LOCUS       NM_010775                923 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus mannose-binding lectin (protein A) 1 (Mbl1), mRNA.
ACCESSION   NM_010775 XM_981944
VERSION     NM_010775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 923)
  AUTHORS   Wu,M., Zheng,W., Song,X., Bao,B., Wang,Y., Ramanan,D., Yang,D.,
            Liu,R., Macbeth,J.C., Do,E.A., Andrade,W.A., Yang,T., Cho,H.S.,
            Gazzaniga,F.S., Ilves,M., Coronado,D., Thompson,C., Hang,S.,
            Chiu,I.M., Moffitt,J.R., Hsiao,A., Mekalanos,J.J., Benoist,C. and
            Kasper,D.L.
  TITLE     Gut complement induced by the microbiota combats pathogens and
            spares commensals
  JOURNAL   Cell 187 (4), 897-913 (2024)
   PUBMED   38280374
REFERENCE   3  (bases 1 to 923)
  AUTHORS   Xu,L., Jiang,H., Xie,J., Xu,Q., Zhou,J., Lu,X., Wang,M., Dong,L.
            and Zuo,D.
  TITLE     Mannan-binding lectin ameliorates renal fibrosis by suppressing
            macrophage-to-myofibroblast transition
  JOURNAL   Heliyon 9 (11), e21882 (2023)
   PUBMED   38034794
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 923)
  AUTHORS   Heja,D., Zhao,D., Cody,E., Cumpelik,A., Lim,P.C., Prado-Acosta,M.,
            Palma,L., Dellepiane,S., Chun,N., Ferrara,J. and Heeger,P.S.
  TITLE     Mannan-Binding Lectin Promotes Murine Graft-versus-Host Disease by
            Amplifying Lipopolysaccharide-Initiated Inflammation
  JOURNAL   Transplant Cell Ther 28 (8), 472 (2022)
   PUBMED   35643350
  REMARK    GeneRIF: Mannan-Binding Lectin Promotes Murine Graft-versus-Host
            Disease by Amplifying Lipopolysaccharide-Initiated Inflammation.
REFERENCE   5  (bases 1 to 923)
  AUTHORS   Ma,Y., Cai,F., Huang,X., Wang,H., Yu,B., Wang,J., Nie,W., Cai,K.,
            Yang,Y., Chen,J., Xiao,L. and Han,F.
  TITLE     Mannose-binding lectin activates the nuclear factor-kappaB and
            renal inflammation in the progression of diabetic nephropathy
  JOURNAL   FASEB J 36 (3), e22227 (2022)
   PUBMED   35195918
  REMARK    GeneRIF: Mannose-binding lectin activates the nuclear factor-kappaB
            and renal inflammation in the progression of diabetic nephropathy.
REFERENCE   6  (bases 1 to 923)
  AUTHORS   Motwani,M., White,R.A., Guo,N., Dowler,L.L., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Mouse surfactant protein-D. cDNA cloning, characterization, and
            gene localization to chromosome 14
  JOURNAL   J Immunol 155 (12), 5671-5677 (1995)
   PUBMED   7499852
REFERENCE   7  (bases 1 to 923)
  AUTHORS   Sastry,R., Wang,J.S., Brown,D.C., Ezekowitz,R.A., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Characterization of murine mannose-binding protein genes Mbl1 and
            Mbl2 reveals features common to other collectin genes
  JOURNAL   Mamm Genome 6 (2), 103-110 (1995)
   PUBMED   7766991
REFERENCE   8  (bases 1 to 923)
  AUTHORS   White,R.A., Dowler,L.L., Adkison,L.R., Ezekowitz,R.A. and
            Sastry,K.N.
  TITLE     The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize
            to chromosomes 14 and 19
  JOURNAL   Mamm Genome 5 (12), 807-809 (1994)
   PUBMED   7894166
REFERENCE   9  (bases 1 to 923)
  AUTHORS   Kuge,S., Ihara,S., Watanabe,E., Watanabe,M., Takishima,K., Suga,T.,
            Mamiya,G. and Kawakami,M.
  TITLE     cDNAs and deduced amino acid sequences of subunits in the binding
            component of mouse bactericidal factor, Ra-reactive factor:
            similarity to mannose-binding proteins
  JOURNAL   Biochemistry 31 (30), 6943-6950 (1992)
   PUBMED   1637828
REFERENCE   10 (bases 1 to 923)
  AUTHORS   Sastry,K., Zahedi,K., Lelias,J.M., Whitehead,A.S. and
            Ezekowitz,R.A.
  TITLE     Molecular characterization of the mouse mannose-binding proteins.
            The mannose-binding protein A but not C is an acute phase reactant
  JOURNAL   J Immunol 147 (2), 692-697 (1991)
   PUBMED   1712818
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124400.4.
            
            On Nov 17, 2006 this sequence version replaced NM_010775.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021762.1, AK034788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC124400.4         93479-93589
            112-274             AC124400.4         95605-95767
            275-391             AC124400.4         96524-96640
            392-466             AC124400.4         99168-99242
            467-923             AC124400.4         100526-100982
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     gene            1..923
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /note="mannose-binding lectin (protein A) 1"
                     /db_xref="GeneID:17194"
                     /db_xref="MGI:MGI:96923"
     exon            1..111
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            112..274
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..840
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /note="mannose binding lectin (A); mannose-binding protein
                     A; mannose binding lectin, serum (A); raRF p28B;
                     mannan-binding protein; ra-reactive factor
                     polysaccharide-binding component p28B"
                     /codon_start=1
                     /product="mannose-binding protein A precursor"
                     /protein_id="NP_034905.1"
                     /db_xref="CCDS:CCDS26961.1"
                     /db_xref="GeneID:17194"
                     /db_xref="MGI:MGI:96923"
                     /translation="MLLLPLLPVLLCVVSVSSSGSQTCEDTLKTCSVIACGRDGRDGP
                     KGEKGEPGQGLRGLQGPPGKLGPPGSVGSPGSPGPKGQKGDHGDNRAIEEKLANMEAE
                     IRILKSKLQLTNKLHAFSMGKKSGKKLFVTNHEKMPFSKVKSLCTELQGTVAIPRNAE
                     ENKAIQEVATGIAFLGITDEATEGQFMYVTGGRLTYSNWKKDEPNNHGSGEDCVIILD
                     NGLWNDISCQASFKAVCEFPA"
     exon            275..391
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            392..466
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            467..923
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      898..903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /note="hexamer: AAGAAA"
     polyA_site      923
                     /gene="Mbl1"
                     /gene_synonym="MBL-A; MBP-A; S-MBP"
                     /note="major polyA site"
ORIGIN      
        1 ttggttcccg gtcaccaggc taatggccct gtcattgggg aggatactac cagaagctgg
       61 actcgagaca tagtttctct tccactgctc ctttactcta aagaaaccct agtaaggacc
      121 atgcttctgc ttccattact ccctgtcctt ctgtgtgtgg tgagtgtgtc ctcatcaggg
      181 tcacaaacct gtgaggacac cctgaagact tgctctgtga tagcctgtgg cagagatggg
      241 agagatggac ccaaagggga gaagggagaa ccaggtcaag ggctcagggg cttgcagggc
      301 cctccaggga aattggggcc tccaggaagt gttggaagcc ctggaagtcc aggaccaaaa
      361 ggccaaaagg gggaccatgg agacaataga gccattgagg agaagctggc aaatatggag
      421 gcagagataa ggatcctgaa atcaaaactg cagctaacca acaagttgca tgccttctca
      481 atgggcaaaa agtctgggaa gaagttgttt gtgaccaacc atgagaagat gcccttttcc
      541 aaagtgaagt ctctgtgcac agagctccaa ggcactgtgg ctatccccag gaatgctgaa
      601 gagaacaagg ccattcaaga agtggccaca ggcattgcct tcctaggcat cacggacgag
      661 gcgactgaag ggcagttcat gtacgtgaca ggggggaggc tcacctacag caactggaaa
      721 aaggatgagc caaataacca tggctctggg gaagactgtg tcattatatt agataatggt
      781 ttgtggaatg acatttcctg tcaagcttcc ttcaaggctg tctgcgagtt cccagcctga
      841 ggaaacgagt gcctccatat tctccttgcc tcctctctgg actctcactt gcttccaaag
      901 aaaattcagt acttgtttct caa
//
