LOCUS       NM_153546               2855 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus membrane bound O-acyltransferase domain containing 1
            (Mboat1), transcript variant 1, mRNA.
ACCESSION   NM_153546
VERSION     NM_153546.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Wedel,M., Frob,F., Elsesser,O., Wittmann,M.T., Lie,D.C., Reis,A.
            and Wegner,M.
  TITLE     Transcription factor Tcf4 is the preferred heterodimerization
            partner for Olig2 in oligodendrocytes and required for
            differentiation
  JOURNAL   Nucleic Acids Res 48 (9), 4839-4857 (2020)
   PUBMED   32266943
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Tabe,S., Hikiji,H., Ariyoshi,W., Hashidate-Yoshida,T., Shindou,H.,
            Okinaga,T., Shimizu,T., Tominaga,K. and Nishihara,T.
  TITLE     Lysophosphatidylethanolamine acyltransferase 1/membrane-bound
            O-acyltransferase 1 regulates morphology and function of P19C6
            cell-derived neurons
  JOURNAL   FASEB J 30 (7), 2591-2601 (2016)
   PUBMED   27048541
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Hishikawa,D., Shindou,H., Kobayashi,S., Nakanishi,H., Taguchi,R.
            and Shimizu,T.
  TITLE     Discovery of a lysophospholipid acyltransferase family essential
            for membrane asymmetry and diversity
  JOURNAL   Proc Natl Acad Sci U S A 105 (8), 2830-2835 (2008)
   PUBMED   18287005
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Tamaki,H., Shimada,A., Ito,Y., Ohya,M., Takase,J., Miyashita,M.,
            Miyagawa,H., Nozaki,H., Nakayama,R. and Kumagai,H.
  TITLE     LPT1 encodes a membrane-bound O-acyltransferase involved in the
            acylation of lysophospholipids in the yeast Saccharomyces
            cerevisiae
  JOURNAL   J Biol Chem 282 (47), 34288-34298 (2007)
   PUBMED   17890783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450321.15 and AL645749.6.
            
            On Mar 24, 2023 this sequence version replaced NM_153546.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023845.1, AK033388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AL450321.15        143290-143536
            248-393             AL450321.15        201310-201455
            394-471             AL450321.15        202484-202561
            472-548             AL450321.15        209099-209175
            549-567             AL645749.6         2001-2019
            568-623             AL645749.6         19235-19290
            624-678             AL645749.6         21973-22027
            679-862             AL645749.6         23982-24165
            863-1055            AL645749.6         25872-26064
            1056-1159           AL645749.6         31563-31666
            1160-1224           AL645749.6         35289-35353
            1225-1357           AL645749.6         37562-37694
            1358-1509           AL645749.6         40763-40914
            1510-2855           AL645749.6         44948-46293
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.14 cM"
     gene            1..2855
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /note="membrane bound O-acyltransferase domain containing
                     1"
                     /db_xref="GeneID:218121"
                     /db_xref="MGI:MGI:2387184"
     exon            1..247
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1630
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.n6"
                     /EC_number="2.3.1.n7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane bound O-acyl transferase family, member 1;
                     O-acyltransferase (membrane bound) domain containing 1;
                     lysophospholipid acyltransferase 1; LPE acyltransferase 1;
                     lyso-PE acyltransferase; lyso-PS acyltransferase;
                     lysophosphatidylserine acyltransferase;
                     1-acylglycerophosphoserine O-acyltransferase;
                     lysophosphatidylethanolamine acyltransferase;
                     O-acyltransferase domain-containing protein 1;
                     1-acylglycerophosphoethanolamine O-acyltransferase;
                     membrane-bound O-acyltransferase domain-containing protein
                     1; 1-acylglycerophosphocholine O-acyltransferase;
                     lysophosphatidylethanolamine acyltransferase 1;
                     1-acylglycerophosphoserine O-acyltransferase MBOAT1;
                     1-acylglycerophosphoethanolamine O-acyltransferase MBOAT1"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 1 isoform 1"
                     /protein_id="NP_705774.1"
                     /db_xref="CCDS:CCDS26414.1"
                     /db_xref="GeneID:218121"
                     /db_xref="MGI:MGI:2387184"
                     /translation="MAARPPASLSYRTTGSTCLHPLSQLLGIPLDQVNFVACQLFALS
                     AAFWFRIYLHPGKASPEVRHTLATILGIYFVVFCFGWYAVHLFVLVLMCYGVMVTASV
                     SNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLG
                     RKAEDLSAEQHRLAVKAKPSLLEYLSYHLNFMSVIAGPCNNFKDYVAFIEGRHIHMKL
                     LEVNWTQRGFQSLPEPSPMGAVIQKLCVTLMSLLLFLTLSKSFPVTFLIDDWFVHKAN
                     FLSRLWYLYVVMQAAKPKYYFAWTLADAVHNAAGFGFNGMDTDGKSRWDLLSNLNIWK
                     IETATSFKMYLENWNIQTSTWLKCVCYERVPWYPTVLTFLLSALWHGVYPGYYFTFLT
                     GVPVTLAARAVRNNYRHHFLSSKARKIAYDVVTWAVTQLAVSYTAAPFVMLAVEPTIS
                     LYKSVFFFLHIICLLIILFLPIKPHQPQRQSRSPNSVKKKAD"
     exon            248..393
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..471
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..567
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..623
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..678
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..862
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1055
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1159
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1224
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1357
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1509
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2855
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2733..2738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /note="hexamer: AATAAA"
     polyA_site      2769
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /note="major polyA site"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /note="hexamer: AATATA"
     polyA_site      2855
                     /gene="Mboat1"
                     /gene_synonym="9130215M02Rik; LPEAT; LPEAT1; LPLAT 1;
                     LPSAT; Moact1; Oact1"
                     /note="major polyA site"
ORIGIN      
        1 agaacgtggg ggccctgccc tcccaggcgc ggggtcccgc agcgccaggt ccgcgccctg
       61 gagtcggcgc caggttcccg cgaggtcctc aggagccctc aaggtggcca gtgtgcagct
      121 cccgggcgac agagcaccct gaagatgcag gatggcagca cggccgcccg ccagcctctc
      181 ttaccgtacc accggctcca cctgcctgca cccgctcagc cagctcctgg gcatcccgct
      241 ggatcaggtt aactttgtgg cttgccagct ctttgccttg tctgctgctt tctggttcag
      301 aatctactta catcctggta aagccagccc tgaggtccgg cacaccttgg ccaccatttt
      361 gggcatctat tttgttgtgt tttgttttgg ttggtatgct gtacatctct ttgtgctggt
      421 gttgatgtgt tatggggtca tggtcactgc aagtgtatcc aatattcaca ggtattcctt
      481 ttttgtagcc atgggctacc ttacgatatg ccacatcagc cgcatttaca tcttccacta
      541 tggaattctc actacagatt tttctgggcc cctgatgatt gtcactcaga agatcacgac
      601 gttggctttc caagttcatg atggattggg tcgaaaagct gaagaccttt ctgctgagca
      661 acaccgactt gctgtgaaag cgaagccctc gcttctggaa tacttaagct accatctcaa
      721 ctttatgagt gtcatagccg gcccttgcaa caatttcaag gactacgtag ccttcatcga
      781 agggagacat atacacatga agttgctgga agtgaactgg acgcaaaggg gtttccagag
      841 tttgccagag ccttctccca tgggagctgt gatacagaag ttgtgtgtga ccttgatgtc
      901 tctcctgttg tttttgacgc tctccaagtc ctttcccgtc accttcctta ttgatgactg
      961 gtttgtacat aaggccaact ttctgagtcg tctctggtac ttatatgtcg tcatgcaagc
     1021 cgcaaagccc aagtattact ttgcgtggac attagcagat gcggtgcaca atgcagctgg
     1081 attcgggttc aatggcatgg acacggatgg gaagtctcgc tgggatttac tatctaacct
     1141 gaacatctgg aagattgaga ctgccacgag tttcaaaatg tacttggaaa actggaatat
     1201 tcagacatct acgtggctga aatgtgtgtg ctatgagcgg gttccctggt accccacagt
     1261 gctcaccttc ctcctgtctg ctctgtggca cggcgtctac cctggatact acttcacatt
     1321 cctaactgga gtccctgtca cattggcagc cagagcggtg aggaacaact acagacacca
     1381 cttcctctct tccaaagctc gaaagattgc ctatgacgtg gtgacctggg ctgtcactca
     1441 gttggctgtc tcttacacgg cagcgccttt cgtcatgttg gcagtcgagc caaccatcag
     1501 tttatacaag tccgtgttct tttttttaca catcatatgt ctgctgataa tcctctttct
     1561 gccaatcaaa ccacaccagc ctcaaaggca gtctcggagt ccaaattctg taaagaagaa
     1621 ggcagactga tacccacaga gaaacggtga acaagagagt tgcgggacat tgggaagaca
     1681 taacggacag gctcaagggt tctccagtga ctcggaggag atgtttacat gtattttttt
     1741 ttttccgctg cagggaatat ttttatgtct tttttttttt ttgtaccatt aaatcaccat
     1801 gtctagcttt gtctgcatac tttacagggc ctttcagaaa cacagcatag acaagaggcc
     1861 actgggtagg ctcttctaaa atcatttgca cctactgaaa tctggaagca tgactccagc
     1921 cgttgcctcc ggcacttagg aggtgtctgc tgagatgact tgtctggagt tttgaaatcg
     1981 gaacattccc aggcatgatt tttttttcct cttggcaact ccagaccctg ggatatgcaa
     2041 cttagtaggc tgtggacaca actcttatgc tcaaaagccc ttggaggaaa gagattgtga
     2101 agggaagttt tcagggtata gaaaaaaaaa agaaaaacct ccaggaactg ggaagattag
     2161 cccctgaatg cttgaatgga tcgatgcgtc cccaaaccaa ctgcattatc accccaactc
     2221 agccaggaat gtaccattcc cttttttcct tctgaattga gccaagattg gacatccgaa
     2281 agctgcctgc gtgccccagg agttggggag agagtggggg ctactggttt ccatttcccg
     2341 tgcttggatc tgattgactt ctattgaccc tgagaaggca cccggatacc aaccagcaca
     2401 ccgtccaaag gcggccaaat gtcttttcaa gaaatagctg cattcagcat gcagaggctc
     2461 ccttttgtct ctgcatatca aggaagtgtc gatgatcacg gccaacgtgt agacactagg
     2521 taacgtctgt aacgggctac agccagcttt attttaggtg atctgtcatg tcggaaagct
     2581 gcaggggaac aacagtgctc tactctgtct ttgttatgaa tgtgctgtgg ctccttcggg
     2641 gaatttctac tggataaaat agtctatgtg aaagaaggaa acataatatt taaaatgtgg
     2701 acgataataa taatgatgat gataataata ataataaaat atgcgcttca atgatgtgcc
     2761 tcaatcaaat ggcctgaaag gtgaaaattt gttctgaaca gatgattttt aaaaaattag
     2821 tttctcactg aataaataat atatttctat tttaa
//
