LOCUS       NM_145442               1509 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MAP3K12 binding inhibitory protein 1 (Mbip), mRNA.
ACCESSION   NM_145442 NM_001164429
VERSION     NM_145442.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Ochieng,J.K., Kundu,S.T., Bajaj,R., Leticia Rodriguez,B.,
            Fradette,J.J. and Gibbons,D.L.
  TITLE     MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis
            by JNK-dependent activation of MMPs
  JOURNAL   Oncogene 39 (43), 6719-6732 (2020)
   PUBMED   32963352
  REMARK    GeneRIF: MBIP (MAP3K12 binding inhibitory protein) drives NSCLC
            metastasis by JNK-dependent activation of MMPs.
REFERENCE   4  (bases 1 to 1509)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1509)
  AUTHORS   Orpinell,M., Fournier,M., Riss,A., Nagy,Z., Krebs,A.R., Frontini,M.
            and Tora,L.
  TITLE     The ATAC acetyl transferase complex controls mitotic progression by
            targeting non-histone substrates
  JOURNAL   EMBO J 29 (14), 2381-2394 (2010)
   PUBMED   20562830
REFERENCE   6  (bases 1 to 1509)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   7  (bases 1 to 1509)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   8  (bases 1 to 1509)
  AUTHORS   Tucker,E.S., Segall,S., Gopalakrishna,D., Wu,Y., Vernon,M.,
            Polleux,F. and Lamantia,A.S.
  TITLE     Molecular specification and patterning of progenitor cells in the
            lateral and medial ganglionic eminences
  JOURNAL   J Neurosci 28 (38), 9504-9518 (2008)
   PUBMED   18799682
REFERENCE   9  (bases 1 to 1509)
  AUTHORS   Zhang,X., Wang,Y., Li,H., Zhang,W., Wu,D. and Mi,H.
  TITLE     The mouse FKBP23 binds to BiP in ER and the binding of C-terminal
            domain is interrelated with Ca2+ concentration
  JOURNAL   FEBS Lett 559 (1-3), 57-60 (2004)
   PUBMED   14960307
REFERENCE   10 (bases 1 to 1509)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154714.3 and AK077125.1.
            
            On or before Feb 3, 2010 this sequence version replaced
            NM_001164429.1, NM_145442.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002277.1, AK077125.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC154714.3         71501-71580
            81-1497             AK077125.1         2-1418
            1498-1509           AC154714.3         89078-89089
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.3 cM"
     gene            1..1509
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /note="MAP3K12 binding inhibitory protein 1"
                     /db_xref="GeneID:217588"
                     /db_xref="MGI:MGI:1918320"
     exon            1..223
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1120
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /note="MUK-binding inhibitory protein; MAPK upstream
                     kinase-binding inhibitory protein"
                     /codon_start=1
                     /product="MAP3K12-binding inhibitory protein 1"
                     /protein_id="NP_663417.1"
                     /db_xref="CCDS:CCDS25920.1"
                     /db_xref="GeneID:217588"
                     /db_xref="MGI:MGI:1918320"
                     /translation="MAAAAELSSSSGSERSLEQCSSPLLTREVLCEVFRSLHTLTRQL
                     NLRDDVVKITIDWNRLQSLSASQPALLLTALEQHVLYLQPFLAKLQSLMKENSTATEI
                     RQTEAETKSELRAIHPTEDLQDEGKPKDCDVGDVKKTQNLFDPEVVQIKAGKAEIDRR
                     ISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAVFTPYPGFKSHVKVSRVVNTY
                     GPQTRPEGIAGSGHKPTGMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKL
                     EDKILELEGISPEYFQSVNFSGKRRKVQPPQQNYSLAELDEKISALKRALLRKSREAD
                     SMAAHLP"
     exon            224..343
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            344..562
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..659
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..725
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            726..878
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..976
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1015
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1509
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1475..1480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /note="hexamer: AATAAA"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /note="hexamer: AACAAA"
     polyA_site      1496
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
     polyA_site      1499
                     /gene="Mbip"
                     /gene_synonym="4933408E06Rik"
                     /note="major polyA site"
ORIGIN      
        1 tctagtttta cgtcatctca gtgcgacgaa gtccgcgagg gaggggtggg gtgagcgctg
       61 ttcgcggtgg ttggggggct gctttgaagg tgtcatggct gctgctgcgg agcttagttc
      121 ctcaagcggc agcgagagga gcctggagca atgctccagc cccctcctca cccgcgaggt
      181 cctctgcgaa gtctttcgct ccttgcacac cctgacaaga cagcttaacc tcagagatga
      241 tgtggtgaaa attacaatcg attggaacag gctccagagc ctctcagcat cccagcctgc
      301 actgctcctt actgcacttg aacaacacgt tttgtattta cagccttttt tagcaaaact
      361 tcagtcttta atgaaagaaa actcaacagc tacagagata agacagacag aagcagagac
      421 caagagtgaa ctaagagcca tacatcccac cgaggaccta caagatgaag ggaagcccaa
      481 agactgtgat gtaggagatg tgaaaaagac acaaaacctt tttgacccag aagtagttca
      541 gatcaaggct ggaaaagcag aaattgacag acgaatatct gcatttattg agagaaaaca
      601 agctgaaatc aatgaaaaca atgtcaggga attttgcaat gttattgatt gtaatcaaga
      661 aaatagttgt gcaagaactg atgctgtctt tactccttat cctggattta aaagtcatgt
      721 aaaggtttct agagttgtga atacatatgg accacagact agacctgaag gaattgcagg
      781 gtcaggtcac aaacctacag gcatgcttcg agattgtggt aatcaggcgg tagaagaacg
      841 actccagaat attgaggctc acctgcgatt gcagacaggt ggcccagtac caagagacat
      901 ctaccaaaga attaaaaagc ttgaagataa aatccttgaa ttggagggca tctctcctga
      961 atacttccaa tctgtaaact tctctggaaa aagaagaaaa gtccaaccac ctcaacagaa
     1021 ctattcactg gctgaactgg atgagaaaat tagtgccctc aaacgagccc tgctcagaaa
     1081 gtcaagagaa gcagactcca tggccgctca ccttccatga gaccactctt gtcacattgc
     1141 tttcctttaa gatgcatatg cttaactatt tgcagtgtat tcctcaacat aaacttgtct
     1201 gacagcaaat agtcagatgc tgcagtgttt ggaaatgatg tacatcttga ccattgcact
     1261 gttggaactt agtcccttct gttttaaagg aggcattttg gatattaagc aacttaattt
     1321 gaaagaactt cttttggtgg actaccagag attattattt tgatagtggt atttaaaagg
     1381 actttatatt tgtaacattg attaaccatt ttttttttag tttatattag tactttgtac
     1441 atagtaggca tttagcaaac atttattgac aaaaaataaa acaaaaactg acaaatgaat
     1501 gtgtataaa
//
