LOCUS       NM_001347171            4306 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus methyl-CpG binding domain protein 6 (Mbd6), transcript
            variant 2, mRNA.
ACCESSION   NM_001347171 XM_006513075
VERSION     NM_001347171.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4306)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4306)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4306)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4306)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4306)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4306)
  AUTHORS   Yotsumoto,S., Shimada,T., Cui,C.Y., Nakashima,H., Fujiwara,H. and
            Ko,M.S.
  TITLE     Expression of adrenomedullin, a hypotensive peptide, in the
            trophoblast giant cells at the embryo implantation site in mouse
  JOURNAL   Dev Biol 203 (2), 264-275 (1998)
   PUBMED   9808778
REFERENCE   7  (bases 1 to 4306)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144852.3, AK158797.1, BC059015.1, BC096027.1 and BC083328.1.
            
            On Nov 17, 2016 this sequence version replaced XM_006513075.3.
            
            Transcript Variant: This variant (2) uses two alternate in-frame
            splice sites in the 3' coding region, compared to variant 1. The
            encoded isoform (2) has the same N- and C-termiini, but is 2 aa
            shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158797.1, SRR13422586.27097.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC144852.3         19018-19145
            129-247             AK158797.1         6-124
            248-505             BC059015.1         1-258
            506-763             BC096027.1         1-258
            764-3104            AK158797.1         641-2981
            3105-4306           BC083328.1         1-1202
FEATURES             Location/Qualifiers
     source          1..4306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..4306
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /note="methyl-CpG binding domain protein 6"
                     /db_xref="GeneID:110962"
                     /db_xref="MGI:MGI:106378"
     exon            1..310
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            311..374
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            375..517
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..3410
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /note="isoform 2 is encoded by transcript variant 2;
                     methyl-CpG-binding protein MBD6"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 6 isoform 2"
                     /protein_id="NP_001334100.1"
                     /db_xref="CCDS:CCDS83762.1"
                     /db_xref="GeneID:110962"
                     /db_xref="MGI:MGI:106378"
                     /translation="MNGDNASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGT
                     ELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKL
                     CNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSVRPPCRAPPTTPLN
                     GGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRGNAPSPAPP
                     PPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTSPPLP
                     PSNNPPGPPGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAA
                     KAQLPPPSTLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPR
                     APAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSG
                     SPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSDGLGMGAGPA
                     CPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPFLSHSLFGVL
                     AGGGQPPPEPLLPPPGGPGPPSAPGEPEGPSLLVASLLSPPPSDLLPPPSAPPSNLLA
                     SFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALL
                     AASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLL
                     SASLLGDLSSLASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLL
                     QSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGK
                     RGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQ
                     HNGELAEGGAEPKDPPLPGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTL
                     EPSPTTRAAVPLPPRARPGRPAKNKRRKLAP"
     exon            518..620
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            621..783
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1824
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2483
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2634
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2804
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3218
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3271
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3335
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..4287
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4287
                     /gene="Mbd6"
                     /gene_synonym="D10Wsu93e"
                     /note="major polyA site"
ORIGIN      
        1 tctcccgtcc gggcagcggc ggcggcggcg gcggcggctg cggcggtggc ggcggcagcg
       61 acggcggcgg cggtagcagc ctgcgcggtg ccttctggga acggaatccc cagggctgcc
      121 cctggcccct atggcgcatg cgcgggaggc cgctcggtga tccgcggcgg cggcggcggc
      181 ggcgcttcct gctaagaccg gccggggccg taccggaggc tcgggctcca ccgacccacc
      241 tcccaccccc tcccactcac cctctgggcc gcgactgcgc agggcggggc cagccgaacc
      301 atgggccgcg gtgtgggcta agctggtggc cccggcttta gactggatcc cacaatgttt
      361 gcagagatgt tcaggcacag gggagctcat cacacacaat gaatggagac aatgcgagca
      421 gtgcagcaga cagagctggg ggccctgccg ccacgcctgt ccccatcccc atcgggtggc
      481 aacgctgtgt gcgagaaggt gctgtgtact atatcagccc aagtggcaca gagctgtctt
      541 ccttggagca aacccgtagc tacctcctca gcgatgggac ctgcaagtgc ggtctggagt
      601 gtccacttaa tgtacccaag gttttcaact ttgaccctct ggccccggtg accccgggtg
      661 gggctggggt ggggcctgca tcagaggagg acatgaccaa gctgtgcaac cacaggcgga
      721 aagctgttgc catggcaact ctgtaccgca gcatggagac cacctgctca cactcttctc
      781 ctggagaggg agcaagcccc cagatgttcc acactgtgtc cccagggccc ccctctgtcc
      841 gccctccttg tcgagctcct cctacaactc cacttaacgg gggtcctggc tccattcccc
      901 aagacccacc ttccgttccc caggccttcc cccctctgac aggccctgca gggctcttcc
      961 caccaccccg gcttcctgat ccagttccct ctgcaggcag cagcagccct tgtttcctcc
     1021 caagaggcaa tgctccctct ccagccccac ctcccccacc tgctatcagc ctcaatgccc
     1081 cctcctacaa ctggggggct tccctccgat ccaacctggt gccctctgac ctgggctctc
     1141 ctccagcccc tcacgcctcc tcttcaccac cctcagactc tcctctcttc cactgtagcg
     1201 atgccttaac atctcctccc ctgcccccaa gcaataaccc ccctggtccc cctggccccc
     1261 ctggtcctgc cactcagcca ccagtgtctt cagccactat gcacctgccc ttggtcctgg
     1321 gatccttggg aggggccccc gcagtggagg ggcctggggc acccccattc cttgctagca
     1381 gtctgctctc tgcagcagcc aaggcccagc tgccccctcc cagcacttta cagggccgaa
     1441 ggccccgtgc ccaggcaccc tcagctgccc atgcatcacc ccgtccctct cagcggcggc
     1501 ctcgccggcc cccaactgtc ttgcggttgc tagaaggggg aggccctcag acccctagac
     1561 ggactcgtcc tcgggcccct gctcctgtcc ctcagccctt tcctctccca gagccatccc
     1621 agcctattct cccctctgtg ctgtccctac tgggactccc cacccctggc ccttcccact
     1681 cggatggaag ctttaacctt ttggggtcag atgcacacct tcctcctccc ccagccctct
     1741 cctcagggag ccctccccag cccaggcacc ccattcagcc ctctctgcct gggaccacca
     1801 gtggcagcct cagcagtgtg ccaggtgccc ctgccccacc agctgcctcc aaagcccccg
     1861 tagtccccag tcctgtgctt caaagcccgt ctgatgggct ggggatgggg gcaggcccag
     1921 cctgccctct gcctcccttg gctggtgggg aggctttccc tttccccagc cctgagcagg
     1981 gcctggctct cagtggagct ggcttcccgg ggatgctagg ggccttgcct ctccctctga
     2041 gtctggggca gcctccccct tctccattcc ttagccacag tttatttggt gtgctggcgg
     2101 ggggaggaca gcctcctcct gagcccctgt tgcccccgcc aggggggcct ggccctccct
     2161 cagccccagg cgagcccgaa gggccttcac tcttggtggc ttctctgctt tcaccacccc
     2221 cttccgacct cctcccgcct ccttctgcac cccctagcaa tctccttgcc tcttttctgc
     2281 ccctgttggc cctgggcccc acagctgggg atggggaagg ctctgcagag ggagctgggg
     2341 gtccaaatgg ggagccattt tcaggtttgg gagacctgcc ccccctatta tttcccccac
     2401 tttcagcccc acccaccctc atagctttaa attctgcgct gctggctgcc agcctggatc
     2461 ccccttcggg gacacccccc cagccctgtg tcctgagtgc cccccaacct ggaccaccta
     2521 cctccagtgt caccacggca actactgacc cgggggcctc ctctctgggc aaggccccct
     2581 ccaactcagg gagaccccaa cttcttagcc ctctgctgag tgccagcctg ctgggtgatc
     2641 tgtcttcact ggccagcagc cctggagccc tccccagcct gttgcagcct cctggccctc
     2701 ttctttccag ccagttaggg ctgcagctcc tccctggggg gggagcgcct cccgccctgt
     2761 cagaggcttc tagtccccta gcctgcctgc tacagagtct ccagatccct ccagagcagc
     2821 cagacgcccc ctgtctgccc cccgagagcc ccgcctcagc cctcgaaccg gagcctgccc
     2881 ggcctcccct cagtgcctta gccccacccc atgcttctcc tgacccccca gtccccgagc
     2941 tgctcactgg gagggggtca gggaaacggg gccggagggg aggaggggga cttaggggca
     3001 ttaacggtga gaccaggcca ggcagaggcc gaaagccggg cagccgccga gagcctggcc
     3061 ggctagcact caagtggggg acacgtggtg gcttcaatgg acaaatggaa cggtccccaa
     3121 gaaggactca ccattggcag cataatgggg agctagcgga agggggtgct gagcccaagg
     3181 atccacccct tcctgggacc cattctgagg accttaaggt gcccccgggg atagtcagaa
     3241 agtctcgtcg tggccggagg agaaaataca accctgcccg gaacagcagc agctcccgcc
     3301 aggacgtgac cttggaaccc agccctacaa cgcgagcagc tgtccctttg cctccccggg
     3361 cccgccctgg acgtcctgcc aaaaataaga ggaggaaact ggccccatag cagccatacc
     3421 tggagctgga atctgaccct gactggggag agctgagtgc tgagccttgg gagcccctgc
     3481 cagccacgtg cacctgtgga cagtgggtgg ggcactactc cccactcaga gcacaaatgc
     3541 aacccctccc ctacaaatcc catcctgagc cattgcaggg gtagggaagc tcacccctcc
     3601 cccccaaagc catgtcactg aagaggcctg gggggtggta tatggcccct ccccatcagg
     3661 cgctaagggg acaccccttc cccaggtctt ttatttgttt aagttatttt tgcacaaatg
     3721 actcttttat atttaattcg acttcattgc ctcccttctt aaagctagca ggctcagttt
     3781 acaaacctgt gagctactgt tggctgctgc cctccttccc agtgaaaggt acagagcaat
     3841 aagcatcatg catctccccg attcccacta gcacccctct gcctctggct caggttgctc
     3901 aaagcacaga tcccctctta tccctgtccc caggaccgaa acacatagcc tcatttcaaa
     3961 gcgtagccag gttccctctg ctttcctctg ggatatggaa agggggccaa gaggactttg
     4021 gatctctcct ccatacacac tacactggcc cttctcccca tcaagcgctc agagacggtg
     4081 tgacgatgcc actgggggtt atgcagcgtg gtccagccgg agcggccagc atgaccagct
     4141 gtccaggggc tgcctcctgc cttttttttt gtaaagacaa gacccttggg agttttcatt
     4201 ctgttttgta cttgccctgt ggggcctcca ctgcttttct atgggagaca ctcttaattt
     4261 aacagatgag aatattttga aactctgaaa aaaaaaaaaa aaaaaa
//
