh,M.H., Gopal,P., Wang,T., Hoare,M., Campbell,P., Hoshida,Y.
            and Zhu,H.
  TITLE     Positive selection of somatically mutated clones identifies
            adaptive pathways in metabolic liver disease
  JOURNAL   Cell 186 (9), 1968-1984 (2023)
   PUBMED   37040760
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Anderson,K.E., Kielkowska,A., Durrant,T.N., Juvin,V., Clark,J.,
            Stephens,L.R. and Hawkins,P.T.
  TITLE     Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to
            maintain physiological levels of PtdIns and PtdInsP(2) in the mouse
  JOURNAL   PLoS One 8 (3), e58425 (2013)
   PUBMED   23472195
  REMARK    GeneRIF: LPIAT1 has an essential role in maintaining physiological
            levels of PtdIns and PtdInsP(2) in the mouse
REFERENCE   7  (bases 1 to 2341)
  AUTHORS   Lee,H.C., Inoue,T., Sasaki,J., Kubo,T., Matsuda,S., Nakasaki,Y.,
            Hattori,M., Tanaka,F., Udagawa,O., Kono,N., Itoh,T., Ogiso,H.,
            Taguchi,R., Arita,M., Sasaki,T. and Arai,H.
  TITLE     LPIAT1 regulates arachidonic acid content in phosphatidylinositol
            and is required for cortical lamination in mice
  JOURNAL   Mol Biol Cell 23 (24), 4689-4700 (2012)
   PUBMED   23097495
  REMARK    GeneRIF: Data show that lysophosphatidylinositol acyltransferase 1
            (LPIAT1, also known as MBOAT7) plays a crucial role in brain
            development in mice.
REFERENCE   8  (bases 1 to 2341)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
  REMARK    GeneRIF: Congenital hydrocephalus in Mboat 7 null mice
REFERENCE   9  (bases 1 to 2341)
  AUTHORS   Lee,H.C., Inoue,T., Imae,R., Kono,N., Shirae,S., Matsuda,S.,
            Gengyo-Ando,K., Mitani,S. and Arai,H.
  TITLE     Caenorhabditis elegans mboa-7, a member of the MBOAT family, is
            required for selective incorporation of polyunsaturated fatty acids
            into phosphatidylinositol
  JOURNAL   Mol Biol Cell 19 (3), 1174-1184 (2008)
   PUBMED   18094042
REFERENCE   10 (bases 1 to 2341)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171680.5.
            
            On Jun 5, 2018 this sequence version replaced NM_029934.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023417.1, AB055410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC171680.5         106074-106319       c
            247-325             AC171680.5         105373-105451       c
            326-455             AC171680.5         105139-105268       c
            456-582             AC171680.5         104595-104721       c
            583-742             AC171680.5         101856-102015       c
            743-1103            AC171680.5         99007-99367         c
            1104-1280           AC171680.5         97142-97318         c
            1281-2341           AC171680.5         91122-92182         c
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.12 cM"
     gene            1..2341
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /note="membrane bound O-acyltransferase domain containing
                     7"
                     /db_xref="GeneID:77582"
                     /db_xref="MGI:MGI:1924832"
     exon            1..246
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     exon            247..325
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1671
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /EC_number="2.3.1.n4"
                     /note="leukocyte receptor cluster (LRC) member 4; bladder
                     and breast carcinoma-overexpressed gene 1 protein;
                     membrane-bound O-acyltransferase domain-containing protein
                     7; lysophosphatidylinositol acyltransferase 1;
                     1-acylglycerophosphatidylinositol O-acyltransferase"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 7"
                     /protein_id="NP_084210.2"
                     /db_xref="CCDS:CCDS20724.1"
                     /db_xref="GeneID:77582"
                     /db_xref="MGI:MGI:1924832"
                     /translation="MTPEEWTYLMVLLISIPVGFLFKKAGPGLKRWGAAAVGLGLTLF
                     TCGPHSLHSLITILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTN
                     AVQLLLTLKLVSLASEVQDLHLAQRKEIASGFHKEPTLGLLPEVPSLMETLSYSYCYV
                     GIMTGPFFRYRTYLDWLEQPFPEAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVR
                     EDAFYARPLPTRLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGP
                     TLQCPPPSSPEIAASLEYDYETIRNIDCYGTDFCVRVRDGMRYWNMTVQWWLAQYIYK
                     SAPFRSYVLRSAWTMLLSAYWHGLHPGYYLSFMTIPLCLAAEGYLESALRRHLSPGGQ
                     KAWDWVHWFLKMRAYDYMCMGFVLLSMADTLRYWASIYFWVHFLALACLGLGLVLGGG
                     SPSKRKTPSQATSSQAKEKLREE"
     exon            326..455
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     exon            456..582
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     exon            583..742
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1103
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1280
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..2341
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /note="hexamer: AATAAA"
     polyA_site      2341
                     /gene="Mboat7"
                     /gene_synonym="5730589L02Rik; BB1; Leng4; Lpiat; Lpiat1;
                     LPLAT 7; m-mboa-7"
                     /note="major polyA site"
ORIGIN      
        1 agctctttgc ccggggacct cctagaaaga tcgcgacagg catcttgcgg cagactggtg
       61 ttctgggtac ctttcttgcg gtgctgtaac tcgtacagcc gcggctctcg gggcctggac
      121 cgcgcagccc tgccggcgcc ctccagaacg ggcagtgcgg gggcgtgctg agctggggag
      181 gcgtggcgcg agccgaggcg gcctcgaaaa ggagctccgc agtcttctgg cccacggacg
      241 gttcagacca tgacacccga agaatggaca tatctaatgg tccttcttat ctccatccct
      301 gttggcttcc tctttaagaa agctggacct gggctgaaga gatggggggc agcagctgtg
      361 ggcctggggc tcaccttatt cacctgtggc ccccacagtt tgcattctct gatcaccatc
      421 ttgggaacct gggccctcat tcaggcccag ccctgctcct gccatgccct ggctcttgcc
      481 tggaccttct cctatctcct cttcttccga gccctcagcc tgctgggcct gcccactccc
      541 acgcccttca ccaatgctgt ccagctgctg ttgacactga agttggtgag tctagctagt
      601 gaagtccagg atctgcatct ggctcagaga aaggaaatag cctccggctt ccacaaggag
      661 cctacgctgg gcctcctgcc tgaggtcccc tctttgatgg agacactcag ctatagctac
      721 tgttacgtgg gaatcatgac aggcccattc ttccgctacc gcacctacct ggattggctg
      781 gaacagccct tcccggaagc cgtgcccagc ctgaggcccc tgctgcgccg cgcctggcca
      841 gccccgctct ttggcctgct cttcctgctg tcctcccatc tcttcccact ggaagctgtg
      901 cgtgaggacg ccttctacgc ccgcccgctg cccacccgcc tcttctacat gatcccggtc
      961 ttcttcgcct tccgcatgcg cttctacgtt gcctggattg cggccgagtg cggttgcatt
     1021 gccgcgggct tcggggccta ccctgtggct gccaaagccc gggccggggg cggccccacc
     1081 ctccaatgcc caccccctag cagtccggag attgcagctt ccctggagta tgactatgag
     1141 accatccgta acatcgactg ctatggcaca gacttctgcg tgcgtgtgcg ggatggcatg
     1201 cgatactgga acatgaccgt gcagtggtgg ctggcacagt acatctacaa gagcgcacct
     1261 ttccgctcct acgttttgag gagtgcctgg accatgctgt tgagtgccta ctggcatggc
     1321 ctccaccctg gttactacct aagcttcatg accatcccgc tgtgcctggc tgctgagggc
     1381 tatttggagt cagccttgcg gagacacctg agccccgggg gccagaaagc ctgggactgg
     1441 gtccactggt tcctgaagat gcgtgcctac gactacatgt gcatgggctt tgtgctcctt
     1501 tccatggctg acacactccg gtactgggcc tccatctact tctgggtcca ctttctagcc
     1561 ctggcttgct tggggctggg gctggttttg ggtgggggca gccccagcaa gaggaagaca
     1621 ccatcccagg ccaccagcag ccaagcgaag gaaaagctcc gggaagagtg agctctgctg
     1681 cattggcctg ccttccagtt caagcttttt tgggaattcc atgaaccagg ctgtttgttt
     1741 ggggtttttg tttgtttgtt tgtttgtttc ctttacccag caagaatccc ttgtttggct
     1801 aagagcctgg agaggatccc ctcttcccaa ataattcctc tgccttctat ttaaagctaa
     1861 ggtatccttc tcttgggctc tctcagcatc ttgacctttt cagaccttcc tctgctaaca
     1921 tcagggtatt actatccact cttgaaccta ttatctctgc aacaatcttc agatgttcaa
     1981 aaagccacac ttcccaaaaa tgcccttgca gggaccagtg gtcatctggc atcttagaca
     2041 gactcccagt gggtccccag tatgggggca ggaacttcag ggccaggttc tgggagaggg
     2101 gagggatagc cttcttgttt tcctctttgt ttttatcatc acaccagtgt ttcagagacc
     2161 atggtcttac acatgctgaa ggagaagcta aaatgtgaga agccccaggg gagcttgctc
     2221 ttacagcagc ttctgcctga gccatttctg ggctccccat acaacctacc acccagtgtc
     2281 atccttggcc tgtgacaggc cagaatgtat aaagctttcc caataaagtg ttacacatgc
     2341 a
//
