LOCUS       NM_001164047            1121 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus myoglobin (Mb), transcript variant 1, mRNA.
ACCESSION   NM_001164047
VERSION     NM_001164047.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1121)
  AUTHORS   Rao,K., Rochon,E., Singh,A., Jagannathan,R., Peng,Z., Mansoor,H.,
            Wang,B., Moulik,M., Zhang,M., Saraf,A., Corti,P. and Shiva,S.
  TITLE     Myoglobin modulates the Hippo pathway to promote cardiomyocyte
            differentiation
  JOURNAL   iScience 27 (3), 109146 (2024)
   PUBMED   38414852
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1121)
  AUTHORS   Aboouf,M.A., Gorr,T.A., Hamdy,N.M., Gassmann,M. and Thiersch,M.
  TITLE     Myoglobin in Brown Adipose Tissue: A Multifaceted Player in
            Thermogenesis
  JOURNAL   Cells 12 (18), 2240 (2023)
   PUBMED   37759463
  REMARK    GeneRIF: Myoglobin in Brown Adipose Tissue: A Multifaceted Player
            in Thermogenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1121)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1121)
  AUTHORS   Aboouf,M.A., Armbruster,J., Guscetti,F., Thiersch,M., Boss,A.,
            Godecke,A., Winning,S., Padberg,C., Fandrey,J., Kristiansen,G.,
            Bicker,A., Hankeln,T., Gassmann,M. and Gorr,T.A.
  TITLE     Endogenous myoglobin expression in mouse models of mammary
            carcinoma reduces hypoxia and metastasis in PyMT mice
  JOURNAL   Sci Rep 13 (1), 7530 (2023)
   PUBMED   37161046
  REMARK    GeneRIF: Endogenous myoglobin expression in mouse models of mammary
            carcinoma reduces hypoxia and metastasis in PyMT mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1121)
  AUTHORS   Aboouf,M.A., Armbruster,J., Thiersch,M., Gassmann,M., Godecke,A.,
            Gnaiger,E., Kristiansen,G., Bicker,A., Hankeln,T., Zhu,H. and
            Gorr,T.A.
  TITLE     Myoglobin, expressed in brown adipose tissue of mice, regulates the
            content and activity of mitochondria and lipid droplets
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (12), 159026 (2021)
   PUBMED   34384891
  REMARK    GeneRIF: Myoglobin, expressed in brown adipose tissue of mice,
            regulates the content and activity of mitochondria and lipid
            droplets.
REFERENCE   6  (bases 1 to 1121)
  AUTHORS   Pingault,V., Puliti,A., Prehu,M.O., Samadi,A., Bondurand,N. and
            Goossens,M.
  TITLE     Human homology and candidate genes for the Dominant megacolon
            locus, a mouse model of Hirschsprung disease
  JOURNAL   Genomics 39 (1), 86-89 (1997)
   PUBMED   9027489
REFERENCE   7  (bases 1 to 1121)
  AUTHORS   Parsons,W.J., Richardson,J.A., Graves,K.H., Williams,R.S. and
            Moreadith,R.W.
  TITLE     Gradients of transgene expression directed by the human myoglobin
            promoter in the developing mouse heart
  JOURNAL   Proc Natl Acad Sci U S A 90 (5), 1726-1730 (1993)
   PUBMED   8446585
REFERENCE   8  (bases 1 to 1121)
  AUTHORS   Drouet,B. and Simon-Chazottes,D.
  TITLE     The microsatellite found in the DNA sequence with the code name
            MMMYOGG1 (GenBank) does not correspond to the myogenin gene (Myog)
            but to myoglobin (Mb) and maps to mouse chromosome 15
  JOURNAL   Mamm Genome 4 (6), 348 (1993)
   PUBMED   8391346
REFERENCE   9  (bases 1 to 1121)
  AUTHORS   Blanchetot,A., Price,M. and Jeffreys,A.J.
  TITLE     The mouse myoglobin gene. Characterisation and sequence comparison
            with other mammalian myoglobin genes
  JOURNAL   Eur J Biochem 159 (3), 469-474 (1986)
   PUBMED   3758071
REFERENCE   10 (bases 1 to 1121)
  AUTHORS   Harris,D.E., Gurnett,A.M., Lehmann,H. and Joysey,K.A.
  TITLE     The myoglobin of rodents Proechimys guairae (casiragua) and Mus
            musculus (house mouse)
  JOURNAL   FEBS Lett 190 (2), 288-292 (1985)
   PUBMED   4043406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157554.7, AK137456.1 and BX527493.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 all encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137456.1, CA786897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC157554.7         14213-14359
            148-1104            AK137456.1         3-959
            1105-1121           BX527493.1         368-384
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.36 cM"
     gene            1..1121
                     /gene="Mb"
                     /note="myoglobin"
                     /db_xref="GeneID:17189"
                     /db_xref="MGI:MGI:96922"
     exon            1..299
                     /gene="Mb"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..669
                     /gene="Mb"
                     /note="pseudoperoxidase MB; nitrite reductase MB"
                     /codon_start=1
                     /product="myoglobin"
                     /protein_id="NP_001157519.1"
                     /db_xref="CCDS:CCDS27597.1"
                     /db_xref="GeneID:17189"
                     /db_xref="MGI:MGI:96922"
                     /translation="MGLSDGEWQLVLNVWGKVEADLAGHGQEVLIGLFKTHPETLDKF
                     DKFKNLKSEEDMKGSEDLKKHGCTVLTALGTILKKKGQHAAEIQPLAQSHATKHKIPV
                     KYLEFISEIIIEVLKKRHSGDFGADAQGAMSKALELFRNDIAAKYKELGFQG"
     exon            300..522
                     /gene="Mb"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1108
                     /gene="Mb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1084..1089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mb"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="Mb"
                     /note="major polyA site"
ORIGIN      
        1 tagctgccca tgtgagggcc agagaaaggc agagattaga cccctggagg gttgagcacg
       61 gtagcaggaa gggcatgtgg cacccagtga tcctggccag actagcatct gggaaggtat
      121 aaaagccctt caggaccagg tggcctcaaa tctcagctga cagccagccc acactctctc
      181 cttttgtcct ctttagaagc caccatgggg ctcagtgatg gggagtggca gctggtgctg
      241 aatgtctggg ggaaggtgga ggccgacctt gctggccatg gacaggaagt cctcatcggt
      301 ctgtttaaga ctcaccctga gaccctggat aagtttgaca agttcaagaa cttgaagtca
      361 gaggaagata tgaagggctc agaggacctg aagaagcatg gttgcaccgt gctcacagcc
      421 ctgggtacca tcctgaagaa gaagggacaa catgctgccg agatccagcc tctagcccaa
      481 tcacacgcca ccaagcacaa gatcccggtc aagtacctgg agtttatctc agaaattatc
      541 attgaagtcc tgaagaagag acattccggg gactttggag cagatgctca gggcgccatg
      601 agcaaggccc tggagctctt ccggaatgac attgccgcca agtacaagga gctaggcttc
      661 cagggctgag ccatgggctc ccactgtcca gcccaccaag ctgggaccca gtgttgtgta
      721 gcaagtagcg tgtgcagtgt tctaggttag cagagaacag aagaggggag catagtgtgg
      781 catccaccca cacccctggg gacagggctc tgggcagtgt taccctggag cccagaggtg
      841 caaagtggcc ttcgtcagct ctgccgggtc atgctcaggt ctcctaagtc ccagtccatt
      901 ttcttctggt tttgggaaaa tctcttttcc actgtcacat ttgaccccaa atccaagtca
      961 ctgactagca gaccctgacc tttgggcgag atggagggtt gcttagaggg agtggagggt
     1021 gaaaacgggg cggtgagcat caagtctccc actgctcagc ttcccgttga cccaccttgt
     1081 ctcaataaaa tatcctgcga gtcctcaaaa aaaaaaaaaa a
//
