LOCUS       NM_010774               3610 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus methyl-CpG binding domain protein 4 (Mbd4), transcript
            variant 1, mRNA.
ACCESSION   NM_010774
VERSION     NM_010774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3610)
  AUTHORS   Han,Y., Wang,Y., Zhang,C., Li,Y., Guo,J. and Tian,C.
  TITLE     Metastasis-associated lung adenocarcinoma transcript 1 induces
            methyl-CpG-binding domain protein 4 in mice with recurrent
            spontaneous abortion caused by anti-phospholipid antibody
            positivity
  JOURNAL   Placenta 137, 38-48 (2023)
   PUBMED   37068447
  REMARK    GeneRIF: Metastasis-associated lung adenocarcinoma transcript 1
            induces methyl-CpG-binding domain protein 4 in mice with recurrent
            spontaneous abortion caused by anti-phospholipid antibody
            positivity.
REFERENCE   2  (bases 1 to 3610)
  AUTHORS   Mendez-Frausto,G., Uresti-Rivera,E.E., Godina-Gonzalez,S.,
            Portales-Perez,D.P., Gonzalez-Amaro,R. and Garcia-Hernandez,M.H.
  TITLE     Expression of mBD4, mBD3 and CRAMP during type II collagen-induced
            arthritis/CIA and their association with inflammation and
            bone-remodeling markers
  JOURNAL   Exp Mol Pathol 123, 104689 (2021)
   PUBMED   34592200
  REMARK    GeneRIF: Expression of mBD4, mBD3 and CRAMP during type II
            collagen-induced arthritis/CIA and their association with
            inflammation and bone-remodeling markers.
REFERENCE   3  (bases 1 to 3610)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3610)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3610)
  AUTHORS   Grigera,F., Wuerffel,R. and Kenter,A.L.
  TITLE     MBD4 Facilitates Immunoglobulin Class Switch Recombination
  JOURNAL   Mol Cell Biol 37 (2), e00316-16 (2017)
   PUBMED   27777312
  REMARK    GeneRIF: Mbd4 is a component of mismatch repair-directed DNA end
            processing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3610)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   7  (bases 1 to 3610)
  AUTHORS   Laub,F., Aldabe,R., Friedrich,V. Jr., Ohnishi,S., Yoshida,T. and
            Ramirez,F.
  TITLE     Developmental expression of mouse Kruppel-like transcription factor
            KLF7 suggests a potential role in neurogenesis
  JOURNAL   Dev Biol 233 (2), 305-318 (2001)
   PUBMED   11336497
REFERENCE   8  (bases 1 to 3610)
  AUTHORS   Hendrich,B., Hardeland,U., Ng,H.H., Jiricny,J. and Bird,A.
  TITLE     The thymine glycosylase MBD4 can bind to the product of deamination
            at methylated CpG sites
  JOURNAL   Nature 401 (6750), 301-304 (1999)
   PUBMED   10499592
  REMARK    GeneRIF: G/T mismatch glycosylse.  Acts to maintain levels of
            5-methylcytosine in the genome by initiating repair of the results
            of deamination of 5-methylcytosine
            Erratum:[Nature 2000 Mar 30;404(6777):525]
REFERENCE   9  (bases 1 to 3610)
  AUTHORS   Hendrich,B., Abbott,C., McQueen,H., Chambers,D., Cross,S. and
            Bird,A.
  TITLE     Genomic structure and chromosomal mapping of the murine and human
            Mbd1, Mbd2, Mbd3, and Mbd4 genes
  JOURNAL   Mamm Genome 10 (9), 906-912 (1999)
   PUBMED   10441743
REFERENCE   10 (bases 1 to 3610)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109169.13.
            
            On Jul 27, 2022 this sequence version replaced NM_010774.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024812.1, AF072249.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC109169.13        11535-11765
            232-453             AC109169.13        14063-14284
            454-1280            AC109169.13        15170-15996
            1281-1355           AC109169.13        19285-19359
            1356-1490           AC109169.13        19454-19588
            1491-1640           AC109169.13        20183-20332
            1641-1744           AC109169.13        20736-20839
            1745-3610           AC109169.13        22340-24205
FEATURES             Location/Qualifiers
     source          1..3610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.72 cM"
     gene            1..3610
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /note="methyl-CpG binding domain protein 4"
                     /db_xref="GeneID:17193"
                     /db_xref="MGI:MGI:1333850"
     exon            1..231
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1822
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyl-CpG-binding protein MBD4; mismatch-specific DNA
                     N-glycosylase"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 4 isoform 1"
                     /protein_id="NP_034904.2"
                     /db_xref="CCDS:CCDS39603.1"
                     /db_xref="GeneID:17193"
                     /db_xref="MGI:MGI:1333850"
                     /translation="MESPNLGDNRVRGESLVPDPPWDRCKEDIAVGLGGVGEDGKDLV
                     ISSERSSLLQEPTASTLSSTTATEGHKPVPCGWERVVKQRLSGKTAGKFDVYFISPQG
                     LKFRSKRSLANYLLKNGETFLKPEDFDFTVLPKGSINPGYKHQSLAALTSLQPNETDV
                     SKQNLKTRSKWKTDVLPLPSGTSESPESSGLSNSNSACLLLREHRDIQDVDSEKRRKS
                     KRKVTVLKGTASQKTKQKCRKSLLESTQRNRKRASVVQKVGADRELVPQESQLNRTLC
                     PADACARETVGLAGEEKSPSPGLDLCFIQVTSGTTNKFHSTEAAGEANREQTFLESEE
                     IRSKGDRKGEAHLHTGVLQDGSEMPSCSQAKKHFTSETFQEDSIPRTQVEKRKTSLYF
                     SSKYNKEALSPPRRKSFKKWTPPRSPFNLVQEILFHDPWKLLIATIFLNRTSGKMAIP
                     VLWEFLEKYPSAEVARAADWRDVSELLKPLGLYDLRAKTIIKFSDEYLTKQWRYPIEL
                     HGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS"
     exon            232..453
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..1280
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1355
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1490
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1640
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1744
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..3610
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3585..3590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcatctg tagctgaagc ggtggcggga aggctgctgt gtgggttgat tgactttcac
       61 gtcggtgttt ggattcggct cagtggtttg agttgtgttt tactccacct ctcggcctgg
      121 agctgcagct gcgccccagt ggaccaaagc agcagggatg gagagcccaa accttgggga
      181 caacagagtc cgtggagaga gcctagttcc agacccgcct tgggatcgct gcaaggaaga
      241 tattgctgtt ggactgggag gagtgggaga agatggaaag gacctggtga taagcagtga
      301 gcgcagctcc cttctccaag agcccactgc ttctactctg tctagtacta cagcgacaga
      361 aggccacaag cctgtcccgt gtggatggga aagagttgtg aagcaaaggt tatctgggaa
      421 aactgcagga aaatttgatg tatactttat cagcccacaa ggattgaagt tcagatcaaa
      481 acgttcactt gctaattatc ttctcaaaaa tggggagact tttcttaagc ctgaagattt
      541 tgattttact gtactgccga aagggagcat caatcccggt tataaacacc aaagtttggc
      601 agctctgact tccctgcagc caaatgaaac tgacgtttca aagcagaacc tcaagacacg
      661 aagcaagtgg aaaacagatg tgttgcctct gcccagtggt acttcagagt cgccagaaag
      721 cagcggactg tctaactcta actcggcttg cttgctattg agagaacata gggacattca
      781 ggatgttgac tctgagaaga ggagaaagtc caaaagaaag gtgactgttt tgaaaggaac
      841 tgcaagtcag aaaaccaaac aaaagtgcag gaagagtctc ttagagtcta ctcaaagaaa
      901 cagaaaaaga gcatctgtgg ttcagaaggt gggtgctgat cgcgagctgg tgccacagga
      961 aagtcaactc aacagaaccc tctgccctgc agatgcctgt gcaagggaga ctgttggcct
     1021 ggctggggaa gaaaaatcac caagcccagg actggatctt tgtttcatac aagtaacttc
     1081 tggcaccaca aacaaattcc attcaactga agcagcaggt gaagcaaatc gtgagcagac
     1141 ttttttagaa tcagaggaaa tcagatcgaa gggagacaga aagggggagg cacatttgca
     1201 tactggtgtt ttacaggatg gctctgaaat gcccagctgc tcacaagcca agaaacactt
     1261 tacttctgag acatttcaag aagacagcat cccacggaca caagtagaaa aaaggaaaac
     1321 aagcctgtat ttttccagca agtacaacaa agaagctctt agccccccaa gacgcaaatc
     1381 cttcaagaaa tggacccctc ctcggtcacc ttttaatctt gttcaagaaa tacttttcca
     1441 tgacccatgg aagctcctca tcgcgactat atttctcaat cggacctcag gcaagatggc
     1501 catccctgtg ctgtgggagt ttctagagaa gtacccttca gctgaagtgg cccgagctgc
     1561 cgactggagg gacgtgtcgg agcttctcaa gcctcttggt ctctacgatc tccgtgcaaa
     1621 aaccattatc aagttctcag atgaatatct gacaaagcag tggaggtatc cgattgagct
     1681 tcatggcatt ggtaaatatg gcaacgactc ctaccggatc ttttgtgtca atgaatggaa
     1741 gcaggtgcac cctgaagacc acaagttaaa taaataccat gactggcttt gggagaatca
     1801 tgaaaaatta agtctatctt gaagctgcct gtttgaagtt tcccatgcgt cgccttgtgc
     1861 ttcggtttct aagggccctg tggtgtgcag tgagctccct tcccggcacg tggatttttt
     1921 ttttcagttt gttagaagcc agtgtatgtc ttaagcctct gccaaaaaaa aaaaaaaatt
     1981 gttagataat gatcctaaaa gtgttcagtt taggttttcc aatgatgaaa ttcaacacgc
     2041 caatgctcaa atccagttac cagcactcct gctaaagaaa gcctaaacat gtattctcct
     2101 tctgtataaa gtgatattgt catgtgtgga aagcctgcca ttcttaatgg gtattccagt
     2161 gttatagctt aaatagtgag gcatttactt tagaaagata tcactaacta aaaaccgaat
     2221 tgaccttaca tggtggcaca cccctgtaat cccagcactc aggaggctga ggaagaagga
     2281 tggaaagttg agggcctgcc tcttctgtgt agagagagac tctgcctcaa gcacaaacag
     2341 ggcagggcca gcaagtggcc cagtaaatga agtcacttgc tgccaggcat gatgatctga
     2401 attccatccc tggaacacac tcctgaaggt tggcctctta ccttcacttg agctcataca
     2461 taacatgtta caaaatacat aaaattttca gaaatggtct gcagagagat ggttcagtag
     2521 tttaatatgc ttgctgcttt tatagaggtt actttttagc acccacatca ggcagctcac
     2581 aactgcttat aacagctcct ggggatctgt caccttcttt tggcttcatt gggtacctta
     2641 gcacatgtgg catatataga tataaagata tacataaaca taaaaaaaaa attaagtcct
     2701 aattacttaa cacttttttt tctttttggt tttccgagac agggtttctc tgtgtagccc
     2761 tggctgtcct ggaactcact ctgtagacca ggctggcctc aaactcagaa atctgcctgc
     2821 ctctgcctcc caagtgctgg gattaaaggc atgcgccacc actgcctggc tacttaacac
     2881 tattttaaaa tgtagtttga aaattaaatt atatctcctc ctcaaggcaa tattactcaa
     2941 aaatgcatag tattccaccc catttttcat taataaaata tatttttcat taataaaata
     3001 tattcaccca tgccagtcat catggtatac tactataatc ctaacacttg ggagtctgga
     3061 gagaatcatg atcaaggcca gcctgggcta tatggtaaga ccctatatca aaaaagagca
     3121 aaaaaacaaa ccaaaagatc cactagtggc acacacacag acaatgagca gatgggcctt
     3181 ataatgtata tgtgatgaaa atacatacac agtacctggg atgctgatgc aagaggacct
     3241 ctgaattcaa ggcagcctgg cttatgagag tgtgaaggca gctttggtta cacagcaaaa
     3301 ccctgtacaa aaaatacaaa ccaagtttgt tggactaaat aagctatgtc tgcagaagtg
     3361 tctgtctgtc ttgtttaatg gaattctttt ttttaaagat ttatttgttt tatgtatatg
     3421 agtacactgt aactgtacag atggttatga gccataatgt gattgttggg aattgaactc
     3481 aggacctctg cttgcttctg gccctgctct ggccccgctc gagtatatgg aattcttaag
     3541 atcctaatat acttatgaaa cctatcactt tgtattaggt agttaataaa atatttttat
     3601 taaaaagtaa
//
