LOCUS       NM_177878               1308 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus metallo-beta-lactamase domain containing 1 (Mblac1),
            mRNA.
ACCESSION   NM_177878
VERSION     NM_177878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Ceyhan,B., LaMar,J., Nategh,P., Neghabi,M., Konjalwar,S.,
            Rodriguez,P., Hahn,M.K., Blakely,R.D. and Ranji,M.
  TITLE     Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1
            Knockout Mice
  JOURNAL   Annu Int Conf IEEE Eng Med Biol Soc 2023, 1-4 (2023)
   PUBMED   38083729
  REMARK    GeneRIF: Optical Imaging Reveals Liver Metabolic Perturbations in
            Mblac1 Knockout Mice.
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Gibson,C.L., Codreanu,S.G., Schrimpe-Rutledge,A.C., Retzlaff,C.L.,
            Wright,J., Mortlock,D.P., Sherrod,S.D., McLean,J.A. and
            Blakely,R.D.
  TITLE     Global untargeted serum metabolomic analyses nominate metabolic
            pathways responsive to loss of expression of the orphan metallo
            beta-lactamase, MBLAC1
  JOURNAL   Mol Omics 14 (3), 142-155 (2018)
   PUBMED   29868674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049381.1 and AI314927.1.
            
            On Mar 10, 2011 this sequence version replaced NM_177878.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1087              AK049381.1         2-1088
            1088-1308           AI314927.1         4-224               c
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.98 cM"
     gene            1..1308
                     /gene="Mblac1"
                     /note="metallo-beta-lactamase domain containing 1"
                     /db_xref="GeneID:330216"
                     /db_xref="MGI:MGI:2679717"
     exon            1..1308
                     /gene="Mblac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..867
                     /gene="Mblac1"
                     /EC_number="3.-.-.-"
                     /note="endoribonuclease MBLAC1"
                     /codon_start=1
                     /product="metallo-beta-lactamase domain-containing protein
                     1"
                     /protein_id="NP_808546.1"
                     /db_xref="CCDS:CCDS19796.1"
                     /db_xref="GeneID:330216"
                     /db_xref="MGI:MGI:2679717"
                     /translation="MNGPVRTEPLHGEIPLLASSGSYSVVVLLRGYAEPQGAGDAVRA
                     DGTVTLVLPRGWASDSSRGLAPSADGGSKTALEEAVRGPILVDTGGPWARGALLEALA
                     TQGVAPEDVTLVVGTHGHSDHIGNLGLFPEAALLVSHDFCLPEGLYLPHGLCETQPLI
                     LGSGLQVWATPGHGGQRDVSVVVEGTSLGTVVVAGDVFERLGDEDSWQALSEDPVAQQ
                     RSRERILSVADVVVPGHGAPFRVVRETVKSSEDLICEGKAVA"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mblac1"
                     /note="hexamer: AATAAA"
     polyA_site      1301
                     /gene="Mblac1"
     polyA_site      1308
                     /gene="Mblac1"
                     /note="major polyA site"
ORIGIN      
        1 gcaccttgga aagagtggcg gggcttgcgg taggattttg gagggactgg gcagacgtcc
       61 gtggcggggt aaatctccct tgtcatgaac ggtccagtgc gcaccgagcc cctgcatggt
      121 gagatccctt tgctggcgtc cagcggctcc tactccgtgg tggttctgct gcgcggctac
      181 gcggagccgc agggagcggg cgacgcggtg cgtgctgatg gcactgtgac tctcgtcctg
      241 cctcggggct gggcctcgga ctccagccgc ggtttggccc catccgcaga cggcggctct
      301 aagactgccc tggaggaggc ggtgcgtggc cccatcctcg tggacaccgg gggaccctgg
      361 gcgcggggtg cgctgctgga agccctggct acacagggcg tggcccccga agatgtgact
      421 ctggtggtgg gcacccacgg acactcggat catattggga acctggggct gtttcccgag
      481 gcagctttgt tagtctccca tgacttctgc cttcccgagg gtctctatct gccccatggg
      541 ctgtgtgaaa cgcagccctt gatactgggc tcgggactgc aggtgtgggc cacgccgggc
      601 cacggaggac agcgggacgt gagcgtcgta gtggagggca ccagcctggg caccgtggtg
      661 gtggctggcg atgtgttcga gcgacttggt gacgaggact cctggcaggc cctgagcgaa
      721 gacccagtag ctcagcagcg gagccgggag aggattctga gcgtagctga tgtggtggtg
      781 cctggtcacg gagccccctt tcgagtggtc agggaaacag tgaaaagttc agaggatttg
      841 atatgtgaag gcaaggcggt tgcttgactg gactccagtc aggaaagccc cttccagcga
      901 ggaaccggcg tcagttggtc cgggagacct agaggacaca gtcaagacaa gcaatatttg
      961 tcacgtgcag ctttctagga ggcagcttcc aaacaggaca gaatgattga catcagtccc
     1021 ctttaatcat tgcaacctaa gcaggacaaa ggactggctt agatccacat cctccatgag
     1081 cctccgtaaa atataggaaa aaaaatagtt aaaatatgta tttgggatgt gcgtgtgtgc
     1141 ctgtggaatt ctgaaggcta ctttggaaga gtcggttctc tccatcctgt gggtccccag
     1201 gatcgagttc aggttgtcgg acttgacgcc agggaccctt tacctgctga gccatcctga
     1261 tttatattct tgttaggacc ttcaaaaata aaaatcgacc gcaagtca
//
