LOCUS       NP_034904                554 aa            linear   ROD 03-SEP-2024
DEFINITION  methyl-CpG-binding domain protein 4 isoform 1 [Mus musculus].
ACCESSION   NP_034904
VERSION     NP_034904.2
DBSOURCE    REFSEQ: accession NM_010774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 554)
  AUTHORS   Han,Y., Wang,Y., Zhang,C., Li,Y., Guo,J. and Tian,C.
  TITLE     Metastasis-associated lung adenocarcinoma transcript 1 induces
            methyl-CpG-binding domain protein 4 in mice with recurrent
            spontaneous abortion caused by anti-phospholipid antibody
            positivity
  JOURNAL   Placenta 137, 38-48 (2023)
   PUBMED   37068447
  REMARK    GeneRIF: Metastasis-associated lung adenocarcinoma transcript 1
            induces methyl-CpG-binding domain protein 4 in mice with recurrent
            spontaneous abortion caused by anti-phospholipid antibody
            positivity.
REFERENCE   2  (residues 1 to 554)
  AUTHORS   Mendez-Frausto,G., Uresti-Rivera,E.E., Godina-Gonzalez,S.,
            Portales-Perez,D.P., Gonzalez-Amaro,R. and Garcia-Hernandez,M.H.
  TITLE     Expression of mBD4, mBD3 and CRAMP during type II collagen-induced
            arthritis/CIA and their association with inflammation and
            bone-remodeling markers
  JOURNAL   Exp Mol Pathol 123, 104689 (2021)
   PUBMED   34592200
  REMARK    GeneRIF: Expression of mBD4, mBD3 and CRAMP during type II
            collagen-induced arthritis/CIA and their association with
            inflammation and bone-remodeling markers.
REFERENCE   3  (residues 1 to 554)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 554)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 554)
  AUTHORS   Grigera,F., Wuerffel,R. and Kenter,A.L.
  TITLE     MBD4 Facilitates Immunoglobulin Class Switch Recombination
  JOURNAL   Mol Cell Biol 37 (2), e00316-16 (2017)
   PUBMED   27777312
  REMARK    GeneRIF: Mbd4 is a component of mismatch repair-directed DNA end
            processing.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 554)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   7  (residues 1 to 554)
  AUTHORS   Laub,F., Aldabe,R., Friedrich,V. Jr., Ohnishi,S., Yoshida,T. and
            Ramirez,F.
  TITLE     Developmental expression of mouse Kruppel-like transcription factor
            KLF7 suggests a potential role in neurogenesis
  JOURNAL   Dev Biol 233 (2), 305-318 (2001)
   PUBMED   11336497
REFERENCE   8  (residues 1 to 554)
  AUTHORS   Hendrich,B., Hardeland,U., Ng,H.H., Jiricny,J. and Bird,A.
  TITLE     The thymine glycosylase MBD4 can bind to the product of deamination
            at methylated CpG sites
  JOURNAL   Nature 401 (6750), 301-304 (1999)
   PUBMED   10499592
  REMARK    GeneRIF: G/T mismatch glycosylse.  Acts to maintain levels of
            5-methylcytosine in the genome by initiating repair of the results
            of deamination of 5-methylcytosine
            Erratum:[Nature 2000 Mar 30;404(6777):525]
REFERENCE   9  (residues 1 to 554)
  AUTHORS   Hendrich,B., Abbott,C., McQueen,H., Chambers,D., Cross,S. and
            Bird,A.
  TITLE     Genomic structure and chromosomal mapping of the murine and human
            Mbd1, Mbd2, Mbd3, and Mbd4 genes
  JOURNAL   Mamm Genome 10 (9), 906-912 (1999)
   PUBMED   10441743
REFERENCE   10 (residues 1 to 554)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109169.13.
            
            On May 13, 2008 this sequence version replaced NP_034904.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024812.1, AF072249.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.72 cM"
     Protein         1..554
                     /product="methyl-CpG-binding domain protein 4 isoform 1"
                     /note="methyl-CpG-binding protein MBD4; mismatch-specific
                     DNA N-glycosylase"
                     /calculated_mol_wt=62448
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2D7.1)"
     Region          66..132
                     /region_name="MBD"
                     /note="Methyl-CpG binding domain; smart00391"
                     /db_xref="CDD:128673"
     Site            order(80,82,84,92,94,103,106,110)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     Region          154..195
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2D7.1)"
     Region          209..252
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2D7.1)"
     Site            296
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95243; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2D7.1)"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95243; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2D7.1)"
     Region          424..>494
                     /region_name="Nth"
                     /note="Endonuclease III [Replication, recombination and
                     repair]; COG0177"
                     /db_xref="CDD:439947"
     CDS             1..554
                     /gene="Mbd4"
                     /gene_synonym="Med1"
                     /coded_by="NM_010774.3:158..1822"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39603.1"
                     /db_xref="GeneID:17193"
                     /db_xref="MGI:MGI:1333850"
ORIGIN      
        1 mespnlgdnr vrgeslvpdp pwdrckedia vglggvgedg kdlvissers sllqeptast
       61 lssttategh kpvpcgwerv vkqrlsgkta gkfdvyfisp qglkfrskrs lanyllknge
      121 tflkpedfdf tvlpkgsinp gykhqslaal tslqpnetdv skqnlktrsk wktdvlplps
      181 gtsespessg lsnsnsacll lrehrdiqdv dsekrrkskr kvtvlkgtas qktkqkcrks
      241 llestqrnrk rasvvqkvga drelvpqesq lnrtlcpada caretvglag eekspspgld
      301 lcfiqvtsgt tnkfhsteaa geanreqtfl eseeirskgd rkgeahlhtg vlqdgsemps
      361 csqakkhfts etfqedsipr tqvekrktsl yfsskynkea lspprrksfk kwtpprspfn
      421 lvqeilfhdp wklliatifl nrtsgkmaip vlweflekyp saevaraadw rdvsellkpl
      481 glydlrakti ikfsdeyltk qwrypielhg igkygndsyr ifcvnewkqv hpedhklnky
      541 hdwlwenhek lsls
//
