LOCUS       NM_010773               1866 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus methyl-CpG binding domain protein 2 (Mbd2), transcript
            variant 1, mRNA.
ACCESSION   NM_010773 XM_001000950
VERSION     NM_010773.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Guo,Y., Wu,D., Li,X., Wang,J., Li,H., Li,Y., Luo,D., Yi,F. and
            Zhang,D.
  TITLE     Proximal tubular MBD2 promotes autophagy to drive the progression
            of AKI caused by vancomycin via regulation of miR-597-5p/S1PR1 axis
  JOURNAL   FASEB J 38 (7), e23562 (2024)
   PUBMED   38578557
  REMARK    GeneRIF: Proximal tubular MBD2 promotes autophagy to drive the
            progression of AKI caused by vancomycin via regulation of
            miR-597-5p/S1PR1 axis.
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Mahmood,N., Arakelian,A., Szyf,M. and Rabbani,S.A.
  TITLE     Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer
            progression through the modulation of epithelial-to-mesenchymal
            transition
  JOURNAL   Exp Mol Med 56 (4), 959-974 (2024)
   PUBMED   38556549
  REMARK    GeneRIF: Methyl-CpG binding domain protein 2 (Mbd2) drives breast
            cancer progression through the modulation of
            epithelial-to-mesenchymal transition.
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Duan,W., Huang,J., Wasti,B., Chen,Z., Yuan,Y., He,Y., Li,D.,
            Jia,J., Liu,S., Liu,Y., Ma,L., Zeng,Q., Zhu,L., Li,J., Zhang,X. and
            Xiang,X.
  TITLE     miR-146a-3p as a potential novel therapeutic by targeting MBD2 to
            mediate Th17 differentiation in Th17 predominant neutrophilic
            severe asthma
  JOURNAL   Clin Exp Med 23 (6), 2839-2854 (2023)
   PUBMED   36961677
  REMARK    GeneRIF: miR-146a-3p as a potential novel therapeutic by targeting
            MBD2 to mediate Th17 differentiation in Th17 predominant
            neutrophilic severe asthma.
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Lax,E., Do Carmo,S., Enuka,Y., Sapozhnikov,D.M., Welikovitch,L.A.,
            Mahmood,N., Rabbani,S.A., Wang,L., Britt,J.P., Hancock,W.W.,
            Yarden,Y. and Szyf,M.
  TITLE     Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of
            autism-risk genes and cognition
  JOURNAL   Transl Psychiatry 13 (1), 259 (2023)
   PUBMED   37443311
  REMARK    GeneRIF: Methyl-CpG binding domain 2 (Mbd2) is an epigenetic
            regulator of autism-risk genes and cognition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Klinowska,T.C., Alexander,C.M., Georges-Labouesse,E., Van der
            Neut,R., Kreidberg,J.A., Jones,C.J., Sonnenberg,A. and Streuli,C.H.
  TITLE     Epithelial development and differentiation in the mammary gland is
            not dependent on alpha 3 or alpha 6 integrin subunits
  JOURNAL   Dev Biol 233 (2), 449-467 (2001)
   PUBMED   11336507
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Hendrich,B., Guy,J., Ramsahoye,B., Wilson,V.A. and Bird,A.
  TITLE     Closely related proteins MBD2 and MBD3 play distinctive but
            interacting roles in mouse development
  JOURNAL   Genes Dev 15 (6), 710-723 (2001)
   PUBMED   11274056
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Guy,J., Hendrich,B., Holmes,M., Martin,J.E. and Bird,A.
  TITLE     A mouse Mecp2-null mutation causes neurological symptoms that mimic
            Rett syndrome
  JOURNAL   Nat Genet 27 (3), 322-326 (2001)
   PUBMED   11242117
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Hendrich,B., Abbott,C., McQueen,H., Chambers,D., Cross,S. and
            Bird,A.
  TITLE     Genomic structure and chromosomal mapping of the murine and human
            Mbd1, Mbd2, Mbd3, and Mbd4 genes
  JOURNAL   Mamm Genome 10 (9), 906-912 (1999)
   PUBMED   10441743
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX239662.1, AF072243.1, AK147008.1 and BU757659.1.
            
            On Dec 30, 2008 this sequence version replaced NM_010773.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046607.1, AF072243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               CX239662.1         10-127
            119-474             AF072243.1         77-432
            475-1844            AK147008.1         360-1729
            1845-1866           BU757659.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 44.54 cM"
     gene            1..1866
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /note="methyl-CpG binding domain protein 2"
                     /db_xref="GeneID:17191"
                     /db_xref="MGI:MGI:1333813"
     exon            1..676
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1370
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyl-CpG-binding protein MBD2; testis-specific
                     methyl-CpG binding protein 2"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 2 isoform 1"
                     /protein_id="NP_034903.2"
                     /db_xref="CCDS:CCDS29335.1"
                     /db_xref="GeneID:17191"
                     /db_xref="MGI:MGI:1333813"
                     /translation="MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPS
                     PVSGVRREGARGGGRGRGRWKQAARGGGVCGRGRGRGRGRGRGRGRGRGRGRPQSGGS
                     GLGGDGGGGAGGCGGGSGGGVAPRRDPVPFPSGSSGPGPRGPRATESGKRMDCPALPP
                     GWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSSFDFRTGKMMP
                     SKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKFTNHPSNKVKSDPQR
                     MNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHT
                     SSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMA
                     DILSRAADTEEVDIDMDSGDEA"
     exon            677..836
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     exon            837..974
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1065
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1243
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1382
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1850
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcgccc gctctatgat gcttgcgcgc gtcccccgcg cgccgctctg cgggcggggc
       61 gggtctccgg gattccaagg gctcggttac ggaagaagcg cagagccggc tggggagggg
      121 gctggatgcg cgcgcacccg gggggaggcc gctgctgccc ggagcaggag gagggggaga
      181 gcgcggcggg cggcagcggc gctggcggcg actccgccat agagcagggg ggccagggca
      241 gcgcgctcgc tccgtccccg gtgagcggcg tgcgcaggga aggcgctcgg ggcggcggcc
      301 gtggccgggg gcggtggaag caggcggccc ggggcggcgg cgtctgtggc cgtggccgtg
      361 gccgtggccg gggtcggggc cgtggccggg gccggggccg gggccgcggc cgtccccaga
      421 gtggcggcag cggccttggc ggcgacggcg gcggcggcgc gggcggctgc ggcggcggca
      481 gcggtggcgg cgtcgccccc cggcgggatc ctgtcccttt cccgtcgggg agctcggggc
      541 cggggcccag gggaccccgg gccacggaga gcgggaagag gatggactgc ccggccctcc
      601 cccccggatg gaagaaggag gaagtgatcc gaaaatcagg gctcagtgct ggcaagagcg
      661 atgtctacta cttcagtcca agtggtaaga agttcagaag taaacctcag ctggcaagat
      721 acctgggaaa tgctgttgac cttagcagtt ttgacttcag gaccggcaag atgatgccta
      781 gtaaattaca gaagaacaag cagagactcc ggaatgaccc cctcaatcag aacaagggta
      841 aaccagacct gaacacaaca ttgccaatta gacaaactgc atcaattttc aagcaaccag
      901 taaccaaatt cacgaaccac ccgagcaata aggtgaagtc agacccccag cggatgaatg
      961 aacaaccacg tcagcttttc tgggagaaga ggctacaagg acttagcgca tcagatgtaa
     1021 cagaacaaat tataaaaacc atggagctac ctaaaggtct tcaaggagtc ggtccaggta
     1081 gcaatgacga gacccttctg tctgctgtgg ccagtgcttt acacacaagc tctgcgccca
     1141 tcacaggaca agtctctgct gccgtggaaa agaaccctgc tgtttggctt aacacatctc
     1201 aacccctctg caaagctttc attgttacag atgaagacat taggaaacag gaagagcgag
     1261 tccaacaagt acgcaagaaa ctggaggagg cactgatggc cgacatcctg tcccgggctg
     1321 cggacacgga ggaagtagac attgacatgg acagtggaga tgaggcgtaa gaatatgatc
     1381 aggtaacttt cgactgacct tccccaagag caaattgcta gaaacagaat taaaacattt
     1441 ccactgggtt tcgcctgtaa gaaaaagtgt acctgagcac atagcttttt aatagcacta
     1501 accaatgcct ttttagatgt atttttgatg tatatatcta ttattccaaa tgatgtttat
     1561 tttgaatcct aggacttaaa atgagtcttt tataatagca agcagggccc ttccggtgca
     1621 gtgcagcttt gaggccaggt gcagtctact ggaaaggtag cacttacgtg aaatatttgt
     1681 ttcccccaca gttttaatat aaacagatca ggagtaccaa ataagtttcc caattaaaga
     1741 ttattatact tcactgtata taaacagatt tttatacttt attgaaagaa gatacctgta
     1801 cattcttcca tcatcactgt aaagacaaat aaatgactat attcacagac aaaaaaaaaa
     1861 aaaaaa
//
