LOCUS       NM_207515               4525 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus muscleblind like splicing factor 2 (Mbnl2), transcript
            variant 2, mRNA.
ACCESSION   NM_207515
VERSION     NM_207515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4525)
  AUTHORS   Piasecka,A., Szczesniak,M.W., Sekrecki,M., Kajdasz,A.,
            Sznajder,L.J., Baud,A. and Sobczak,K.
  TITLE     MBNL splicing factors regulate the microtranscriptome of skeletal
            muscles
  JOURNAL   Nucleic Acids Res 52 (19), 12055-12073 (2024)
   PUBMED   39258536
REFERENCE   2  (bases 1 to 4525)
  AUTHORS   Yadava,R.S., Mandal,M. and Mahadevan,M.S.
  TITLE     Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle
            Regeneration
  JOURNAL   Int J Mol Sci 25 (5), 2687 (2024)
   PUBMED   38473933
  REMARK    GeneRIF: Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal
            Muscle Regeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4525)
  AUTHORS   Nutter,C.A., Kidd,B.M., Carter,H.A., Hamel,J.I., Mackie,P.M.,
            Kumbkarni,N., Davenport,M.L., Tuyn,D.M., Gopinath,A., Creigh,P.D.,
            Sznajder,L.J., Wang,E.T., Ranum,L.P.W., Khoshbouei,H., Day,J.W.,
            Sampson,J.B., Prokop,S. and Swanson,M.S.
  TITLE     Choroid plexus mis-splicing and altered cerebrospinal fluid
            composition in myotonic dystrophy type 1
  JOURNAL   Brain 146 (10), 4217-4232 (2023)
   PUBMED   37143315
REFERENCE   4  (bases 1 to 4525)
  AUTHORS   Khandelwal,A., Cushman,J., Choi,J., Zhuravka,I., Rajbhandari,A.,
            Valiulahi,P., Li,X., Zhou,C., Comai,L. and Reddy,S.
  TITLE     Mbnl2 loss alters novel context processing and impairs object
            recognition memory
  JOURNAL   iScience 26 (5), 106732 (2023)
   PUBMED   37216102
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4525)
  AUTHORS   Huang,C.W., Lee,K.Y., Lin,P.T., Nian,F.S., Cheng,H.Y., Chang,C.H.,
            Liao,C.Y., Su,Y.L., Seah,C., Li,C., Chen,Y.F., Lee,M.H. and
            Tsai,J.W.
  TITLE     Muscleblind-like 2 knockout shifts adducin 1 isoform expression and
            alters dendritic spine dynamics of cortical neurons during brain
            development
  JOURNAL   Neuropathol Appl Neurobiol 49 (2), e12890 (2023)
   PUBMED   36765387
  REMARK    GeneRIF: Muscleblind-like 2 knockout shifts adducin 1 isoform
            expression and alters dendritic spine dynamics of cortical neurons
            during brain development.
REFERENCE   6  (bases 1 to 4525)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4525)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 4525)
  AUTHORS   Kanadia,R.N., Urbinati,C.R., Crusselle,V.J., Luo,D., Lee,Y.J.,
            Harrison,J.K., Oh,S.P. and Swanson,M.S.
  TITLE     Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2
            and Mbnl3
  JOURNAL   Gene Expr Patterns 3 (4), 459-462 (2003)
   PUBMED   12915312
REFERENCE   9  (bases 1 to 4525)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4525)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198796.1, AK085709.1, BB673209.1, BE336239.1, BC079898.1 and
            AI461681.1.
            
            On Apr 5, 2007 this sequence version replaced NM_207515.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            coding region segment, compared to variant 1. The resulting protein
            (isoform 2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.188177.1,
                                           SRR1660815.222573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY198796.1         2-39
            39-1486             AK085709.1         2-1449
            1487-2426           AK085709.1         1504-2443
            2427-2792           BB673209.1         75-440
            2793-3252           BE336239.1         62-521
            3253-4496           BC079898.1         3294-4537
            4497-4525           AI461681.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..4525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 64.44 cM"
     gene            1..4525
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /note="muscleblind like splicing factor 2"
                     /db_xref="GeneID:105559"
                     /db_xref="MGI:MGI:2145597"
     exon            1..237
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     exon            238..856
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     CDS             683..1750
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /note="isoform 2 is encoded by transcript variant 2;
                     muscleblind-like protein 2; muscleblind-like 2"
                     /codon_start=1
                     /product="muscleblind-like protein 2 isoform 2"
                     /protein_id="NP_997398.1"
                     /db_xref="CCDS:CCDS49568.1"
                     /db_xref="GeneID:105559"
                     /db_xref="MGI:MGI:2145597"
                     /translation="MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQ
                     VENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQ
                     FMFPGTPLHPVPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSP
                     PVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVC
                     MDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALH
                     PLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQHTAFIPTVPMMHSATSATVSAA
                     TTPATSVPFAATATANQIILK"
     exon            857..1021
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1222
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1486
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1640
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1735
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..4499
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4477..4482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /note="hexamer: AATAAA"
     polyA_site      4499
                     /gene="Mbnl2"
                     /gene_synonym="1110002M11Rik; MBLL; mKIAA4072"
                     /note="major polyA site"
ORIGIN      
        1 gtgggaagga agggctgcag ctcacagcaa cagagtttag actgtctttg cttcatcatc
       61 tgaaggtaaa attttccagc cacggccggc ggctcgcaga gtacaataaa cagggacgga
      121 gaactatttg catggacccc ccttcctcat gatgcggtgg agaagccacg gccactcggt
      181 cctgccagat gttcttgggg ttactgtaca tggggaagac gagcagagct aaacaagaat
      241 ttaaagagga cgaaggaagg aaagcgccat cctgctcaaa tacaaagatc taagagggtt
      301 gttttcccac atcctccaaa gctgtgagca ttagaactaa tattttccca aagagtgcca
      361 tcgtattaaa gccactttat taaggagggg tgtatctgca aaacagtcaa gagactagaa
      421 ccctgggagc cagagatgac agtgagcacg cactgcttgt ggctcacagt cttccagtgg
      481 ggcctatcga tcggtgactg acttcctgct tgctgacaca ttccccctcc ccggtttcct
      541 ggattggact gcattaaaga attcactgct taccttcaaa cttacatgtt ggagttttca
      601 cggcggttgt tttgagatca ttgagactcg gattgatttc gacatttaac cgaaaggaac
      661 agagcccaaa gtagttctca tcatggcctt gaacgttgcc cccgtgagag acacaaagtg
      721 gctgacgctg gaggtctgca gacagtacca gagaggaacg tgctcacgct ccgacgaaga
      781 atgcaagttt gctcaccccc ccaaaagttg ccaggttgaa aatggaagag taattgcctg
      841 ctttgattcc ctcaagggcc gctgttcaag agagaactgc aaatatcttc atcctccgac
      901 acacttaaaa acccagctag agattaatgg gaggaacaat ttgatccagc aaaaaactgc
      961 agcagcgatg cttgcccagc agatgcaatt tatgtttcca ggaacgccgc tccatcctgt
     1021 gcccactttt cctgtaggtc ccaccatagg gacaaatgcg gctattagct ttgctcctta
     1081 cttagcgcct gtcacccctg gagttgggtt agtcccaaca gaggttctac ccactacacc
     1141 ggtcattgtt cccggaagtc caccggtcac tgtcccgggc tcaactgcaa ctcagaaact
     1201 tctcaggact gataaactgg aggtatgcag ggagttccag cgaggaaact gtgcccgggg
     1261 agagacagac tgccgctttg cacacccggc agacagcacc atgatcgaca caaacgacaa
     1321 caccgtaacc gtttgtatgg attacataaa ggggcgttgc atgagggaga aatgcaaata
     1381 ttttcaccct cctgcacact tgcaggccaa aatcaaagct gcgcagcacc aagccaacca
     1441 ggccgcggtg gccgcccagg cagccgcggc cgcggccaca gtcatggcct tccctccggg
     1501 tgctcttcat cccttaccaa agagacaagc acttgaaaaa agcaacgggg ccagcacggt
     1561 cttcaacccc agcgtcttgc actaccagca ggctctgacc agtgcgcagc tgcagcagca
     1621 cacggcgttc atccccacag tacccatgat gcacagcgct acgtccgcca ctgtctctgc
     1681 agcaacaact cctgcaacaa gtgtcccctt cgcagcaaca gccacagcca atcagataat
     1741 tctgaaataa tcaacagaaa tggaatggaa tgccaagaat ctgcattgag aataactaaa
     1801 cattgttact gtacatatta ccccgtttcc tcctcaatag aattgccaca aactgcatgc
     1861 taaatttagt tcttctggac agaccacaac cctaaggcta gttctgctat gtcatatatg
     1921 agtattaaat atggtatgct tagtatactc cagcctaaga tagttaacca cctgagacca
     1981 gctgtgatgt tcgaagacat acaggatgag gttttctttc acagggttct gagcatagtt
     2041 tctgtcccag gaatattgtc ttatctccat aactatagct gatgcagaaa gtccagacaa
     2101 tatactcatt tcgactcaga atatttcaaa tttagcaata aacagttagc tttagtttta
     2161 agtacctatt ccaagggcag gttcgattgt aactccaatc acaaccattt catttcctga
     2221 ctggatcgaa gggtatgatt cacttcttga ggagacggac agtcgcagca gagagaagtg
     2281 aagtaaaaca tacgcctgcc tcgcaggtct aaagtctgag tggcagctca agcacaattg
     2341 ccaggggaca catcagagtg tggggttcgc tttgccagga gatgccgcac tgaatcatgg
     2401 gattctagaa taacattgca tagattgaaa aaaaaaaaaa aactttgcac ggtatgagct
     2461 tcatacccaa cccaacaaag tcttgaaggt attattttac aagtatattt ttaaagttgt
     2521 tttataagag agactttgta gaagtgccta gattttgcca gacttcatcc agcttgacaa
     2581 gaatgaaagg ctcatgccaa tagtcgaatc taagggattg gtctttcaaa ctcgccctcc
     2641 ggttgcctgt taccgaataa ctcttctaaa ctaaaaccta gtcaaacagg gaagctgtag
     2701 gtgaggaggt ctgtataata ttccagttta agtacgtctg agtttagtca ctacagatgc
     2761 aaactgtgac tttaatctaa attactatgt aaacgaaaaa aaaaagtaga tagtttcact
     2821 ttttaaaaac tccattactg tttttgcatt ttaagagttg gattaaaggg ttgtaagtaa
     2881 ctgcagcatg gaaaaatagt tcttttaatt ctttcacctt aaagcatatt ttatgtctca
     2941 aaagtataaa aaactttaat acaagtacac acatattata tatacacata catatatata
     3001 ctatatatgg atgaaacata ttttaatgtt gtttactttt tttaaatact tggttgatct
     3061 tcaaggtaat agcgatacaa ttaaattttg ttcagaaagt ttgttttaaa gtttatttta
     3121 agcactatcg taccaaatat ttcatatttc acattttata tgttgcacat agcctacaca
     3181 gtacctacat agtttttaaa ttattgttta agaaatgaaa cagctgttat aaatggatat
     3241 tatgtgtaat tgtttaaaac atccattttc tttgtgaaca ttttagtgat tgaagtattt
     3301 tgacttttga gattgaatgt aaaatatttt aaattttggt atcatcgcct gttctgaaaa
     3361 ctagaggcat ccaaccatat catttttttt gattgaaaaa agatctgcat ttaattcatg
     3421 ttggtcaaag tctaattact atttatctta catcatagat ctgataactg tatcgaaaag
     3481 agaaatcaca ttctgagtgt aatcttgcat agtgcttgtg tcgtgtttgt ttttaatttg
     3541 tggaaaggta ttgtatctaa cttgtatcac cttgatagtt ctcatcttta tgtattattg
     3601 atatttgtaa tttcctcagc tataacaatg tagttacgct acaacttgcc taaaacactc
     3661 atactttttt ttttctttac ttactcattt aaactcattg agaagatagt agactaaaaa
     3721 ggtaaattat gggaatcact gaaatatttt tgtagactaa ttgttgtaac tgtcctttct
     3781 tcctttcatt tcatgatttt tattttaaaa attattagca catagctatt ttcagccctt
     3841 taataactga tcatcaaaac atcacctgta tcccccagcc aatatagatg actgtatttt
     3901 ttactatgat atccattttc cagaattgtg attataatat gcagagtcaa atatgccatt
     3961 tacaataagg aggaggccag gcaaatgcat agatgtacaa atatatgtac aacagatttt
     4021 gctttttatt tatttataat gtaattttat agaataattc tgggatttga gaggatctaa
     4081 aactattttt ctgtataaat attatttgcc aaaagtttgt ttatattcag aagtctgact
     4141 atgatggata aatcttaaat gctttgttta attacaaaaa caaaatcacc aatatccaag
     4201 acaggaagat ctcagttcaa cagctccggt agttagggaa ctaactccac ttgcacagga
     4261 cttcatttca ctcttggttt tcaggctata acagcacttc acagaactat tctttcagcc
     4321 atacaccact ggtcacattt ctactaaatc tttctgtaac acttcttaaa gaattccctc
     4381 attcgttatc ttacagtgta aacaggactc taatttgtat caattatatg ttttggttgt
     4441 aatattcagt tcactcaccc aatgtacaac caatgaaata aaagaagcat ttaaaaggaa
     4501 aaaaaaaaaa aaaaaaaaaa aaaaa
//
