LOCUS       NM_026037               2802 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus membrane bound O-acyltransferase domain containing 2
            (Mboat2), transcript variant 1, mRNA.
ACCESSION   NM_026037
VERSION     NM_026037.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2802)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2802)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2802)
  AUTHORS   Tabe,S., Hikiji,H., Ariyoshi,W., Hashidate-Yoshida,T., Shindou,H.,
            Shimizu,T., Okinaga,T., Seta,Y., Tominaga,K. and Nishihara,T.
  TITLE     Lysophosphatidylcholine acyltransferase 4 is involved in
            chondrogenic differentiation of ATDC5 cells
  JOURNAL   Sci Rep 7 (1), 16701 (2017)
   PUBMED   29196633
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2802)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   5  (bases 1 to 2802)
  AUTHORS   Hishikawa,D., Shindou,H., Kobayashi,S., Nakanishi,H., Taguchi,R.
            and Shimizu,T.
  TITLE     Discovery of a lysophospholipid acyltransferase family essential
            for membrane asymmetry and diversity
  JOURNAL   Proc Natl Acad Sci U S A 105 (8), 2830-2835 (2008)
   PUBMED   18287005
REFERENCE   6  (bases 1 to 2802)
  AUTHORS   Tamaki,H., Shimada,A., Ito,Y., Ohya,M., Takase,J., Miyashita,M.,
            Miyagawa,H., Nozaki,H., Nakayama,R. and Kumagai,H.
  TITLE     LPT1 encodes a membrane-bound O-acyltransferase involved in the
            acylation of lysophospholipids in the yeast Saccharomyces
            cerevisiae
  JOURNAL   J Biol Chem 282 (47), 34288-34298 (2007)
   PUBMED   17890783
REFERENCE   7  (bases 1 to 2802)
  AUTHORS   Dequeant,M.L., Glynn,E., Gaudenz,K., Wahl,M., Chen,J., Mushegian,A.
            and Pourquie,O.
  TITLE     A complex oscillating network of signaling genes underlies the
            mouse segmentation clock
  JOURNAL   Science 314 (5805), 1595-1598 (2006)
   PUBMED   17095659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU067514.1, AK031824.1, AK034873.1, AK003295.1 and AC159307.2.
            
            On Apr 4, 2007 this sequence version replaced NM_026037.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.5426.1,
                                           SRR1660819.119210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AU067514.1         1-16
            17-400              AK031824.1         2-385
            401-496             AK034873.1         145-240
            497-1999            AK031824.1         386-1888
            2000-2195           AK003295.1         874-1069
            2196-2802           AC159307.2         52344-52950         c
FEATURES             Location/Qualifiers
     source          1..2802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.5 cM"
     gene            1..2802
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /note="membrane bound O-acyltransferase domain containing
                     2"
                     /db_xref="GeneID:67216"
                     /db_xref="MGI:MGI:1914466"
     exon            1..176
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1661
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.n7"
                     /note="isoform a is encoded by transcript variant 1;
                     O-acyltransferase (membrane bound) domain containing 2;
                     lysophospholipid acyltransferase 2; LPC acyltransferase 4;
                     LPCAT; LPEAT; LPLAT 2; mLPCAT4; lyso-PE acyltransferase;
                     lyso-PC acyltransferase 4; lysophosphatidylcholine
                     acyltransferase 4; lysophosphatidylethanolamine
                     acyltransferase; 1-acylglycerophosphocholine
                     O-acyltransferase; O-acyltransferase domain-containing
                     protein 2; 1-acylglycerophosphoethanolamine
                     O-acyltransferase; membrane-bound O-acyltransferase
                     domain-containing protein 2"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 2 isoform a"
                     /protein_id="NP_080313.2"
                     /db_xref="CCDS:CCDS25845.1"
                     /db_xref="GeneID:67216"
                     /db_xref="MGI:MGI:1914466"
                     /translation="MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAVWFRT
                     YLHSSKTSSFIRHVVATLLGLYLAFFCFGWYALHFLVQSGISYCIMIIAGVESMQQCC
                     FVFALGYLSVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAYEIHDGMFRKDEELT
                     PSQRGLAVRRMPSLLEYVSYTCNFMGILAGPLCSYKDYIAFIEGRASHVAQPSENGKD
                     EQHGKADPSPNAAVTEKLLVCGLSLLFHLTISNMLPVEYNIDEHFQATASWPTKATYL
                     YVSLLAARPKYYFAWTLADAINNAAGFGFRGYDKNGVARWDLISNLRIQQIEMSTSFK
                     MFLDNWNIQTALWLKRVCYERATFSPTIQTFFLSAIWHGVYPGYYLTFLTGVLMTLAA
                     RAVRNNFRHYFLEPPQLKLFYDLITWVATQITISYTVVPFVLLSIKPSFTFYSSWYYC
                     LHVCSILVLLLLPVKKSQRRTSTQENVHLSQAKKFDERDNPLGQNSFSTMNNVCNQNR
                     DTGSRHSSLTQ"
     exon            177..322
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..400
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..496
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..552
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            553..607
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..788
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..981
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1085
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1150
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1283
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1435
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..2802
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /note="major polyA site"
     regulatory      2771..2776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /note="hexamer: ATTAAA"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
                     /note="hexamer: ATTAAA"
     polyA_site      2790
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
     polyA_site      2802
                     /gene="Mboat2"
                     /gene_synonym="2810049G06Rik; LPCAT4; Moact2; Oact2"
ORIGIN      
        1 gcgccgctgc atccccatcc tcggcgtagc tcggcacaga gcgagcaagc aagcaagcgg
       61 cgcctggccg gagcgagcgg acgcagcgcc gaggcccggc catggccacc accagcacca
      121 cgggctccac cctgctgcag cccctcagca acgccgtgca actgcccatc gatcaggtca
      181 actttgtagt gtgccagctc tttgccttgt tagcagccgt ttggtttcga acttatctac
      241 actcaagcaa aactagctct tttatcagac acgtagttgc tacccttttg ggcctttatc
      301 ttgcattttt ttgctttgga tggtatgcct tacactttct tgtacaaagt gggatttcct
      361 actgcatcat gatcatagca ggagtggaga gcatgcagca atgttgcttt gtgtttgctt
      421 tgggatacct ctcagtgtgt cagattacta gagtctatat ctttgattat ggacaatatt
      481 ctgctgattt ttcaggccca atgatgatca ttacgcagaa gatcactagt ttggcttacg
      541 aaattcacga cgggatgttt cggaaggatg aagaactgac tccgtcgcag aggggattag
      601 ctgtgaggcg catgccaagt ctcctggagt atgtaagtta tacctgcaac ttcatgggca
      661 tcctggcagg cccactgtgc tcctacaaag actacattgc cttcattgaa ggcagagcat
      721 cccacgtggc acagcccagt gaaaatggaa aagacgagca gcatgggaaa gcagatccat
      781 ctccaaatgc agcagttacg gagaagctcc tggtctgtgg actctcctta ttattccacc
      841 tgaccatctc caacatgcta cccgtggagt acaacatcga tgagcatttc caagccactg
      901 cgtcgtggcc gactaaagcc acctatctgt acgtctctct cttggctgcc agacctaagt
      961 actattttgc atggacctta gctgacgcca ttaacaatgc tgcgggcttc ggtttcagag
     1021 gatacgacaa gaatggagtg gctcgctggg acttaatttc caacttgaga attcagcaaa
     1081 tagagatgtc aacaagtttt aagatgtttc ttgataactg gaatatccag acagctcttt
     1141 ggctcaaaag ggtgtgctat gaacgagcaa ccttcagtcc gacaatccag acattctttc
     1201 tctctgccat ttggcatggg gtctacccag gatactatct gacattccta acgggagtgc
     1261 taatgacgtt agcagctcgg gctgtgagaa ataactttag gcactatttc ctggagcccc
     1321 ctcaacttaa gttattttat gacctcataa cctgggtggc cacccagata acaataagtt
     1381 acacagttgt tccgtttgtg ctcctctcca taaaaccgtc gttcacgttt tacagctcct
     1441 ggtattactg ccttcacgtc tgtagtatct tggtgttgct gttgctgcct gtgaaaaagt
     1501 ctcaaagaag aacgagcaca caggaaaatg ttcatctctc acaggccaaa aagtttgacg
     1561 aaagggacaa tcctctggga cagaacagtt tttccacgat gaataacgtt tgcaatcaga
     1621 accgagacac tggctccaga cactcgtcac taacacagtg actgcgagag cgtgtgatgg
     1681 ctgtttcccg gctgtgaaca gaagccagtc ttgaggcctt tgcagagcct cttgtttaag
     1741 gaagagagac taactgggtg gaaagggatg gtctcggata gggggtttcc tatacactag
     1801 attggaaatg gaaagagata acccctccca tgccatgttc ctgtgggtca cgccttatac
     1861 aaaatcttcc cttgtttcaa tagggcactc tgacctcagc atctgccctc aaggtcatct
     1921 gtgtaccctg ttgctgaatg tacactgcgt atcccaaggc actgaagagg tggaaaataa
     1981 tcatgtcgtc tggatgatta accttttcca aatgaatgtc ttgccttaaa tcttcctaaa
     2041 atgttgttcc cggatggtat ttccaagtgt aaaatcgtga ggagacgatt tcagtattcg
     2101 atatggtgtg ctacagagag gattgaggga agtctaaaac cagatactta agatcgtggg
     2161 tactttaaaa atgcaataaa catctcagta ttcgaagggt tttcttaagg tatcttagag
     2221 gactgtgtgc atggtgggac tgtaaacagt cagggcttaa ttacaggtgt cagtcagggg
     2281 ccccttctag gaggactttc ttaaacataa ttaaaggttg gtaatgtgat attttaggct
     2341 tattttctta agaacaaaaa aaaaaaacaa aacaataaga gggaagctaa gataaggagg
     2401 cccgaacaag gaaagcacct cggagcctgg agccggtggc agagggcttc ccacttctgt
     2461 gtccgagatt agtgtaactg tatgggacac aacagcttac tgatgagaac actgtggact
     2521 ttctgaagaa atccctcgag cataaattac atagagttac agggggttat aagaataaca
     2581 gtgatagatg atttgaaggt tttgaaagaa atctctagta attaaggttc ttgtatggtt
     2641 catcggtttc ttgttcctgt ccctttcatt gctatttggg aaagatgtag ggaaaagaaa
     2701 acttagttga tgagtctaag tgactttttt tttttaatta aattagtttc tatactcttt
     2761 aacttcatgc attaaaattc ttccattaaa ctcttgttaa aa
//
