LOCUS       NM_010776               1103 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus mannose-binding lectin (protein C) 2 (Mbl2),
            transcript variant 1, mRNA.
ACCESSION   NM_010776
VERSION     NM_010776.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1103)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 1103)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1103)
  AUTHORS   Wu,M., Zheng,W., Song,X., Bao,B., Wang,Y., Ramanan,D., Yang,D.,
            Liu,R., Macbeth,J.C., Do,E.A., Andrade,W.A., Yang,T., Cho,H.S.,
            Gazzaniga,F.S., Ilves,M., Coronado,D., Thompson,C., Hang,S.,
            Chiu,I.M., Moffitt,J.R., Hsiao,A., Mekalanos,J.J., Benoist,C. and
            Kasper,D.L.
  TITLE     Gut complement induced by the microbiota combats pathogens and
            spares commensals
  JOURNAL   Cell 187 (4), 897-913 (2024)
   PUBMED   38280374
REFERENCE   4  (bases 1 to 1103)
  AUTHORS   He,T., Zhou,B., Sun,G., Yan,Q., Lin,S., Ma,G., Yao,Q., Wu,X.,
            Zhong,Y., Gan,D., Huo,S., Jin,W., Chen,D., Bai,X., Cheng,T., Cao,H.
            and Xiao,G.
  TITLE     The bone-liver interaction modulates immune and hematopoietic
            function through Pinch-Cxcl12-Mbl2 pathway
  JOURNAL   Cell Death Differ 31 (1), 90-105 (2024)
   PUBMED   38062244
  REMARK    GeneRIF: The bone-liver interaction modulates immune and
            hematopoietic function through Pinch-Cxcl12-Mbl2 pathway.
REFERENCE   5  (bases 1 to 1103)
  AUTHORS   Xu,L., Jiang,H., Xie,J., Xu,Q., Zhou,J., Lu,X., Wang,M., Dong,L.
            and Zuo,D.
  TITLE     Mannan-binding lectin ameliorates renal fibrosis by suppressing
            macrophage-to-myofibroblast transition
  JOURNAL   Heliyon 9 (11), e21882 (2023)
   PUBMED   38034794
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1103)
  AUTHORS   Epifano,O., Liang,L.F. and Dean,J.
  TITLE     Mouse Zp1 encodes a zona pellucida protein homologous to egg
            envelope proteins in mammals and fish
  JOURNAL   J Biol Chem 270 (45), 27254-27258 (1995)
   PUBMED   7592984
REFERENCE   7  (bases 1 to 1103)
  AUTHORS   Sastry,R., Wang,J.S., Brown,D.C., Ezekowitz,R.A., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Characterization of murine mannose-binding protein genes Mbl1 and
            Mbl2 reveals features common to other collectin genes
  JOURNAL   Mamm Genome 6 (2), 103-110 (1995)
   PUBMED   7766991
REFERENCE   8  (bases 1 to 1103)
  AUTHORS   White,R.A., Dowler,L.L., Adkison,L.R., Ezekowitz,R.A. and
            Sastry,K.N.
  TITLE     The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize
            to chromosomes 14 and 19
  JOURNAL   Mamm Genome 5 (12), 807-809 (1994)
   PUBMED   7894166
REFERENCE   9  (bases 1 to 1103)
  AUTHORS   Kuge,S., Ihara,S., Watanabe,E., Watanabe,M., Takishima,K., Suga,T.,
            Mamiya,G. and Kawakami,M.
  TITLE     cDNAs and deduced amino acid sequences of subunits in the binding
            component of mouse bactericidal factor, Ra-reactive factor:
            similarity to mannose-binding proteins
  JOURNAL   Biochemistry 31 (30), 6943-6950 (1992)
   PUBMED   1637828
REFERENCE   10 (bases 1 to 1103)
  AUTHORS   Sastry,K., Zahedi,K., Lelias,J.M., Whitehead,A.S. and
            Ezekowitz,R.A.
  TITLE     Molecular characterization of the mouse mannose-binding proteins.
            The mannose-binding protein A but not C is an acute phase reactant
  JOURNAL   J Immunol 147 (2), 692-697 (1991)
   PUBMED   1712818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149484.1 and DV653788.1.
            
            On Jul 24, 2018 this sequence version replaced NM_010776.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149484.1, CA478654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1101              AK149484.1         2-1102
            1102-1103           DV653788.1         591-592
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 25.14 cM"
     gene            1..1103
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /note="mannose-binding lectin (protein C) 2"
                     /db_xref="GeneID:17195"
                     /db_xref="MGI:MGI:96924"
     exon            1..85
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /inference="alignment:Splign:2.1.0"
     exon            86..196
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /inference="alignment:Splign:2.1.0"
     exon            197..380
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..940
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /note="mannose-binding protein C; mannose binding lectin,
                     liver (C); mannan-binding protein; RA-reactive factor P28A
                     subunit"
                     /codon_start=1
                     /product="mannose-binding protein C precursor"
                     /protein_id="NP_034906.1"
                     /db_xref="CCDS:CCDS29742.1"
                     /db_xref="GeneID:17195"
                     /db_xref="MGI:MGI:96924"
                     /translation="MSIFTSFLLLCVVTVVYAETLTEGVQNSCPVVTCSSPGLNGFPG
                     KDGRDGAKGEKGEPGQGLRGLQGPPGKVGPTGPPGNPGLKGAVGPKGDRGDRAEFDTS
                     EIDSEIAALRSELRALRNWVLFSLSEKVGKKYFVSSVKKMSLDRVKALCSEFQGSVAT
                     PRNAEENSAIQKVAKDIAYLGITDVRVEGSFEDLTGNRVRYTNWNDGEPNNTGDGEDC
                     VVILGNGKWNDVPCSDSFLAICEFSD"
     exon            381..497
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /inference="alignment:Splign:2.1.0"
     exon            498..566
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1103
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1077..1082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /note="hexamer: AATAAA"
     polyA_site      1098
                     /gene="Mbl2"
                     /gene_synonym="L-MBP; MBL; MBL-C; MBP-C; RARF/P28A"
                     /note="major polyA site"
ORIGIN      
        1 actttgaggc atctgttctg gtggaagagg agcttccttg cctcctgagt ctttgctgtg
       61 ccaaagccct gaaatatcat atctggccat cagacactgg taagttggag gtgtgaactt
      121 gtttggctct ccctgcctgc agtgacacca gagacctgga caccagtgac ctccctcaga
      181 agggcgtctc ctgcacgtga ggagcatgtc cattttcaca tccttccttc tgctgtgtgt
      241 ggtgacagtg gtttatgcag agaccttaac cgaaggtgtt caaaattcct gccctgtggt
      301 tacctgcagt tctccaggcc tgaatggctt cccaggcaaa gatggacgtg acggtgccaa
      361 gggagaaaag ggagaaccag gtcaagggct cagaggcttg caaggccctc ctggaaaagt
      421 aggacctaca ggacccccag ggaatccggg gttaaaagga gcagtgggac cgaaaggaga
      481 ccgtggggac agagcagaat ttgatactag cgaaattgat tcagaaattg cagccctacg
      541 atcagagctg agagccctga gaaactgggt gctcttctct ctgagtgaaa aagttggaaa
      601 gaagtatttt gtgagcagtg ttaaaaagat gagccttgac agagtgaagg ccctgtgctc
      661 cgaattccag ggctctgtgg ccactcccag gaatgctgag gaaaactcgg ccatccagaa
      721 agtggccaaa gatattgcct acttgggcat cacagatgtg agggttgaag gcagttttga
      781 ggatctgaca ggaaacagag tgcgctatac taattggaat gatggggagc ccaacaacac
      841 gggcgatggg gaagactgtg tggtgatctt gggaaatggc aagtggaacg atgtcccctg
      901 ctctgactct tttttggcaa tctgtgaatt ctctgactga gggtgcttgt ttctcagccc
      961 tccttgattc tttagggtac tcctgacgtc cgcagtttgt tctgaaaaat aaaatatggg
     1021 aaaatataaa caattcaaca ttggttaccc aatgcattct cttgtgaagg tgtagaaata
     1081 aagtgagttt agttttcatt tat
//
